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A cellular screening assay using analysis of metal-modified fluorescence lifetime (2010)
Journal Article
Richards, D., Ng, T., Fruhwirth, G., Cade, N. I., & Archibald, S. J. (2010). A cellular screening assay using analysis of metal-modified fluorescence lifetime. Biophysical journal, 98(11), 2752-2757. doi:10.1016/j.bpj.2010.03.016

Current methods for screening cell receptor internalization often require complex image analysis with limited sensitivity. Here we describe a novel bioassay based on detection of changes in global fluorescence lifetime above a gold substrate, with su... Read More