All Outputs (378)

Epidemiological pathology of Aβ deposition in the ageing brain in CFAS: addition of multiple Aβ-derived measures does not improve dementia assessment using logistic regression and machine learning approaches (2019)
Journal Article
Wharton, S. B., Wang, D., Parikh, C., Matthews, F. E., Brayne, C., & Ince, P. G. (2019). Epidemiological pathology of Aβ deposition in the ageing brain in CFAS: addition of multiple Aβ-derived measures does not improve dementia assessment using logistic regression and machine learning approaches. Acta Neuropathologica Communications, 7(1), 198. https://doi.org/10.1186/s40478-019-0858-4

Aβ-amyloid deposition is a key feature of Alzheimer's disease, but Consortium to Establish a Registry for Alzheimer's Disease (CERAD) assessment, based on neuritic plaque density, shows a limited relationships to dementia. Thal phase is based on a ne... Read More about Epidemiological pathology of Aβ deposition in the ageing brain in CFAS: addition of multiple Aβ-derived measures does not improve dementia assessment using logistic regression and machine learning approaches.

Social isolation, cognitive reserve, and cognition in older people with depression and anxiety (2019)
Journal Article
Evans, I. E., Llewellyn, D. J., Matthews, F. E., Woods, R. T., Brayne, C., & Clare, L. (2019). Social isolation, cognitive reserve, and cognition in older people with depression and anxiety. Aging and Mental Health, 23(12), 1691-1700. https://doi.org/10.1080/13607863.2018.1506742

Objectives: Poor social connections may be associated with poor cognition in older people who are not experiencing mental health problems, and the trajectory of this association may be moderated by cognitive reserve. However, it is unclear whether th... Read More about Social isolation, cognitive reserve, and cognition in older people with depression and anxiety.

Perceptual and conceptual processing of visual objects across the adult lifespan (2019)
Journal Article
Bruffaerts, R., Tyler, L. K., Shafto, M., Tsvetanov, K. A., Brayne, C., Bullmore, E. T., Calder, A. C., Cusack, R., Dalgleish, T., Duncan, J., Henson, R. N., Matthews, F. E., Marslen-Wilson, W. D., Rowe, J. B., Campbell, K., Cheung, T., Davis, S., Geerligs, L., Kievit, R., McCarrey, A., …Clarke, A. (2019). Perceptual and conceptual processing of visual objects across the adult lifespan. Scientific reports, 9(1), https://doi.org/10.1038/s41598-019-50254-5

Making sense of the external world is vital for multiple domains of cognition, and so it is crucial that object recognition is maintained across the lifespan. We investigated age differences in perceptual and conceptual processing of visual objects i... Read More about Perceptual and conceptual processing of visual objects across the adult lifespan.

Two-decade change in prevalence of cognitive impairment in the UK (2019)
Journal Article
Richardson, C., Stephan, B. C., Robinson, L., Brayne, C., & Matthews, F. E. (2019). Two-decade change in prevalence of cognitive impairment in the UK. European Journal of Epidemiology, 34(11), 1085-1092. https://doi.org/10.1007/s10654-019-00554-x

Identification of individuals at high risk of dementia has usually focused attention on the clinical concept of mild cognitive impairment (MCI), which captures an intermediate state between normal cognitive ageing and dementia. In many countries age... Read More about Two-decade change in prevalence of cognitive impairment in the UK.

Anticholinergic and benzodiazepine medication use and risk of incident dementia: A UK cohort study (2019)
Journal Article
Grossi, C. M., Richardson, K., Fox, C., Maidment, I., Steel, N., Loke, Y. K., Arthur, A., Myint, P. K., Campbell, N., Boustani, M., Robinson, L., Brayne, C., Matthews, F. E., & Savva, G. M. (2019). Anticholinergic and benzodiazepine medication use and risk of incident dementia: A UK cohort study. BMC Geriatrics, 19(1), https://doi.org/10.1186/s12877-019-1280-2

Background: Studies suggest that anticholinergic medication or benzodiazepine use could increase dementia risk. We tested this hypothesis using data from a UK cohort study. Methods: We used data from the baseline (Y0), 2-year (Y2) and 10-year (Y10) w... Read More about Anticholinergic and benzodiazepine medication use and risk of incident dementia: A UK cohort study.

Cognitive Diversity in a Healthy Aging Cohort: Cross-Domain Cognition in the Cam-CAN Project (2019)
Journal Article
Shafto, M. A., Henson, R. N., Matthews, F. E., Taylor, J. R., Emery, T., Erzinclioglu, S., Hanley, C., Rowe, J. B., Cusack, R., Calder, A. J., Marslen-Wilson, W. D., Duncan, J., Dalgleish, T., Brayne, C., Cam-CAN, & Tyler, L. K. (2020). Cognitive Diversity in a Healthy Aging Cohort: Cross-Domain Cognition in the Cam-CAN Project. Journal of Aging and Health, 32(9), 1029-1041. https://doi.org/10.1177/0898264319878095

Objective: Studies of “healthy” cognitive aging often focus on a limited set of measures that decline with age. The current study argues that defining and supporting healthy cognition requires understanding diverse cognitive performance across the li... Read More about Cognitive Diversity in a Healthy Aging Cohort: Cross-Domain Cognition in the Cam-CAN Project.

Changing prevalence and treatment of depression among older people over two decades (2019)
Journal Article
Arthur, A., Savva, G. M., Barnes, L. E., Borjian-Boroojeny, A., Dening, T., Jagger, C., Matthews, F. E., Robinson, L., Brayne, C., The Cognitive Function, Green, E., Gao, L., Barnes, R., Baldwin, C., Comas-Herrera, A., Forster, G., Harrison, S., Ince, P. G., McKeith, I. G., Parry, B., …Woods, B. (2020). Changing prevalence and treatment of depression among older people over two decades. British Journal of Psychiatry, 216(1), 49-54. https://doi.org/10.1192/bjp.2019.193

Background Depression is a leading cause of disability, with older people particularly susceptible to poor outcomes.Aims To investigate whether the prevalence of depression and antidepressant use have changed across two decades in older people.Method... Read More about Changing prevalence and treatment of depression among older people over two decades.

Relationship between depressive symptoms and capability to live well in people with mild to moderate dementia and their carers: results from the Improving the experience of Dementia and Enhancing Active Life (IDEAL) programme (2019)
Journal Article
Wu, Y. T., Clare, L., & Matthews, F. E. (2021). Relationship between depressive symptoms and capability to live well in people with mild to moderate dementia and their carers: results from the Improving the experience of Dementia and Enhancing Active Life (IDEAL) programme. Aging and Mental Health, 25(1), 38-45. https://doi.org/10.1080/13607863.2019.1671316

Objectives: Depression is a common condition in dementia and has a substantial impact on quality of life and wellbeing. There is limited evidence on how depressive symptoms in the person with dementia impact on the carer, and vice versa. The aim of t... Read More about Relationship between depressive symptoms and capability to live well in people with mild to moderate dementia and their carers: results from the Improving the experience of Dementia and Enhancing Active Life (IDEAL) programme.

Estimation of life expectancies using continuous-time multi-state models (2019)
Journal Article
van den Hout, A., Sum Chan, M., & Matthews, F. (2019). Estimation of life expectancies using continuous-time multi-state models. Computer Methods and Programs in Biomedicine, 178, 11-18. https://doi.org/10.1016/j.cmpb.2019.06.004

Background and objective: There is increasing interest in multi-state modelling of health-related stochastic processes. Given a fitted multi-state model with one death state, it is possible to estimate state-specific and marginal life expectancies. T... Read More about Estimation of life expectancies using continuous-time multi-state models.

Putative risk alleles for LATE-NC with hippocampal sclerosis in population-representative autopsy cohorts (2019)
Journal Article
Hokkanen, S. R., Kero, M., Kaivola, K., Hunter, S., Keage, H. A., Kiviharju, A., Raunio, A., Tienari, P. J., Paetau, A., Matthews, F. E., Fleming, J., Graff, C., Polvikoski, T. M., Myllykangas, L., & Brayne, C. (2020). Putative risk alleles for LATE-NC with hippocampal sclerosis in population-representative autopsy cohorts. Brain Pathology, 30(2), 364-372. https://doi.org/10.1111/bpa.12773

Limbic-predominant age-related TAR-DNA-binding protein-43 (TDP-43) encephalopathy with hippocampal sclerosis pathology (LATE-NC + HS) is a neurodegenerative disorder characterized by severe hippocampal CA1 neuron loss and TDP-43-pathology, leading to... Read More about Putative risk alleles for LATE-NC with hippocampal sclerosis in population-representative autopsy cohorts.

Socio-economic inequalities in life expectancy of older adults with and without multimorbidity: A record linkage study of 1.1 million people in England (2019)
Journal Article
Chan, M. S., Van Den Hout, A., Pujades-Rodriguez, M., Jones, M. M., Matthews, F. E., Jagger, C., Raine, R., & Bajekal, M. (2019). Socio-economic inequalities in life expectancy of older adults with and without multimorbidity: A record linkage study of 1.1 million people in England. International Journal of Epidemiology, 48(4), 1340-1351. https://doi.org/10.1093/ije/dyz052

Background: Age of onset of multimorbidity and its prevalence are well documented. However, its contribution to inequalities in life expectancy has yet to be quantified. Methods: A cohort of 1.1 million English people aged 45 and older were followed... Read More about Socio-economic inequalities in life expectancy of older adults with and without multimorbidity: A record linkage study of 1.1 million people in England.

History of Benzodiazepine Prescriptions and Risk of Dementia: Possible Bias Due to Prevalent Users and Covariate Measurement Timing in a Nested Case-Control Study (2019)
Journal Article
Richardson, K., Mattishent, K., Loke, Y. K., Steel, N., Fox, C., Grossi, C. M., Bennett, K., Maidment, I., Boustani, M., Matthews, F. E., Myint, P. K., Campbell, N. L., Brayne, C., Robinson, L., & Savva, G. M. (2019). History of Benzodiazepine Prescriptions and Risk of Dementia: Possible Bias Due to Prevalent Users and Covariate Measurement Timing in a Nested Case-Control Study. American Journal of Epidemiology, 188(7), 1228-1236. https://doi.org/10.1093/aje/kwz073

Previous estimates of whether long-term exposure to benzodiazepines increases dementia risk are conflicting and are compromised by the difficulty of controlling for confounders and by reverse causation. We investigated how estimates for the associati... Read More about History of Benzodiazepine Prescriptions and Risk of Dementia: Possible Bias Due to Prevalent Users and Covariate Measurement Timing in a Nested Case-Control Study.

Social isolation, cognitive reserve, and cognition in healthy older people (2019)
Journal Article
Evans, I. E., Llewellyn, D. J., Matthews, F. E., Woods, R. T., Brayne, C., Clare, L., Clarra, L., Windle, G., Burholt, V., Philips, J., McCracken, C., & Bennett, K. (2019). Social isolation, cognitive reserve, and cognition in healthy older people. PLoS ONE, 13(8), https://doi.org/10.1371/journal.pone.0201008

There is evidence to suggest that social isolation is associated with poor cognitive health, although findings are contradictory. One reason for inconsistency in reported findings may be a lack of consideration of underlying mechanisms that could inf... Read More about Social isolation, cognitive reserve, and cognition in healthy older people.

The impact of co-morbidity on the quality of life of people with dementia: Findings from the IDEAL study (2019)
Journal Article
Nelis, S. M., Wu, Y. T., Matthews, F. E., Martyr, A., Quinn, C., Rippon, I., Rusted, J., Thom, J. M., Kopelman, M. D., Hindle, J. V., Jones, R. W., & Clare, L. (2019). The impact of co-morbidity on the quality of life of people with dementia: Findings from the IDEAL study. Age and ageing, 48(3), 361-367. https://doi.org/10.1093/ageing/afy155

Background: The aim was to investigate the co-morbidity profile of people with dementia and examine the associations between severity of co-morbidity, health-related quality of life (HRQoL) and quality of life (QoL). Methods: The improving the experi... Read More about The impact of co-morbidity on the quality of life of people with dementia: Findings from the IDEAL study.

What is the evidence that people with frailty have needs for palliative care at the end of life? A systematic review and narrative synthesis (2019)
Journal Article
Stow, D., Spiers, G., Matthews, F. E., & Hanratty, B. (2019). What is the evidence that people with frailty have needs for palliative care at the end of life? A systematic review and narrative synthesis. Palliative medicine, 33(4), 399-414. https://doi.org/10.1177/0269216319828650

Background: The number of older people living and dying with frailty is rising, but our understanding of their end-of-life care needs is limited. Aim: To synthesise evidence on the end-of-life care needs of people with frailty. Design: Systematic rev... Read More about What is the evidence that people with frailty have needs for palliative care at the end of life? A systematic review and narrative synthesis.

Living alone and cognitive function in later life (2019)
Journal Article
Evans, I. E., Llewellyn, D. J., Matthews, F. E., Woods, R. T., Brayne, C., & Clare, L. (2019). Living alone and cognitive function in later life. Archives of Gerontology and Geriatrics, 81, 222-233. https://doi.org/10.1016/j.archger.2018.12.014

Background: Living alone may be associated with greater risk for social isolation and loneliness. Living alone, social isolation, loneliness, and limited engagement in social activity have all been associated with poorer cognitive function in later l... Read More about Living alone and cognitive function in later life.

Autism prevalence in China is comparable to Western prevalence (2019)
Journal Article
Sun, X., Allison, C., Wei, L., Matthews, F. E., Auyeung, B., Wu, Y. Y., Griffiths, S., Zhang, J., Baron-Cohen, S., & Brayne, C. (2019). Autism prevalence in China is comparable to Western prevalence. Molecular Autism, 10(1), https://doi.org/10.1186/s13229-018-0246-0

Background: Autism prevalence in the West is approximately 1% of school age children. Autism prevalence in China has been reported to be lower than in the West. This is likely due to at least two reasons: (1) most studies in China only included the s... Read More about Autism prevalence in China is comparable to Western prevalence.

Translational research on reserve against neurodegenerative disease: Consensus report of the International Conference on Cognitive Reserve in the Dementias and the Alzheimer's Association Reserve, Resilience and Protective Factors Professional Interest Area working groups (2019)
Journal Article
Perneczky, R., Kempermann, G., Korczyn, A. D., Matthews, F. E., Ikram, M. A., Scarmeas, N., Chetelat, G., Stern, Y., & Ewers, M. (2019). Translational research on reserve against neurodegenerative disease: Consensus report of the International Conference on Cognitive Reserve in the Dementias and the Alzheimer's Association Reserve, Resilience and Protective Factors Professional Interest Area working groups. BMC medicine, 17(1), https://doi.org/10.1186/s12916-019-1283-z

Background: The concept of reserve was established to account for the observation that a given degree of neurodegenerative pathology may result in varying degrees of symptoms in different individuals. There is a large amount of evidence on epidemiolo... Read More about Translational research on reserve against neurodegenerative disease: Consensus report of the International Conference on Cognitive Reserve in the Dementias and the Alzheimer's Association Reserve, Resilience and Protective Factors Professional Interest Area working groups.

Strong and specific associations between cardiovascular risk factors and white matter micro- and macrostructure in healthy aging (2019)
Journal Article
Fuhrmann, D., Nesbitt, D., Shafto, M., Rowe, J. B., Price, D., Gadie, A., Tyler, L. K., Brayne, C., Bullmore, E. T., Calder, A. C., Cusack, R., Dalgleish, T., Duncan, J., Henson, R. N., Matthews, F. E., Marslen-Wilson, W. D., Shafto, M. A., Campbell, K., Cheung, T., Davis, S., …Kievit, R. A. (2019). Strong and specific associations between cardiovascular risk factors and white matter micro- and macrostructure in healthy aging. Neurobiology of Aging, 74, 46-55. https://doi.org/10.1016/j.neurobiolaging.2018.10.005

Cardiovascular health declines with age, increasing the risk of hypertension and elevated heart rate in middle and old age. Here, we used multivariate techniques to investigate the associations between cardiovascular health (diastolic blood pressure,... Read More about Strong and specific associations between cardiovascular risk factors and white matter micro- and macrostructure in healthy aging.

Does older adults’ use of social care influence their healthcare utilisation? A systematic review of international evidence (2019)
Journal Article
Spiers, G., Matthews, F. E., Moffatt, S., Barker, R., Jarvis, H., Stow, D., Kingston, A., & Hanratty, B. (2019). Does older adults’ use of social care influence their healthcare utilisation? A systematic review of international evidence. Health and Social Care in the Community, 27(5), e651-e662. https://doi.org/10.1111/hsc.12798

Improving our understanding of the complex relationship between health and social care utilisation is vital as populations age. This systematic review aimed to synthesise evidence on the relationship between older adults’ use of social care and their... Read More about Does older adults’ use of social care influence their healthcare utilisation? A systematic review of international evidence.