All Outputs (378)

Exploring patterns of response across the lifespan: The Cambridge Centre for Ageing and Neuroscience (Cam-CAN) study (2018)
Journal Article
Green, E., Bennett, H., Brayne, C., Tyler, L. K., Bullmore, E. T., Calder, A. C., Cusack, R., Dalgleish, T., Duncan, J., Henson, R. N., Marslen-Wilson, W. D., Rowe, J. B., Shafto, M. A., Campbell, K., Cheung, T., Davis, S., Geerligs, L., Kievit, R., McCarrey, A., Mustafa, A., …Matthews, F. E. (2018). Exploring patterns of response across the lifespan: The Cambridge Centre for Ageing and Neuroscience (Cam-CAN) study. BMC public health, 18(1), https://doi.org/10.1186/s12889-018-5663-7

Background: With declining rates of participation in epidemiological studies there is an important need to attempt to understand what factors might affect response. This study examines the pattern of response at different adult ages within a contempo... Read More about Exploring patterns of response across the lifespan: The Cambridge Centre for Ageing and Neuroscience (Cam-CAN) study.

Sample size and classification error for Bayesian change-point models with unlabelled sub-groups and incomplete follow-up (2018)
Journal Article
White, S. R., Muniz-Terrera, G., & Matthews, F. E. (2018). Sample size and classification error for Bayesian change-point models with unlabelled sub-groups and incomplete follow-up. Statistical Methods in Medical Research, 27(5), 1476-1497. https://doi.org/10.1177/0962280216662298

Many medical (and ecological) processes involve the change of shape, whereby one trajectory changes into another trajectory at a specific time point. There has been little investigation into the study design needed to investigate these models. We con... Read More about Sample size and classification error for Bayesian change-point models with unlabelled sub-groups and incomplete follow-up.

Medication usage change in older people (65+) in England over 20 years: Findings from CFAS I and CFAS II (2018)
Journal Article
Gao, L., Maidment, I., Matthews, F. E., Robinson, L., & Brayne, C. (2018). Medication usage change in older people (65+) in England over 20 years: Findings from CFAS I and CFAS II. Age and ageing, 47(2), 220-225. https://doi.org/10.1093/ageing/afx158

Background: medical practice has changed over the last decades reflecting the ageing population, when multi-morbidity requiring multiple medications is more common. Objective: describe and quantify self-reported medicine use including both prescripti... Read More about Medication usage change in older people (65+) in England over 20 years: Findings from CFAS I and CFAS II.

Evolution of dementia diagnosis over time (1988–2013): Evidence from French and English cohorts. Implication for secular trends analyses (2018)
Journal Article
Grasset, L., Matthews, F. E., Pérès, K., Foubert-Samier, A., Helmer, C., Dartigues, J. F., & Brayne, C. (2018). Evolution of dementia diagnosis over time (1988–2013): Evidence from French and English cohorts. Implication for secular trends analyses. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 10, 490-497. https://doi.org/10.1016/j.dadm.2018.07.005

Introduction: The aims of this study are to examine the evolution of clinical dementia diagnosis over 3 decades and to investigate secular trends of dementia. Methods: Four cohorts covering a period from 1988 to 2013 were used: the Personnes Agées Qu... Read More about Evolution of dementia diagnosis over time (1988–2013): Evidence from French and English cohorts. Implication for secular trends analyses.

Anticholinergic drugs and risk of dementia: Case-control study (2018)
Journal Article
Richardson, K., Fox, C., Maidment, I., Steel, N., Loke, Y. K., Arthur, A., Myint, P. K., Grossi, C. M., Mattishent, K., Bennett, K., Campbell, N. L., Boustani, M., Robinson, L., Brayne, C., Matthews, F. E., & Savva, G. M. (2018). Anticholinergic drugs and risk of dementia: Case-control study. BMJ, 361, https://doi.org/10.1136/bmj.k1315

Objectives: To estimate the association between the duration and level of exposure to different classes of anticholinergic drugs and subsequent incident dementia. Design: Case-control study. Setting: General practices in the UK contributing to the Cl... Read More about Anticholinergic drugs and risk of dementia: Case-control study.

Cognitive reserve as a moderator of the negative association between mood and cognition: Evidence from a population-representative cohort (2018)
Journal Article
Opdebeeck, C., Matthews, F. E., Wu, Y. T., Woods, R. T., Brayne, C., & Clare, L. (2018). Cognitive reserve as a moderator of the negative association between mood and cognition: Evidence from a population-representative cohort. Psychological Medicine, 48(1), 61-71. https://doi.org/10.1017/S003329171700126X

Background Cognitive reserve (CR) has been associated with better cognitive function and lower risk of depression in older people, yet it remains unclear whether CR moderates the association between mood and cognition. This study aimed to investigate... Read More about Cognitive reserve as a moderator of the negative association between mood and cognition: Evidence from a population-representative cohort.

Dying comfortably in very old age with or without dementia in different care settings - A representative "older old" population study (2017)
Journal Article
Fleming, J., Calloway, R., Perrels, A., Farquhar, M., Barclay, S., Brayne, C., Allinson, K., Buck, J., Cosco, T., Davies, D., Dening, T., Hokkanen, S., Hunter, S., Keage, H., Lee, C., Matthews, F., Minett, T., Mukaetova-Ladinska, E., Terrera, G. M., Polvikoski, T., …Zhao, E. (2017). Dying comfortably in very old age with or without dementia in different care settings - A representative "older old" population study. BMC Geriatrics, 17(1), https://doi.org/10.1186/s12877-017-0605-2

Background: Comfort is frequently ranked important for a good death. Although rising numbers of people are dying in very old age, many with dementia, little is known about symptom control for "older old" people or whether care in different settings e... Read More about Dying comfortably in very old age with or without dementia in different care settings - A representative "older old" population study.

Trends in the incidence of dementia: design and methods in the Alzheimer Cohorts Consortium (2017)
Journal Article
Chibnik, L. B., Wolters, F. J., Bäckman, K., Beiser, A., Berr, C., Bis, J. C., Boerwinkle, E., Bos, D., Brayne, C., Dartigues, J. F., Darweesh, S. K., Debette, S., Davis-Plourde, K. L., Dufouil, C., Fornage, M., Grasset, L., Gudnason, V., Hadjichrysanthou, C., Helmer, C., Ikram, M. A., …Hofman, A. (2017). Trends in the incidence of dementia: design and methods in the Alzheimer Cohorts Consortium. European Journal of Epidemiology, 32(10), 931-938. https://doi.org/10.1007/s10654-017-0320-5

Several studies have reported a decline in incidence of dementia which may have large implications for the projected burden of disease, and provide important guidance to preventive efforts. However, reports are conflicting or inconclusive with regard... Read More about Trends in the incidence of dementia: design and methods in the Alzheimer Cohorts Consortium.

Neuropsychological profiles of vascular disease and risk of dementia: Implications for defining vascular cognitive impairment no dementia (VCI-ND) (2017)
Journal Article
Stephan, B. C. M., Minett, T., Muniz-Terrera, G., Harrison, S. L., Matthews, F. E., & Brayne, C. (2017). Neuropsychological profiles of vascular disease and risk of dementia: Implications for defining vascular cognitive impairment no dementia (VCI-ND). Age and ageing, 46(5), 755-760. https://doi.org/10.1093/ageing/afx016

Background: vascular cognitive impairment no dementia (VCI-ND) defines a preclinical phase of cognitive decline associated with vascular disorders. The neuropsychological profile of VCI-ND may vary according to different vascular conditions. Objectiv... Read More about Neuropsychological profiles of vascular disease and risk of dementia: Implications for defining vascular cognitive impairment no dementia (VCI-ND).

Micro-scale environment and mental health in later life: Results from the Cognitive Function and Ageing Study II (CFAS II) (2017)
Journal Article
Wu, Y. T., Prina, A. M., Jones, A., Barnes, L. E., Matthews, F. E., & Brayne, C. (2017). Micro-scale environment and mental health in later life: Results from the Cognitive Function and Ageing Study II (CFAS II). Journal of affective disorders, 218, 359-364. https://doi.org/10.1016/j.jad.2017.05.001

Background Poor micro-scale environmental features, such as graffiti and broken windows, have been associated with crime and signs of social disorder with a potential impact on mental health. The aim of this study is to investigate the association be... Read More about Micro-scale environment and mental health in later life: Results from the Cognitive Function and Ageing Study II (CFAS II).

Potential Value of Impaired Cognition in Stroke Prediction: A U.K. Population-Based Study (2017)
Journal Article
Stephan, B. C., Richardson, K., Savva, G. M., Matthews, F. E., Brayne, C., & Hachinski, V. (2017). Potential Value of Impaired Cognition in Stroke Prediction: A U.K. Population-Based Study. Journal of the American Geriatrics Society, 65(8), 1756-1762. https://doi.org/10.1111/jgs.14878

Objectives: To determine whether the association between impaired cognition and greater risk of incident stroke is also observed when cognitive impairment is defined using different criteria for mild cognitive impairment (MCI). Design: Prospective co... Read More about Potential Value of Impaired Cognition in Stroke Prediction: A U.K. Population-Based Study.

Changes over time in the health and functioning of older people moving into care homes: Analysis of data from the English Longitudinal Study of Ageing (2017)
Journal Article
Green, I., Stow, D., Matthews, F. E., & Hanratty, B. (2017). Changes over time in the health and functioning of older people moving into care homes: Analysis of data from the English Longitudinal Study of Ageing. Age and ageing, 46(4), 693-696. https://doi.org/10.1093/ageing/afx046

Background: the number of people requiring care home support is projected to rise in future years, but little information is available on the needs of new care home residents.Objective: to measure the health and functioning of people moving into care... Read More about Changes over time in the health and functioning of older people moving into care homes: Analysis of data from the English Longitudinal Study of Ageing.

The Built Environment and Cognitive Disorders: Results From the Cognitive Function and Ageing Study II (2017)
Journal Article
Wu, Y. T., Prina, A. M., Jones, A., Matthews, F. E., & Brayne, C. (2017). The Built Environment and Cognitive Disorders: Results From the Cognitive Function and Ageing Study II. American Journal of Preventive Medicine, 53(1), 25-32. https://doi.org/10.1016/j.amepre.2016.11.020

Introduction Built environment features have been related to behavior modification and might stimulate cognitive activity with a potential impact on cognitive health in later life. This study investigated cross-sectional associations between features... Read More about The Built Environment and Cognitive Disorders: Results From the Cognitive Function and Ageing Study II.

The changing prevalence and incidence of dementia over time-current evidence (2017)
Journal Article
Wu, Y. T., Beiser, A. S., Breteler, M. M., Fratiglioni, L., Helmer, C., Hendrie, H. C., Honda, H., Ikram, M. A., Langa, K. M., Lobo, A., Matthews, F. E., Ohara, T., Pérès, K., Qiu, C., Seshadri, S., Sjölund, B. M., Skoog, I., & Brayne, C. (2017). The changing prevalence and incidence of dementia over time-current evidence. Nature Reviews Neurology, 13(6), 327-339. https://doi.org/10.1038/nrneurol.2017.63

Dementia is an increasing focus for policymakers, civil organizations and multidisciplinary researchers. The most recent descriptive epidemiological research into dementia is enabling investigation into how the prevalence and incidence are changing o... Read More about The changing prevalence and incidence of dementia over time-current evidence.

Preserved cognitive functions with age are determined by domain-dependent shifts in network responsivity (2017)
Journal Article
Samu, D., Campbell, K. L., Tsvetanov, K. A., Shafto, M. A., Brayne, C., Bullmore, E. T., Calder, A. C., Cusack, R., Dalgleish, T., Duncan, J., Henson, R. N., Matthews, F. E., Marslen-Wilson, W. D., Rowe, J. B., Cheung, T., Davis, S., Geerligs, L., Kievit, R., McCarrey, A., Mustafa, A., …Tyler, L. K. (2017). Preserved cognitive functions with age are determined by domain-dependent shifts in network responsivity. Nature communications, 8, https://doi.org/10.1038/ncomms14743

Healthy ageing has disparate effects on different cognitive domains. The neural basis of these differences, however, is largely unknown. We investigated this question by using Independent Components Analysis to obtain functional brain components from... Read More about Preserved cognitive functions with age are determined by domain-dependent shifts in network responsivity.

Metaflammasome components in the human brain: a role in dementia with Alzheimer's pathology? (2017)
Journal Article
Taga, M., Minett, T., Classey, J., Matthews, F. E., Brayne, C., Ince, P. G., Nicoll, J. A., Hugon, J., & Boche, D. (2017). Metaflammasome components in the human brain: a role in dementia with Alzheimer's pathology?. Brain Pathology, 27(3), 266-275. https://doi.org/10.1111/bpa.12388

Epidemiological and genetic studies have identified metabolic disorders and inflammation as risk factors for Alzheimer's disease (AD). Evidence in obesity and type-2 diabetes suggests a role for a metabolic inflammasome (“metaflammasome”) in mediatin... Read More about Metaflammasome components in the human brain: a role in dementia with Alzheimer's pathology?.

Patterns and persistence of behavioural and psychological symptoms in those with cognitive impairment: the importance of apathy (2017)
Journal Article
van der Linde, R. M., Matthews, F. E., Dening, T., & Brayne, C. (2017). Patterns and persistence of behavioural and psychological symptoms in those with cognitive impairment: the importance of apathy. International journal of geriatric psychiatry, 32(3), 306-315. https://doi.org/10.1002/gps.4464

Objective: To study the stability and emergence of a range of behavioural and psychological symptoms (BPS), their association with mortality and the effect of covariates on these transitions in a population-based study of cognitively impaired older p... Read More about Patterns and persistence of behavioural and psychological symptoms in those with cognitive impairment: the importance of apathy.

Association of delirium with cognitive decline in late life: A neuropathologic study of 3 population-based cohort studies (2017)
Journal Article
Davis, D. H., Muniz-Terrera, G., Keage, H. A., Stephan, B. C., Fleming, J., Ince, P. G., Matthews, F. E., Cunningham, C., Ely, E. W., MacLullich, A. M., Brayne, C., McKeith, I., Polvikoski, T., Sulkava, R., Hardy, J., Melzer, D., Myllykangas, L., Nicoll, J., Singleton, A., Tienari, P., …Oinas, M. (2017). Association of delirium with cognitive decline in late life: A neuropathologic study of 3 population-based cohort studies. JAMA Psychiatry, 74(3), 244-251. https://doi.org/10.1001/jamapsychiatry.2016.3423

Importance: Delirium is associated with accelerated cognitive decline. The pathologic substrates of this association are not yet known, that is, whether they are the same as those associated with dementia, are independent, or are interrelated. Object... Read More about Association of delirium with cognitive decline in late life: A neuropathologic study of 3 population-based cohort studies.

Potentially modifiable lifestyle factors, cognitive reserve, and cognitive function in later life: A cross-sectional study (2017)
Journal Article
Clare, L., Wu, Y. T., Teale, J. C., MacLeod, C., Matthews, F., Brayne, C., & Woods, B. (2017). Potentially modifiable lifestyle factors, cognitive reserve, and cognitive function in later life: A cross-sectional study. PLoS Medicine, 14(3), https://doi.org/10.1371/journal.pmed.1002259

Background: Potentially modifiable lifestyle factors may influence cognitive health in later life and offer potential to reduce the risk of cognitive decline and dementia. The concept of cognitive reserve has been proposed as a mechanism to explain i... Read More about Potentially modifiable lifestyle factors, cognitive reserve, and cognitive function in later life: A cross-sectional study.

Age-related cognitive decline and associations with sex, education and apolipoprotein E genotype across ethnocultural groups and geographic regions: a collaborative cohort study (2017)
Journal Article
Lipnicki, D. M., Crawford, J. D., Dutta, R., Thalamuthu, A., Kochan, N. A., Andrews, G., Lima-Costa, M. F., Castro-Costa, E., Brayne, C., Matthews, F. E., Stephan, B. C., Lipton, R. B., Katz, M. J., Ritchie, K., Scali, J., Ancelin, M. L., Scarmeas, N., Yannakoulia, M., Dardiotis, E., Lam, L. C., …Sachdev, P. S. (2017). Age-related cognitive decline and associations with sex, education and apolipoprotein E genotype across ethnocultural groups and geographic regions: a collaborative cohort study. PLoS Medicine, 14(3), https://doi.org/10.1371/journal.pmed.1002261

Background: The prevalence of dementia varies around the world, potentially contributed to by international differences in rates of age-related cognitive decline. Our primary goal was to investigate how rates of age-related decline in cognitive test... Read More about Age-related cognitive decline and associations with sex, education and apolipoprotein E genotype across ethnocultural groups and geographic regions: a collaborative cohort study.