All Outputs (378)

Patterns and persistence of behavioural and psychological symptoms in those with cognitive impairment: the importance of apathy (2017)
Journal Article
van der Linde, R. M., Matthews, F. E., Dening, T., & Brayne, C. (2017). Patterns and persistence of behavioural and psychological symptoms in those with cognitive impairment: the importance of apathy. International journal of geriatric psychiatry, 32(3), 306-315. https://doi.org/10.1002/gps.4464

Objective: To study the stability and emergence of a range of behavioural and psychological symptoms (BPS), their association with mortality and the effect of covariates on these transitions in a population-based study of cognitively impaired older p... Read More about Patterns and persistence of behavioural and psychological symptoms in those with cognitive impairment: the importance of apathy.

Age-related delay in visual and auditory evoked responses is mediated by white-and grey-matter differences (2017)
Journal Article
Price, D., Tyler, L. K., Neto Henriques, R., Campbell, K. L., Williams, N., Treder, M. S., Taylor, J. R., Henson, R. N., Brayne, C., Bullmore, E. T., Calder, A. C., Cusack, R., Dalgleish, T., Duncan, J., Matthews, F. E., Marslen-Wilson, W. D., Rowe, J. B., Shafto, M. A., Cheung, T., Davis, S., …Villis, L. (2017). Age-related delay in visual and auditory evoked responses is mediated by white-and grey-matter differences. Nature communications, 8, https://doi.org/10.1038/ncomms15671

Slowing is a common feature of ageing, yet a direct relationship between neural slowing and brain atrophy is yet to be established in healthy humans. We combine magnetoencephalo-graphic (MEG) measures of neural processing speed with magnetic resonanc... Read More about Age-related delay in visual and auditory evoked responses is mediated by white-and grey-matter differences.

Cross sectional associations between socio-demographic factors and cognitive performance in an older british population: The European investigation of cancer in Norfolk (EPIC-Norfolk) study (2016)
Journal Article
Hayat, S. A., Luben, R., Dalzell, N., Moore, S., Anuj, S., Matthews, F. E., Wareham, N., Brayne, C., & Khaw, K. T. (2016). Cross sectional associations between socio-demographic factors and cognitive performance in an older british population: The European investigation of cancer in Norfolk (EPIC-Norfolk) study. PLoS ONE, 11(12), https://doi.org/10.1371/journal.pone.0166779

Background: Cognition covers a range of abilities, such as memory, response time and language, with tests assessing either specific or generic aspects. However differences between measures may be observed within the same individuals. Objective: To in... Read More about Cross sectional associations between socio-demographic factors and cognitive performance in an older british population: The European investigation of cancer in Norfolk (EPIC-Norfolk) study.

Modelling life course blood pressure trajectories using Bayesian adaptive splines (2016)
Journal Article
Muniz-Terrera, G., Bakra, E., Hardy, R., Matthews, F. E., & Lunn, D. (2016). Modelling life course blood pressure trajectories using Bayesian adaptive splines. Statistical Methods in Medical Research, 25(6), 2767-2780. https://doi.org/10.1177/0962280214532576

No single study has collected data over individuals' entire lifespans. To understand changes over the entire life course, it is necessary to combine data from various studies that cover the whole life course. Such combination may be methodologically... Read More about Modelling life course blood pressure trajectories using Bayesian adaptive splines.

Ageing increases reliance on sensorimotor prediction through structural and functional differences in frontostriatal circuits (2016)
Journal Article
Wolpe, N., Ingram, J. N., Tsvetanov, K. A., Geerligs, L., Kievit, R. A., Henson, R. N., Wolpert, D. M., Rowe, J. B., Tyler, L. K., Brayne, C., Bullmore, E., Calder, A., Cusack, R., Dalgleish, T., Duncan, J., Matthews, F. E., Marslen-Wilson, W., Shafto, M. A., Campbell, K., Cheung, T., …Villis, L. (2016). Ageing increases reliance on sensorimotor prediction through structural and functional differences in frontostriatal circuits. Nature communications, 7, https://doi.org/10.1038/ncomms13034

The control of voluntary movement changes markedly with age. A critical component of motor control is the integration of sensory information with predictions of the consequences of action, arising from internal models of movement. This leads to senso... Read More about Ageing increases reliance on sensorimotor prediction through structural and functional differences in frontostriatal circuits.

Multiple determinants of lifespan memory differences (2016)
Journal Article
Henson, R. N., Campbell, K. L., Davis, S. W., Taylor, J. R., Emery, T., Erzinclioglu, S., Kievit, R. A., Tyler, L. K., Brayne, C., Bullmore, E. T., Calder, A. C., Cusack, R., Dalgleish, T., Duncan, J., Matthews, F. E., Marslen-Wilson, W. D., Rowe, J. B., Shafto, M. A., Cheung, T., Geerligs, L., …Villis, L. (2016). Multiple determinants of lifespan memory differences. Scientific reports, 6, https://doi.org/10.1038/srep32527

Memory problems are among the most common complaints as people grow older. Using structural equation modeling of commensurate scores of anterograde memory from a large (N = 315), population-derived sample (www.cam-can.org), we provide evidence for th... Read More about Multiple determinants of lifespan memory differences.

Who lives where and does it matter? Changes in the health profiles of older people living in long term care and the community over two decades in a high income country (2016)
Journal Article
Matthews, F. E., Bennett, H., Wittenberg, R., Jagger, C., Dening, T., & Brayne, C. (2016). Who lives where and does it matter? Changes in the health profiles of older people living in long term care and the community over two decades in a high income country. PLoS ONE, 11(9), https://doi.org/10.1371/journal.pone.0161705

Background: There have been fundamental shifts in the attitude towards, access to and nature of long term care in high income countries. The proportion and profile of the older population living in such settings varies according to social, cultural,... Read More about Who lives where and does it matter? Changes in the health profiles of older people living in long term care and the community over two decades in a high income country.

Microglial immunophenotype in dementia with Alzheimer's pathology (2016)
Journal Article
Minett, T., Classey, J., Matthews, F. E., Fahrenhold, M., Taga, M., Brayne, C., Ince, P. G., Nicoll, J. A., & Boche, D. (2016). Microglial immunophenotype in dementia with Alzheimer's pathology. Journal of Neuroinflammation, 13(1), https://doi.org/10.1186/s12974-016-0601-z

Background: Genetic risk factors for Alzheimer's disease imply that inflammation plays a causal role in development of the disease. Experimental studies suggest that microglia, as the brain macrophages, have diverse functions, with their main role in... Read More about Microglial immunophenotype in dementia with Alzheimer's pathology.

A two decade dementia incidence comparison from the Cognitive Function and Ageing Studies i and II (2016)
Journal Article
Matthews, F. E., Stephan, B. C., Robinson, L., Jagger, C., Barnes, L. E., Arthur, A., Brayne, C., Comas-Herrera, A., Wittenberg, R., Dening, T., McCracke, C. F., Moody, C., Parry, B., Green, E., Barnes, R., Warwick, J., Gao, L., Mattison, A., Baldwin, C., Harrison, S., …Forster, G. (2016). A two decade dementia incidence comparison from the Cognitive Function and Ageing Studies i and II. Nature communications, 7, https://doi.org/10.1038/ncomms11398

Dramatic global increases in future numbers of people with dementia have been predicted. No multicentre population-based study powered to detect changes over time has reported dementia incidence. MRC Cognitive Function and Ageing Study (CFAS) underto... Read More about A two decade dementia incidence comparison from the Cognitive Function and Ageing Studies i and II.

Retinal nerve fiber layer measures and cognitive function in the EPIC-Norfolk cohort study (2016)
Journal Article
Khawaja, A. P., Chan, M. P., Yip, J. L., Broadway, D. C., Garway-Heath, D. F., Luben, R., Hayat, S., Matthews, F. E., Brayne, C., Khaw, K. T., & Foster, P. J. (2016). Retinal nerve fiber layer measures and cognitive function in the EPIC-Norfolk cohort study. Investigative ophthalmology & visual science, 57(4), 1921-1926. https://doi.org/10.1167/iovs.16-19067

PURPOSE. We examined the relationship between retinal nerve fiber layer (RNFL) thickness and cognitive function in a population of older British adults. METHODS. Participants of the European Prospective Investigation of Cancer (EPIC) Norfolk cohort s... Read More about Retinal nerve fiber layer measures and cognitive function in the EPIC-Norfolk cohort study.

Land use mix and five-year mortality in later life: Results from the Cognitive Function and Ageing Study (2016)
Journal Article
Wu, Y. T., Prina, A. M., Jones, A., Barnes, L. E., Matthews, F. E., Brayne, C., & CFAS, M. R. (2016). Land use mix and five-year mortality in later life: Results from the Cognitive Function and Ageing Study. Health and Place, 38, 54-60. https://doi.org/10.1016/j.healthplace.2015.12.002

This study explores the potential modifying effect of age and mediation effect of co-morbidity on the association between land use mix, a measure of neighbourhood walkability, and five-year mortality among the 2424 individuals participating in the ye... Read More about Land use mix and five-year mortality in later life: Results from the Cognitive Function and Ageing Study.

A comparison of health expectancies over two decades in England: Results of the Cognitive Function and Ageing Study i and II (2016)
Journal Article
Jagger, C., Matthews, F. E., Wohland, P., Fouweather, T., Stephan, B. C., Robinson, L., Arthur, A., & Brayne, C. (2016). A comparison of health expectancies over two decades in England: Results of the Cognitive Function and Ageing Study i and II. Lancet, 387(10020), 779-786. https://doi.org/10.1016/S0140-6736%2815%2900947-2

Background Whether rises in life expectancy are increases in good-quality years is of profound importance worldwide, with population ageing. We investigate how various health expectancies have changed in England between 1991 and 2011, with identical... Read More about A comparison of health expectancies over two decades in England: Results of the Cognitive Function and Ageing Study i and II.

Epidemiological pathology of Tau in the ageing brain: application of staging for neuropil threads (BrainNet Europe protocol) to the MRC cognitive function and ageing brain study (2016)
Journal Article
Wharton, S. B., Minett, T., Drew, D., Forster, G., Matthews, F., Brayne, C., & Ince, P. G. (2016). Epidemiological pathology of Tau in the ageing brain: application of staging for neuropil threads (BrainNet Europe protocol) to the MRC cognitive function and ageing brain study. Acta Neuropathologica Communications, 4, 11. https://doi.org/10.1186/s40478-016-0275-x

INTRODUCTION: Deposition of abnormally phosphorylated tau (phospho-tau) occurs in Alzheimer's disease but also with brain ageing. The Braak staging scheme focused on neurofibrillary tangles, but abundant p-tau is also present in neuropil threads, and... Read More about Epidemiological pathology of Tau in the ageing brain: application of staging for neuropil threads (BrainNet Europe protocol) to the MRC cognitive function and ageing brain study.

Neuronal DNA damage response-associated dysregulation of signalling pathways and cholesterol metabolism at the earliest stages of Alzheimer-type pathology (2016)
Journal Article
Simpson, J. E., Ince, P. G., Minett, T., Matthews, F. E., Heath, P. R., Shaw, P. J., Goodall, E., Garwood, C. J., Ratcliffe, L. E., Brayne, C., Rattray, M., & Wharton, S. B. (2016). Neuronal DNA damage response-associated dysregulation of signalling pathways and cholesterol metabolism at the earliest stages of Alzheimer-type pathology. Neuropathology and Applied Neurobiology, 42(2), 167-179. https://doi.org/10.1111/nan.12252

Aims: Oxidative damage and an associated DNA damage response (DDR) are evident in mild cognitive impairment and early Alzheimer's disease, suggesting that neuronal dysfunction resulting from oxidative DNA damage may account for some of the cognitive... Read More about Neuronal DNA damage response-associated dysregulation of signalling pathways and cholesterol metabolism at the earliest stages of Alzheimer-type pathology.

Dementia in western Europe: Epidemiological evidence and implications for policy making (2016)
Journal Article
Wu, Y. T., Fratiglioni, L., Matthews, F. E., Lobo, A., Breteler, M. M., Skoog, I., & Brayne, C. (2016). Dementia in western Europe: Epidemiological evidence and implications for policy making. Lancet Neurology, 15(1), 116-124. https://doi.org/10.1016/S1474-4422%2815%2900092-7

Dementia is receiving increasing attention from governments and politicians. Epidemiological research based on western European populations done 20 years ago provided key initial evidence for dementia policy making, but these estimates are now out of... Read More about Dementia in western Europe: Epidemiological evidence and implications for policy making.

Adult lifespan cognitive variability in the cross-sectional cam-CAN cohort (2015)
Journal Article
Green, E., Shafto, M. A., Matthews, F. E., Cam-Can, & White, S. R. (2015). Adult lifespan cognitive variability in the cross-sectional cam-CAN cohort. International Journal of Environmental Research and Public Health, 12(12), 15516-15530. https://doi.org/10.3390/ijerph121215003

This study examines variability across the age span in cognitive performance in a cross-sectional, population-based, adult lifespan cohort from the Cambridge Centre for Ageing and Neuroscience (Cam-CAN) study (n = 2680). A key question we highlight i... Read More about Adult lifespan cognitive variability in the cross-sectional cam-CAN cohort.

Changes in health in England, with analysis by English regions and areas of deprivation, 1990-2013: A systematic analysis for the Global Burden of Disease Study 2013 (2015)
Journal Article
Newton, J. N., Briggs, A. D., Murray, C. J., Dicker, D., Foreman, K. J., Wang, H., Naghavi, M., Forouzanfar, M. H., Ohno, S. L., Barber, R. M., Vos, T., Stanaway, J. D., Schmidt, J. C., Hughes, A. J., Fay, D. F., Ecob, R., Gresser, C., McKee, M., Rutter, H., Abubakar, I., …Davis, A. C. (2015). Changes in health in England, with analysis by English regions and areas of deprivation, 1990-2013: A systematic analysis for the Global Burden of Disease Study 2013. Lancet, 386(10010), 2257-2274. https://doi.org/10.1016/S0140-6736%2815%2900195-6

Background In the Global Burden of Disease Study 2013 (GBD 2013), knowledge about health and its determinants has been integrated into a comparable framework to inform health policy. Outputs of this analysis are relevant to current policy questions i... Read More about Changes in health in England, with analysis by English regions and areas of deprivation, 1990-2013: A systematic analysis for the Global Burden of Disease Study 2013.

The nuclear retention of transcription factor FOXO3a correlates with a DNA damage response and increased glutamine synthetase expression by astrocytes suggesting a neuroprotective role in the ageing brain (2015)
Journal Article
Fluteau, A., Ince, P. G., Minett, T., Matthews, F. E., Brayne, C., Garwood, C. J., Ratcliffe, L. E., Morgan, S., Heath, P. R., Shaw, P. J., Wharton, S. B., & Simpson, J. E. (2015). The nuclear retention of transcription factor FOXO3a correlates with a DNA damage response and increased glutamine synthetase expression by astrocytes suggesting a neuroprotective role in the ageing brain. Neuroscience letters, 609, 11-17. https://doi.org/10.1016/j.neulet.2015.10.001

The accumulation of reactive oxygen species leading to oxidative damage and cell death plays an important role in a number of neurodegenerative disorders. FOXO3a, the main isoform of FOXO transcription factors, mediates the cellular response to oxida... Read More about The nuclear retention of transcription factor FOXO3a correlates with a DNA damage response and increased glutamine synthetase expression by astrocytes suggesting a neuroprotective role in the ageing brain.

The prevalence of mild cognitive impairment in diverse geographical and ethnocultural regions: The COSMIC Collaboration (2015)
Journal Article
Sachdev, P. S., Lipnicki, D. M., Kochan, N. A., Crawford, J. D., Thalamuthu, A., Andrews, G., Brayne, C., Matthews, F. E., Stephan, B. C., Lipton, R. B., Katz, M. J., Ritchie, K., Carrière, I., Ancelin, M. L., Lam, L. C., Wong, C. H., Fung, A. W., Guaita, A., Vaccaro, R., Davin, A., …Lobo, E. (2015). The prevalence of mild cognitive impairment in diverse geographical and ethnocultural regions: The COSMIC Collaboration. PLoS ONE, 10(11), https://doi.org/10.1371/journal.pone.0142388

Background Changes in criteria and differences in populations studied and methodology have produced a wide range of prevalence estimates for mild cognitive impairment (MCI). Methods Uniform criteria were applied to harmonized data from 11 studies fro... Read More about The prevalence of mild cognitive impairment in diverse geographical and ethnocultural regions: The COSMIC Collaboration.

Community environment, cognitive impairment and dementia in later life: Results from the Cognitive Function and Ageing Study (2015)
Journal Article
Wu, Y. T., Prina, A. M., Jones, A. P., Barnes, L. E., Matthews, F. E., & Brayne, C. (2015). Community environment, cognitive impairment and dementia in later life: Results from the Cognitive Function and Ageing Study. Age and ageing, 44(6), 1005-1011. https://doi.org/10.1093/ageing/afv137

Background: few studies have investigated the impact of the community environment, as distinct from area deprivation, on cognition in later life. This study explores cross-sectional associations between cognitive impairment and dementia and environme... Read More about Community environment, cognitive impairment and dementia in later life: Results from the Cognitive Function and Ageing Study.