All Outputs (3)

A Cdc42- and Rac-interactive binding (CRIB) domain mediates functions of coronin (2013)
Journal Article
Swaminathan, K., Müller-Taubenberger, A., Faix, J., Rivero, F., & Noegel, A. A. (2014). A Cdc42- and Rac-interactive binding (CRIB) domain mediates functions of coronin. Proceedings of the National Academy of Sciences of the United States of America, 111(1), E25-E33. https://doi.org/10.1073/pnas.1315368111

The Cdc42- and Rac-interactive binding motif (CRIB) of coronin binds to Rho GTPases with a preference for GDP-loaded Rac. Mutation of the Cdc42- and Rac-interactive binding motif abrogates Rac binding. This results in increased 1evels of activated Ra... Read More about A Cdc42- and Rac-interactive binding (CRIB) domain mediates functions of coronin.

An attenuating role of a WASP-related protein, WASP-B, in the regulation of F-actin polymerization and pseudopod formation via the regulation of RacC during Dictyostelium chemotaxis (2013)
Journal Article
Chung, C. Y., Feoktistov, A., Hollingsworth, R. J., Rivero, F., & Mandel, N. S. (2013). An attenuating role of a WASP-related protein, WASP-B, in the regulation of F-actin polymerization and pseudopod formation via the regulation of RacC during Dictyostelium chemotaxis. Biochemical and biophysical research communications, 436(4), 719-724. https://doi.org/10.1016/j.bbrc.2013.06.022

The WASP family of proteins has emerged as important regulators that connect multiple signaling pathways to regulate the actin cytoskeleton. Dictyostelium cells express WASP, as well as a WASP related protein, WASP-B, endoded by wasB gene. WASP-B con... Read More about An attenuating role of a WASP-related protein, WASP-B, in the regulation of F-actin polymerization and pseudopod formation via the regulation of RacC during Dictyostelium chemotaxis.

GxcC connects Rap and Rac signaling during Dictyostelium development (2013)
Journal Article
Plak, K., Veltman, D., Fusetti, F., Beeksma, J., Rivero, F., Van Haastert, P. J., & Kortholt, A. (2013). GxcC connects Rap and Rac signaling during Dictyostelium development. BMC cell biology, 14(1), Article 6. https://doi.org/10.1186/1471-2121-14-6

Background: Rap proteins belong to the Ras family of small G-proteins. Dictyostelium RapA is essential and implicated in processes throughout the life cycle. In early development and chemotaxis competent cells RapA induces pseudopod formation by acti... Read More about GxcC connects Rap and Rac signaling during Dictyostelium development.