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The mitochondrial phosphate carrier TbMCP11 is essential for mitochondrial function in the procyclic form of Trypanosoma brucei (2020)
Journal Article
Gao, F., Voncken, F., & Colasante, C. (in press). The mitochondrial phosphate carrier TbMCP11 is essential for mitochondrial function in the procyclic form of Trypanosoma brucei. Molecular and Biochemical Parasitology, https://doi.org/10.1016/j.molbiopara.2020.111275

Conserved amongst all eukaryotes is a family of mitochondrial carrier proteins (SLC25A) responsible for the import of various solutes across the inner mitochondrial membrane. We previously reported that the human parasite Trypanosoma brucei possesses... Read More about The mitochondrial phosphate carrier TbMCP11 is essential for mitochondrial function in the procyclic form of Trypanosoma brucei.

Characterisation of a mitochondrial iron transporter of the pathogen Trypanosoma brucei (2019)
Journal Article
Zheng, F., Colasante, C., & Voncken, F. (2019). Characterisation of a mitochondrial iron transporter of the pathogen Trypanosoma brucei. Molecular and Biochemical Parasitology, 233, 111221. https://doi.org/10.1016/j.molbiopara.2019.111221

Similar to higher eukaryotes, the protist parasite T. brucei harbours several iron-containing proteins that regulate DNA and protein processing, oxidative stress defence and mitochondrial respiration. The synthesis of these proteins occurs either in... Read More about Characterisation of a mitochondrial iron transporter of the pathogen Trypanosoma brucei.

A plant-like mitochondrial carrier family protein facilitates mitochondrial transport of di- and tricarboxylates in Trypanosoma brucei (2018)
Journal Article
Colasante, C., Zheng, F., Kemp, C., & Voncken, F. (2018). A plant-like mitochondrial carrier family protein facilitates mitochondrial transport of di- and tricarboxylates in Trypanosoma brucei. Molecular and Biochemical Parasitology, 221, 36-51. https://doi.org/10.1016/j.molbiopara.2018.03.003

The procyclic form of the human parasite Trypanosoma brucei harbors one single, large mitochondrion containing all tricarboxylic acid (TCA) cycle enzymes and respiratory chain complexes present also in higher eukaryotes. Metabolite exchange among sub... Read More about A plant-like mitochondrial carrier family protein facilitates mitochondrial transport of di- and tricarboxylates in Trypanosoma brucei.


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