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Genomic analysis of companion rabbit Staphylococcus aureus (2016)
Journal Article
Holmes, M. A., Harrison, E. M., Fisher, E. A., Graham, E. M., Parkhill, J., Foster, G., & Paterson, G. K. (2016). Genomic analysis of companion rabbit Staphylococcus aureus. PloS one, 11(3), (e0151458). doi:10.1371/journal.pone.0151458. ISSN 1932-6203

© 2016 Holmes et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are cre... Read More

The effect of genetic structure on molecular dating and tests for temporal signal (2015)
Journal Article
Murray, G. G. R., Murray, G. G., Murray, G. G. . R., Wang, F., Harrison, E. M., Paterson, G. K., …Welch, J. J. (2015). The effect of genetic structure on molecular dating and tests for temporal signal. Methods in ecology and evolution British Ecological Society, 7(1), (80-89). doi:10.1111/2041-210x.12466. ISSN 2041-210X

© 2016 British Ecological Society. 'Dated-tip' methods of molecular dating use DNA sequences sampled at different times, to estimate the age of their most recent common ancestor. Several tests of 'temporal signal' are available to determine whether d... Read More

Draft genome sequence of the Streptococcus pneumoniae Avery strain A66 (2015)
Journal Article
Hahn, C., Harrison, E. M., Parkhill, J., Holmes, M. A., & Paterson, G. K. (2018). Draft genome sequence of the Streptococcus pneumoniae Avery strain A66. Genome announcements, 3(3), (e00697-15). doi:10.1128/genomeA.00697-15. ISSN 2169-8287

We have used HiSeq 2000 technology to generate a draft genome sequence of Streptococcus pneumoniae strain A66. This is a common study strain used in investigations of pneumococcal bacterium-host interactions and was used in the seminal genetic studie... Read More

Mechanisms of methicillin resistance in Staphylococcus aureus (2015)
Journal Article
Peacock, S. J., & Paterson, G. K. (2015). Mechanisms of methicillin resistance in Staphylococcus aureus. Annual review of biochemistry, 84(1), 577-601. doi:10.1146/annurev-biochem-060614-034516

Staphylococcus aureus is a major human and veterinary pathogen worldwide. Methicillin-resistant S. aureus (MRSA) poses a significant and enduring problem to the treatment of infection by such strains. Resistance is usually conferred by the acquisitio... Read More

Capturing the cloud of diversity reveals complexity and heterogeneity of MRSA carriage, infection and transmission (2015)
Journal Article
Paterson, G. K., Harrison, E. M., Murray, G. G. R., Welch, J. J., Warland, J. H., Holden, M. T. G., …Holmes, M. A. (2015). Capturing the cloud of diversity reveals complexity and heterogeneity of MRSA carriage, infection and transmission. Nature communications, 6(1), doi:10.1038/ncomms7560

Genome sequencing is revolutionizing clinical microbiology and our understanding of infectious diseases. Previous studies have largely relied on the sequencing of a single isolate from each individual. However, it is not clear what degree of bacteria... Read More

The emergence of mecC methicillin-resistant Staphylococcus aureus (2013)
Journal Article
Paterson, G. K., Harrison, E. M., & Holmes, M. A. (2014). The emergence of mecC methicillin-resistant Staphylococcus aureus. Trends in microbiology, 22(1), (42-47). doi:10.1016/j.tim.2013.11.003. ISSN 0966-842X

The report of methicillin-resistant Staphylococcus aureus (MRSA) encoding a divergent mecA gene in 2011 was highly significant. This homologue, designated mecC, poses diagnostic problems with the potential to be misdiagnosed as methicillin-sensitive... Read More

A novel hybrid SCCmec-mecC region in Staphylococcus sciuri (2013)
Journal Article
Harrison, E. M., Paterson, G. K., Holden, M. T. G., Ba, X., Rolo, J., Morgan, F. J. E., …Holmes, M. A. (2014). A novel hybrid SCCmec-mecC region in Staphylococcus sciuri. The journal of antimicrobial chemotherapy, 69(4), (911-918). doi:10.1093/jac/dkt452. ISSN 0305-7453

Objectives Methicillin resistance in Staphylococcus spp. results from the expression of an alternative penicillin-binding protein 2a (encoded by mecA) with a low affinity for β-lactam antibiotics. Recently, a novel variant of mecA known as mecC (form... Read More