Skip to main content

Research Repository

Advanced Search

All Outputs (29)

Sacral neuromodulation for the management of severe constipation: development of a constipation treatment protocol (2011)
Journal Article
Sharma, A., Liu, B., Waudby, P., & Duthie, G. S. (2011). Sacral neuromodulation for the management of severe constipation: development of a constipation treatment protocol. International Journal of Colorectal Disease, 26(12), 1583-1587. https://doi.org/10.1007/s00384-011-1257-x

Background Constipation is a common multifactorial gastrointestinal symptom with quality of life implications. Sacral neuromodulation has been used in the management of severe constipation with mixed results. The aim of this study was to review our... Read More about Sacral neuromodulation for the management of severe constipation: development of a constipation treatment protocol.

Artificial neural networks to predict presence of significant pathology in patients presenting to routine colorectal clinics (2010)
Journal Article
Maslekar, S., Gardiner, A. B., Monson, J. R. T., & Duthie, G. S. (2010). Artificial neural networks to predict presence of significant pathology in patients presenting to routine colorectal clinics. Colorectal Disease, 12(12), 1254-1259. https://doi.org/10.1111/j.1463-1318.2009.02005.x

Aim Artificial neural networks (ANNs) are computer programs used to identify complex relations within data. Routine predictions of presence of colorectal pathology based on population statistics have little meaning for individual patient. This result... Read More about Artificial neural networks to predict presence of significant pathology in patients presenting to routine colorectal clinics.

Quality assurance in flexible sigmoidoscopy: Medical and nonmedical endoscopists (2009)
Journal Article
Maslekar, S., Waudby, P., Avery, G., Monson, J. R. T., & Duthie, G. S. (2010). Quality assurance in flexible sigmoidoscopy: Medical and nonmedical endoscopists. Surgical Endoscopy, 24(1), 89-93. https://doi.org/10.1007/s00464-009-0553-9

Purpose: The clinical assessment of position in colon and hence completion during flexible sigmoidoscopy (FS) is believed to be inaccurate. The technique of applying endomucosal clips with follow-up X-ray has previously been used for establishing com... Read More about Quality assurance in flexible sigmoidoscopy: Medical and nonmedical endoscopists.

Randomized controlled trial of patient-controlled sedation for colonoscopy: Entonox vs modified patient-maintained target-controlled propofol (2009)
Journal Article
Maslekar, S., Balaji, P., Gardiner, A., Culbert, B., Monson, J. R., & Duthie, G. S. (2011). Randomized controlled trial of patient-controlled sedation for colonoscopy: Entonox vs modified patient-maintained target-controlled propofol. Colorectal Disease, 13(1), 48-57. https://doi.org/10.1111/j.1463-1318.2009.01988.x

Aim Propofol sedation is often associated with deep sedation and decreased manoeuvrability. Patient-maintained sedation has been used in such patients with minimal side-effects. We aimed to compare novel modified patient-maintained target-controlled... Read More about Randomized controlled trial of patient-controlled sedation for colonoscopy: Entonox vs modified patient-maintained target-controlled propofol.

Randomized clinical trial of Entonox versus midazolam-fentanyl sedation for colonoscopy (2009)
Journal Article
Maslekar, S., Gardiner, A., & Duthie, G. (2009). Randomized clinical trial of Entonox versus midazolam-fentanyl sedation for colonoscopy. British journal of surgery, 96(4), 361 - 368. https://doi.org/10.1002/bjs.6467

BACKGROUND Intravenous sedation for colonoscopy is associated with cardiorespiratory complications and delayed recovery. The aim of this randomized clinical trial was to compare the efficacy of Entonox (50 per cent nitrous oxide and 50 per cent oxyge... Read More about Randomized clinical trial of Entonox versus midazolam-fentanyl sedation for colonoscopy.

Quality assurance in colonoscopy: role of endomucosal clips (2009)
Journal Article
Maslekar, S., Avery, G., & Duthie, G. S. (2010). Quality assurance in colonoscopy: role of endomucosal clips. Colorectal Disease, 12(7), 651-656. https://doi.org/10.1111/j.1463-1318.2009.01874.x

Objective Quality assurance in colonoscopy is important, and subjective assessment of completion based on endoscopic signs can be inaccurate leading to missed lesions. We aimed to determine the technique of endomucosal clips with follow-up X-rays in... Read More about Quality assurance in colonoscopy: role of endomucosal clips.

Randomized clinical trial of Entonox ® versus midazolam-fentanyl sedation for colonoscopy (2009)
Journal Article
Maslekar, S., Gardiner, A., Hughes, M., Culbert, B., & Duthie, G. S. (2009). Randomized clinical trial of Entonox ® versus midazolam-fentanyl sedation for colonoscopy. British journal of surgery, 96(4), 361-368. https://doi.org/10.1002/bjs.6467

Background: Intravenous sedation for colonoscopy is associated with cardiorespiratory complications and delayed recovery. The aim of this randomized clinical trial was to compare the efficacy of Entonox ® (50 per cent nitrous oxide and 50 per cent o... Read More about Randomized clinical trial of Entonox ® versus midazolam-fentanyl sedation for colonoscopy.

Anterior anal sphincter repair for fecal incontinence: Good longterm results are possible (2006)
Journal Article
Maslekar, S., Gardiner, A. B., & Duthie, G. S. (2007). Anterior anal sphincter repair for fecal incontinence: Good longterm results are possible. Journal of The American College of Surgeons, 204(1), 40-46. https://doi.org/10.1016/j.jamcollsurg.2006.10.008

Background: Anterior anal sphincter repair (ASR) is standard treatment for fecal incontinence resulting from an obstetrically damaged anal sphincter. Longterm results of repair have generally been shown to be poor. This review of single-unit series a... Read More about Anterior anal sphincter repair for fecal incontinence: Good longterm results are possible.

A new method of assessing anal sphincter integrity using inverted vectormanometry (2006)
Journal Article
Kaur, G., Gardiner, A., & Duthie, G. S. (2006). A new method of assessing anal sphincter integrity using inverted vectormanometry. Diseases of the colon & rectum, 49(8), 1160-1166. doi:10.1007/s10350-006-0556-8

PURPOSE: Vectorgraphy as an integrated mapping of radial pressure profiles of the anal canal has been used to attempt identification of pressure-related defects with doubtful reliability since vectorgraphs bear no resemblance to endoanal ultrasound s... Read More about A new method of assessing anal sphincter integrity using inverted vectormanometry.

Investigation and treatment of faecal incontinence (2006)
Journal Article
Maslekar, S., Gardiner, A., Maklin, C., & Duthie, G. S. (2006). Investigation and treatment of faecal incontinence. Postgraduate Medical Journal, 82(968), 363-371. https://doi.org/10.1136/pgmj.2005.044099

Faecal incontinence is a debilitating condition affecting people of all ages, and significantly impairs quality of life. Proper clinical assessment followed by conservative medical therapy leads to improvement in more than 50% of cases, including pat... Read More about Investigation and treatment of faecal incontinence.

Abstracts of the AGA Institute (2006)
Journal Article
Gardiner, A., Maslekar, S., & Duthie, G. (2006). Abstracts of the AGA Institute. Gastroenterology, 130(4), A-1-A-747. https://doi.org/10.1016/s0016-5085%2806%2960008-5

Aims: Artificial neural networks (ANN) are computer programs used to identify complexrelations within data that cannot be detected with conventional linear-statistical analysis.The routine clinical predictions of need for lower gastrointestinal endos... Read More about Abstracts of the AGA Institute.

Non-medical colonoscopy (2006)
Journal Article
Maslekar, S. K., Gardiner, A., Hughes, M., & Duthie, G. S. (2006). Non-medical colonoscopy. Gastrointestinal Endoscopy, 63(5), AB114. https://doi.org/10.1016/j.gie.2006.03.148

Aims: There is increasing demand for colonoscopy especially with introduction of screening programmes. Though colonoscopy is performed by doctors and nurses, there is an acute shortage of trained colonoscopists

Early results of a rotational flap to treat chronic anal fissures (2004)
Journal Article
Singh, M., Sharma, A., Gardiner, A., & Duthie, G. S. (2005). Early results of a rotational flap to treat chronic anal fissures. International Journal of Colorectal Disease, 20(4), (339-342). doi:10.1007/s00384-004-0663-8. ISSN 0179-1958

Background: Treatment of anal fissures has changed dramatically in the past decade. Only a few fail to respond to medical therapy. Sphincterotomy and anal dilatation have fallen out of favour due to the risk of incontinence. Island flaps have been pr... Read More about Early results of a rotational flap to treat chronic anal fissures.

Rectal irrigation for relief of functional bowel disorders (2004)
Journal Article
Gardiner, A., Marshall, J., & Duthie, G. (2004). Rectal irrigation for relief of functional bowel disorders. Nursing standard : official newspaper of the Royal College of Nursing, 19(9), 39-42. https://doi.org/10.7748/ns2004.11.19.9.39.c3755

This article examines the use of rectal irrigation for the symptomatic relief of functional bowel disorders in certain groups of patients. The authors undertook a study of 80 patients and conclude that it is a valuable treatment for some patients.

Neural network analysis of anal sphincter repair (2004)
Journal Article
Gardiner, A., Kaur, G., Cundall, J., Ilstrup, D. M., Gardiner, A., & Duthie, G. (2004). Neural network analysis of anal sphincter repair. Diseases of the colon & rectum, 47(2), 192-197. https://doi.org/10.1007/s10350-003-0026-5

PURPOSE: Prediction of success after anterior sphincter repair for incontinence is difficult. Standard multivariate analysis techniques have only 75 to 80 percent accuracy. Artificial intelligence, including artificial neural networks, has been used... Read More about Neural network analysis of anal sphincter repair.

Hyperbaric oxygen in the treatment of fecal incontinence secondary to pudendal neuropathy (2003)
Journal Article
Cundall, J. D., Gardiner, A., Chin, K., Laden, G., Grout, P., & Duthie, G. S. (2003). Hyperbaric oxygen in the treatment of fecal incontinence secondary to pudendal neuropathy. Diseases of the colon & rectum, 46(11), 1549-1554. doi:10.1007/s10350-004-6812-x

PURPOSE: Hyperbaric oxygen therapy has several physiologic effects on damaged nerves in animal models, which lead to an improvement in neurologic function. Idiopathic fecal incontinence secondary to pudendal neuropathy is usually treated with biofeed... Read More about Hyperbaric oxygen in the treatment of fecal incontinence secondary to pudendal neuropathy.

Anal sphincter injury, fecal and urinary incontinence (2003)
Journal Article
Lindow, S., Gardiner, A., & Duthie, G. (2003). Anal sphincter injury, fecal and urinary incontinence. Diseases of the colon & rectum, 46(8), (1083 - 1088). ISSN 0012-3706

Purpose: This study was designed to determine the long-term outcome of forceps delivery in terms of evidence of anal sphincter injury and the incidence of fecal and urinary incontinence. Methods: Women who delivered in 1964 were evaluated by using en... Read More about Anal sphincter injury, fecal and urinary incontinence.

Anal sphincter injury, fecal and urinary incontinence: a 34-year follow-up after forceps delivery (2003)
Journal Article
Bollard, R. C., Gardiner, A., Duthie, G. S., & Lindow, S. W. (2003). Anal sphincter injury, fecal and urinary incontinence: a 34-year follow-up after forceps delivery. Diseases of the colon & rectum, 46(8), 1083-1088. doi:10.1007/s10350-004-7284-8

PURPOSE: This study was designed to determine the long-term outcome of forceps delivery in terms of evidence of anal sphincter injury and the incidence of fecal and urinary incontinence. METHODS: Women who delivered in 1964 were evaluated by using en... Read More about Anal sphincter injury, fecal and urinary incontinence: a 34-year follow-up after forceps delivery.

Rectoanal reflex parameters in incontinence and constipation (2002)
Journal Article
Kaur, G., Gardiner, A., & Duthie, G. S. (2002). Rectoanal reflex parameters in incontinence and constipation. Diseases of the colon & rectum, 45(7), 928-933. doi:10.1007/s10350-004-6331-9

PURPOSE: The transient relaxation of the internal anal sphincter in response to rectal distention is believed to play an important role in the continence mechanism. Most anorectal physiology laboratories merely report the rectoanal inhibitory reflex... Read More about Rectoanal reflex parameters in incontinence and constipation.

Normal female anal sphincter: difficulties in interpretation explained (2002)
Journal Article
Bollard, R. C., Gardiner, A., Lindow, S., Phillips, K., & Duthie, G. S. (2002). Normal female anal sphincter: difficulties in interpretation explained. Diseases of the colon & rectum, 45(2), 171-175. doi:10.1007/s10350-004-6139-7

PURPOSE: Our aims were to quantify the nature, characteristics, and frequency of variations in female anal sphincter anatomy. METHODS: Nulliparous patients from the antenatal clinic and healthy volunteers of both genders were studied. Sphincter lengt... Read More about Normal female anal sphincter: difficulties in interpretation explained.