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A 18F radiolabelled Zn(ii) sensing fluorescent probe (2018)
Journal Article
Price, T. W., Firth, G., Eling, C. J., Kinnon, M., Long, N. J., Sturge, J., & Stasiuk, G. J. (2018). A 18F radiolabelled Zn(ii) sensing fluorescent probe. Chemical communications : Chem comm / the Royal Society of Chemistry, 54(26), 3227-3230. doi:10.1039/c8cc00687c

A selective fluorescent probe for Zn(ii), AQA-F, has been synthesized. AQA-F exhibits a ratiometric shift in emission of up to 80 nm upon binding Zn(ii) ([AQA-F] = 0.1 mM, [Zn(ii)Cl 2 ] = 0-300 μM). An enhancement of quantum yield from Φ = 4.2% to Φ... Read More

Dual-modal SERS/fluorescence AuNP probe for mitochondrial imaging (2017)
Journal Article
Eling, C. J., Price, T. W., Marshall, A. R. L., Narda Viscomi, F., Adawi, A. M., Bouillard, J. G., …Viscomi, F. (2017). Dual-modal SERS/fluorescence AuNP probe for mitochondrial imaging. ChemPlusChem, 82(5), (674-680). doi:10.1002/cplu.201600593. ISSN 2192-6506

A novel SERS/fluorescent multimodal imaging probe for mitochondria has been synthesised using 12 nm diameter gold nanoparticles (AuNP) surface functionalised with a rhodamine thiol derivative ligand. The normal pH dependant acidic fluorescence of the... Read More

Amino acid based gallium-68 chelators capable of radiolabeling at neutral pH (2017)
Journal Article
Kubicek, V., Bohmova, Z., Price, T. W., Gallo, J., Kubíček, V., Böhmová, Z., …Stasiuk, G. J. (2017). Amino acid based gallium-68 chelators capable of radiolabeling at neutral pH. Dalton transactions : an international journal of inorganic chemistry / RSoC, 46(48), (16973-16982). doi:10.1039/c7dt03398b. ISSN 1477-9226

Gallium-68 ( 68 Ga) has been the subject of increasing interest for its potential in the production of radiotracers for diagnosis of diseases. In this work we report the complexation of 68 Ga by the amino acid based tripodal chelate H 3 Dpaa, and two... Read More

Synthesis, structures and cytotoxicity studies of p-sulfonatocalix[4]arene lanthanide complexes (2016)
Journal Article
Miller-Shakesby, D. M., Burke, B. P., Nigam, S., Stasiuk, G. J., Prior, T. J., Archibald, S. J., & Redshaw, C. (2016). Synthesis, structures and cytotoxicity studies of p-sulfonatocalix[4]arene lanthanide complexes. CrystEngComm RSC, 18(26), (4977-4987). doi:10.1039/c6ce00209a. ISSN 1466-8033

A number of p-sulfonatocalix[4]arene complexes of the lanthanides (Tb, Gd, and Eu) have been prepared, some in the presence of tetraazamacrocycle 1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid (DO3A), and fully characterised. Crystal structure d... Read More

Pancreatic β-cell imaging in humans: Fiction or option? (2015)
Journal Article
Laurent, D., Vinet, L., Lamprianou, S., Daval, M., Filhoulaud, G., Ktorza, A., …Hecksher-Sørensen, J. (2016). Pancreatic β-cell imaging in humans: Fiction or option?. Diabetes, Obesity and Metabolism, 18(1), 6-15. doi:10.1111/dom.12544

Diabetes mellitus is a growing worldwide epidemic disease, currently affecting 1 in 12 adults. Treatment of disease complications typically consumes ∼10% of healthcare budgets in developed societies. Whilst immune‐mediated destruction of insulin‐secr... Read More

Dual-modal magnetic resonance/fluorescent zinc probes for pancreatic β-cell mass imaging (2015)
Journal Article
Stasiuk, G. J., Allegrini, P. R., Beeby, A., Duckworth, A. R., Juretschke, H., Laurent, D., …Sae-Heng, M. (2015). Dual-modal magnetic resonance/fluorescent zinc probes for pancreatic β-cell mass imaging. Chemistry : a European journal, 21(13), (5023-5033). doi:10.1002/chem.201406008. ISSN 0947-6539

Despite the contribution of changes in pancreatic β-cell mass to the development of all forms of diabetes mellitus, few robust approaches currently exist to monitor these changes prospectively in vivo. Although magnetic-resonance imaging (MRI) provid... Read More

Tuning the relaxation rates of dual-mode T₁/T₂ nanoparticle contrast agents: a study into the ideal system (2015)
Journal Article
Banobre-Lopez, M., Stasiuk, G. J., Bañobre-López, M., Gallo, J., Keasberry, N. A., Long, N. J., & Wood, C. (2015). Tuning the relaxation rates of dual-mode T₁/T₂ nanoparticle contrast agents: a study into the ideal system. Nanoscale, 7(38), (16119-16128). doi:10.1039/c5nr04400f. ISSN 2040-3364

Magnetic resonance imaging (MRI) is an excellent imaging modality. However the low sensitivity of the technique poses a challenge to achieving an accurate image of function at the molecular level. To overcome this, contrast agents are used; typically... Read More

Towards understanding the design of dual-modal MR/fluorescent probes to sense zinc ions (2014)
Journal Article
Stasiuk, G. J., Long, N. J., Rivas, C., & Sae-Heng, M. (2015). Towards understanding the design of dual-modal MR/fluorescent probes to sense zinc ions. Dalton transactions : an international journal of inorganic chemistry / RSoC, 44(11), (4976-4985). doi:10.1039/c4dt02981j. ISSN 1477-9226

A series of gadolinium complexes were synthesised in order to test the design of dual-modal probes that display a change in fluorescence or relaxivity response upon binding of zinc. A dansyl-DO3ATA gadolinium complex [GdL1] displayed an increase and... Read More

Multimetallic complexes and functionalized gold nanoparticles based on a combination of d- and f-Elements (2014)
Journal Article
Stasiuk, G. J., Bell, J. D., Holmes, H., Sung, S., Toscani, A., Wainwright, L., …Wilton-Ely, J. D. E. T. (2014). Multimetallic complexes and functionalized gold nanoparticles based on a combination of d- and f-Elements. Inorganic chemistry, 53(4), (1989-2005). doi:10.1021/ic401936w. ISSN 0020-1669

The new DO3A-derived dithiocarbamate ligand, DO3A-ᵗBu-CS₂K, is formed by treatment of the ammonium salt [DO3A-ᵗBu]HBr with K₂CO₃ and carbon disulfide. DO3A-ᵗBu-CS₂K reacts with the ruthenium complexes cis-[RuCl₂(dppm)₂] and [Ru(CH═CHC₆H₄Me-4)Cl(CO)(B... Read More

Lanthanide(III) complexes of rhodamine-DO3A conjugates as agents for dual-modal imaging (2013)
Journal Article
Stasiuk, G. J., Gallo, J., Long, N. J., Minuzzi, F., Rivas, C., & Rutter, G. A. (2013). Lanthanide(III) complexes of rhodamine-DO3A conjugates as agents for dual-modal imaging. Inorganic chemistry, 52(24), (14284-14293). doi:10.1021/ic402233g. ISSN 0020-1669

Two novel dual-modal MRI/optical probes based on a rhodamine-DO3A conjugate have been prepared. The bis aqua-Gd(III) complex Gd.L1 and mono aqua-Gd(III) complex Gd.L2 behave as dual-modal imaging probes (r1 = 8.5 and 3.8 mM-1s-1 for Gd.L1 and Gd.L2 r... Read More