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Intersex in scrobicularia plana: transcriptomic analysis reveals novel genes involved in endocrine disruption (2012)
Journal Article
Ciocan, C. M., Cubero-Leon, E., Peck, M. R., Langston, W. J., Pope, N., Minier, C., & Rotchell, J. M. (2012). Intersex in scrobicularia plana: transcriptomic analysis reveals novel genes involved in endocrine disruption. Environmental Science and Technology, 46(23), 12936-12942. doi:10.1021/es302948g

Intersex, the appearance of female characteristics in male gonads, has been identified in a wide range of aquatic species worldwide, yet the underpinning molecular etiology remains uncharacterised. The presence of intersex has been shown to be a wide... Read More

Combined effect of cadmium and estradiol on the endocrine system of roach (Rutilus rutilus): In vitro and in vivo approaches (2012)
Journal Article
Gerbron, M., Geraudie, P., Xuereb, B., Hill, E. M., Rotchell, J., & Minier, C. (2012). Combined effect of cadmium and estradiol on the endocrine system of roach (Rutilus rutilus): In vitro and in vivo approaches. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 163(Supplement), S34-S34. doi:10.1016/j.cbpa.2012.05.099

Two CYP3A-like genes in the marine mussel Mytilus edulis: mRNA expression modulation following short-term exposure to endocrine disruptors (2012)
Journal Article
Cubero-Leon, E., Puinean, A. M., Labadie, P., Ciocan, C., Itoh, N., Kishida, M., …Rotchell, J. M. (2012). Two CYP3A-like genes in the marine mussel Mytilus edulis: mRNA expression modulation following short-term exposure to endocrine disruptors. Marine environmental research, 74, (32-39). doi:10.1016/j.marenvres.2011.11.012. ISSN 0141-1136

Members of the vertebrate CYP3A subfamily are involved in the metabolism of steroids and a wide range of xenobiotics. In this study two CYP3A- like mRNAs have been isolated from the mussel (Mytilus edulis), and their seasonal expression profile and m... Read More

Metabolomic analysis of sex specific metabolites in gonads of the mussel, Mytilus edulis (2012)
Journal Article
Cubero-Leon, E., Minier, C., Hill, E. M., & Rotchell, J. (2012). Metabolomic analysis of sex specific metabolites in gonads of the mussel, Mytilus edulis. Comparative Biochemistry and Physiology - Part D: Genomics and Proteomics, 7(2), (212-219). doi:10.1016/j.cbd.2012.03.002. ISSN 1744-117X

Marine mussels have been used as sentinel organisms to monitor exposure to a variety of chemical contaminants, including endocrine disrupting chemicals, in the aquatic environment. Although they are an important species for use in ecotoxicology inves... Read More

Transcriptional responses of cancer-related genes in turbot Scophthalmus maximus and mussels Mytilus edulis exposed to heavy fuel oil no. 6 and styrene (2012)
Journal Article
Ruiz, P., Orbea, A., Rotchell, J. M., & Cajaraville, M. P. (2012). Transcriptional responses of cancer-related genes in turbot Scophthalmus maximus and mussels Mytilus edulis exposed to heavy fuel oil no. 6 and styrene. Ecotoxicology, 21(3), 820-831. doi:10.1007/s10646-011-0843-6

Recent spills in European waters have released polycyclic aromatic hydrocarbons, important components of heavy fuel oil, and the hydrocarbon styrene. Heavy fuel oil and styrene are classified as potentially genotoxic and carcinogenic. Here we investi... Read More

Reference gene selection for qPCR in mussel, Mytilus edulis, during gametogenesis and exogenous estrogen exposure (2012)
Journal Article
Cubero-Leon, E., Ciocan, C. M., Minier, C., & Rotchell, J. M. (2012). Reference gene selection for qPCR in mussel, Mytilus edulis, during gametogenesis and exogenous estrogen exposure. Environmental science and pollution research international, 19(7), (2728-2733). doi:10.1007/s11356-012-0772-9. ISSN 0944-1344

Purpose: The aim of this study is to develop a normalization method for real-time PCR data by analyzing the most stably expressed control genes in mussel (Mytilus edulis) reproductive tissue. Methods: To facilitate this, six candidate genes, includin... Read More