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Seasonal expression patterns of clock-associated genes in the blue mussel Mytilus edulis (2017)
Journal Article
Chapman, E. C., O’Dell, A. R., Meligi, N. M., Parsons, D. R., & Rotchell, J. M. (2017). Seasonal expression patterns of clock-associated genes in the blue mussel Mytilus edulis. Chronobiology International, 34(9), 1300-1314. https://doi.org/10.1080/07420528.2017.1363224

Environmental cues allow organisms to synchronise their internal biological rhythms with external environmental cycles. These rhythms are regulated on a molecular level by oscillating interactions between clock genes and their proteins. Light is a pa... Read More

Environmental concentration of carbamazepine accelerates fish embryonic development and disturbs larvae behavior (2016)
Journal Article
Qiang, L., Cheng, J., Yi, J., Rotchell, J. M., Zhu, X., & Zhou, J. (2016). Environmental concentration of carbamazepine accelerates fish embryonic development and disturbs larvae behavior. Ecotoxicology, 25(7), 1426-1437. https://doi.org/10.1007/s10646-016-1694-y

Environmental pollution caused by pharmaceuticals has been recognized as a major threat to the aquatic ecosystems. Carbamazepine, as the widely prescribed antiepileptic drug, has been frequently detected in the aquatic environment and has created con... Read More

Silver nanoparticles affect the neural development of zebrafish embryos: AgNPs affect the embryonic neural development (2015)
Journal Article
Xin, Q., Rotchell, J. M., Cheng, J., Yi, J., & Zhang, Q. (2015). Silver nanoparticles affect the neural development of zebrafish embryos: AgNPs affect the embryonic neural development. Journal of Applied Toxicology, 35(12), 1481-1492. https://doi.org/10.1002/jat.3164

Silver nanoparticles (AgNPs) have been widely used in commercial products. This study aims to understand the impact of AgNPs on the early developmental stages in zebrafish (Danio rerio) embryos. Embryos were exposed to two sizes of AgNPs at three dos... Read More

Molecular characterization of an estrogen receptor and estrogen-related receptor and their autoregulatory capabilities in two Mytilus species (2015)
Journal Article
Nagasawa, K., Treen, N., Kondo, R., Otoki, Y., Itoh, N., Rotchell, J. M., & Osada, M. (2015). Molecular characterization of an estrogen receptor and estrogen-related receptor and their autoregulatory capabilities in two Mytilus species. Gene, 564(2), 153-159. https://doi.org/10.1016/j.gene.2015.03.073

Vertebrate-like sex steroid hormones have been widely detected in mollusks, and numerous experiments have shown the importance of steroids in gonad development. Nevertheless, their signaling pathways in invertebrates have not been uncovered yet. Ster... Read More

Use of the enhanced frog embryo teratogenesis assay-Xenopus (FETAX) to determine chemically-induced phenotypic effects (2014)
Journal Article
Hu, L., Zhu, J., Rotchell, J. M., Wu, L., Gao, J., & Shi, H. (2015). Use of the enhanced frog embryo teratogenesis assay-Xenopus (FETAX) to determine chemically-induced phenotypic effects. The Science of the total environment, 508, 258-265. https://doi.org/10.1016/j.scitotenv.2014.11.086

The frog embryo teratogenesis assay-Xenopus (FETAX) is an established method for the evaluation of the developmental toxicities of chemicals. To develop an enhanced FETAX that is appropriate for common environmental contaminants, we exposed Xenopus t... Read More

Metabolomic analysis of sex specific metabolites in gonads of the mussel, Mytilus edulis (2012)
Journal Article
Cubero-Leon, E., Minier, C., Hill, E. M., & Rotchell, J. (2012). Metabolomic analysis of sex specific metabolites in gonads of the mussel, Mytilus edulis. Comparative Biochemistry and Physiology - Part D: Genomics and Proteomics, 7(2), (212-219). doi:10.1016/j.cbd.2012.03.002. ISSN 1744-117X

Marine mussels have been used as sentinel organisms to monitor exposure to a variety of chemical contaminants, including endocrine disrupting chemicals, in the aquatic environment. Although they are an important species for use in ecotoxicology inves... Read More

Transcriptional responses of cancer-related genes in turbot Scophthalmus maximus and mussels Mytilus edulis exposed to heavy fuel oil no. 6 and styrene (2012)
Journal Article
Ruiz, P., Orbea, A., Rotchell, J. M., & Cajaraville, M. P. (2012). Transcriptional responses of cancer-related genes in turbot Scophthalmus maximus and mussels Mytilus edulis exposed to heavy fuel oil no. 6 and styrene. Ecotoxicology, 21(3), 820-831. doi:10.1007/s10646-011-0843-6

Recent spills in European waters have released polycyclic aromatic hydrocarbons, important components of heavy fuel oil, and the hydrocarbon styrene. Heavy fuel oil and styrene are classified as potentially genotoxic and carcinogenic. Here we investi... Read More

Analytical challenges and the development of biomarkers to measure and to monitor the effects of ocean acidification (2011)
Journal Article
Hardege, J., Rotchell, J., Terschak, J., & Greenway, G. (2011). Analytical challenges and the development of biomarkers to measure and to monitor the effects of ocean acidification. Trends in Analytical Chemistry, 30(8), 1320-1326. https://doi.org/10.1016/j.trac.2011.07.004

Changing ocean-carbonate chemistry caused by oceanic uptake of anthropogenic atmospheric carbon dioxide leads to the formation of carbonic acid, thus lowering the pH of the sea with predictions of a decrease from current levels at 8.15 to 7.82 by the... Read More

Estrogens disrupt serotonin receptor and cyclooxygenase mRNA expression in the gonads of mussels (Mytilus edulis) (2010)
Journal Article
Cubero-Leon, E., Ciocan, C. M., Hill, E. M., Osada, M., Kishida, M., Itoh, N., …Rotchell, J. M. (2010). Estrogens disrupt serotonin receptor and cyclooxygenase mRNA expression in the gonads of mussels (Mytilus edulis). Aquatic Toxicology, 98(2), (178-187). doi:10.1016/j.aquatox.2010.02.007. ISSN 0166-445X

Estrogenic contaminants in the aquatic environment are associated with feminisation of male fish, however their effects on some invertebrate species, such as bivalve molluscs, have yet to be characterised. Gametogenesis represents a critical step in... Read More

Anchoring novel molecular biomarker responses to traditional responses in fish exposed to environmental contamination (2009)
Journal Article
Nogueira, P., Pacheco, M., Lourdes Pereira, M., Mendo, S., & Rotchell, J. M. (2010). Anchoring novel molecular biomarker responses to traditional responses in fish exposed to environmental contamination. Environmental pollution, 158(5), (1783-1790). doi:10.1016/j.envpol.2009.11.007. ISSN 0269-7491

The responses of Dicentrarchus labrax and Liza aurata to aquatic pollution were assessed in a contaminated coastal lagoon, using both traditional and novel biomarkers combined. DNA damage, assessed by comet assay, was higher in both fish species from... Read More

Transcript profiling and DNA damage in the European eel (Anguilla anguilla L.) exposed to 7,12-dimethylbenz[a]anthracene (2009)
Journal Article
Nogueira, P., Lourenço, J., Rodriguez, E., Pacheco, M., Santos, C., Rotchell, J. M., & Mendo, S. (2009). Transcript profiling and DNA damage in the European eel (Anguilla anguilla L.) exposed to 7,12-dimethylbenz[a]anthracene. Aquatic Toxicology, 94(2), (123-130). doi:10.1016/j.aquatox.2009.06.007. ISSN 0166-445X

The molecular responses induced during and after an acute exposure to 7,12-dimethylbenz[a]anthracene (DMBA) were analysed in liver, gill and blood cells of juvenile Anguilla anguilla with the aim of developing molecular biomarkers of environmental PA... Read More

Estrogenic activity of cadmium, copper and zinc in the yeast estrogen screen (2009)
Journal Article
Denier, X., Hill, E. M., Rotchell, J., & Minier, C. (2009). Estrogenic activity of cadmium, copper and zinc in the yeast estrogen screen. Toxicology in Vitro, 23(4), (569-573). doi:10.1016/j.tiv.2009.01.006. ISSN 0887-2333

Heavy metals are increasingly studied due to their apparent ability to disrupt signaling pathways of living organisms including humans. Among various mechanisms of action, metals are suspected of exerting estrogenic activity in human and wildlife. In... Read More

A novel population health approach: using fish retinoblastoma gene profiles as a surrogate for humans (2008)
Journal Article
Rotchell, J. M., du Corbier, F. A., Stentiford, G. D., Lyons, B. P., Liddle, A. R., & Ostrander, G. K. (2009). A novel population health approach: using fish retinoblastoma gene profiles as a surrogate for humans. Comparative Biochemistry and Physiology - Part C: Toxicology and Pharmacology, 149(2), (134-140). doi:10.1016/j.cbpc.2008.09.009. ISSN 1532-0456

Retinoblastoma, a tumor suppressor gene, is frequently mutated in diverse types of human tumors. We have previously shown that two types of fish tumor, eye and liver, also possess mutant Rb genes. Our aim is to determine if the Rb allele status is li... Read More

Ras gene in marine mussels: A molecular level response to petrochemical exposure (2008)
Journal Article
Lima, I., Peck, M. R., Rendón-Von Osten, J., Soares, A. M. V. M., Guilhermino, L., & Rotchell, J. (2008). Ras gene in marine mussels: A molecular level response to petrochemical exposure. Marine pollution bulletin, 56(4), (633-640). doi:10.1016/j.marpolbul.2008.01.018. ISSN 0025-326X

Mussels are susceptible to numerous toxicants and are often employed as bioindicators. This study investigated the status of the ras proto-oncogene in Mytilus galloprovincialis following petrochemical exposure. A M. galloprovincialis homologue of the... Read More

To what extent are hepatic concentrations of heavy metals in Anguilla anguilla at a site in a contaminated estuary related to body size and age and reflected in the metallothionein concentrations? (2007)
Journal Article
Bird, D. J., Rotchell, J. M., Hesp, S. A., Newton, L. C., Hall, N. G., & Potter, I. C. (2008). To what extent are hepatic concentrations of heavy metals in Anguilla anguilla at a site in a contaminated estuary related to body size and age and reflected in the metallothionein concentrations?. Environmental pollution, 151(3), (641-651). doi:10.1016/j.envpol.2007.03.018. ISSN 0269-7491

We explored how hepatic [metal]s in Anguilla anguilla at a contaminated estuarine site are influenced by body size, age and season, and the extent that [Cu], [Cd] and [Zn]s are reflected in [metallothionein (MT)]s. Although each [metal] and [MT] incr... Read More

Conservation of cancer genes in the marine invertebrate Mytilus edulis (2005)
Journal Article
Ciocan, C. M., & Rotchell, J. M. (2005). Conservation of cancer genes in the marine invertebrate Mytilus edulis. Environmental Science and Technology, 39(9), (3029-3033). doi:10.1021/es0400887. ISSN 0013-936X

Mussels are susceptible to a wide range of environmental toxicants, including carcinogens, and thus are often employed as bioindicator species. To elucidate the molecular aetiology of such neoplastic damage, we have cloned Mytilus edulis homologues o... Read More