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TGFβ1-Endo180-dependent collagen deposition is dysregulated at the tumour-stromal interface in bone metastasis (2011)
Journal Article
Caley, M. P., Kogianni, G., Adamarek, A., Gronau, J. H., Rodriguez-Teja, M., Fonseca, A., …Sturge, J. (2012). TGFβ1-Endo180-dependent collagen deposition is dysregulated at the tumour-stromal interface in bone metastasis. Journal of Pathology, 226(5), 775-783. doi:10.1002/path.3958

Cellular niches in adult tissue can harbour dysregulated microenvironments that become the driving force behind disease progression. The major environmental change when metastatic cells arrive in the bone is the destruction of mineralized type I coll... Read More about TGFβ1-Endo180-dependent collagen deposition is dysregulated at the tumour-stromal interface in bone metastasis.

Bone metastasis in prostate cancer: Emerging therapeutic strategies (2011)
Journal Article
Sturge, J., Caley, M. P., & Waxman, J. (2011). Bone metastasis in prostate cancer: Emerging therapeutic strategies. Nature Reviews Clinical Oncology, 8(6), (357-368). doi:10.1038/nrclinonc.2011.67. ISSN 1759-4774

Metastatic bone disease (MBD) in advanced-stage cancer increases the risk of intractable bone pain, pathological skeletal fracture, spinal-cord compression and decreased survival. The disease manifestation course during MBD is largely driven by homot... Read More about Bone metastasis in prostate cancer: Emerging therapeutic strategies.