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Biological and clinical implications of nicastrin expression in invasive breast cancer (2010)
Journal Article
Filipović, A., Gronau, J. H., Green, A. R., Wang, J., Vallath, S., Shao, D., …Coombes, R. C. (2010). Biological and clinical implications of nicastrin expression in invasive breast cancer. Breast cancer research and treatment, 125(1), 43-53. doi:10.1007/s10549-010-0823-1

Nicastrin is an essential component of the gamma secretase (GS) enzyme complex, required for its synthesis and recognition of substrates for proteolytic cleavage. The purpose of this study was to investigate whether nicastrin has prognostic value or... Read More

Collagen remodelling by osteoblast and prostate vancer vell interactions in metastatic bone lesions (2009)
Conference Proceeding
Sturge, J. (2009). Collagen remodelling by osteoblast and prostate vancer vell interactions in metastatic bone lesions

A major clinical complication in patients with advanced prostate cancer is metastasis to bone where osteoblastic and/or osteoclastic activity results in a highly destructive tissue remodelling process.Recent in vivo studies have identified important... Read More

Endo180 expression with cofunctional partners MT1-MMP and uPAR-uPA is correlated with prostate cancer progression (2008)
Journal Article
Kogianni, G., Walker, M. M., Waxman, J., & Sturge, J. (2009). Endo180 expression with cofunctional partners MT1-MMP and uPAR-uPA is correlated with prostate cancer progression. European Journal of Cancer, 45(4), 685-693. https://doi.org/10.1016/j.ejca.2008.11.023

Endo180 (CD280; MRC2; uPARAP) regulates collagen remodelling and chemotactic cell migration through cooperation with membrane type-1 matrix metalloproteinase (MT1-MMP), urokinase-type plasminogen activator receptor (uPAR) and urokinase-type plasminog... Read More

The Collagen Receptor Endo180 (CD280) Is Expressed on Basal-like Breast Tumor Cells and Promotes Tumor Growth In vivo (2007)
Journal Article
Wienke, D., Davies, G. C., Johnson, D. A., Sturge, J., Lambros, M. B., Savage, K., …Isacke, C. M. (2007). The Collagen Receptor Endo180 (CD280) Is Expressed on Basal-like Breast Tumor Cells and Promotes Tumor Growth In vivo. Cancer Research, 67(21), 10230-10240. https://doi.org/10.1158/0008-5472.can-06-3496

Tumor cell invasion into the surrounding stroma requires increased cell motility and extensive remodeling of the extracellular matrix. Endo180 (CD280, MRC2, urokinase-type plasminogen activator receptor-associated protein) is a recycling endocytic re... Read More

Mannose receptor regulation of macrophage cell migration (2007)
Journal Article
Sturge, J., Todd, S. K., Kogianni, G., McCarthy, A., & Isacke, C. M. (2007). Mannose receptor regulation of macrophage cell migration. Journal of Leukocyte Biology, 82(3), 585-593. https://doi.org/10.1189/jlb.0107053

The migration of macrophages through peripheral tissues is an essential step in the host response to infection, inflammation, and ischemia as well as in tumor progression and tissue repair. The mannose receptor (MR; CD206, previously known as the mac... Read More

Endo180 (2006)
Digital Artefact
Wienke, D., Sturge, J., Pirinen, N. J., Henry, L. A., Davies, G. C., & Isacke, C. M. Endo180

Endosomes generate localized Rho–ROCK–MLC2–based contractile signals via Endo180 to promote adhesion disassembly (2006)
Journal Article
Sturge, J., Wienke, D., & Isacke, C. M. (2006). Endosomes generate localized Rho–ROCK–MLC2–based contractile signals via Endo180 to promote adhesion disassembly. Journal of Cell Biology, 175(2), 337-347. https://doi.org/10.1083/jcb.200602125

The regulated assembly and disassembly of focal adhesions and adherens junctions contributes to cell motility and tumor invasion. Pivotal in this process is phosphorylation of myosin light chain-2 (MLC2) by Rho kinase (ROCK) downstream of Rho activat... Read More

GPI-anchored uPAR requires Endo180 for rapid directional sensing during chemotaxis (2003)
Journal Article
Sturge, J., Wienke, D., East, L., Jones, G. E., & Isacke, C. M. (2003). GPI-anchored uPAR requires Endo180 for rapid directional sensing during chemotaxis. Journal of Cell Biology, 162(5), 789-794. https://doi.org/10.1083/jcb.200302124

Urokinase-type plasminogen activator (uPA) and its receptor (uPAR) play an important role in cell guidance and chemotaxis during normal and pathological events. uPAR is GPI-anchored and the mechanism by which it transmits intracellular polarity cues... Read More

A targeted deletion in the endocytic receptor gene Endo180 results in a defect in collagen uptake (2003)
Journal Article
East, L., McCarthy, A., Wienke, D., Sturge, J., Ashworth, A., & Isacke, C. M. (2003). A targeted deletion in the endocytic receptor gene Endo180 results in a defect in collagen uptake. EMBO Reports, 4(7), 710-716. https://doi.org/10.1038/sj.embor.embor882

The four members of the mannose receptor family (the mannose receptor, the M‐type phospholipase A2 receptor, DEC‐205 and Endo180) share a common extracellular arrangement of an amino‐terminal cysteine‐rich domain followed by a fibronectin type II (FN... Read More

Regulation of breast cancer cell chemotaxis by the phosphoinositide 3-Kinase p110δ (2003)
Journal Article
Sawyer, C., Sturge, J., Bennett, D. C., O'Hare, M. J., Allen, W. E., Bain, J., …Vanhaesebroeck, B. (2003). Regulation of breast cancer cell chemotaxis by the phosphoinositide 3-Kinase p110δ. Cancer Research, 63(7), 1667-1675

Class IA phosphoinositide 3′-kinases (PI3Ks) regulate many cellular processes downstream of tyrosine kinases and Ras. Despite a clear implication of PI3K in cancer, little is known about the distribution of the different PI3K isoforms in malignant ce... Read More

N-WASP activation by a β1-integrin-dependent mechanism supports PI3K-independent chemotaxis stimulated by urokinase-type plasminogen activator (2002)
Journal Article
Sturge, J., Hamelin, J., & Jones, G. (2002). N-WASP activation by a β1-integrin-dependent mechanism supports PI3K-independent chemotaxis stimulated by urokinase-type plasminogen activator. Journal of cell science, 115(4), 699-711

Urokinase-type plasminogen activator (uPA)-uPA receptor (uPAR) and epidermal growth factor (EGF)-EGF receptor (EGFR) expression is highly correlated with breast cancer metastasis. Phosphoinositide 3-kinase (PI3K), small Rho GTPases, such as Cdc42 and... Read More

Fibrin monomer and fibrinopeptide B act additively to increase DNA synthesis in smooth muscle cells cultured from human saphenous vein (2001)
Journal Article
Sturge, J., Carey, N., Davies, A. H., & Powell, J. T. (2001). Fibrin monomer and fibrinopeptide B act additively to increase DNA synthesis in smooth muscle cells cultured from human saphenous vein. Journal of vascular surgery, 33(4), 847-853. https://doi.org/10.1067/mva.2001.111984

Purpose: We investigated the hypothesis that fibrinogen increased DNA synthesis (and cell proliferation) of smooth muscle cells (SMCs) cultured from human saphenous vein and that the increased DNA synthesis was attenuated when cells were cultured on... Read More

Regulation by fibrinogen and its products of intercellular adhesion molecule-1 expression in human saphenous vein endothelial cells (2000)
Journal Article
Harley, S. L., Sturge, J., & Powell, J. T. (2000). Regulation by fibrinogen and its products of intercellular adhesion molecule-1 expression in human saphenous vein endothelial cells. Arteriosclerosis, Thrombosis, and Vascular Biology, 20(3), 652-658. https://doi.org/10.1161/01.atv.20.3.652

It has been reported that fibrinogen may act as a bridging ligand, binding to intercellular adhesion molecule-1 (ICAM-1) on human umbilical vein endothelial cells and to Mac-1 on THP-1 cells (a monocytic cell line) to increase adhesion. In this study... Read More