All Outputs (52)

An investigation into the TRPV1-CGRP signalling pathway in vessel development (2024)
Thesis
Bates, A. An investigation into the TRPV1-CGRP signalling pathway in vessel development. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4865918

TRPV1 is a non-selective cation channel which is activated through various different factors including, but not limited to, raised temperature and acidic pH. It has been linked in the past to endothelial cell proliferation in acidic conditions, but a... Read More about An investigation into the TRPV1-CGRP signalling pathway in vessel development.

Environmental factors influence cross-talk between a heat shock protein and an oxidative stress protein modification in the lizard Gallotia galloti (2024)
Journal Article
Gilbert, E., Žagar, A., López-Darias, M., Megía-Palma, R., Lister, K. A., Jones, M. D., …Wollenberg Valero, K. C. (2024). Environmental factors influence cross-talk between a heat shock protein and an oxidative stress protein modification in the lizard Gallotia galloti. PLoS ONE, 19(3 March), Article e0300111. https://doi.org/10.1371/journal.pone.0300111

Better understanding how organisms respond to their abiotic environment, especially at the biochemical level, is critical in predicting population trajectories under climate change. In this study, we measured constitutive stress biomarkers and protei... Read More about Environmental factors influence cross-talk between a heat shock protein and an oxidative stress protein modification in the lizard Gallotia galloti.

Sex-related responses of blue mussels to the plasticiser DEHP under climate change scenarios (2023)
Thesis
Mincarelli, L. F. Sex-related responses of blue mussels to the plasticiser DEHP under climate change scenarios. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4436320

Climate change and plastic pollution are both pressing environmental issues. Little is known, however, about the combined effect of climate change conditions (such as global warming and ocean acidification) and plastic contaminants (such as the addit... Read More about Sex-related responses of blue mussels to the plasticiser DEHP under climate change scenarios.

Investigating the effects of arginine methylation inhibitors on microdissected brain tumour biopsies maintained in a miniaturised perfusion system (2023)
Journal Article
Barry, A., Samuel, S. F., Hosni, I., Moursi, A., Feugere, L., Sennett, C. J., …Beltran-Alvarez, P. (2023). Investigating the effects of arginine methylation inhibitors on microdissected brain tumour biopsies maintained in a miniaturised perfusion system. Lab on a chip, 23(11), 2664-2682. https://doi.org/10.1039/d3lc00204g

Arginine methylation is a post-translational modification that consists of the transfer of one or two methyl (CH3) groups to arginine residues in proteins. Several types of arginine methylation occur, namely monomethylation, symmetric dimethylation a... Read More about Investigating the effects of arginine methylation inhibitors on microdissected brain tumour biopsies maintained in a miniaturised perfusion system.

Heat induces multiomic and phenotypic stress propagation in zebrafish embryos (2023)
Journal Article
Feugere, L., Bates, A., Emagbetere, T., Chapman, E., Malcolm, L., Bulmer, K., …Wollenberg Valero, K. C. (2023). Heat induces multiomic and phenotypic stress propagation in zebrafish embryos. PNAS Nexus, 2(5), Article pgad137. https://doi.org/10.1093/pnasnexus/pgad137

Heat alters biology from molecular to ecological levels, but may also have unknown indirect effects. This includes the concept that animals exposed to abiotic stress can induce stress in naive receivers. Here, we provide a comprehensive picture of th... Read More about Heat induces multiomic and phenotypic stress propagation in zebrafish embryos.

The language of abiotic stress in aquatic animals : molecular characterisation of stress metabolite-mediated stress communication (2022)
Thesis
Feugère, L. The language of abiotic stress in aquatic animals : molecular characterisation of stress metabolite-mediated stress communication. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4311814

It is well established that aquatic animals inform their neighbours of predation risk through chemical cues. In this thesis, I tested the hypothesis that stress propagation is a widespread mechanism also activated by abiotic stressors – such as those... Read More about The language of abiotic stress in aquatic animals : molecular characterisation of stress metabolite-mediated stress communication.

Sex and gametogenesis stage are strong drivers of gene expression in Mytilus edulis exposed to environmentally relevant plasticiser levels and pH 7.7 (2022)
Journal Article
Mincarelli, L., Chapman, E. C., Rotchell, J. M., Turner, A., & Wollenberg Valero, K. C. (in press). Sex and gametogenesis stage are strong drivers of gene expression in Mytilus edulis exposed to environmentally relevant plasticiser levels and pH 7.7. Environmental science and pollution research, https://doi.org/10.1007/s11356-022-23801-3

Plastic pollution and changes in oceanic pH are both pressing environmental issues. Little emphasis, however, has been placed on the influence of sex and gametogenesis stage when investigating the effects of such stressors. Here, we examined histolog... Read More about Sex and gametogenesis stage are strong drivers of gene expression in Mytilus edulis exposed to environmentally relevant plasticiser levels and pH 7.7.

Behavioural stress propagation in benthic invertebrates caused by acute pH drop-induced metabolites (2021)
Journal Article
Feugere, L., Angell, L., Fagents, J., Nightingale, R., Rowland, K., Skinner, S., …Wollenberg Valero, K. C. (2021). Behavioural stress propagation in benthic invertebrates caused by acute pH drop-induced metabolites. Frontiers in Marine Science, 8, Article 773870. https://doi.org/10.3389/fmars.2021.773870

Studies on pH stress in marine animals typically focus on direct or species-specific aspects. We here test the hypothesis that a drop to pH = 7.6 indirectly affects the intra- and interspecific interactions of benthic invertebrates by means of chemic... Read More about Behavioural stress propagation in benthic invertebrates caused by acute pH drop-induced metabolites.

Functional genomics of abiotic environmental adaptation in lacertid lizards and other vertebrates (2021)
Journal Article
Wollenberg Valero, K. C., Garcia-Porta, J., Irisarri, I., Feugere, L., Bates, A., Kirchhof, S., Jovanovic Glavas, O., Pafilis, P., Samuel, S. F., Müller, J., Vences, M., Turner, A. P., Beltran-Alvarez, P., & Storey, K. B. (in press). Functional genomics of abiotic environmental adaptation in lacertid lizards and other vertebrates. The journal of animal ecology, https://doi.org/10.1111/1365-2656.13617

Understanding the genomic basis of adaptation to different abiotic environments is important in the context of climate change and resulting short-term environmental fluctuations. Using functional and comparative genomics approaches, we here investiga... Read More about Functional genomics of abiotic environmental adaptation in lacertid lizards and other vertebrates.

Thermal stress induces a positive phenotypic and molecular feedback loop in zebrafish embryos (2021)
Journal Article
Feugere, L., Wollenberg Valero, K. C., Scott, V., Rodriguez-Barucg, Q., & Beltran-Alvarez, P. (2021). Thermal stress induces a positive phenotypic and molecular feedback loop in zebrafish embryos. Journal of Thermal Biology, 102, Article 103114. https://doi.org/10.1016/j.jtherbio.2021.103114

Aquatic organisms must cope with both rising and rapidly changing temperatures. These thermal changes can affect numerous traits, from molecular to ecological scales. Biotic stressors are already known to induce the release of chemical cues which tri... Read More about Thermal stress induces a positive phenotypic and molecular feedback loop in zebrafish embryos.

Consequences of combined exposure to thermal stress and the plasticiser DEHP in Mytilus spp. differ by sex (2021)
Journal Article
Mincarelli, L. F., Rotchell, J. M., Chapman, E. C., Turner, A. P., & Wollenberg Valero, K. C. (2021). Consequences of combined exposure to thermal stress and the plasticiser DEHP in Mytilus spp. differ by sex. Marine pollution bulletin, 170, Article 112624. https://doi.org/10.1016/j.marpolbul.2021.112624

Little is known about the combined effect of environmental factors and contaminants on commercially important marine species, and whether this effect differs by sex. In this study, blue mussels were exposed for seven days to both single and combined... Read More about Consequences of combined exposure to thermal stress and the plasticiser DEHP in Mytilus spp. differ by sex.

Aligning functional network constraint to evolutionary outcomes (2020)
Journal Article
Wollenberg Valero, K. C. (2020). Aligning functional network constraint to evolutionary outcomes. BMC evolutionary biology, 20(1), Article 58. https://doi.org/10.1186/s12862-020-01613-8

Background. Functional constraint through genomic architecture is suggested to be an important dimension of genome evolution, but quantitative evidence for this idea is rare. In this contribution, existing evidence and discussions on genomi... Read More about Aligning functional network constraint to evolutionary outcomes.

Saxitoxin and tetrodotoxin bioavailability increases in future oceans (2019)
Journal Article
Roggatz, C. C., Fletcher, N., Benoit, D. M., Algar, A. C., Doroff, A., Wright, B., Wollenberg Valero, K. C., & Hardege, J. D. (2019). Saxitoxin and tetrodotoxin bioavailability increases in future oceans. Nature Climate Change, 9(11), 840-844. https://doi.org/10.1038/s41558-019-0589-3

© 2019, The Author(s), under exclusive licence to Springer Nature Limited. Increasing atmospheric CO2 levels are largely absorbed by the ocean, decreasing surface water pH1. In combination with increasing ocean temperatures, these changes have been i... Read More about Saxitoxin and tetrodotoxin bioavailability increases in future oceans.

Transcriptomic signatures of experimental alkaloid consumption in a poison frog (2019)
Journal Article
Sanchez, E., Rodríguez, A., Grau, J. H., Lötters, S., Künzel, S., Saporito, R. A., Ringler, E., Schulz, S., Wollenberg Valero, K. C., & Vences, M. (2019). Transcriptomic signatures of experimental alkaloid consumption in a poison frog. Genes, 10(10), 733. https://doi.org/10.3390/genes10100733

© 2019 by the authors. Licensee MDPI, Basel, Switzerland. In the anuran family Dendrobatidae, aposematic species obtain their toxic or unpalatable alkaloids from dietary sources, a process known as sequestering. To understand how toxicity evolved in... Read More about Transcriptomic signatures of experimental alkaloid consumption in a poison frog.

Environmental temperatures shape thermal physiology as well as diversification and genome-wide substitution rates in lizards (2019)
Journal Article
García-Porta, J., Irisarri, I., Kirchner, M., Rodriguez, A., Kirchhof, S., Brown, J. L., MacLeod, A., Turner, A. P., Ahmadzadeh, F., Albaladejo, G., Crnobrnja-Isailovic, J., De la Riva, I., Fawzi, A., Galan, P., Göçmen, B., Harris, D. J., Jiménez-Robles, O., Joger, U., Jovanović Glavaš, O., Karış, M., …Wollenberg Valero, K. C. (2019). Environmental temperatures shape thermal physiology as well as diversification and genome-wide substitution rates in lizards. Nature communications, 10(1), Article 4077. https://doi.org/10.1038/s41467-019-11943-x

© 2019, The Author(s). Climatic conditions changing over time and space shape the evolution of organisms at multiple levels, including temperate lizards in the family Lacertidae. Here we reconstruct a dated phylogenetic tree of 262 lacertid species b... Read More about Environmental temperatures shape thermal physiology as well as diversification and genome-wide substitution rates in lizards.

Patterns, mechanisms and genetics of speciation in reptiles and amphibians (2019)
Journal Article
Wollenberg Valero, K. C., Marshall, J. C., Bastiaans, E., Caccone, A., Camargo, A., Morando, M., Niemiller, M. L., Pabijan, M., Russello, M. A., Sinervo, B., Werneck, F. P., Sites, Jr., J. W., Wiens, J. J., & Steinfartz, S. (2019). Patterns, mechanisms and genetics of speciation in reptiles and amphibians. Genes, 10(9), Article 646. https://doi.org/10.3390/genes10090646

© 2019 by the authors. Licensee MDPI, Basel, Switzerland. In this contribution, the aspects of reptile and amphibian speciation that emerged from research performed over the past decade are reviewed. First, this study assesses how patterns and proces... Read More about Patterns, mechanisms and genetics of speciation in reptiles and amphibians.

Ecomorphological Variation in Three Species of Cybotoid Anoles (2017)
Journal Article
Kahrl, A. F., Ivanov, B. M., Valero, K. C. W., & Johnson, M. A. (2018). Ecomorphological Variation in Three Species of Cybotoid Anoles. Herpetologica, 74(1), 29-37. https://doi.org/10.1655/Herpetologica-D-17-00040

© 2018 by The Herpetologists' League, Inc. Caribbean Anolis lizards exhibit a complex suite of ecological, morphological, and behavioral traits that allow their specialization to particular microhabitats. These microhabitat specialists, called ecomor... Read More about Ecomorphological Variation in Three Species of Cybotoid Anoles.

Plant phenology supports the multi-emergence hypothesis for ebola spillover events (2017)
Journal Article
Wollenberg Valero, K. C., Douglas, N. E., Isokpehi, R. D., Johnson, B., McGill, A., Sivasundaram, S., & Wootson, K. (2018). Plant phenology supports the multi-emergence hypothesis for ebola spillover events. EcoHealth, 15(3), 497–508. https://doi.org/10.1007/s10393-017-1288-z

Ebola virus disease outbreaks in animals (including humans and great apes) start with sporadic host switches from unknown reservoir species. The factors leading to such spillover events are little explored. Filoviridae viruses have a wide range of na... Read More about Plant phenology supports the multi-emergence hypothesis for ebola spillover events.

Plant phenology supports the multi-emergence hypothesis for Ebola spillover events (2017)
Other
Wollenberg Valero, K. C., Isokpehi, R., Douglas, N. E., Sivasundaram, S., Johnson, B., Wootson, K., & McGill, A. (2017). Plant phenology supports the multi-emergence hypothesis for Ebola spillover events. EcoHealth

Ebola virus disease outbreaks in animals (including humans and great apes) start with sporadic host switches from unknown reservoir species. The factors leading to such spillover events are little explored. Filoviridae viruses have a wide range of na... Read More about Plant phenology supports the multi-emergence hypothesis for Ebola spillover events.

Genomic and phenotypic signatures of climate adaptation in an Anolis lizard (2017)
Journal Article
Rodríguez, A., Rusciano, T., Hamilton, R., Holmes, L., Jordan, D., & Wollenberg Valero, K. C. (2017). Genomic and phenotypic signatures of climate adaptation in an Anolis lizard. Ecology and Evolution, 7(16), 6390-6403. https://doi.org/10.1002/ece3.2985

Integrated knowledge on phenotype, physiology and genomic adaptations is required to understand the effects of climate on evolution. The functional genomic basis of organismal adaptation to changes in the abiotic environment, its phenotypic consequen... Read More about Genomic and phenotypic signatures of climate adaptation in an Anolis lizard.