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The inhibitory subunit of cardiac troponin (cTnI) is modified by arginine methylation in the human heart (2019)
Journal Article
Onwuli, D. O., Samuel, S., Sfyri, P., Welham, K., Goddard, M., Abu-Omar, Y., …Beltran-Alvarez, P. (in press). The inhibitory subunit of cardiac troponin (cTnI) is modified by arginine methylation in the human heart. International journal of cardiology,

Background The inhibitory subunit of cardiac troponin (cTnI) is a gold standard cardiac biomarker and also an essential protein in cardiomyocyte excitation-contraction coupling. The interactions of cTnI with other proteins are fine-tuned by post-tra... Read More

A disposable microfluidic device with a screen printed electrode for mimicking phase II metabolism (2016)
Journal Article
Vasiliadou, R., Esfahani, M. M. N., Brown, N., & Welham, K. (2016). A disposable microfluidic device with a screen printed electrode for mimicking phase II metabolism. Sensors, 16(9), (1418). doi:10.3390/s16091418. ISSN 1424-8220

Human metabolism is investigated using several in vitro methods. However, the current methodologies are often expensive, tedious and complicated. Over the last decade, the combination of electrochemistry (EC) with mass spectrometry (MS) has a simpler... Read More

Preconcentration of milk proteins using octadecylated monolithic silica microchip (2013)
Journal Article
Alzahrani, E., & Welham, K. (2013). Preconcentration of milk proteins using octadecylated monolithic silica microchip. Analytica Chimica Acta, 798, (40-47). doi:10.1016/j.aca.2013.08.035. ISSN 0003-2670

Sample preparation is a bottleneck in systems for chemical analysis and it is a required step in order to remove interference and preconcentrate the target analytes. Much research in recent years has focused on porous monolithic materials since they... Read More

Identification of a female sex pheromone in Carcinus maenas (2011)
Journal Article
Bublitz, R., Walther, T., Welham, K., Davidson, L., Smith, M., Harley, M., …Terschak, J. (2011). Identification of a female sex pheromone in Carcinus maenas. Marine ecology progress series, 436, 177-189. doi:10.3354/meps09226

Despite major progress in our understanding of animal signaling systems, the identification of chemical signals in aquatic organisms is still in its infancy. Exemplary for this is the lack of structural knowledge of crustacean sex pheromones despite... Read More

Design and evaluation of synthetic silica-based monolithic materials in shrinkable tube for efficient protein extraction (2011)
Journal Article
Alzahrani, E., & Welham, K. (2011). Design and evaluation of synthetic silica-based monolithic materials in shrinkable tube for efficient protein extraction. The Analyst, 136(20), (4321-4327). doi:10.1039/c1an15447h. ISSN 0003-2654

Sample pretreatment is a required step in proteomics in order to remove interferences and preconcentrate the samples. Much research in recent years has focused on porous monolithic materials since they are highly permeable to liquid flow and show hig... Read More

Evidence that 1-methyl-L-tryptophan is a food-related odorant for the Senegalese sole (Solea senegalensis) (2011)
Journal Article
Velez, Z., Hubbard, P. C., Hardege, J. D., Welham, K. J., Barata, E. N., & Canário, A. V. M. (2011). Evidence that 1-methyl-L-tryptophan is a food-related odorant for the Senegalese sole (Solea senegalensis). Aquaculture, 314(1-4), (153-158). doi:10.1016/j.aquaculture.2011.01.025. ISSN 0044-8486

Nocturnal animals often rely heavily on olfactory cues to locate their food. This is especially true for fish whose prey live buried in the substrate. The aim of the current study was to identify non-polar odorants released by the ragworm (Hediste di... Read More

Detection of nitric oxide in tissue samples by ESI-MS (2009)
Journal Article
Shen, Z., Webster, A., Welham, K. J., Dyer, C. E., Greenman, J., & Haswell, S. J. (2010). Detection of nitric oxide in tissue samples by ESI-MS. The Analyst, 135(2), (302-305). doi:10.1039/b917643h. ISSN 0003-2654

A novel method to determine nitric oxide (NO) in biological tissue samples with minimal interference from the cellular detritus is described. Methylpiperazinobenzenediamine, consisting of an o-phenylenediamine and a methyl piperazine group, was chose... Read More

Proteomic identification of putative biomarkers of radiotherapy resistance: a possible role for the 26S proteasome? (2009)
Journal Article
Smith, L., Qutob, O., Watson, M. B., Beavis, A. W., Potts, D., Welham, K. J., …Cawkwell, L. (2009). Proteomic identification of putative biomarkers of radiotherapy resistance: a possible role for the 26S proteasome?. Neoplasia, 11(11), (1194-1207). doi:10.1593/neo.09902. ISSN 1522-8002

PURPOSE: We aimed to identify putative predictive protein biomarkers of radioresistance. EXPERIMENTAL DESIGN: Three breast cancer cell lines (MCF7, MDA-MB-231, and T47D) were used as in vitro models to study radioresistance. Inherent radiosensitiviti... Read More