All Outputs (3)

Phosphoproteomic analysis of platelet signalling cascades by flow cytometry (2014)
Thesis
Spurgeon, B. E. J. Phosphoproteomic analysis of platelet signalling cascades by flow cytometry. (Thesis). Hull York Medical School, the University of Hull and the University of York. https://hull-repository.worktribe.com/output/4216373

The activation of blood platelets is a critical haemostatic response that serves to prevent haemorrhage, but unregulated platelet activation is associated with arterial thrombosis. Endothelial-derived inhibitors prostacyclin (PGI₂) and nitric oxide (... Read More about Phosphoproteomic analysis of platelet signalling cascades by flow cytometry.

GLP-1R, a novel receptor in platelets; and the use of liraglutide in the treatment of obesity in women with PCOS (2013)
Thesis
Kahal, H. GLP-1R, a novel receptor in platelets; and the use of liraglutide in the treatment of obesity in women with PCOS. (Thesis). Hull York Medical School, the University of Hull and the University of York. https://hull-repository.worktribe.com/output/4215983

Studies investigating atherothrombotic risk in women with polycystic ovary syndrome (PCOS), in particular platelet function and carotid intima-media wall thickness (cIMT), have been confounded by not adequately accounting for obesity. Liraglutide is... Read More about GLP-1R, a novel receptor in platelets; and the use of liraglutide in the treatment of obesity in women with PCOS.

Regulation of blood platelet function by nitric oxide (2013)
Thesis
Wake, J. D. Regulation of blood platelet function by nitric oxide. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4214507

Upon vascular injury, platelets instantly adhere to the exposed extracellular matrix resulting in platelet activation and aggregation to form a haemostatic plug. This self-amplifying mechanism requires a tight control to prevent uncontrolled platelet... Read More about Regulation of blood platelet function by nitric oxide.