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cGMP signaling inhibits platelet shape change through regulation of the RhoA-Rho Kinase-MLC phosphatase signaling pathway (2017)
Journal Article
Aburima, A., Walladbegi, K., Wake, J. D., & Naseem, K. M. (2017). cGMP signaling inhibits platelet shape change through regulation of the RhoA-Rho Kinase-MLC phosphatase signaling pathway. Journal of thrombosis and haemostasis : JTH, 15(8), 1668-1678. doi:10.1111/jth.13738

Essentials Platelet shape change requires cytoskeletal rearrangement via myosin‐mediated actin contraction. We investigated whether nitric oxide (NO) affected thrombin‐induced platelet shape change. NO inhibits shape change, RhoA/ROCK signalling a... Read More