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Diuretic Treatment in Patients with Heart Failure: Current Evidence and Future Directions-Part II: Combination Therapy (2024)
Journal Article
Cuthbert, J., Clark, A., & Cleland, J. (2024). Diuretic Treatment in Patients with Heart Failure: Current Evidence and Future Directions-Part II: Combination Therapy. Current Heart Failure Reports, https://doi.org/10.1007/s11897-024-00644-2

Purpose of Review Fluid retention or congestion is a major cause of symptoms, poor quality of life, and adverse outcome in patients with heart failure (HF). Despite advances in disease-modifying therapy, the mainstay of treatment for congestion loop... Read More about Diuretic Treatment in Patients with Heart Failure: Current Evidence and Future Directions-Part II: Combination Therapy.

Dynamic risk stratification using Markov chain modelling in patients with chronic heart failure (2022)
Journal Article
Kazmi, S., Kambhampati, C., Cleland, J., Cuthbert, J., Kazmi, K. S., Pellicori, P., …Clark, A. L. (2022). Dynamic risk stratification using Markov chain modelling in patients with chronic heart failure. ESC Heart Failure, https://doi.org/10.1002/ehf2.14028

Aims: Risk changes with the progression of disease and the impact of treatment. We developed a dynamic risk stratification Markov chain model using artificial intelligence in patients with chronic heart failure (CHF). Methods and results: We describe... Read More about Dynamic risk stratification using Markov chain modelling in patients with chronic heart failure.

Relation Between Thyroid Function and Mortality in Patients With Chronic Heart Failure (2020)
Journal Article
Samuel, N. A., Cuthbert, J. J., Brown, O. I., Kazmi, S., Cleland, J. G., Rigby, A. S., & Clark, A. L. (2021). Relation Between Thyroid Function and Mortality in Patients With Chronic Heart Failure. The American journal of cardiology, 139, 57-63. https://doi.org/10.1016/j.amjcard.2020.10.034

Thyroid dysfunction is common in patients with chronic heart failure (CHF), but there is conflicting evidence regarding its prognostic significance. We investigated the relation between thyroid function and prognosis in a large, well characterized co... Read More about Relation Between Thyroid Function and Mortality in Patients With Chronic Heart Failure.

Prevalence and incidence of atrial fibrillation in ambulatory patients with heart failure (2019)
Journal Article
Pellicori, P., Urbinati, A., Kaur, K., Zhang, J., Shah, P., Kazmi, S., …Clark, A. L. (2019). Prevalence and incidence of atrial fibrillation in ambulatory patients with heart failure. The American journal of cardiology, https://doi.org/10.1016/j.amjcard.2019.08.018

Heart failure (HF) and atrial fibrillation (AF) commonly co-exist. We aimed to determine the prevalence and incidence of AF in ambulatory patients with HF.

High sensitivity C-Reactive Protein in Chronic heart failure: Patient Characteristics, Phenotypes and mode of death (2019)
Journal Article
Pellicori, P., Zhang, J., Cuthbert, J., Urbinati, A., Shah, P., Kazmi, S., …Cleland, J. (2020). High sensitivity C-Reactive Protein in Chronic heart failure: Patient Characteristics, Phenotypes and mode of death. Cardiovascular research, 116(1), 91-100. https://doi.org/10.1093/cvr/cvz198

Aims: Plasma concentrations of high sensitivity C-reactive protein (hsCRP) are often raised in chronic heart failure (CHF) and might indicate inflammatory processes that could be a therapeutic target. We aimed to study the associations between hsCRP,... Read More about High sensitivity C-Reactive Protein in Chronic heart failure: Patient Characteristics, Phenotypes and mode of death.

Clinical and prognostic association of total atrial and conduction time in patients with heart failure: a report from Studies Investigating Co-morbidities Aggravating Heart Failure (2019)
Journal Article
Nuzzi, V., Pellicori, P., Nikolaidou, T., Kallvikbacka-Bennett, A., Torromeo, C., Barilla, F., …Clark, A. (2019). Clinical and prognostic association of total atrial and conduction time in patients with heart failure: a report from Studies Investigating Co-morbidities Aggravating Heart Failure. European journal of heart failure, 20(7), 442–449. https://doi.org/10.2459/JCM.0000000000000802

Background The total atrial conduction time can be measured as the time from the onset of the P wave on the ECG to the peak of the A wave recorded at the mitral annulus using tissue Doppler imaging (A′; P-A′TDI); when prolonged, it might predict inci... Read More about Clinical and prognostic association of total atrial and conduction time in patients with heart failure: a report from Studies Investigating Co-morbidities Aggravating Heart Failure.

Characteristics and outcome of acute heart failure patients according to the severity of peripheral oedema (2019)
Journal Article
Shoaib, A., Mamas, M. A., Ahmad, Q. S., McDonagh, T. M., Hardman, S. M., Rashid, M., …Cleland, J. G. F. (2019). Characteristics and outcome of acute heart failure patients according to the severity of peripheral oedema. International journal of cardiology, 285, 40-46. https://doi.org/10.1016/j.ijcard.2019.03.020

Background Most trials of patients hospitalized for heart failure focus on breathlessness (alveolar pulmonary oedema) but worsening peripheral oedema is also an important presentation. We investigated the relationship between the severity of periphe... Read More about Characteristics and outcome of acute heart failure patients according to the severity of peripheral oedema.

Dynamic risk stratification using serial measurements of plasma concentrations of natriuretic peptides in patients with heart failure (2018)
Journal Article
Zhang, J., Pellicori, P., Pan, D., Dierckx, R., Clark, A. L., & Cleland, J. (2018). Dynamic risk stratification using serial measurements of plasma concentrations of natriuretic peptides in patients with heart failure. International journal of cardiology, 269, 196-200. https://doi.org/10.1016/j.ijcard.2018.06.070

Background Prognostic models for patients with chronic heart failure are generally based on a single assessment but treatment is often given with the intention of changing risk; re- evaluation of risk is an important aspect of care. The prognostic va... Read More about Dynamic risk stratification using serial measurements of plasma concentrations of natriuretic peptides in patients with heart failure.

Validation of U.S. mortality prediction models for hospitalized heart failure in the United Kingdom and Japan: Validation of risk models in decompensated heart failure (2018)
Journal Article
Nagai, T., Sundaram, V., Shoaib, A., Shiraishi, Y., Kohsaka, S., Rothnie, K. J., …Cleland, J. G. (2018). Validation of U.S. mortality prediction models for hospitalized heart failure in the United Kingdom and Japan: Validation of risk models in decompensated heart failure. European journal of heart failure, 20(8), 1179-1190. https://doi.org/10.1002/ejhf.1210

Aims: Prognostic models for hospitalised heart failure (HHF) were developed predominantly for patients of European origin in the United States of America; it is unclear whether they perform similarly in other health-care systems or for different ethn... Read More about Validation of U.S. mortality prediction models for hospitalized heart failure in the United Kingdom and Japan: Validation of risk models in decompensated heart failure.

Clinical and prognostic relationships of pulmonary artery to aorta diameter ratio in patients with heart failure: a cardiac magnetic resonance imaging study (2018)
Journal Article
Pellicori, P., Urbinati, A., Zhang, J., Joseph, A. C., Costanzo, P., Lukaschuk, E., …Clark, A. L. (2018). Clinical and prognostic relationships of pulmonary artery to aorta diameter ratio in patients with heart failure: a cardiac magnetic resonance imaging study. Clinical cardiology, 41(1), 20-27. https://doi.org/10.1002/clc.22840

Background The pulmonary artery (PA) distends as pressure increases. Hypothesis The ratio of PA to aortic (Ao) diameter may be an indicator of pulmonary hypertension and consequently carry prognostic information in patients with chronic heart failur... Read More about Clinical and prognostic relationships of pulmonary artery to aorta diameter ratio in patients with heart failure: a cardiac magnetic resonance imaging study.

Beta-blockers for heart failure with reduced, mid-range, and preserved ejection fraction: An individual patient-level analysis of double-blind randomized trials (2017)
Journal Article
Cleland, J. G., Bunting, K. V., Flather, M., Altman, D. G., Holmes, J., Coats, A. J., …Beta-blockers in Heart Failure Collaborative Group. (2018). Beta-blockers for heart failure with reduced, mid-range, and preserved ejection fraction: An individual patient-level analysis of double-blind randomized trials. European Heart Journal, 39(1), 26-35. https://doi.org/10.1093/eurheartj/ehx564

Aims: Recent guidelines recommend that patients with heart failure and left ventricular ejection fraction (LVEF) 40-49% should be managed similar to LVEF ≥50%. We investigated the effect of beta-blockers according to LVEF in double-blind, randomised,... Read More about Beta-blockers for heart failure with reduced, mid-range, and preserved ejection fraction: An individual patient-level analysis of double-blind randomized trials.

Prevalence, predictors, and prognostic implications of PR interval prolongation in patients with heart failure (2017)
Journal Article
Nikolaidou, T., Pellicori, P., Zhang, J., Kazmi, S., Goode, K. M., Cleland, J. G., & Clark, A. L. (2018). Prevalence, predictors, and prognostic implications of PR interval prolongation in patients with heart failure. Clinical Research in Cardiology, 107(2), 108-119. https://doi.org/10.1007/s00392-017-1162-6

© 2017 The Author(s) Aims: To determine the prevalence, incidence, predictors, and prognostic implications of PR interval prolongation in patients referred with suspected heart failure. Methods and results: Consecutive patients referred with suspecte... Read More about Prevalence, predictors, and prognostic implications of PR interval prolongation in patients with heart failure.

Estimated peak functional capacity: an accurate method for assessing change in peak oxygen consumption after cardiac rehabilitation? (2017)
Journal Article
Nichols, S., Gleadall-Siddall, D. O., Antony, R., Clark, A. L., Cleland, J. G. F., Carroll, S., & Ingle, L. (2018). Estimated peak functional capacity: an accurate method for assessing change in peak oxygen consumption after cardiac rehabilitation?. Clinical physiology and functional imaging, 38(4), 681-688. https://doi.org/10.1111/cpf.12468

Summary Objective Cardiopulmonary exercise testing (CPET) is the ‘gold standard’ method of determining VO2peak. When CPET is unavailable, VO2peak may be estimated from treadmill or cycle ergometer workloads and expressed as estimated metabolic equiva... Read More about Estimated peak functional capacity: an accurate method for assessing change in peak oxygen consumption after cardiac rehabilitation?.

Heart rate and rhythm and the benefit of beta-blockers in patients with heart failure (2017)
Journal Article
Kotecha, D., Flather, M. D., Altman, D. G., Holmes, J., Rosano, G., Wikstrand, J., …Cleland, J. G. (2017). Heart rate and rhythm and the benefit of beta-blockers in patients with heart failure. Journal of the American College of Cardiology, 69(24), 2885-2896. https://doi.org/10.1016/j.jacc.2017.04.001

Background The relationship between mortality and heart rate remains unclear for patients with heart failure with reduced ejection fraction in either sinus rhythm or atrial fibrillation (AF). Objectives This analysis explored the prognostic importan... Read More about Heart rate and rhythm and the benefit of beta-blockers in patients with heart failure.

Non-invasive measurement of right atrial pressure by near-infrared spectroscopy: preliminary experience. A report from the SICA-HF study (2017)
Journal Article
Pellicori, P., Clark, A. L., Kallvikbacka-Bennett, A., Zhang, J., Urbinati, A., Monzo, L., …Cleland, J. G. (2017). Non-invasive measurement of right atrial pressure by near-infrared spectroscopy: preliminary experience. A report from the SICA-HF study. European journal of heart failure, 19(7), 883-892. https://doi.org/10.1002/ejhf.825

Background: Jugular venous distension, reflecting raised right atrial pressure (RAP), is a classical sign of congestive heart failure (CHF), but its clinical assessment can be difficult. Methods: RAP was measured non-invasively using near-infrared sp... Read More about Non-invasive measurement of right atrial pressure by near-infrared spectroscopy: preliminary experience. A report from the SICA-HF study.

The effects of short-term omission of daily medication on the pathophysiology of heart failure (2017)
Journal Article
Dovancescu, S., Pellicori, P., Mabote, T., Torabi, A., Clark, A. L., & Cleland, J. G. (2017). The effects of short-term omission of daily medication on the pathophysiology of heart failure. European journal of heart failure, 19(5), 643-649. https://doi.org/10.1002/ejhf.748

Aims Pharmacological therapies for heart failure (HF) aim to improve congestion, symptoms, and prognosis. Failing to take medication is a potential cause of worsening HF. Characterizing the effects of short-term medication omission could inform the d... Read More about The effects of short-term omission of daily medication on the pathophysiology of heart failure.

Statins attenuate but do not eliminate the reverse epidemiology of total serum cholesterol in patients with non-ischemic chronic heart failure (2017)
Journal Article
Fröhlich, H., Raman, N., Täger, T., Schellberg, D., Goode, K. M., Kazmi, S., …Frankenstein, L. (2017). Statins attenuate but do not eliminate the reverse epidemiology of total serum cholesterol in patients with non-ischemic chronic heart failure. International journal of cardiology, 238, 97-104. https://doi.org/10.1016/j.ijcard.2017.03.028

© 2017 Elsevier B.V. Background In patients with chronic heart failure (CHF) increasing levels of total serum cholesterol are associated with improved survival – while statin usage is not. The impact of statin treatment on the “reverse epidemiology”... Read More about Statins attenuate but do not eliminate the reverse epidemiology of total serum cholesterol in patients with non-ischemic chronic heart failure.

What proportion of patients with chronic heart failure are eligible for sacubitril-valsartan? (2017)
Journal Article
Pellicori, P., Urbinati, A., Shah, P., MacNamara, A., Kazmi, S., Dierckx, R., …Clark, A. L. (2017). What proportion of patients with chronic heart failure are eligible for sacubitril-valsartan?. European journal of heart failure, 19(6), 768-778. https://doi.org/10.1002/ejhf.788

Aims The PARADIGM-HF trial showed that sacubitril–valsartan, an ARB–neprilysin inhibitor, is more effective than enalapril for some patients with heart failure (HF). It is uncertain what proportion of patients with HF would be eligible for sacubitril... Read More about What proportion of patients with chronic heart failure are eligible for sacubitril-valsartan?.

Exploring the relation between changes in NT-proBNP and renal function in patients with suspected heart failure using structural equation modelling (2017)
Journal Article
Zhang, J., Wong, K., Clark, A. L., & Cleland, J. G. (2017). Exploring the relation between changes in NT-proBNP and renal function in patients with suspected heart failure using structural equation modelling. International journal of cardiology, 233, 67-72. https://doi.org/10.1016/j.ijcard.2017.01.127

Background The relation between changes in NT-proBNP and renal function has commonly been studied using multiple regressions, which may ignore the complexity of relations between related variables. Methods and results Data were collected from patient... Read More about Exploring the relation between changes in NT-proBNP and renal function in patients with suspected heart failure using structural equation modelling.

Internet-based training of coronary artery patients: the Heart Cycle Trial (2016)
Journal Article
Skobel, E., Knackstedt, C., Martinez-Romero, A., Salvi, D., Vera-Munoz, C., Napp, A., …Cleland, J. (2017). Internet-based training of coronary artery patients: the Heart Cycle Trial. Heart and vessels, 32(4), 408-418. https://doi.org/10.1007/s00380-016-0897-8

© 2016, Springer Japan. Low adherence to cardiac rehabilitation (CR) might be improved by remote monitoring systems that can be used to motivate and supervise patients and tailor CR safely and effectively to their needs. The main objective of this st... Read More about Internet-based training of coronary artery patients: the Heart Cycle Trial.