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Exercise training as a mediator for enhancing coronary collateral circulation: A review of the evidence (2019)
Journal Article
Nickolay, T., Nichols, S., Ingle, L., & Hoye, A. (2019). Exercise training as a mediator for enhancing coronary collateral circulation: A review of the evidence. Current Cardiology Reviews, 15, https://doi.org/10.2174/1573403x15666190819144336

Coronary collateral vessels supply blood to areas of myocardium at risk after arterial occlusion. Flow through these channels is driven by a pressure gradient between the donor and occluded artery. Concomitant with increased collateral flow is an inc... Read More

Home-based exercise programmes for individuals with intermittent claudication: A protocol for an updated systematic review and meta-analysis (2018)
Journal Article
Pymer, S., Tew, G. A., Palmer, J., Ingle, L., Smith, G. E., Chetter, I., & Harwood, A. E. (2018). Home-based exercise programmes for individuals with intermittent claudication: A protocol for an updated systematic review and meta-analysis. SAGE Open Medicine, 6, 205031211881829. doi:10.1177/2050312118818295

Background: The aim of this updated review is to consider the evidence base for the effectiveness of home-based exercise programmes (HEP) as a treatment option for improving walking distance in patients with IC. Methods: The Medline, EMBASE, CINAHL,... Read More

Preferred exercise modalities in patients with intermittent claudication (2018)
Journal Article
Harwood, A., Hitchman, L. H., Ingle, L., Doherty, P., & Chetter, I. C. (2018). Preferred exercise modalities in patients with intermittent claudication. Journal of Vascular Nursing, 36(2), 81-84. https://doi.org/10.1016/j.jvn.2017.12.002

Conventional supervised exercise programs (SEPs) for claudicants are traditionally based on time-constrained, group-based structured programs usually at a hospital site. Uptake of an SEP is poor, despite the high-level evidence demonstrating its clin... Read More

The effects of acute interval exercise and strawberry intake on postprandial lipemia (2017)
Journal Article
O’Doherty, A., Jones, H. S., Sathyapalan, T., Ingle, L., & Carroll, S. (2017). The effects of acute interval exercise and strawberry intake on postprandial lipemia. Medicine and Science in Sports and Exercise, 49(11), 2315-2323. https://doi.org/10.1249/MSS.0000000000001341

Purpose: Raised postprandial triglycerides (TAG) and related oxidative stresses are strongly associated with increased cardiovascular disease (CVD) risk. Acute exercise and strawberry ingestion independently ameliorate postprandial lipid excursions a... Read More

Estimated peak functional capacity: an accurate method for assessing change in peak oxygen consumption after cardiac rehabilitation? (2017)
Journal Article
Nichols, S., Gleadall-Siddall, D. O., Antony, R., Clark, A. L., Cleland, J. G. F., Carroll, S., & Ingle, L. (2018). Estimated peak functional capacity: an accurate method for assessing change in peak oxygen consumption after cardiac rehabilitation?. Clinical physiology and functional imaging, 38(4), 681-688. https://doi.org/10.1111/cpf.12468

Summary Objective Cardiopulmonary exercise testing (CPET) is the ‘gold standard’ method of determining VO2peak. When CPET is unavailable, VO2peak may be estimated from treadmill or cycle ergometer workloads and expressed as estimated metabolic equiva... Read More

The repeatability of the abbreviated (4-h) Oral Fat Tolerance Test and influence of prior acute aerobic exercise (2016)
Journal Article
O’Doherty, A. F., Sathyapalan, T., Rigby, A. S., Ingle, L., & Carroll, S. (2018). The repeatability of the abbreviated (4-h) Oral Fat Tolerance Test and influence of prior acute aerobic exercise. European Journal of Nutrition, 57(1), 309-318. https://doi.org/10.1007/s00394-016-1320-z

© 2016 The Author(s) Purpose: The Oral Fat Tolerance Test (OFTT) is regarded as a repeatable measure used to assess postprandial triglyceride (TAG) levels, with higher levels observed in cardio-metabolic disorders. Acute aerobic exercise intervention... Read More

The relation between repeated 6-minute walk test performance and outcome in patients with chronic heart failure (2014)
Journal Article
Ingle, L., Cleland, J. G., & Clark, A. L. (2014). The relation between repeated 6-minute walk test performance and outcome in patients with chronic heart failure. Annals of physical and rehabilitation medicine, 57(4), 244-253. https://doi.org/10.1016/j.rehab.2014.03.004

Objective: To assess the prognostic implications of the 6-minute walk test (6-MWT) distance measured twice, one year apart, in a large sample of patients with chronic heart failure (CHF) followed for an extended period ( > . 8. years from baseline).... Read More

The long-term prognostic significance of 6-minute walk test distance in patients with chronic heart failure (2014)
Journal Article
Ingle, L., Cleland, J. G., & Clark, A. L. (2014). The long-term prognostic significance of 6-minute walk test distance in patients with chronic heart failure. Biomed research international, 2014, 1-7. https://doi.org/10.1155/2014/505969

Background. The 6-minute walk test (6-MWT) is used to assess patients with chronic heart failure (CHF). The prognostic significance of the 6-MWT distance during long-term followup ( > 5 years) is unclear. Methods. 1,667 patients (median [inter-quarti... Read More

Development of a composite model derived from cardiopulmonary exercise tests to predict mortality risk in patients with mild-to-moderate heart failure (2014)
Journal Article
Ingle, L., Rigby, A. S., Sloan, R., Carroll, S., Goode, K. M., Cleland, J. G., & Clark, A. L. (2014). Development of a composite model derived from cardiopulmonary exercise tests to predict mortality risk in patients with mild-to-moderate heart failure. Heart, 100(10), 781-786. https://doi.org/10.1136/heartjnl-2013-304614

Objective: Cardiopulmonary exercise testing (CPET) is used to predict outcome in patients with mild-to-moderate heart failure (HF). Single CPET-derived variables are often used, but we wanted to see if a composite score achieved better predictive pow... Read More

Prognostic significance of different measures of the ventilation-carbon dioxide relation in patients with suspected heart failure (2011)
Journal Article
Ingle, L., Sloan, R., Carroll, S., Goode, K., Cleland, J. G., & Clark, A. L. (2011). Prognostic significance of different measures of the ventilation-carbon dioxide relation in patients with suspected heart failure. European journal of heart failure, 13(5), 537-542. https://doi.org/10.1093/eurjhf/hfq238

Aims We studied the prognostic significance of the ventilatory equivalent of carbon dioxide production (VEqCO 2 ) at different time-points of a maximal cardiopulmonary exercise test (CPET) in patients with suspected heart failure (HF). Methods and re... Read More

Experiences of air travel in patients with chronic heart failure (2011)
Journal Article
Ingle, L., Hobkirk, J., Damy, T., Nabb, S., Clark, A. L., & Cleland, J. G. (2012). Experiences of air travel in patients with chronic heart failure. International journal of cardiology, 158(1), (66-70). doi:10.1016/j.ijcard.2010.12.101. ISSN 0167-5273

AIM: To conduct a survey in a representative cohort of ambulatory patients with stable, well managed chronic heart failure (CHF) to discover their experiences of air travel. METHODS: An expert panel including a cardiologist, an exercise scientist, an... Read More

Cardiac output does not limit submaximal exercise capacity in patients with chronic heart failure (2010)
Journal Article
Clark, A. L., Ingle, L., Rigby, A. S., Cleland, J. G., Shelton, R. J., & Witte, K. K. (2010). Cardiac output does not limit submaximal exercise capacity in patients with chronic heart failure. European journal of heart failure, 12(9), 983-989. doi:10.1093/eurjhf/hfq086

Aims Mechanisms of exercise limitation in patients with chronic heart failure (CHF) are incompletely understood. During matched submaximal, fixed-rate exercise, oxygen uptake is similar in patients and healthy controls. However, the importance of car... Read More

Derivation and validation of a simple clinical risk-model in heart failure based on 6 minute walk test performance and NT-proBNP status - Do we need specificity for sex and beta-blockers? (2009)
Journal Article
Frankenstein, L., Goode, K., Ingle, L., Remppis, A., Schellberg, D., Nelles, M., …Zugck, C. (2011). Derivation and validation of a simple clinical risk-model in heart failure based on 6 minute walk test performance and NT-proBNP status - Do we need specificity for sex and beta-blockers?. International journal of cardiology, 147(1), 74-78. https://doi.org/10.1016/j.ijcard.2009.08.005

BACKGROUND It is unclear whether risk prediction strategies in chronic heart failure (CHF) need to be specific for sex or beta-blockers. We examined this problem and developed and validated the consequent risk models based on 6-minute-walk-test and N... Read More

Impact of different diagnostic criteria on the prevalence and prognostic significance of exertional oscillatory ventilation in patients with chronic heart failure (2009)
Journal Article
Ingle, L., Isted, A., Witte, K. K., Cleland, J. G. F., & Clark, A. L. (2009). Impact of different diagnostic criteria on the prevalence and prognostic significance of exertional oscillatory ventilation in patients with chronic heart failure. European journal of cardiovascular prevention and rehabilitation, 16(4), (451-456). doi:10.1097/HJR.0b013e32832a4f54. ISSN 1741-8267

Introduction Exertional oscillatory ventilation (EOV) occurs in many patients with chronic heart failure. Two different definitions of EOV have been proposed by Corra and Leite. We aimed to compare the prevalence of EOV and its prognostic significanc... Read More

Combining the ventilatory response to exercise and peak oxygen consumption is no better than peak oxygen consumption alone in predicting mortality in chronic heart failure (2008)
Journal Article
Ingle, L., Witte, K. K., Cleland, J. G. F., & Clark, A. L. (2008). Combining the ventilatory response to exercise and peak oxygen consumption is no better than peak oxygen consumption alone in predicting mortality in chronic heart failure. European journal of heart failure, 10(1), 85-88. doi:10.1016/j.ejheart.2007.10.010

Background: A low peak oxygen uptake (pV(O2)) and steep V-E/V-CO2 slope are independently associated with a worse prognosis in patients with chronic heart failure (CHF). We wished to confirm whether combining these variables as a ratio would lead to... Read More

Perception of symptoms is out of proportion to cardiac pathology in patients with "diastolic heart failure'' (2007)
Journal Article
Ingle, L., Cleland, J. G. F., & Clark, A. L. (2008). Perception of symptoms is out of proportion to cardiac pathology in patients with "diastolic heart failure''. Heart, 94(6), 748-753. doi:10.1136/hrt.2007.131144

Background: Epidemiological studies suggest that "diastolic heart failure'' (DHF) is common and has a prognosis similar to that of systolic heart failure (SHF). We wanted to assess whether patients with breathlessness who were being treated for DHF h... Read More

The reproducibility and sensitivity of the 6-min walk test in elderly patients with chronic heart failure (2005)
Journal Article
Ingle, L., Shelton, R. J., Rigby, A. S., Nabb, S., Clark, A. L., & Cleland, J. G. (2005). The reproducibility and sensitivity of the 6-min walk test in elderly patients with chronic heart failure. European Heart Journal, 26(17), 1742-1751. https://doi.org/10.1093/eurheartj/ehi259

Aims: The 6-min walk test (6-MWT) is used to estimate functional capacity. However, in elderly patients with chronic heart failure (CHF): (i) 1 year reproducibility of the 6-MWT; (ii) sensitivity of the 6-MWT to self-perceived changes in symptoms of... Read More