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Inhaled corticosteriod use and the risk of pneumonia and COPD exacerbations in the UPLIFT study (2017)
Journal Article
Morjaria, J. B., Morice, A. H., Morice, A., Rigby, A., & Morjaria, J. (2017). Inhaled corticosteriod use and the risk of pneumonia and COPD exacerbations in the UPLIFT study. Lung, 195(3), 281-288. https://doi.org/10.1007/s00408-017-9990-8

Rationale Unlike many other COPD studies, the 4-year UPLIFT trial permitted inhaled corticosteroid (ICS) use during run-in and treatment phases. This provided the opportunity to prospectively observe the continuing effects of ICS on respiratory event... Read More about Inhaled corticosteriod use and the risk of pneumonia and COPD exacerbations in the UPLIFT study.

Influence of case definition on incidence and outcome of acute coronary syndromes (2016)
Journal Article
Torabi, A., Cleland, J. G. F., Sherwi, N., Atkin, P., Panahi, H., Kilpatrick, E., …Rigby, A. (2016). Influence of case definition on incidence and outcome of acute coronary syndromes. Open heart, 3(2), e000487. https://doi.org/10.1136/openhrt-2016-000487

© 2016, BMJ Publishing Group. All rights reserved. Objective: Acute coronary syndromes (ACS) are common, but their incidence and outcome might depend greatly on how data are collected. We compared case ascertainment rates for ACS and myocardial infar... Read More about Influence of case definition on incidence and outcome of acute coronary syndromes.

STAAR: a randomised controlled trial of electronic adherence monitoring with reminder alarms and feedback to improve clinical outcomes for children with asthma (2016)
Journal Article
Morton, R. W., Elphick, H. E., Rigby, A. S., Daw, W. J., King, D. A., Smith, L. J., & Everard, M. L. (2017). STAAR: a randomised controlled trial of electronic adherence monitoring with reminder alarms and feedback to improve clinical outcomes for children with asthma. Thorax, 72(4), 347-354. https://doi.org/10.1136/thoraxjnl-2015-208171

Background Suboptimal adherence to inhaled steroids is common in children with asthma and is associated with poor disease control, reduced quality of life and even death. Previous studies using feedback of electronically monitored adherence data have... Read More about STAAR: a randomised controlled trial of electronic adherence monitoring with reminder alarms and feedback to improve clinical outcomes for children with asthma.

Effect of soy in men with type 2 diabetes mellitus and subclinical hypogonadism: a randomised controlled study (2016)
Journal Article
Sathyapalan, T., Rigby, A. S., Bhasin, S., Thatcher, N. J., Kilpatrick, E. S., & Atkin, S. L. (2017). Effect of soy in men with type 2 diabetes mellitus and subclinical hypogonadism: a randomised controlled study. Journal of Clinical Endocrinology and Metabolism, 102(2), 425-433. https://doi.org/10.1210/jc.2016-2875

Context: Isoflavones found in soy products have a chemical structure similar to estrogen, leading to concerns of an adverse estrogenic effect in men, particularly in those with type 2 diabetes mellitus (T2DM) who have low testosterone levels due to h... Read More about Effect of soy in men with type 2 diabetes mellitus and subclinical hypogonadism: a randomised controlled study.

Determination of deoxynivalenol in the urine of pregnant women in the UK (2016)
Journal Article
Rigby, A., Sathyapalan, T., Wells, L., Atkin, S., Brera, C., De Santis, B., …Williams, C. (2016). Determination of deoxynivalenol in the urine of pregnant women in the UK. Toxins, 8(11), 306. https://doi.org/10.3390/toxins8110306

Deoxynivalenol (DON) is one of the most commonly occurring trichothecenes, produced mainly by Fusarium graminearum. Little is known about the effect of DON exposure or the levels of DON exposure that occur during pregnancy. The project aimed to provi... Read More about Determination of deoxynivalenol in the urine of pregnant women in the UK.

The repeatability of the abbreviated (4-h) Oral Fat Tolerance Test and influence of prior acute aerobic exercise (2016)
Journal Article
O’Doherty, A. F., Sathyapalan, T., Rigby, A. S., Ingle, L., & Carroll, S. (2018). The repeatability of the abbreviated (4-h) Oral Fat Tolerance Test and influence of prior acute aerobic exercise. European Journal of Nutrition, 57(1), 309-318. https://doi.org/10.1007/s00394-016-1320-z

© 2016 The Author(s) Purpose: The Oral Fat Tolerance Test (OFTT) is regarded as a repeatable measure used to assess postprandial triglyceride (TAG) levels, with higher levels observed in cardio-metabolic disorders. Acute aerobic exercise intervention... Read More about The repeatability of the abbreviated (4-h) Oral Fat Tolerance Test and influence of prior acute aerobic exercise.

Internet-based training of coronary artery patients: the Heart Cycle Trial (2016)
Journal Article
Skobel, E., Knackstedt, C., Martinez-Romero, A., Salvi, D., Vera-Munoz, C., Napp, A., …Cleland, J. (2017). Internet-based training of coronary artery patients: the Heart Cycle Trial. Heart and vessels, 32(4), 408-418. https://doi.org/10.1007/s00380-016-0897-8

© 2016, Springer Japan. Low adherence to cardiac rehabilitation (CR) might be improved by remote monitoring systems that can be used to motivate and supervise patients and tailor CR safely and effectively to their needs. The main objective of this st... Read More about Internet-based training of coronary artery patients: the Heart Cycle Trial.

Soy reduces bone turnover markers in women during early menopause: a randomized controlled trial (2016)
Journal Article
Sathyapalan, T., Aye, M., Rigby, A. S., Fraser, W. D., Thatcher, N. J., Kilpatrick, E. S., & Atkin, S. L. (2017). Soy reduces bone turnover markers in women during early menopause: a randomized controlled trial. Journal of Bone and Mineral Research, 32(1), 157-164. https://doi.org/10.1002/jbmr.2927

Menopausal estrogen loss leads to an increased bone loss. Soy isoflavones can act as selective estrogen receptor modulators, their role in bone turnover is unclear. The primary outcome was assessing changes in plasma bone turnover markers. The second... Read More about Soy reduces bone turnover markers in women during early menopause: a randomized controlled trial.

Pilot investigation of a virtual gastric band hypnotherapy intervention (2016)
Journal Article
Greetham, S., Goodwin, S., Wells, L., Whitham, C., Jones, H., Rigby, A., …Atkin, S. (2016). Pilot investigation of a virtual gastric band hypnotherapy intervention. International Journal of Clinical and Experimental Hypnosis, 64(4), 419-433. https://doi.org/10.1080/00207144.2016.1209037

This was a pilot investigation of 30 men and women with a BMI > 27kg/m² over a 24 week period. It aimed to determine whether virtual gastric band (VGB) hypnotherapy has an effect on weight loss in overweight adults, compared to relaxation hypnotherap... Read More about Pilot investigation of a virtual gastric band hypnotherapy intervention.

Prevalence and outcomes of anemia and hematinic deficiencies in patients with chronic heart failure (2016)
Journal Article
Cleland, J. G., Zhang, J., Pellicori, P., Dicken, B., Dierckx, R., Shoaib, A., …Clark, A. L. (2016). Prevalence and outcomes of anemia and hematinic deficiencies in patients with chronic heart failure. JAMA Cardiology, 1(5), 539-547. https://doi.org/10.1001/jamacardio.2016.1161

Copyright © 2016 American Medical Association. All rights reserved. Importance: Detailed information on the prevalence, associations, and consequences of anemia and iron deficiency in epidemiologically representative outpatients with chronic heart fa... Read More about Prevalence and outcomes of anemia and hematinic deficiencies in patients with chronic heart failure.

Effect of age and sex on efficacy and tolerability of β blockers in patients with heart failure with reduced ejection fraction: individual patient data meta-analysis (2016)
Journal Article
Kotecha, D., Manzano, L., Krum, H., Rosano, G., Holmes, J., Altman, D. G., …Flather, M. D. (2016). Effect of age and sex on efficacy and tolerability of β blockers in patients with heart failure with reduced ejection fraction: individual patient data meta-analysis. BMJ, 353, i1855. https://doi.org/10.1136/bmj.i1855

© BMJ Publishing Group Ltd 2016. OBJECTIVES: To determine the efficacy and tolerability of β blockers in a broad age range of women and men with heart failure with reduced ejection fraction (HFrEF) by pooling individual patient data from placebo cont... Read More about Effect of age and sex on efficacy and tolerability of β blockers in patients with heart failure with reduced ejection fraction: individual patient data meta-analysis.

Is the diagnostic coding position of acute heart failure related to mortality? A report from the Euro Heart Failure Survey-1 (2016)
Journal Article
Shoaib, A., Farag, M., Nasir, M., John, J., Gupta, S., Pellicori, P., …Cleland, J. G. (2016). Is the diagnostic coding position of acute heart failure related to mortality? A report from the Euro Heart Failure Survey-1. European journal of heart failure, 18(5), 556-563. https://doi.org/10.1002/ejhf.505

© 2016 The Authors. European Journal of Heart Failure. Aims Most studies on acute heart failure (HF) exploring the relationship between admissions to hospital for HF and subsequent outcomes have focused only on HF coded as the primary diagnosis, but... Read More about Is the diagnostic coding position of acute heart failure related to mortality? A report from the Euro Heart Failure Survey-1.

Development of a human model for the study of effects of hypoxia, exercise, and sildenafil on cardiac and vascular function in chronic heart failure (2015)
Journal Article
Damy, T., Hobkirk, J., Walters, M., Ciobanu, A., Rigby, A. S., Kallvikbacka-Bennett, A., …Cleland, J. G. F. (2015). Development of a human model for the study of effects of hypoxia, exercise, and sildenafil on cardiac and vascular function in chronic heart failure. Journal of Cardiovascular Pharmacology, 66(3), 229-238. https://doi.org/10.1097/fjc.0000000000000262

Background: Pulmonary hypertension is associated with poor outcome in patients with chronic heart failure (CHF) and may be a therapeutic target. Our aims were to develop a noninvasive model for studying pulmonary vasoreactivity in CHF and characteriz... Read More about Development of a human model for the study of effects of hypoxia, exercise, and sildenafil on cardiac and vascular function in chronic heart failure.

Aspartame sensitivity? : a double blind randomised crossover study (2015)
Journal Article
Sathyapalan, T., Thatcher, N. J., Hammersley, R., Rigby, A. S., Pechlivanis, A., Gooderham, N. J., …Courts, F. (2015). Aspartame sensitivity? : a double blind randomised crossover study. PLoS ONE, 10(3), e0116212. https://doi.org/10.1371/journal.pone.0116212

Background Aspartame is a commonly used intense artificial sweetener, being approximately 200 times sweeter than sucrose. There have been concerns over aspartame since approval in the 1980s including a large anecdotal database reporting severe sympto... Read More about Aspartame sensitivity? : a double blind randomised crossover study.

Efficacy of β blockers in patients with heart failure plus atrial fibrillation: An individual-patient data meta-analysis (2014)
Journal Article
Kotecha, D., Holmes, J., Krum, H., Altman, D. G., Manzano, L., Cleland, J. G., …Flather, M. D. (2014). Efficacy of β blockers in patients with heart failure plus atrial fibrillation: An individual-patient data meta-analysis. Lancet, 384(9961), 2235-2243. https://doi.org/10.1016/S0140-6736%2814%2961373-8

Background: Atrial fibrillation and heart failure often coexist, causing substantial cardiovascular morbidity and mortality. β blockers are indicated in patients with symptomatic heart failure with reduced ejection fraction; however, the efficacy of... Read More about Efficacy of β blockers in patients with heart failure plus atrial fibrillation: An individual-patient data meta-analysis.

Fracture healing following high energy tibial trauma: Ilizarov versus Taylor Spatial Frame (2014)
Journal Article
Menakaya, C., Rigby, A., Hadland, Y., Barron, E., & Sharma, H. (2014). Fracture healing following high energy tibial trauma: Ilizarov versus Taylor Spatial Frame. Annals of the Royal College of Surgeons of England, 96(2), 106-110. https://doi.org/10.1308/003588414x13824511650335

Introduction: The optimal treatment of high energy tibial fractures remains controversial and a challenging orthopaedic problem. The role of external fi xators for all these tibial fractures has been shown to be crucial. Methods: A fi ve-year consecu... Read More about Fracture healing following high energy tibial trauma: Ilizarov versus Taylor Spatial Frame.

Development of a composite model derived from cardiopulmonary exercise tests to predict mortality risk in patients with mild-to-moderate heart failure (2014)
Journal Article
Ingle, L., Rigby, A. S., Sloan, R., Carroll, S., Goode, K. M., Cleland, J. G., & Clark, A. L. (2014). Development of a composite model derived from cardiopulmonary exercise tests to predict mortality risk in patients with mild-to-moderate heart failure. Heart, 100(10), 781-786. https://doi.org/10.1136/heartjnl-2013-304614

Objective: Cardiopulmonary exercise testing (CPET) is used to predict outcome in patients with mild-to-moderate heart failure (HF). Single CPET-derived variables are often used, but we wanted to see if a composite score achieved better predictive pow... Read More about Development of a composite model derived from cardiopulmonary exercise tests to predict mortality risk in patients with mild-to-moderate heart failure.

Acute hypertriglyceridemia induces platelet hyperactivity that is not attenuated by insulin in polycystic ovary syndrome. (2014)
Journal Article
Aye, M. M., Kilpatrick, E. S., Aburima, A., Wraith, K. S., Magwenzi, S., Spurgeon, B., …Atkin, S. L. (2014). Acute hypertriglyceridemia induces platelet hyperactivity that is not attenuated by insulin in polycystic ovary syndrome. Journal of the American Heart Association, 3(1), https://doi.org/10.1161/JAHA.113.000706

Atherothrombosis is associated with platelet hyperactivity. Hypertriglyceridemia and insulin resistance (IR) are features of polycystic ovary syndrome (PCOS). The effect of induced hypertriglyceridemia on IR and platelet function was examined in youn... Read More about Acute hypertriglyceridemia induces platelet hyperactivity that is not attenuated by insulin in polycystic ovary syndrome..

Glucagon-like peptide-1 analogue, liraglutide, improves liver fibrosis markers in obese women with polycystic ovary syndrome and nonalcoholic fatty liver disease (2013)
Journal Article
Kahal, H., Abouda, G., Rigby, A. S., Coady, A. M., Kilpatrick, E. S., & Atkin, S. L. (2014). Glucagon-like peptide-1 analogue, liraglutide, improves liver fibrosis markers in obese women with polycystic ovary syndrome and nonalcoholic fatty liver disease. Clinical Endocrinology, 81(4), 523-528. https://doi.org/10.1111/cen.12369

© 2013 John Wiley & Sons Ltd. Introduction: Nonalcoholic fatty liver disease (NAFLD) has been linked to polycystic ovary syndrome (PCOS) and carries an increased risk of liver cirrhosis. Procollagen type 3 amino-terminal peptide (PIIINP) is an inde... Read More about Glucagon-like peptide-1 analogue, liraglutide, improves liver fibrosis markers in obese women with polycystic ovary syndrome and nonalcoholic fatty liver disease.

Glycemic Control in the 12 Months following a Change to SI Hemoglobin A1c Reporting Units (2013)
Journal Article
Rigby, A., Atkin, S., Barth, J. H., & Kilpatrick, E. (2013). Glycemic Control in the 12 Months following a Change to SI Hemoglobin A1c Reporting Units. Clinical Chemistry, 59(10), 1457-1460. https://doi.org/10.1373/clinchem.2013.206334

BACKGROUND Many countries have implemented, or are considering, a change in hemoglobin A1c (Hb A1c) units from traditional percentage values [Diabetes Control and Complications Trial (DCCT)] to the new Système International d'Unités (SI) unit in mill... Read More about Glycemic Control in the 12 Months following a Change to SI Hemoglobin A1c Reporting Units.