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All Outputs (103)

Effects of reducing inspired oxygen concentration for one hour in patients with chronic heart failure: implications for air travel (2013)
Journal Article
Hobkirk, J. P., Damy, T., Walters, M., Bennett, A., Smith, S. J., Ingle, L., …Cleland, J. G. (2013). Effects of reducing inspired oxygen concentration for one hour in patients with chronic heart failure: implications for air travel. European journal of heart failure, 15(5), 505-510. https://doi.org/10.1093/eurjhf/hft003

AimsThe objective of this study was to establish the acute effects of hypoxia on clinical, spirometric, haemodynamic, and echocardiographic variables. Reducing inspired oxygen to 15%, as experienced during commercial air travel, decreases arterial ox... Read More about Effects of reducing inspired oxygen concentration for one hour in patients with chronic heart failure: implications for air travel.

Abnormalities of the ventilatory equivalent for carbon dioxide in patients with chronic heart failure (2012)
Journal Article
Ingle, L., Sloan, R., Carroll, S., Goode, K., Cleland, J. G., & Clark, A. L. (2012). Abnormalities of the ventilatory equivalent for carbon dioxide in patients with chronic heart failure. Pulmonary Medicine, 2012, 589164. https://doi.org/10.1155/2012/589164

Introduction. The relation between minute ventilation (VE) and carbon dioxide production (VCO(2)) can be characterised by the instantaneous ratio of ventilation to carbon dioxide production, the ventilatory equivalent for CO(2) (VEqCO(2)). We hypothe... Read More about Abnormalities of the ventilatory equivalent for carbon dioxide in patients with chronic heart failure.

Minimally clinically important difference in chronic breathlessness: every little helps (2012)
Journal Article
Oxberry, S. G., Bland, J. M., Clark, A. L., Cleland, J. G., & Johnson, M. (2012). Minimally clinically important difference in chronic breathlessness: every little helps. American Heart Journal, 164(2), 229-235. https://doi.org/10.1016/j.ahj.2012.05.003

ObjectivesThe aim of the study was to determine the minimally clinically important difference (MCID) for breathlessness due to chronic heart failure (CHF). BackgroundThe measurement of breathlessness is difficult because it is subjective and multifac... Read More about Minimally clinically important difference in chronic breathlessness: every little helps.

Chronotropic incompetence and survival in chronic heart failure (2012)
Journal Article
Al-Najjar, Y., Witte, K. K., & Clark, A. L. (2012). Chronotropic incompetence and survival in chronic heart failure. International journal of cardiology, 157(1), 48-52. https://doi.org/10.1016/j.ijcard.2010.11.018

Background: Failure of the heart rate to rise normally during an incremental exercise test is termed chronotropic incompetence (CI). It is common in patients with chronic heart failure (CHF), and we wanted to explore the relation between CI and outco... Read More about Chronotropic incompetence and survival in chronic heart failure.

Creating Non-Believed Memories for Recent Autobiographical Events (2012)
Journal Article
Clark, A., Nash, R. A., Fincham, G., & Mazzoni, G. (2012). Creating Non-Believed Memories for Recent Autobiographical Events. PloS one, 7(3), 1334 - 1340. doi:10.1371/journal.pone.0032998

A recent study showed that many people spontaneously report vivid memories of events that they do not believe to have occurred [1]. In the present experiment we tested for the first time whether, after powerful false memories have been created, debri... Read More about Creating Non-Believed Memories for Recent Autobiographical Events.

Prevalence of, associations with, and prognostic value of tricuspid annular plane systolic excursion (TAPSE) among out-patients referred for the evaluation of heart failure (2012)
Journal Article
Damy, T., Kallvikbacka-Bennett, A., Goode, K., Khaleva, O., Lewinter, C., Hobkirk, J., …Cleland, J. G. F. (2012). Prevalence of, associations with, and prognostic value of tricuspid annular plane systolic excursion (TAPSE) among out-patients referred for the evaluation of heart failure. Journal of cardiac failure, 18(3), 216-225. https://doi.org/10.1016/j.cardfail.2011.12.003

Background: Prevalence, predictors, and prognostic value of right ventricular (RV) function measured by the tricuspid annular plane systolic excursion (TAPSE) in patients with chronic heart failure (CHF) symptoms with a broad range of left ventricula... Read More about Prevalence of, associations with, and prognostic value of tricuspid annular plane systolic excursion (TAPSE) among out-patients referred for the evaluation of heart failure.

Does the physical examination still have a role in patients with suspected heart failure? (2011)
Journal Article
Damy, T., Kallvikbacka-Bennett, A., Zhang, J., Goode, K., Buga, L., Hobkirk, J., …Clark, A. L. (2011). Does the physical examination still have a role in patients with suspected heart failure?. European journal of heart failure, 13(12), 1340-1348. https://doi.org/10.1093/eurjhf/hfr128

AIMS: The prognostic value of signs of congestion in patients suspected of having chronic heart failure (CHF) is unknown. Our objectives were to define their prevalence and specificity in diagnosing CHF and to determine their prognostic value in pati... Read More about Does the physical examination still have a role in patients with suspected heart failure?.

Influence of step length on 6-minute walk test performance in patients with chronic heart failure (2011)
Journal Article
Pepera, G. K., Sandercock, G. R., Sloan, R., Cleland, J. J., Ingle, L., & Clark, A. L. (2012). Influence of step length on 6-minute walk test performance in patients with chronic heart failure. Physiotherapy, 98(4), 325-329. https://doi.org/10.1016/j.physio.2011.08.005

Objective: To investigate the influence of gait parameters including step length and walking speed during performance of the 6-minute walking test (6MWT) in patients with chronic heart failure (CHF). Design: Observational study. Setting: Specialist h... Read More about Influence of step length on 6-minute walk test performance in patients with chronic heart failure.

Prevalence of scarred and dysfunctional myocardium in patients with heart failure of ischaemic origin: A cardiovascular magnetic resonance study (2011)
Journal Article
Bourantas, C. V., Nikitin, N. P., Loh, H. P., Lukaschuk, E. I., Sherwi, N., de Silva, R., …Cleland, J. G. (2011). Prevalence of scarred and dysfunctional myocardium in patients with heart failure of ischaemic origin: A cardiovascular magnetic resonance study. Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance, 13(53), Article ARTN 53. https://doi.org/10.1186/1532-429x-13-53

BackgroundCardiovascular magnetic resonance (CMR) with late gadolinium enhancement (LGE) can provide unique data on the transmural extent of scar/viability. We assessed the prevalence of dysfunctional myocardium, including partial thickness scar, whi... Read More about Prevalence of scarred and dysfunctional myocardium in patients with heart failure of ischaemic origin: A cardiovascular magnetic resonance study.

Limited role for ivabradine in the treatment of chronic heart failure (2011)
Journal Article
Cullington, D., Goode, K. M., Cleland, J. G. F., & Clark, A. L. (2011). Limited role for ivabradine in the treatment of chronic heart failure. Heart, 97(23), 1961-1966. https://doi.org/10.1136/heartjnl-2011-300041

ObjectiveTo quantify the proportion of patients attending a community heart failure clinic with left ventricular systolic impairment who might be suitable for ivabradine therapy.BackgroundHigh resting heart rate is an important and potentially modifi... Read More about Limited role for ivabradine in the treatment of chronic heart failure.

Short-term opioids for breathlessness in stable chronic heart failure: A randomized controlled trial (2011)
Journal Article
Oxberry, S. G., Torgerson, D. J., Bland, J. M., Clark, A. L., Cleland, J. G. F., & Johnson, M. J. (2011). Short-term opioids for breathlessness in stable chronic heart failure: A randomized controlled trial. European journal of heart failure, 13(9), 1006-1012. https://doi.org/10.1093/eurjhf/hfr068

Aims To assess the effect of oral opioids vs. placebo on breathlessness in patients with chronic heart failure (CHF). Methods and results Oral morphine (Oramorph), oral oxycodone (Oxynorm), and placebo were studied in an outpatient setting. Once rand... Read More about Short-term opioids for breathlessness in stable chronic heart failure: A randomized controlled trial.

Prognostic significance of different measures of the ventilation-carbon dioxide relation in patients with suspected heart failure (2011)
Journal Article
Ingle, L., Sloan, R., Carroll, S., Goode, K., Cleland, J. G., & Clark, A. L. (2011). Prognostic significance of different measures of the ventilation-carbon dioxide relation in patients with suspected heart failure. European journal of heart failure, 13(5), 537-542. https://doi.org/10.1093/eurjhf/hfq238

Aims We studied the prognostic significance of the ventilatory equivalent of carbon dioxide production (VEqCO 2 ) at different time-points of a maximal cardiopulmonary exercise test (CPET) in patients with suspected heart failure (HF). Methods and re... Read More about Prognostic significance of different measures of the ventilation-carbon dioxide relation in patients with suspected heart failure.

Experiences of air travel in patients with chronic heart failure (2011)
Journal Article
Ingle, L., Hobkirk, J., Damy, T., Nabb, S., Clark, A. L., & Cleland, J. G. (2012). Experiences of air travel in patients with chronic heart failure. International journal of cardiology, 158(1), 66-70. https://doi.org/10.1016/j.ijcard.2010.12.101

AIM: To conduct a survey in a representative cohort of ambulatory patients with stable, well managed chronic heart failure (CHF) to discover their experiences of air travel. METHODS: An expert panel including a cardiologist, an exercise scientist, an... Read More about Experiences of air travel in patients with chronic heart failure.

Cardiac output does not limit submaximal exercise capacity in patients with chronic heart failure (2010)
Journal Article
Shelton, R. J., Ingle, L., Rigby, A. S., Witte, K. K., Cleland, J. G., & Clark, A. L. (2010). Cardiac output does not limit submaximal exercise capacity in patients with chronic heart failure. European journal of heart failure, 12(9), 983-989. https://doi.org/10.1093/eurjhf/hfq086

Aims Mechanisms of exercise limitation in patients with chronic heart failure (CHF) are incompletely understood. During matched submaximal, fixed-rate exercise, oxygen uptake is similar in patients and healthy controls. However, the importance of ca... Read More about Cardiac output does not limit submaximal exercise capacity in patients with chronic heart failure.

Measurement of breathlessness in clinical trials in patients with chronic heart failure: the need for a standardized approach: a systematic review (2010)
Journal Article
Johnson, M. J., Oxberry, S. G., Cleland, J. G., & Clark, A. L. (2010). Measurement of breathlessness in clinical trials in patients with chronic heart failure: the need for a standardized approach: a systematic review. European journal of heart failure, 12(2), 137-147. https://doi.org/10.1093/eurjhf/hfp194

AIMS: Chronic breathlessness is a major symptom for patients with compensated chronic heart failure (CHF) and its impact is different to the breathlessness resulting from pulmonary oedema. This systematic review aims to establish which tools have bee... Read More about Measurement of breathlessness in clinical trials in patients with chronic heart failure: the need for a standardized approach: a systematic review.

Lack of diastolic reserve in patients with heart failure and normal ejection fraction (2009)
Journal Article
Chattopadhyay, S., Alamgir, M. F., Nikitin, N. P., Rigby, A. S., Clark, A. L., & Cleland, J. G. F. (2010). Lack of diastolic reserve in patients with heart failure and normal ejection fraction. Circulation. Heart failure, 3(1), 35-43. https://doi.org/10.1161/CIRCHEARTFAILURE.108.824888

Background-The genesis of symptoms in patients with heart failure (HF) and normal ejection fraction (HFNEF) is unclear. Most investigations of HFNEF have focused on cardiac function at rest although most of these patients are breathless only on exerc... Read More about Lack of diastolic reserve in patients with heart failure and normal ejection fraction.

Derivation and validation of a simple clinical risk-model in heart failure based on 6 minute walk test performance and NT-proBNP status - Do we need specificity for sex and beta-blockers? (2009)
Journal Article
Frankenstein, L., Goode, K., Ingle, L., Remppis, A., Schellberg, D., Nelles, M., …Zugck, C. (2011). Derivation and validation of a simple clinical risk-model in heart failure based on 6 minute walk test performance and NT-proBNP status - Do we need specificity for sex and beta-blockers?. International journal of cardiology, 147(1), 74-78. https://doi.org/10.1016/j.ijcard.2009.08.005

BACKGROUND It is unclear whether risk prediction strategies in chronic heart failure (CHF) need to be specific for sex or beta-blockers. We examined this problem and developed and validated the consequent risk models based on 6-minute-walk-test and N... Read More about Derivation and validation of a simple clinical risk-model in heart failure based on 6 minute walk test performance and NT-proBNP status - Do we need specificity for sex and beta-blockers?.

Impact of different diagnostic criteria on the prevalence and prognostic significance of exertional oscillatory ventilation in patients with chronic heart failure (2009)
Journal Article
Ingle, L., Isted, A., Witte, K. K., Cleland, J. G., & Clark, A. L. (2009). Impact of different diagnostic criteria on the prevalence and prognostic significance of exertional oscillatory ventilation in patients with chronic heart failure. European journal of cardiovascular prevention and rehabilitation, 16(4), 451-456. https://doi.org/10.1097/HJR.0b013e32832a4f54

INTRODUCTION: Exertional oscillatory ventilation (EOV) occurs in many patients with chronic heart failure. Two different definitions of EOV have been proposed by Corrá and Leite. We aimed to compare the prevalence of EOV and its prognostic significan... Read More about Impact of different diagnostic criteria on the prevalence and prognostic significance of exertional oscillatory ventilation in patients with chronic heart failure.