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The influence of solvent representation on nuclear shielding calculations of protonation states of small biological molecules (2018)
Journal Article
Roggatz, C. C., Lorch, M., & Benoit, D. M. (2018). The influence of solvent representation on nuclear shielding calculations of protonation states of small biological molecules. Journal of chemical theory and computation : JCTC, 14(5), 2684-2695. doi:10.1021/acs.jctc.7b01020

In this study, we assess the influence of solvation on the accuracy and reliability of isotropic nuclear magnetic shielding calculations for amino acids in comparison to experimental data. We focus particularly on the performance of solvation methods... Read More

Ocean acidification affects marine chemical communication by changing structure and function of peptide signalling molecules (2016)
Journal Article
Roggatz, C. C., Lorch, M., Hardege, J. D., & Benoit, D. M. (2016). Ocean acidification affects marine chemical communication by changing structure and function of peptide signalling molecules. Global change biology, 22(12), (3914-3926). doi:10.1111/gcb.13354. ISSN 1354-1013

Ocean acidification is a global challenge that faces marine organisms in the near future with a predicted rapid drop in pH of up to 0.4 units by the end of this century. Effects of the change in ocean carbon chemistry and pH on the development, growt... Read More

Conformational photoswitching of a synthetic peptide foldamer bound within a phospholipid bilayer (2016)
Journal Article
Lorch, M., Clayden, J., De Poli, M., Quinonero, O., Webb, S. J., & Zawodny, W. (2016). Conformational photoswitching of a synthetic peptide foldamer bound within a phospholipid bilayer. Science, 352(6285), (575-580). doi:10.1126/science.aad8352. ISSN 0036-8075

The dynamic properties of foldamers, synthetic molecules that mimic folded biomolecules, have mainly been explored in free solution.We report on the design, synthesis, and conformational behavior of photoresponsive foldamers bound in a phospholipid b... Read More

Chelator free gallium-68 radiolabelling of silica coated iron oxide nanorods via surface interactions (2015)
Journal Article
Burke, B. P., Baghdadi, N., Kownacka, A. E., Nigam, S., Clemente, G. S., Al-Yassiry, M. M., …Archibald, S. J. (2015). Chelator free gallium-68 radiolabelling of silica coated iron oxide nanorods via surface interactions. Nanoscale, 7(36), (14889-14896). doi:10.1039/c5nr02753e. ISSN 2040-3364

The commercial availability of combined magnetic resonance imaging (MRI)/positron emission tomography (PET) scanners for clinical use has increased demand for easily prepared agents which offer signal or contrast in both modalities. Herein we describ... Read More

Whiter, brighter, and more stable cellulose paper coated with TiO 2/SiO2 core/shell nanoparticles using a layer-by-layer approach (2013)
Journal Article
Cheng, F., Kelly, S. M., Lorch, M., Kornherr, A., & Sajedin, S. M. (2013). Whiter, brighter, and more stable cellulose paper coated with TiO 2/SiO2 core/shell nanoparticles using a layer-by-layer approach. ChemSusChem, 6(8), (1392-1399). doi:10.1002/cssc.201300305. ISSN 1864-5631

To inhibit the photocatalytic degradation of organic material supports induced by small titania (TiO2) nanoparticles, four kinds of TiO2 nanoparticles, that is, commercial P25-TiO2, commercial rutile phase TiO2, rutile TiO2 nanorods and rutile TiO2 s... Read More

Identification of a female sex pheromone in Carcinus maenas (2011)
Journal Article
Bublitz, R., Walther, T., Welham, K., Davidson, L., Smith, M., Harley, M., …Terschak, J. (2011). Identification of a female sex pheromone in Carcinus maenas. Marine ecology progress series, 436, 177-189. doi:10.3354/meps09226

Despite major progress in our understanding of animal signaling systems, the identification of chemical signals in aquatic organisms is still in its infancy. Exemplary for this is the lack of structural knowledge of crustacean sex pheromones despite... Read More

Cholesterol and lipid phases influence the interactions between serotonin receptor agonists and lipid bilayers (2010)
Journal Article
Lorch, M., Batchelor, R., Buchoux, S., & Windle, C. J. (2010). Cholesterol and lipid phases influence the interactions between serotonin receptor agonists and lipid bilayers. Journal of Biological Chemistry, 285(53), (41402-41411). doi:10.1074/jbc.M110.155176. ISSN 0021-9258

Solid state NMR techniques have been used to investigate the effect that two serotonin receptor 1a agonists (quipazine and LY-165,163) have on the phase behavior of, and interactions within, cholesterol/phosphocholine lipid bilayers. The presence of... Read More

Access to a primary aminosporopollenin solid support from plant spores (2010)
Journal Article
Loebbert, A., Boasman, A. J., Löbbert, A., Barrier, S., Mackenzie, G., Atkin, S. L., …Boa, A. N. (2010). Access to a primary aminosporopollenin solid support from plant spores. Green chemistry : an international journal and green chemistry resource : GC, 12(2), 234-240. doi:10.1039/b913215e

Sporopollenin, which is a naturally occurring and highly resilient organic polymer constituting the external shell of spores and pollen grains, has been converted into a primary amine form with a loading of 0.58 +/- 0.04 mmol. g(-1) by reductive amin... Read More

MRI contrast agent delivery using spore capsules: controlled release in blood plasma (2009)
Journal Article
Lorch, M., Thomasson, M. J., Diego-Taboada, A., Barrier, S., Atkin, S. L., Mackenzie, G., & Archibald, S. J. (2009). MRI contrast agent delivery using spore capsules: controlled release in blood plasma. Chemical communications : Chem comm / the Royal Society of Chemistry, (6442-6444). doi:10.1039/b909551a. ISSN 1359-7345

The exine coatings of spores can be used to encapsulate drug molecules. We have demonstrated that these microcapsules can be filled with a commercial gadolinium(III) MRI contrast agent (in this proof of concept study Gd-DTPA-BMA was used) which is sl... Read More

Phosphatidylglycerol lipids enhance folding of an α helical membrane protein (2008)
Journal Article
Seddon, A. M., Lorch, M., Ces, O., Templer, R. H., Macrae, F., & Booth, P. J. (2008). Phosphatidylglycerol lipids enhance folding of an α helical membrane protein. Journal of Molecular Biology, 380(3), (548-556). doi:10.1016/j.jmb.2008.05.001. ISSN 0022-2836

Membrane lipids are increasingly being recognised as active participants in biological events. The precise roles that individual lipids or global properties of the lipid bilayer play in the folding of membrane proteins remain to be elucidated, Here,... Read More

Location and orientation of serotonin receptor 1a agonists in model and complex lipid membranes (2008)
Journal Article
Lorch, M., & Lopez, J. J. (2008). Location and orientation of serotonin receptor 1a agonists in model and complex lipid membranes. Journal of Biological Chemistry, 283(12), 7813-7822. doi:10.1074/jbc.M707480200

Magic angle spinning (MAS) NMR has been used to investigate the location and orientation of five serotonin receptor 1a agonists (serotonin, buspirone, quipazine, 8-OH-DPAT, and LY-163,165) in single component model lipid and brain lipid membranes. Th... Read More

Characterisation of Schiff base and chromophore in green proteorhodopsin by solid-state NMR (2007)
Journal Article
Pfleger, N., Lorch, M., Woerner, A. C., Shastri, S., & Glaubitz, C. (2008). Characterisation of Schiff base and chromophore in green proteorhodopsin by solid-state NMR. Journal of Biomolecular NMR, 40(1), (15-21). doi:10.1007/s10858-007-9203-5. ISSN 0925-2738

The proteorhodopsin family consists of hundreds of homologous retinal containing membrane proteins found in bacteria in the photic zone of the oceans. They are colour tuned to their environment and act as light-driven proton pumps with a potential en... Read More

Transport cycle intermediate in small multidrug resistance protein is revealed by substrate fluorescence (2007)
Journal Article
Basting, D., Lorch, M., Lehner, I., & Glaubitz, C. (2008). Transport cycle intermediate in small multidrug resistance protein is revealed by substrate fluorescence. FASEB Journal, 22(2), 365-373. doi:10.1096/fj.07-9162com

Efflux pumps of the small multidrug resistance family bind cationic, lipophilic antibiotics and transport them across the membrane in exchange for protons. The transport cycle must involve various conformational states of the protein needed for subst... Read More