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Interactions between taste receptors and the gastrointestinal microbiome in inflammatory bowel disease (2019)
Journal Article
Turner, A., Chijoff, E., Veysey, M., Keely, S., Scarlett, C. J., Lucock, M., & Beckett, E. L. (2019). Interactions between taste receptors and the gastrointestinal microbiome in inflammatory bowel disease. Journal of Nutrition and Intermediary Metabolism, 18, 100106. https://doi.org/10.1016/j.jnim.2019.100106

Incidence rates of inflammatory bowel disease (IBD) are increasing worldwide. This correlates with increased consumption of red meats, alcohol, refined sugars, oils and animal fats, typical of a “Western” diet. Poor dietary habits are the most ubiqui... Read More about Interactions between taste receptors and the gastrointestinal microbiome in inflammatory bowel disease.

Micronutrients and bioactive compounds in oral inflammatory diseases (2019)
Journal Article
Kaur, K., Sculley, D., Wallace, J., Turner, A., Ferraris, C., Veysey, M., …Beckett, E. L. (2019). Micronutrients and bioactive compounds in oral inflammatory diseases. Journal of Nutrition and Intermediary Metabolism, 18, https://doi.org/10.1016/j.jnim.2019.100105

Oral disorders are a significant public health concern. Oral inflammatory diseases are periodontal infections, oral mucosal lesions, pulpal and periapical lesions. The aetiology is multi-factorial and usually associated with a microbial origin, often... Read More about Micronutrients and bioactive compounds in oral inflammatory diseases.

Folate and Inflammation – links between folate and features of inflammatory conditions (2019)
Journal Article
Jones, P., Lucock, M., Scarlett, C. J., Veysey, M., & Beckett, E. L. (2019). Folate and Inflammation – links between folate and features of inflammatory conditions. Journal of Nutrition and Intermediary Metabolism, 18, https://doi.org/10.1016/j.jnim.2019.100104

Folate serves as a cofactor for one-carbon (1C) transfer reactions. These reactions are involved in the synthesis of DNA nucleotides, the amino acid methionine, and in the regulation of homocysteine (Hcy) levels. Emerging evidence suggests that these... Read More about Folate and Inflammation – links between folate and features of inflammatory conditions.

Budesonide treatment for microscopic colitis: systematic review and meta-analysis (2019)
Journal Article
Sebastian, S., Wilhelm, A., Lisle, J., Myers, S., & Veysey, M. (2019). Budesonide treatment for microscopic colitis: systematic review and meta-analysis. European Journal of Gastroenterology and Hepatology, 31(8), 919–927. https://doi.org/10.1097/MEG.0000000000001456

Microscopic colitis (MC), encompassing lymphocytic and collagenous colitis, is a common cause for chronic nonbloody diarrhoea, which impacts significantly on the quality of life for patients. Despite increasing awareness of the condition and its trea... Read More about Budesonide treatment for microscopic colitis: systematic review and meta-analysis.

Early lifecycle UV‐exposure calibrates adult vitamin D metabolism: Evidence for a developmentally originated vitamin D homeostat that may alter related adult phenotypes (2019)
Journal Article
Lucock, M., Thota, R., Garg, M., Martin, C., Jones, P., Furst, J., …Beckett, E. (2019). Early lifecycle UV‐exposure calibrates adult vitamin D metabolism: Evidence for a developmentally originated vitamin D homeostat that may alter related adult phenotypes. American journal of human biology : the official journal of the Human Biology Council, 31(4), https://doi.org/10.1002/ajhb.23272

Objectives Within the Developmental Origins of Adult Disease (DOHaD) model, early life environmental exposures can confer a long‐term legacy on human health. This mechanism may be adaptive or maladaptive depending on lifestyle circumstances. This ar... Read More about Early lifecycle UV‐exposure calibrates adult vitamin D metabolism: Evidence for a developmentally originated vitamin D homeostat that may alter related adult phenotypes.

Relationship between B-vitamin biomarkers and dietary intake with apolipoprotein E є4 in Alzheimer’s disease (2019)
Journal Article
D’Cunha, N. M., Georgousopoulou, E. N., Boyd, L., Veysey, M., Sturm, J., O’Brien, B., …Naumovski, N. (2019). Relationship between B-vitamin biomarkers and dietary intake with apolipoprotein E є4 in Alzheimer’s disease. Journal of Nutrition in Gerontology and Geriatrics, 38(2), 173-195. https://doi.org/10.1080/21551197.2019.1590287

The potential for B-vitamins to reduce plasma homocysteine (Hcy) and reduce the risk of Alzheimer’s disease (AD) has been described previously. However, the role of Apolipoprotein E є4 (APOE4) in this relationship has not been adequately addressed. T... Read More about Relationship between B-vitamin biomarkers and dietary intake with apolipoprotein E є4 in Alzheimer’s disease.

Population based study: atopy and autoimmune diseases are associated with functional dyspepsia and irritable bowel syndrome, independent of psychological distress (2019)
Journal Article
Koloski, N., Jones, M., Walker, M. M., Veysey, M., Zala, A., Keely, S., …Talley, N. J. (2019). Population based study: atopy and autoimmune diseases are associated with functional dyspepsia and irritable bowel syndrome, independent of psychological distress. Alimentary Pharmacology and Therapeutics, 49(5), 546-555. https://doi.org/10.1111/apt.15120

Background: The pathogenesis of functional GI disorders (FGIDs) is uncertain. However, underlying immune activation and psychological distress has been documented in irritable bowel syndrome (IBS) and functional dyspepsia (FD). Epidemiological data f... Read More about Population based study: atopy and autoimmune diseases are associated with functional dyspepsia and irritable bowel syndrome, independent of psychological distress.

Interactions between bitter taste, diet and dysbiosis: Consequences for appetite and obesity (2018)
Journal Article
Turner, A., Veysey, M., Keely, S., Scarlett, C., Lucock, M., & Beckett, E. (2018). Interactions between bitter taste, diet and dysbiosis: Consequences for appetite and obesity. Nutrients, 10(10), https://doi.org/10.3390/nu10101336

The type 2 family of taste receptors (T2Rs) detect and respond to bitter tastants. These receptors are expressed throughout the gastrointestinal (GI) tract, with location dependant roles. In the oral cavity, T2Rs are involved in the conscious percept... Read More about Interactions between bitter taste, diet and dysbiosis: Consequences for appetite and obesity.

Vitamin D and folate: A reciprocal environmental association based on seasonality and genetic disposition (2018)
Journal Article
Lucock, M., Thota, R., Garg, M., Martin, C., Jones, P., Furst, J., …Beckett, E. (2018). Vitamin D and folate: A reciprocal environmental association based on seasonality and genetic disposition. American journal of human biology : the official journal of the Human Biology Council, 30(5), https://doi.org/10.1002/ajhb.23166

Objectives: The purpose of this study was (1) to elucidate any reciprocal seasonal relationship that might exist between red cell folate (RCF) and serum vitamin D3 Levels; (2) to explore whether folate-related gene variants that influence/alter DNA-t... Read More about Vitamin D and folate: A reciprocal environmental association based on seasonality and genetic disposition.

The vitamin D–folate hypothesis as an evolutionary model for skin pigmentation: An update and integration of current ideas (2018)
Journal Article
Jones, P., Lucock, M., Veysey, M., & Beckett, E. (2018). The vitamin D–folate hypothesis as an evolutionary model for skin pigmentation: An update and integration of current ideas. Nutrients, 10(5), https://doi.org/10.3390/nu10050554

© 2018 by the authors. Licensee MDPI, Basel, Switzerland. Vitamin D is unique in being generated in our skin following ultraviolet radiation (UVR) exposure. Ongoing research into vitamin D must therefore always consider the influence of UVR on vitami... Read More about The vitamin D–folate hypothesis as an evolutionary model for skin pigmentation: An update and integration of current ideas.

Standard setting in Australian medical schools (2018)
Journal Article
Ward, H., Chiavaroli, N., Fraser, J., Mansfield, K., Starmer, D., Surmon, L., …O'Mara, D. (2018). Standard setting in Australian medical schools. BMC Medical Education, 18(1), https://doi.org/10.1186/s12909-018-1190-6

© 2018 The Author(s). Background: Standard setting of assessment is critical in quality assurance of medical programs. The aims of this study were to identify and compare the impact of methods used to establish the passing standard by the 13 medical... Read More about Standard setting in Australian medical schools.

Nutrigenetics—Personalized Nutrition in the Genetic Age (2017)
Journal Article
Beckett, E., Jones, P., Veysey, M., & Lucock, M. (2017). Nutrigenetics—Personalized Nutrition in the Genetic Age. Exploratory research and hypothesis in medicine, 2(4), 109-116. https://doi.org/10.14218/ERHM.2017.00027

Diet is an important modifiable determinant of disease, and it is becoming clear that diet and genetic risk factors are interactive in determining risk for diseases such as cardiovascular disease, diabetes and cancers. Advances in technology have imp... Read More about Nutrigenetics—Personalized Nutrition in the Genetic Age.

Frequency of folate-related polymorphisms varies by skin pigmentation (2017)
Journal Article
Jones, P., Lucock, M., Veysey, M., Jablonski, N., Chaplin, G., & Beckett, E. (2018). Frequency of folate-related polymorphisms varies by skin pigmentation. American Journal of Human Biology, 30(2), https://doi.org/10.1002/ajhb.23079

© 2017 Wiley Periodicals, Inc. Objectives: Folate-mediated 1-carbon transfer processes are vital in human health but are susceptible to independent and interactive influences of genetic variance and environmental exposures. Evidence suggests folate l... Read More about Frequency of folate-related polymorphisms varies by skin pigmentation.

InsuTAG: A novel physiologically relevant predictor for insulin resistance and metabolic syndrome (2017)
Journal Article
Thota, R. N., Abbott, K. A., Ferguson, J. J. A., Veysey, M., Lucock, M., Niblett, S., …Garg, M. L. (2017). InsuTAG: A novel physiologically relevant predictor for insulin resistance and metabolic syndrome. Scientific reports, 7(1), https://doi.org/10.1038/s41598-017-15460-z

© 2017 The Author(s). The aim of this study was to investigate whether a novel physiologically relevant marker, InsuTAG (fasting insulin × fasting triglycerides) can predict insulin resistance (IR) and metabolic syndrome (MetS). Data of 618 participa... Read More about InsuTAG: A novel physiologically relevant predictor for insulin resistance and metabolic syndrome.

Undiagnosed pancreatic exocrine insufficiency and chronic pancreatitis in functional GI disorder patients with diarrhea or abdominal pain (2017)
Journal Article
Talley, N., Holtmann, G., Nguyen, Q., Gibson, P., Bampton, P., Veysey, M., …Jones, M. (2017). Undiagnosed pancreatic exocrine insufficiency and chronic pancreatitis in functional GI disorder patients with diarrhea or abdominal pain. Journal of Gastroenterology and Hepatology, 32(11), 1813-1817. https://doi.org/10.1111/jgh.13791

© 2017 Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd Background and Aim: A previous UK study showed that 6.1% of patients with diarrhea-predominant irritable bowel syndrome (IBS-D) had evidence of severe... Read More about Undiagnosed pancreatic exocrine insufficiency and chronic pancreatitis in functional GI disorder patients with diarrhea or abdominal pain.

VDR gene methylation as a molecular adaption to light exposure: Historic, recent and genetic influences (2017)
Journal Article
Beckett, E., Jones, P., Veysey, M., Duesing, K., Martin, C., Furst, J., …Lucock, M. (2017). VDR gene methylation as a molecular adaption to light exposure: Historic, recent and genetic influences. American Journal of Human Biology, 29(5), https://doi.org/10.1002/ajhb.23010

Objectives The vitamin D receptor (VDR) is a member of the nuclear receptor family of transcription factors. We examined whether degree of VDR gene methylation acts as a molecular adaptation to light exposure. We explored this in the context of phot... Read More about VDR gene methylation as a molecular adaption to light exposure: Historic, recent and genetic influences.

Reduced plasma homocysteine levels in elderly Australians following mandatory folic acid fortification – A comparison of two cross-sectional cohorts (2017)
Journal Article
Beckett, E., Martin, C., Boyd, L., Porter, T., King, K., Niblett, S., …Lucock, M. (2017). Reduced plasma homocysteine levels in elderly Australians following mandatory folic acid fortification – A comparison of two cross-sectional cohorts. Journal of Nutrition and Intermediary Metabolism, 8, 14-20. https://doi.org/10.1016/j.jnim.2017.04.001

© 2017 Objective In 2009, Australia implemented mandatory folic acid fortification in wheat flour for bread-making. The primary aim was to improve folate status in reproductive-aged women to reduce neural tube defect incidence. However, folic acid co... Read More about Reduced plasma homocysteine levels in elderly Australians following mandatory folic acid fortification – A comparison of two cross-sectional cohorts.

A potential sex dimorphism in the relationship between bitter taste and alcohol consumption (2017)
Journal Article
Beckett, E., Duesing, K., Boyd, L., Yates, Z., Veysey, M., & Lucock, M. (2017). A potential sex dimorphism in the relationship between bitter taste and alcohol consumption. Food and Function, 8(3), 1116-1123. https://doi.org/10.1039/c6fo01759b

© The Royal Society of Chemistry. Background: Bitterness is an innate aversive taste important in detecting potentially toxic substances, including alcohol. However, bitter compounds exist in many foods and beverages, and can be desirable, such as in... Read More about A potential sex dimorphism in the relationship between bitter taste and alcohol consumption.

Regulation of IL-12p40 by HIF controls Th1/Th17 responses to prevent mucosal inflammation (2017)
Journal Article
Marks, E., Naudin, C., Nolan, G., Goggins, B. J., Burns, G., Mateer, S. W., …Keely, S. (2017). Regulation of IL-12p40 by HIF controls Th1/Th17 responses to prevent mucosal inflammation. Mucosal Immunology, 10(5), 1224-1236. https://doi.org/10.1038/mi.2016.135

Intestinal inflammatory lesions are inherently hypoxic, due to increased metabolic demands created by cellular infiltration and proliferation, and reduced oxygen supply due to vascular damage. Hypoxia stabilizes the transcription factor hypoxia-induc... Read More about Regulation of IL-12p40 by HIF controls Th1/Th17 responses to prevent mucosal inflammation.