Liver resection surgery compared with thermal ablation in high surgical risk patients with colorectal liver metastases: the LAVA international RCT

Davidson, Brian; Gurusamy, Kurinchi; Corrigan, Neil; Croft, Julie; Ruddock, Sharon; Pullan, Alison; Brown, Julia; Twiddy, Maureen; Birtwistle, Jaqueline; Morris, Stephen; Woodward, Nick; Bandula, Steve; Hochhauser, Daniel; Prasad, Raj; Damink, Steven Olde; Coolson, Marielle; van Laarhoven, K.; de Wilt, Johannes H.W.

doi:10.3310/hta24210

All Outputs (8)

Microplastic contamination of seafood intended for human consumption: a systematic review and meta-analysis (2020)
Journal Article
Danopoulos, E., Jenner, L., Twiddy, M., & Rotchell, J. M. (2020). Microplastic contamination of seafood intended for human consumption: a systematic review and meta-analysis. Environmental Health Perspectives, 128(12), 126002-1-126002-32. https://doi.org/10.1289/EHP7171

Background: Microplastics (MPs) have contaminated all compartments of the marine environment including biota such as seafood; ingestion from such sources is one of the two major uptake routes identified for human exposure. Objectives: The objectives... Read More about Microplastic contamination of seafood intended for human consumption: a systematic review and meta-analysis.

Microplastic contamination of salt intended for human consumption: a systematic review and meta-analysis (2020)
Journal Article
Danopoulos, E., Jenner, L., Twiddy, M., & Rotchell, J. M. (2020). Microplastic contamination of salt intended for human consumption: a systematic review and meta-analysis. SN Applied Sciences, 2(12), Article 1950. https://doi.org/10.1007/s42452-020-03749-0

Microplastics (MPs) are an emerging contaminant ubiquitous in the environment. There is growing concern regarding potential human health effects, a major human exposure route being dietary uptake. We have undertaken a systematic review (SR) and meta-... Read More about Microplastic contamination of salt intended for human consumption: a systematic review and meta-analysis.

Characterising heterogeneity and the role of attitudes in patient preferences: a case study in preferences for outpatient parenteral intravenous antimicrobial therapy (OPAT) services (2020)
Journal Article
Hess, S., Meads, D., Twiddy, M., Mason, S., Czoski-Murray, C., & Minton, J. (2021). Characterising heterogeneity and the role of attitudes in patient preferences: a case study in preferences for outpatient parenteral intravenous antimicrobial therapy (OPAT) services. Journal of Choice Modelling, 38, Article 100252. https://doi.org/10.1016/j.jocm.2020.100252

Choice modelling techniques have established themselves as a key analysis tool in health economics and have been used to understand patient and practitioner preferences across a wide variety of settings. A key interest in recent years has been the in... Read More about Characterising heterogeneity and the role of attitudes in patient preferences: a case study in preferences for outpatient parenteral intravenous antimicrobial therapy (OPAT) services.

Searching for Programme Theories for a realist evaluation: A case study comparing an academic database search and a simple Google search (2020)
Journal Article
Coleman, S., Wright, J. M., Nixon, J., Schoonhoven, L., Twiddy, M., & Greenhalgh, J. (2020). Searching for Programme Theories for a realist evaluation: A case study comparing an academic database search and a simple Google search. BMC Medical Research Methodology, 20(1), 217. https://doi.org/10.1186/s12874-020-01084-x

BACKGROUND: Realist methodologies are increasingly being used to evaluate complex interventions in health and social care. Programme theory (ideas and assumptions of how a particular intervention works) development is the first step in a realist eval... Read More about Searching for Programme Theories for a realist evaluation: A case study comparing an academic database search and a simple Google search.

Microplastic contamination of drinking water: a systematic review. (2020)
Journal Article
Danopoulos, E., Twiddy, M., & Rotchell, J. M. (2020). Microplastic contamination of drinking water: a systematic review. PLoS ONE, 15(7 July), Article e0236838. https://doi.org/10.1371/journal.pone.0236838

Background Microplastics (MPs) are omnipresent in the environment, including the human food chain; a likely important contributor to human exposure is drinking water. Objective To undertake a systematic review of MP contamination of drinking water... Read More about Microplastic contamination of drinking water: a systematic review..

high INtensity Interval Training In pATiEnts with intermittent claudication (INITIATE): protocol for a multi-centre, proof-of-concept, prospective interventional study (2020)
Journal Article
Pymer, S., Harwood, A., Ibeggazene, S., McGregor, G., Huang, C., Twiddy, M., …Chetter, I. C. (2020). high INtensity Interval Training In pATiEnts with intermittent claudication (INITIATE): protocol for a multi-centre, proof-of-concept, prospective interventional study. BMJ open, 10(7), Article e038825. https://doi.org/10.1136/bmjopen-2020-038825

Introduction: The first-line recommended treatment for patients with intermittent claudication (IC), is a supervised exercise programme (SEP), which includes a minimum of 2 hours exercise per week over a 12-week period. However, provision, uptake, an... Read More about high INtensity Interval Training In pATiEnts with intermittent claudication (INITIATE): protocol for a multi-centre, proof-of-concept, prospective interventional study.

Laparoscopic versus open colorectal surgery in the acute setting (LaCeS trial): a multicentre randomized feasibility trial (2020)
Journal Article
Cardozo, W., Baker, R., Berger, C., Chapman, S., Codd, R., Coyne, P., …Brown, J. (in press). Laparoscopic versus open colorectal surgery in the acute setting (LaCeS trial): a multicentre randomized feasibility trial. British journal of surgery, https://doi.org/10.1002/bjs.11703

Abstract Background Approximately 30,000 people per annum undergo major, emergency abdominal, gastrointestinal surgery, of which 36% (~10,800) are carried out for emergency colorectal pathology. Approximately 14% of all patients requiring emergency... Read More about Laparoscopic versus open colorectal surgery in the acute setting (LaCeS trial): a multicentre randomized feasibility trial.

Liver resection surgery compared with thermal ablation in high surgical risk patients with colorectal liver metastases: the LAVA international RCT (2020)
Journal Article
Davidson, B., Gurusamy, K., Corrigan, N., Croft, J., Ruddock, S., Pullan, A., …de Wilt, J. H. (2020). Liver resection surgery compared with thermal ablation in high surgical risk patients with colorectal liver metastases: the LAVA international RCT. Health Technology Assessment, 24(21), 1-66. https://doi.org/10.3310/hta24210

Background: Although surgical resection has been considered the only curative option for colorectal liver metastases, thermal ablation has recently been suggested as an alternative curative treatment. There have been no adequately powered trials comp... Read More about Liver resection surgery compared with thermal ablation in high surgical risk patients with colorectal liver metastases: the LAVA international RCT.