All Outputs (62)

A Qualitative Study to Understand the Challenges of Conducting Randomised Controlled Trials of Complex Interventions in Metastatic Colorectal Cancer (2025)
Journal Article
McKigney, N., Seligmann, J., Twiddy, M., Bach, S., Mohamed, F., Fearnhead, N., Brown, J., & Harji, D. (2025). A Qualitative Study to Understand the Challenges of Conducting Randomised Controlled Trials of Complex Interventions in Metastatic Colorectal Cancer. Trials, 26, Article 98. https://doi.org/10.1186/s13063-025-08811-z

The use of interventions such as major liver and lung resection, radiofrequency ablation and transarterial chemoembolization in the management of metastatic colorectal cancer (mCRC) is now relatively commonplace in clinical practice. However, the evi... Read More about A Qualitative Study to Understand the Challenges of Conducting Randomised Controlled Trials of Complex Interventions in Metastatic Colorectal Cancer.

Interventions to improve clinical trial recruitment with a focus on clinical staff from the recruiting site: a systematic review (2024)
Journal Article
Hermann, L., Arundel, C., Thomas, A., Twiddy, M., & Clark, L. (in press). Interventions to improve clinical trial recruitment with a focus on clinical staff from the recruiting site: a systematic review. Research Methods in Medicine & Health Sciences, https://doi.org/10.1177/26320843241289094

Abstract
Background
Difficulties recruiting to clinical trials are well-documented. Strategies to engage staff from the clinical site where recruitment takes place may be helpful in increasing recruitment rates.
Aim
To systematically review the l... Read More about Interventions to improve clinical trial recruitment with a focus on clinical staff from the recruiting site: a systematic review.

Factors Influencing the Implementation of Digital Advance Care Planning: Qualitative Interview Study (2024)
Journal Article
Bradshaw, A., Birtwistle, J., Evans, C. J., Sleeman, K. E., Richards, S., Foy, R., Martin, P. M., Carder, P., Allsop, M. J., & Twiddy, M. (2024). Factors Influencing the Implementation of Digital Advance Care Planning: Qualitative Interview Study. Journal of medical Internet research, 26, Article e50217. https://doi.org/10.2196/50217

BACKGROUND: Palliative care aims to improve the quality of life for people with life-limiting illnesses. Advance care planning conversations that establish a patient's wishes and preferences for care are part of a person-centered approach. Internatio... Read More about Factors Influencing the Implementation of Digital Advance Care Planning: Qualitative Interview Study.

"What influences how well householders living in previously flooded communities feel they are protected or could recover from future flooding?: Results of a survey" (2024)
Journal Article
Twiddy, M., & Ramsden, S. (2024). "What influences how well householders living in previously flooded communities feel they are protected or could recover from future flooding?: Results of a survey". PLoS ONE, 19(8 AUGUST), Article e0306593. https://doi.org/10.1371/journal.pone.0306593

In England, the Environment Agency (EA) estimates that over 3 million properties in England are at risk of surface water flooding. Heavy and prolonged rainfall that drives surface water flooding is projected to increase in the future due to climate c... Read More about "What influences how well householders living in previously flooded communities feel they are protected or could recover from future flooding?: Results of a survey".

Using PURPOSE T In Clinical Practice: A Realist Evaluation (2024)
Journal Article
Coleman, S., Greenhalgh, J., Schoonhoven, L., Twiddy, M., & Nixon, J. (2024). Using PURPOSE T In Clinical Practice: A Realist Evaluation. Journal of tissue viability, 33(4), 672-680. https://doi.org/10.1016/j.jtv.2024.06.014

Aim
To explain how the clinical and organisational context influenced the way the Pressure Ulcer Risk Primary or Secondary Evaluation Tool (PURPOSE-T) is used by nursing staff to support their clinical judgement and decision making about care planni... Read More about Using PURPOSE T In Clinical Practice: A Realist Evaluation.

Home-based high intensity interval training in patients with intermittent claudication: a systematic review protocol (2024)
Journal Article
Prosser, J., Staniland, T., Harwood, A., Ravindhran, B., McGregor, G., Huang, C., Twiddy, M., Nicholls, A., Ingle, L., Long, J., Chetter, I., & Pymer, S. (2024). Home-based high intensity interval training in patients with intermittent claudication: a systematic review protocol. Journal of Vascular Societies Great Britain and Ireland, 3(3), 155-159. https://doi.org/10.54522/jvsgbi.2024.103

Introduction: The aim of this systematic review is to consider the evidence base for home-based high intensity interval training (HIIT) in patients with intermittent claudication (IC). Prior knowledge of the evidence base suggests that there may be l... Read More about Home-based high intensity interval training in patients with intermittent claudication: a systematic review protocol.

Improving the Detection, Assessment, Management and Prevention of Delirium in Hospices (the DAMPen-D study): Feasibility study of a flexible and scalable implementation strategy to deliver guideline-adherent delirium care (2024)
Journal Article
Jackson, G. P., Jackson, C., Boland, J. W., Featherstone, I., Huang, C., Ogden, M., Sartain, K., Siddiqi, N., Twiddy, M., Pearson, M., & Johnson, M. J. (2024). Improving the Detection, Assessment, Management and Prevention of Delirium in Hospices (the DAMPen-D study): Feasibility study of a flexible and scalable implementation strategy to deliver guideline-adherent delirium care. Palliative medicine, 38(4), 447-456. https://doi.org/10.1177/02692163241236325

Background: Delirium is a complex condition, stressful for all involved. Although highly prevalent in palliative care settings, it remains underdiagnosed and associated with poor outcomes. Guideline-adherent delirium care may improve its detection, a... Read More about Improving the Detection, Assessment, Management and Prevention of Delirium in Hospices (the DAMPen-D study): Feasibility study of a flexible and scalable implementation strategy to deliver guideline-adherent delirium care.

High INtensity Interval Training in pATiEnts with Intermittent Claudication: A Qualitative Acceptability Study (2024)
Journal Article
Pymer, S., Harwood, A., Ibeggazene, S., McGregor, G., Huang, C., Nicholls, A., Ingle, L., Long, J., Rooms, M., Chetter, I. C., & Twiddy, M. (2024). High INtensity Interval Training in pATiEnts with Intermittent Claudication: A Qualitative Acceptability Study. Annals of vascular surgery, 102, 17-24. https://doi.org/10.1016/j.avsg.2023.11.043

Background: A novel high-intensity interval training (HIIT) program has demonstrated feasibility for patients with intermittent claudication (IC). The aim of this study was to explore patient perspectives of the HIIT program to inform refinement and... Read More about High INtensity Interval Training in pATiEnts with Intermittent Claudication: A Qualitative Acceptability Study.

Views of patients with progressive illness and carers about the role of digital advance care planning systems to record and share information: a qualitative study (2024)
Journal Article
Birtwistle, J., Allsop, M. J., Bradshaw, A., Millares Martin, P., Sleeman, K. E., Twiddy, M., & Evans, C. J. (2024). Views of patients with progressive illness and carers about the role of digital advance care planning systems to record and share information: a qualitative study. Palliative medicine, 38(7), 711-724. https://doi.org/10.1177/02692163241255511

Background: Digital approaches are being explored internationally to support the elicitation, documentation and sharing of advance care planning information. However, the views and experiences of patients and carers are little understood, impeding th... Read More about Views of patients with progressive illness and carers about the role of digital advance care planning systems to record and share information: a qualitative study.

Evaluating the Role of Ultrasound in Prostate Cancer trial – phase 1: Early experience of micro-ultrasound in the United Kingdom (2024)
Journal Article
Parker, P., Twiddy, M., Rigby, A., Whybrow, P., & Simms, M. (2024). Evaluating the Role of Ultrasound in Prostate Cancer trial – phase 1: Early experience of micro-ultrasound in the United Kingdom. Ultrasound, https://doi.org/10.1177/1742271X231226302

Purpose: The purpose of this study was to evaluate if the use of micro-ultrasound can detect clinically significant prostate pathology when compared to histology obtained during a transperineal prostate biopsy. Methods: Patients suspected of having p... Read More about Evaluating the Role of Ultrasound in Prostate Cancer trial – phase 1: Early experience of micro-ultrasound in the United Kingdom.

Exploring the contextual assumptions, interventions and outcomes of digital advance care planning systems: A theory of change approach to understand implementation and evaluation (2024)
Journal Article
Bradshaw, A., Allsop, M. J., Birtwistle, J., Evans, C. J., Relton, S. D., Richards, S. H., Twiddy, M., Foy, R., Millares Martin, P., Yardley, S., Sleeman, K. E., & On Behalf of the OPTIMAL CARE Project. (2024). Exploring the contextual assumptions, interventions and outcomes of digital advance care planning systems: A theory of change approach to understand implementation and evaluation. Palliative medicine, https://doi.org/10.1177/02692163241280134

Background: Digital advance care planning systems are used internationally to document and share patients’ wishes and preferences to inform care delivery. However, their use is impeded by a limited understanding of factors influencing implementation... Read More about Exploring the contextual assumptions, interventions and outcomes of digital advance care planning systems: A theory of change approach to understand implementation and evaluation.

Patient influence on general practice service improvement decision making: a participatory research mixed-methods intervention study (2023)
Journal Article
Drinkwater, J., MacFarlane, A., Twiddy, M., Meads, D., Chadwick, R. H., Donnelly, A., Gleeson, P., Hayward, N., Kelly, M., Mir, R., Prestwich, G., Rathfelder, M., & Foy, R. (2024). Patient influence on general practice service improvement decision making: a participatory research mixed-methods intervention study. The British journal of general practice : the journal of the Royal College of General Practitioners, 74(745), e552-e559. https://doi.org/10.3399/BJGP.2023.0263

BACKGROUND: Health policy promotes patient participation in decision making about service organisation. In English general practice this happens through contractually required patient participation groups (PPGs). However, there are problems with the... Read More about Patient influence on general practice service improvement decision making: a participatory research mixed-methods intervention study.

Associations between physical activity, sedentary behaviour, and alcohol consumption among UK adults: Findings from the Health Behaviours during the COVID-19 pandemic (HEBECO) study (2023)
Journal Article
Akwa, L. G., Smith, L., Twiddy, M., Abt, G., Garnett, C., Oldham, M., Shahab, L., & Herbec, A. (2023). Associations between physical activity, sedentary behaviour, and alcohol consumption among UK adults: Findings from the Health Behaviours during the COVID-19 pandemic (HEBECO) study. PLoS ONE, 18(10 October), Article e0287199. https://doi.org/10.1371/journal.pone.0287199

Introduction The COVID-19 pandemic and attendant lockdowns have had a substantial negative effect on alcohol consumption and physical activity globally. Pre-pandemic evidence in the adult population suggests that higher levels of physical activity we... Read More about Associations between physical activity, sedentary behaviour, and alcohol consumption among UK adults: Findings from the Health Behaviours during the COVID-19 pandemic (HEBECO) study.

Surgical and rehabilitation outcomes of patients undergoing through knee amputation compared with above knee amputation (2023)
Journal Article
Gordon, H., Hebenton, J., Davie-Smith, F., Twiddy, M., Smith, G., & Carradice, D. (2023). Surgical and rehabilitation outcomes of patients undergoing through knee amputation compared with above knee amputation. Journal of Vascular Societies Great Britain and Ireland, 2(4), 208-214. https://doi.org/10.54522/jvsgbi.2023.081

Background: Through knee amputation (TKA) may offer benefits over above knee amputation (AKA) in patients unsuitable for below knee amputation. This retrospective analysis compared surgical and rehabilitation outcomes post TKA and AKA.

Methods: Al... Read More about Surgical and rehabilitation outcomes of patients undergoing through knee amputation compared with above knee amputation.

Transforming adult social care systems? A systematic review of the costs and outcomes of local area coordination in England and Wales (2023)
Journal Article
Thiery, H., Cook, J., Burchell, J., Wilberforce, M., Twiddy, M., Nikolova, S., Martin, A., & Hulme, C. (2023). Transforming adult social care systems? A systematic review of the costs and outcomes of local area coordination in England and Wales. Social Sciences & Humanities Open, 8(1), Article 100714. https://doi.org/10.1016/j.ssaho.2023.100714

Adult Social Care (ASC) in England faces an ‘existential crisis’, caught between increased demand for services and continued cuts to social care and local government budgets. Increasingly, it is argued that this crisis cannot be solved without reform... Read More about Transforming adult social care systems? A systematic review of the costs and outcomes of local area coordination in England and Wales.

Embedding new technology into clinical ultrasound practice: Is role extension for sonographers the key to improving patient pathways? (2022)
Journal Article
Parker, P., Edwards, H., Twiddy, M., Whybrow, P., & Rigby, A. (2022). Embedding new technology into clinical ultrasound practice: Is role extension for sonographers the key to improving patient pathways?. Ultrasound, 31(2), 84-90. https://doi.org/10.1177/1742271X221139210

Introduction: MicroUS is a new imaging technique that may have potential to reliably monitor prostate disease and therefore release capacity in MRI departments. Firstly, however, it is essential to identify which healthcare staff may be suitable to l... Read More about Embedding new technology into clinical ultrasound practice: Is role extension for sonographers the key to improving patient pathways?.

Extracorporeal shockwave therapy compared with standard care for diabetic foot ulcer healing: An updated systematic review (2022)
Journal Article
Hitchman, L., Totty, J., Smith, G. E., Carradice, D., Twiddy, M., Iglesias, C., Russell, D., & Chetter, I. C. (2022). Extracorporeal shockwave therapy compared with standard care for diabetic foot ulcer healing: An updated systematic review. International wound journal, https://doi.org/10.1111/iwj.14035

Emerging evidence suggests that extracorporeal shockwave therapy (ESWT) may improve time to DFU healing. The aim of this review was to appraise the evidence on role of ESWT in DFU healing and impact of different ESWT doses. Databases were searched fo... Read More about Extracorporeal shockwave therapy compared with standard care for diabetic foot ulcer healing: An updated systematic review.

Recruiting to surgical trials in the emergency setting: using a mixed methods study to understand clinician and patient perspectives (2022)
Journal Article
Twiddy, M., Birtwistle, J., Edmondson, A., Croft, J., Gordon, K., Meads, D., Burke, D., Griffiths, B., Rose, A., Sagar, P., Stocken, D., Brown, J. M. B., & Harji, D. (2022). Recruiting to surgical trials in the emergency setting: using a mixed methods study to understand clinician and patient perspectives. BJS Open, 6(6), Article zrac137. https://doi.org/10.1093/bjsopen/zrac137

Background: Undertaking randomized clinical trials (RCTs) in emergency surgical settings is associated with methodological and practical challenges. This study explored patients' and clinicians' perspectives associated with the conduct of an RCT comp... Read More about Recruiting to surgical trials in the emergency setting: using a mixed methods study to understand clinician and patient perspectives.

Understanding the long-term impact of flooding on the wellbeing of residents: A mixed methods study (2022)
Journal Article
Twiddy, M., Trump, B., & Ramsden, S. (2022). Understanding the long-term impact of flooding on the wellbeing of residents: A mixed methods study. PLoS ONE, 17(9), Article e0274890. https://doi.org/10.1371/journal.pone.0274890

As the effects of climate change become more visible, extreme weather events are becoming more common. The effects of flooding on health are understood but the long-term impact on the well-being of those affected need to be considered. This mixed met... Read More about Understanding the long-term impact of flooding on the wellbeing of residents: A mixed methods study.

Improving the Detection, Assessment, Management and Prevention of Delirium in Hospices (the DAMPen-D study): protocol for a co-design and feasibility study of a flexible and scalable implementation strategy to deliver guideline-adherent delirium care (2022)
Journal Article
Pearson, M., Jackson, G., Jackson, C., Boland, J., Featherstone, I., Huang, C., Ogden, M., Sartain, K., Siddiqi, N., Twiddy, M., & Johnson, M. (2022). Improving the Detection, Assessment, Management and Prevention of Delirium in Hospices (the DAMPen-D study): protocol for a co-design and feasibility study of a flexible and scalable implementation strategy to deliver guideline-adherent delirium care. BMJ open, 12(7), Article e060450. https://doi.org/10.1136/bmjopen-2021-060450

INTRODUCTION: Delirium is a complex condition in which altered mental state and cognition causes severe distress and poor clinical outcomes for patients and families, anxiety and stress for the health professionals and support staff providing care, a... Read More about Improving the Detection, Assessment, Management and Prevention of Delirium in Hospices (the DAMPen-D study): protocol for a co-design and feasibility study of a flexible and scalable implementation strategy to deliver guideline-adherent delirium care.