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Characterizing and Modeling Bone Formation during Mouse Calvarial Development (2019)
Journal Article
Marghoub, A., Libby, J., Babbs, C., Ventikos, Y., Fagan, M. J., & Moazen, M. (2019). Characterizing and Modeling Bone Formation during Mouse Calvarial Development. Physical review letters, 122(4), https://doi.org/10.1103/PhysRevLett.122.048103

© 2019 American Physical Society. The newborn mammalian cranial vault consists of five flat bones that are joined together along their edges by soft fibrous tissues called sutures. Early fusion of these sutures leads to a medical condition known as c... Read More about Characterizing and Modeling Bone Formation during Mouse Calvarial Development.

Predicting calvarial growth in normal and craniosynostotic mice using a computational approach (2017)
Journal Article
Marghoub, A., Libby, J., Babbs, C., Pauws, E., Fagan, M. J., & Moazen, M. (2018). Predicting calvarial growth in normal and craniosynostotic mice using a computational approach. Journal of anatomy, 232(3), 440-448. https://doi.org/10.1111/joa.12764

© 2017 Anatomical Society During postnatal calvarial growth the brain grows gradually and the overlying bones and sutures accommodate that growth until the later juvenile stages. The whole process is coordinated through a complex series of biological... Read More about Predicting calvarial growth in normal and craniosynostotic mice using a computational approach.

Modelling human skull growth: a validated computational model (2017)
Journal Article
Libby, J., Marghoub, A., Johnson, D., Khonsari, R. H., Fagan, M. J., & Moazen, M. (2017). Modelling human skull growth: a validated computational model. Journal of the Royal Society interface / the Royal Society, 14(130), 20170202. https://doi.org/10.1098/rsif.2017.0202

© 2017 The Author(s) Published by the Royal Society. All rights reserved. During the first year of life, the brain grows rapidly and the neurocranium increases to about 65% of its adult size. Our understanding of the relationship between the biomecha... Read More about Modelling human skull growth: a validated computational model.

Application of Far Cortical Locking Technology in Periprosthetic Femoral Fracture Fixation: A Biomechanical Study (2016)
Journal Article
Moazen, M., Leonidou, A., Pagkalos, J., Marghoub, A., Fagan, M. J., & Tsiridis, E. (2016). Application of Far Cortical Locking Technology in Periprosthetic Femoral Fracture Fixation: A Biomechanical Study. Journal of Arthroplasty, 31(8), 1849-1856. https://doi.org/10.1016/j.arth.2016.02.013

© 2016 Elsevier Inc. Background Lack of fracture movement could be a potential cause of periprosthetic femoral fracture (PFF) fixation failures. This study aimed to test whether the use of distal far cortical locking screws reduces the overall stiffn... Read More about Application of Far Cortical Locking Technology in Periprosthetic Femoral Fracture Fixation: A Biomechanical Study.

Intracranial pressure changes during mouse development (2015)
Journal Article
Moazen, M., Alazmani, A., Rafferty, K., Liu, Z., Gustafson, J., Cunningham, M. L., …Herring, S. W. (2016). Intracranial pressure changes during mouse development. Journal of biomechanics, 49(1), 123-126. https://doi.org/10.1016/j.jbiomech.2015.11.012

During early stages of postnatal development, pressure from the growing brain as well as cerebrospinal fluid, i.e. intracranial pressure (ICP), load the calvarial bones. It is likely that such loading contributes to the peripheral bone formation at t... Read More about Intracranial pressure changes during mouse development.

Mechanical properties of calvarial bones in a mouse model for craniosynostosis (2015)
Journal Article
Moazen, M., Peskett, E., Babbs, C., Pauws, E., & Fagan, M. J. (2015). Mechanical properties of calvarial bones in a mouse model for craniosynostosis. PloS one, 10(5), e0125757. https://doi.org/10.1371/journal.pone.0125757

The mammalian cranial vault largely consists of five flat bones that are joined together along their edges by soft fibrous tissues called sutures. Premature closure of the cranial sutures, craniosynostosis, can lead to serious clinical pathology unle... Read More about Mechanical properties of calvarial bones in a mouse model for craniosynostosis.

Biomechanical assessment of evolutionary changes in the lepidosaurian skull (2009)
Journal Article
Moazen, M., Curtis, N., O'Higgins, P., Evans, S. E., & Fagan, M. J. (2009). Biomechanical assessment of evolutionary changes in the lepidosaurian skull. Proceedings of the National Academy of Sciences of the United States of America, 106(20), 8273-8277. https://doi.org/10.1073/pnas.0813156106

The lepidosaurian skull has long been of interest to functional morphologists and evolutionary biologists. Patterns of bone loss and gain, particularly in relation to bars and fenestrae, have led to a variety of hypotheses concerning skull use and ki... Read More about Biomechanical assessment of evolutionary changes in the lepidosaurian skull.

Assessment of the role of sutures in a lizard skull: a computer modelling study (2009)
Journal Article
Moazen, M., Curtis, N., O'Higgins, P., Jones, M. E., Evans, S. E., & Fagan, M. J. (2009). Assessment of the role of sutures in a lizard skull: a computer modelling study. Proceedings of the Royal Society B: Biological Sciences, 276(1654), 39-46. https://doi.org/10.1098/rspb.2008.0863

Sutures form an integral part of the functioning skull, but their role has long been debated among vertebrate morphologists and palaeontologists. Furthermore, the relationship between typical skull sutures, and those involved in cranial kinesis, is p... Read More about Assessment of the role of sutures in a lizard skull: a computer modelling study.

Combined finite element and multibody dynamics analysis of biting in aUromastyx hardwickiilizard skull (2008)
Journal Article
Moazen, M., Curtis, N., Evans, S. E., O’Higgins, P., & Fagan, M. J. (2008). Combined finite element and multibody dynamics analysis of biting in aUromastyx hardwickiilizard skull. Journal of anatomy, 213(5), 499-508. https://doi.org/10.1111/j.1469-7580.2008.00980.x

Lizard skulls vary greatly in shape and construction, and radical changes in skull form during evolution have made this an intriguing subject of research. The mechanics of feeding have surely been affected by this change in skull form, but whether th... Read More about Combined finite element and multibody dynamics analysis of biting in aUromastyx hardwickiilizard skull.

Predicting skull loading: applying multibody dynamics analysis to a macaque skull (2008)
Journal Article
Curtis, N., Kupczik, K., O'Higgins, P., Moazen, M., & Fagan, M. (2008). Predicting skull loading: applying multibody dynamics analysis to a macaque skull. Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology, 291(5), 491-501. https://doi.org/10.1002/ar.20689

Evaluating stress and strain fields in anatomical structures is a way to test hypotheses that relate specific features of facial and skeletal morphology to mechanical loading. Engineering techniques such as finite element analysis are now commonly us... Read More about Predicting skull loading: applying multibody dynamics analysis to a macaque skull.

Rigid-body analysis of a lizard skull: modelling the skull of Uromastyx hardwickii (2008)
Journal Article
Moazen, M., Curtis, N., Evans, S. E., O'Higgins, P., & Fagan, M. J. (2008). Rigid-body analysis of a lizard skull: modelling the skull of Uromastyx hardwickii. Journal of biomechanics, 41(6), 1274-1280. https://doi.org/10.1016/j.jbiomech.2008.01.012

Lizard skulls vary greatly in their detailed morphology. Theoretical models and practical studies have posited a definite relationship between skull morphology and bite performance, but this can be difficult to demonstrate in vivo. Computer modelling... Read More about Rigid-body analysis of a lizard skull: modelling the skull of Uromastyx hardwickii.