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All Outputs (73)

Back to the bones: do muscle area assessment techniques predict functional evolution across a macroevolutionary radiation? (2021)
Journal Article
Bates, K. T., Wang, L., Dempsey, M., Broyde, S., Fagan, M. J., & Cox, P. G. (2021). Back to the bones: do muscle area assessment techniques predict functional evolution across a macroevolutionary radiation?. Interface, 18(180), Article 20210324. https://doi.org/10.1098/rsif.2021.0324

Measures of attachment or accommodation area on the skeleton are a popular means of rapidly generating estimates of muscle proportions and functional performance for use in large-scale macroevolutionary studies. Herein, we provide the first evaluatio... Read More about Back to the bones: do muscle area assessment techniques predict functional evolution across a macroevolutionary radiation?.

Correction to: Evolutionary biomechanics: Hard tissues and soft evidence? (Proc. R. Soc. B (2021) 288 (20202809) DOI: 10.1098/rspb.2020.2809) (2021)
Journal Article
Broyde, S., Dempsey, M., Wang, L., Cox, P. G., Fagan, M., & Bates, K. T. (2021). Correction to: Evolutionary biomechanics: Hard tissues and soft evidence? (Proc. R. Soc. B (2021) 288 (20202809) DOI: 10.1098/rspb.2020.2809). Proceedings of the Royal Society B: Biological Sciences, 288(1950), Article 20202809. https://doi.org/10.1098/rspb.2021.0831

Further analysis of our finite element (FE) models, as part of ongoing work, has revealed a systematic error running through all 30 models in our original analysis. In all 30 FE models, the force magnitudes applied to represent maximum isometric cont... Read More about Correction to: Evolutionary biomechanics: Hard tissues and soft evidence? (Proc. R. Soc. B (2021) 288 (20202809) DOI: 10.1098/rspb.2020.2809).

Evolutionary biomechanics: hard tissues and soft evidence? (2021)
Journal Article
Broyde, S., Dempsey, M., Wang, L., Cox, P. G., Fagan, M., & Bates, K. T. (2021). Evolutionary biomechanics: hard tissues and soft evidence?. Proceedings of the Royal Society B: Biological Sciences, 288(1945), Article 20202809. https://doi.org/10.1098/rspb.2020.2809

Biomechanical modelling is a powerful tool for quantifying the evolution of functional performance in extinct animals to understand key anatomical innovations and selective pressures driving major evolutionary radiations. However, the fossil record i... Read More about Evolutionary biomechanics: hard tissues and soft evidence?.

The biomechanical role of the chondrocranium and the material properties of cartilage (2020)
Journal Article
Jones, M. E. H., Gröning, F., Aspden, R. M., Dutel, H., Sharp, A., Moazen, M., …Evans, S. E. (2020). The biomechanical role of the chondrocranium and the material properties of cartilage. Vertebrate Zoology, 70(4), 699-715. https://doi.org/10.26049/VZ70-4-2020-10

The chondrocranium is the cartilage component of the vertebrate braincase. Among jawed vertebrates it varies greatly in structure, mineralisation, and in the extent to which it is replaced by bone during development. In mammals, birds, and some bony... Read More about The biomechanical role of the chondrocranium and the material properties of cartilage.

Mathematical modeling of canonical and non-canonical NF-κB pathways in TNF stimulation (2020)
Journal Article
Ji, B., Zhang, Y., Zhen, C., Fagan, M. J., & Yang, Q. (2020). Mathematical modeling of canonical and non-canonical NF-κB pathways in TNF stimulation. Computer Methods and Programs in Biomedicine, 196, Article 105677. https://doi.org/10.1016/j.cmpb.2020.105677

Background and objective: NF-κB can be activated by the canonical and non-canonical pathways. These two pathways interplay via the TRAF1|NIK complex after stimulation by TNF. However existing mathematical models of two pathways are inadequate. In thi... Read More about Mathematical modeling of canonical and non-canonical NF-κB pathways in TNF stimulation.

Towards an early 3D-diagnosis of craniofacial asymmetry by computing the accurate midplane: A PCA-based method (2020)
Journal Article
Ortún-Terrazas, J., Fagan, M. J., Cegoñino, J., Illipronti-Filho, E., & Pérez del Palomar, A. (2020). Towards an early 3D-diagnosis of craniofacial asymmetry by computing the accurate midplane: A PCA-based method. Computer Methods and Programs in Biomedicine, 191, Article 105397. https://doi.org/10.1016/j.cmpb.2020.105397

Background and objective: Craniofacial asymmetry is a common growth disorder often caused by unilateral chewing. Although an early orthodontic treatment would avoid surgical procedures later in life, the uncertainty of defining the accurate sagittal... Read More about Towards an early 3D-diagnosis of craniofacial asymmetry by computing the accurate midplane: A PCA-based method.

Neurocranial development of the coelacanth and the evolution of the sarcopterygian head (2019)
Journal Article
Dutel, H., Galland, M., Tafforeau, P., Long, J. A., Fagan, M. J., Janvier, P., …Herbin, M. (2019). Neurocranial development of the coelacanth and the evolution of the sarcopterygian head. Nature, 569, 556–559. https://doi.org/10.1038/s41586-019-1117-3

The neurocranium of sarcopterygian fishes was originally divided into an anterior (ethmosphenoid) and posterior (otoccipital) portion by an intracranial joint, and underwent major changes in its overall geometry before fusing into a single unit in lu... Read More about Neurocranial development of the coelacanth and the evolution of the sarcopterygian head.

Mathematical modelling of bone remodelling cycles including the NFκB signalling pathway (2019)
Journal Article
Ji, B., Zhang, Y., Zhen, C., Fagan, M. J., & Yang, Q. (2019). Mathematical modelling of bone remodelling cycles including the NFκB signalling pathway. Computers in biology and medicine, 107, 257-264. https://doi.org/10.1016/j.compbiomed.2019.03.003

RANKL can promote the differentiation of osteoclast precursors into mature osteoclasts by binding to RANK expressed on the surfaces of osteoclast progenitor cells during bone remodelling. The NF-κB signalling pathway is downstream of RANKL and transm... Read More about Mathematical modelling of bone remodelling cycles including the NFκB signalling pathway.

Bite force and cranial bone strain in four species of lizards (2018)
Journal Article
Ross, C. F., Porro, L. B., Herrel, A., Evans, S. E., & Fagan, M. J. (2018). Bite force and cranial bone strain in four species of lizards. The journal of experimental biology, 221(23), jeb.180240. https://doi.org/10.1242/jeb.180240

In vivo bone strain data provide direct evidence of strain patterns in the cranium during biting. Compared to mammals, in vivo bone strains in lizard skulls are poorly documented. This paper presents strain data from the skulls of Anolis equestris, G... Read More about Bite force and cranial bone strain in four species of lizards.

The role of miniaturization in the evolution of the mammalian jaw and middle ear (2018)
Journal Article
Lautenschlager, S., Gill, P. G., Luo, Z. X., Fagan, M. J., & Rayfield, E. J. (2018). The role of miniaturization in the evolution of the mammalian jaw and middle ear. Nature, 561(7724), 533-537. https://doi.org/10.1038/s41586-018-0521-4

The evolution of the mammalian jaw is one of the most important innovations in vertebrate history, and underpins the exceptional radiation and diversification of mammals over the last 220 million years. In particular, the transformation of the mandi... Read More about The role of miniaturization in the evolution of the mammalian jaw and middle ear.

The biomechanical role of the chondrocranium and sutures in a lizard cranium (2017)
Journal Article
Jones, M. E. H., Gröning, F., Dutel, H., Sharp, A., Fagan, M. J., & Evans, S. E. (2017). The biomechanical role of the chondrocranium and sutures in a lizard cranium. Journal of the Royal Society interface / the Royal Society, 14(137), Article 20170637. https://doi.org/10.1098/rsif.2017.0637

The role of soft tissues in skull biomechanics remains poorly understood. Not least, the chondrocranium, the portion of the braincase which persists as cartilage with varying degrees of mineralization. It also remains commonplace to overlook the biom... Read More about The biomechanical role of the chondrocranium and sutures in a lizard cranium.

Form-function relationships in dragonfly mandibles under an evolutionary perspective (2017)
Journal Article
Blanke, A., Schmitz, H., Patera, A., Dutel, H., & Fagan, M. J. (2017). Form-function relationships in dragonfly mandibles under an evolutionary perspective. Journal of the Royal Society interface / the Royal Society, 14(128), Article 20161038. https://doi.org/10.1098/rsif.2016.1038

© 2017 The Author(s). Functional requirements may constrain phenotypic diversification or foster it. For insect mouthparts, the quantification of the relationship between shape and function in an evolutionary framework remained largely unexplored. He... Read More about Form-function relationships in dragonfly mandibles under an evolutionary perspective.

Morphological evolution of the mammalian jaw adductor complex (2016)
Journal Article
Lautenschlager, S., Gill, P., Luo, Z., Fagan, M. J., & Rayfield, E. J. (2017). Morphological evolution of the mammalian jaw adductor complex. Biological Reviews, 92(4), 1910-1940. https://doi.org/10.1111/brv.12314

The evolution of the mammalian jaw during the transition from non-mammalian synapsids to crown mammals is a key event in vertebrate history and characterised by the gradual reduction of its individual bones into a single element and the concomitant t... Read More about Morphological evolution of the mammalian jaw adductor complex.

Application of Far Cortical Locking Technology in Periprosthetic Femoral Fracture Fixation: A Biomechanical Study (2016)
Journal Article
Moazen, M., Leonidou, A., Pagkalos, J., Marghoub, A., Fagan, M. J., & Tsiridis, E. (2016). Application of Far Cortical Locking Technology in Periprosthetic Femoral Fracture Fixation: A Biomechanical Study. Journal of Arthroplasty, 31(8), 1849-1856. https://doi.org/10.1016/j.arth.2016.02.013

© 2016 Elsevier Inc. Background Lack of fracture movement could be a potential cause of periprosthetic femoral fracture (PFF) fixation failures. This study aimed to test whether the use of distal far cortical locking screws reduces the overall stiffn... Read More about Application of Far Cortical Locking Technology in Periprosthetic Femoral Fracture Fixation: A Biomechanical Study.

Intracranial pressure changes during mouse development (2015)
Journal Article
Moazen, M., Alazmani, A., Rafferty, K., Liu, Z., Gustafson, J., Cunningham, M. L., …Herring, S. W. (2016). Intracranial pressure changes during mouse development. Journal of biomechanics, 49(1), 123-126. https://doi.org/10.1016/j.jbiomech.2015.11.012

During early stages of postnatal development, pressure from the growing brain as well as cerebrospinal fluid, i.e. intracranial pressure (ICP), load the calvarial bones. It is likely that such loading contributes to the peripheral bone formation at t... Read More about Intracranial pressure changes during mouse development.

Validity and sensitivity of a human cranial finite element model: Implications for comparative studies of biting performance (2015)
Journal Article
Toro-Ibacache, V., Fitton, L. C., Fagan, M. J., & O'Higgins, P. (2016). Validity and sensitivity of a human cranial finite element model: Implications for comparative studies of biting performance. Journal of anatomy, 228(1), 70-84. https://doi.org/10.1111/joa.12384

Finite element analysis (FEA) is a modelling technique increasingly used in anatomical studies investigating skeletal form and function. In the case of the cranium this approach has been applied to both living and fossil taxa to (for example) investi... Read More about Validity and sensitivity of a human cranial finite element model: Implications for comparative studies of biting performance.

A virtual approach to evaluate therapies for management of multiple myeloma induced bone disease: Modelling Therapies for Multiple Myeloma Induced Bone Disease (2015)
Journal Article
Ji, B., Genever, P. G., & Fagan, M. J. (2016). A virtual approach to evaluate therapies for management of multiple myeloma induced bone disease: Modelling Therapies for Multiple Myeloma Induced Bone Disease. International journal for numerical methods in biomedical engineering, 32(3), e02735. https://doi.org/10.1002/cnm.2735

Multiple myeloma bone disease is devastating for patients and a major cause of morbidity. The disease leads to bone destruction by inhibiting osteoblast activity while stimulating osteoclast activity. Recent advances in multiple myeloma research have... Read More about A virtual approach to evaluate therapies for management of multiple myeloma induced bone disease: Modelling Therapies for Multiple Myeloma Induced Bone Disease.

Mechanical properties of calvarial bones in a mouse model for craniosynostosis (2015)
Journal Article
Moazen, M., Peskett, E., Babbs, C., Pauws, E., & Fagan, M. J. (2015). Mechanical properties of calvarial bones in a mouse model for craniosynostosis. PLoS ONE, 10(5), e0125757. https://doi.org/10.1371/journal.pone.0125757

The mammalian cranial vault largely consists of five flat bones that are joined together along their edges by soft fibrous tissues called sutures. Premature closure of the cranial sutures, craniosynostosis, can lead to serious clinical pathology unle... Read More about Mechanical properties of calvarial bones in a mouse model for craniosynostosis.

Investigating the efficacy of bisphosphonates treatment against multiple myeloma induced bone disease using a computational model (2014)
Journal Article
Ji, B., Yang, Q., Genever, P. G., & Fagan, M. J. (2014). Investigating the efficacy of bisphosphonates treatment against multiple myeloma induced bone disease using a computational model. Bio-medical materials and engineering, 24(6), 3373-3378. https://doi.org/10.3233/BME-141160

Multiple myeloma (MM)-induced bone disease is mortal for most MM patients. Bisphosphonates are first-line treatment for MM-induced bone disease, since it can inhibit osteoclast activity and the resultant bone resorption by suppressing the differentia... Read More about Investigating the efficacy of bisphosphonates treatment against multiple myeloma induced bone disease using a computational model.

Masticatory biomechanics in the rabbit: a multi-body dynamics analysis (2014)
Journal Article
Watson, P. J., Gröning, F., Curtis, N., Fitton, L. C., Herrel, A., McCormack, S. W., & Fagan, M. J. (2014). Masticatory biomechanics in the rabbit: a multi-body dynamics analysis. Journal of the Royal Society interface / the Royal Society, 11(99), Article 20140564. https://doi.org/10.1098/rsif.2014.0564

Multi-body dynamics is a powerful engineering tool which is becoming increasingly popular for the simulation and analysis of skull biomechanics. This paper presents the first application of multi-body dynamics to analyse the biomechanics of the rabbi... Read More about Masticatory biomechanics in the rabbit: a multi-body dynamics analysis.