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Bite force and cranial bone strain in four species of lizards (2018)
Journal Article
Ross, C. F., Porro, L. B., Herrel, A., Evans, S. E., & Fagan, M. J. (2018). Bite force and cranial bone strain in four species of lizards. The journal of experimental biology, 221(23), jeb.180240. doi:10.1242/jeb.180240

In vivo bone strain data provide direct evidence of strain patterns in the cranium during biting. Compared to mammals, in vivo bone strains in lizard skulls are poorly documented. This paper presents strain data from the skulls of Anolis equestris, G... Read More

The role of miniaturization in the evolution of the mammalian jaw and middle ear (2018)
Journal Article
Lautenschlager, S., Gill, P. G., Luo, Z. X., Fagan, M. J., & Rayfield, E. J. (2018). The role of miniaturization in the evolution of the mammalian jaw and middle ear. Nature, 561(7724), 533-537. doi:10.1038/s41586-018-0521-4

The evolution of the mammalian jaw is one of the most important innovations in vertebrate history, and underpins the exceptional radiation and diversification of mammals over the last 220 million years. In particular, the transformation of the mandi... Read More

Mechanical adaptation of trabecular bone morphology in the mammalian mandible (2018)
Journal Article
Watson, P. J., Fitton, L. C., Meloro, C., Fagan, M. J., & Gröning, F. (2018). Mechanical adaptation of trabecular bone morphology in the mammalian mandible. Scientific reports, 8(1), doi:10.1038/s41598-018-25597-0. ISSN 2045-2322

Alveolar bone, together with the underlying trabecular bone, fulfils an important role in providing structural support against masticatory forces. Diseases such as osteoporosis or periodontitis cause alveolar bone resorption which weakens this struct... Read More

Predicting calvarial growth in normal and craniosynostotic mice using a computational approach (2017)
Journal Article
Marghoub, A., Libby, J., Babbs, C., Pauws, E., Fagan, M. J., & Moazen, M. (2018). Predicting calvarial growth in normal and craniosynostotic mice using a computational approach. Journal of anatomy, 232(3), (440-448). doi:10.1111/joa.12764. ISSN 0021-8782

© 2017 Anatomical Society During postnatal calvarial growth the brain grows gradually and the overlying bones and sutures accommodate that growth until the later juvenile stages. The whole process is coordinated through a complex series of biological... Read More

The biomechanical role of the chondrocranium and sutures in a lizard cranium (2017)
Journal Article
Jones, M. E. H., Gröning, F., Dutel, H., Sharp, A., Fagan, M. J., & Evans, S. E. (2017). The biomechanical role of the chondrocranium and sutures in a lizard cranium. Journal of the Royal Society interface / the Royal Society, 14(137), doi:10.1098/rsif.2017.0637. ISSN 1742-5689

The role of soft tissues in skull biomechanics remains poorly understood. Not least, the chondrocranium, the portion of the braincase which persists as cartilage with varying degrees of mineralization. It also remains commonplace to overlook the biom... Read More

Inclusion of periodontal ligament fibres in mandibular finite element models leads to an increase in alveolar bone strains (2017)
Journal Article
McCormack, S. W., Witzel, U., Watson, P. J., Fagan, M. J., & Gröning, F. (2017). Inclusion of periodontal ligament fibres in mandibular finite element models leads to an increase in alveolar bone strains. PloS one, 12(11), (e0188707). doi:10.1371/journal.pone.0188707. ISSN 1932-6203

Alveolar bone remodelling is vital for the success of dental implants and orthodontic treatments. However, the underlying biomechanical mechanisms, in particular the function of the periodontal ligament (PDL) in bone loading and remodelling, are not... Read More

Modelling human skull growth: a validated computational model (2017)
Journal Article
Libby, J., Marghoub, A., Johnson, D., Khonsari, R. H., Fagan, M. J., & Moazen, M. (2017). Modelling human skull growth: a validated computational model. Journal of the Royal Society interface / the Royal Society, 14(130), (20170202). doi:10.1098/rsif.2017.0202. ISSN 1742-5689

© 2017 The Author(s) Published by the Royal Society. All rights reserved. During the first year of life, the brain grows rapidly and the neurocranium increases to about 65% of its adult size. Our understanding of the relationship between the biomecha... Read More

Form-function relationships in dragonfly mandibles under an evolutionary perspective (2017)
Journal Article
Blanke, A., Schmitz, H., Patera, A., Dutel, H., & Fagan, M. J. (2017). Form-function relationships in dragonfly mandibles under an evolutionary perspective. Journal of the Royal Society interface / the Royal Society, 14(128), doi:10.1098/rsif.2016.1038. ISSN 1742-5689

© 2017 The Author(s). Functional requirements may constrain phenotypic diversification or foster it. For insect mouthparts, the quantification of the relationship between shape and function in an evolutionary framework remained largely unexplored. He... Read More

The effect of boundary constraints on finite element modelling of the human pelvis (2017)
Journal Article
Watson, P., Dostanpor, A., Fagan, M. J., & Dobson, C. A. (2017). The effect of boundary constraints on finite element modelling of the human pelvis. Medical engineering & physics, 43, (48-57). doi:10.1016/j.medengphy.2017.02.001. ISSN 1350-4533

The use of finite element analysis (FEA) to investigate the biomechanics of anatomical systems critically relies on the specification of physiologically representative boundary conditions. The biomechanics of the pelvis has been the specific focus of... Read More

Computational biomechanics changes our view on insect head evolution (2017)
Journal Article
Blanke, A., Watson, P. J., Holbrey, R., & Fagan, M. J. (2017). Computational biomechanics changes our view on insect head evolution. Proceedings. the Royal Society. Biological sciences /, 284(1848), doi:10.1098/rspb.2016.2412. ISSN 0962-8452

© 2017 The Author(s) Published by the Royal Society. All rights reserved. Despite large-scale molecular attempts, the relationships of the basal winged insect lineages dragonflies, mayflies and neopterans, are still unresolved. Other data sources, su... Read More

Morphological evolution of the mammalian jaw adductor complex (2016)
Journal Article
Lautenschlager, S., Gill, P., Luo, Z., Fagan, M. J., & Rayfield, E. J. (2017). Morphological evolution of the mammalian jaw adductor complex. Biological Reviews, 92(4), (1910-1940). doi:10.1111/brv.12314. ISSN 1464-7931

The evolution of the mammalian jaw during the transition from non-mammalian synapsids to crown mammals is a key event in vertebrate history and characterised by the gradual reduction of its individual bones into a single element and the concomitant t... Read More

The Impact of Vein Mechanical Compliance on Arteriovenous Fistula Outcomes (2016)
Journal Article
Smith, G. E., Barnes, R., Chetter, I. C., Barnes, R., & Fagan, M. (2016). The Impact of Vein Mechanical Compliance on Arteriovenous Fistula Outcomes. Annals of vascular surgery, 32, (9-14). doi:10.1016/j.avsg.2015.11.002. ISSN 0890-5096

© 2016 Elsevier Inc. Background Arteriovenous fistulae (AVFs) are the preferred access for hemodialysis but suffer a high early failure rate. The aim of this study was to determine how venous distensibility, as measured in vitro, relates to early out... Read More

Application of Far Cortical Locking Technology in Periprosthetic Femoral Fracture Fixation: A Biomechanical Study (2016)
Journal Article
Moazen, M., Leonidou, A., Pagkalos, J., Marghoub, A., Fagan, M. J., & Tsiridis, E. (2016). Application of Far Cortical Locking Technology in Periprosthetic Femoral Fracture Fixation: A Biomechanical Study. Journal of Arthroplasty, 31(8), (1849-1856). doi:10.1016/j.arth.2016.02.013. ISSN 0883-5403

© 2016 Elsevier Inc. Background Lack of fracture movement could be a potential cause of periprosthetic femoral fracture (PFF) fixation failures. This study aimed to test whether the use of distal far cortical locking screws reduces the overall stiffn... Read More

Intracranial pressure changes during mouse development (2015)
Journal Article
Moazen, M., Alazmani, A., Rafferty, K., Liu, Z., Gustafson, J., Cunningham, M. L., …Herring, S. W. (2016). Intracranial pressure changes during mouse development. Journal of biomechanics, 49(1), (123-126). doi:10.1016/j.jbiomech.2015.11.012. ISSN 0021-9290

During early stages of postnatal development, pressure from the growing brain as well as cerebrospinal fluid, i.e. intracranial pressure (ICP), load the calvarial bones. It is likely that such loading contributes to the peripheral bone formation at t... Read More

Validity and sensitivity of a human cranial finite element model: Implications for comparative studies of biting performance (2015)
Journal Article
Toro-Ibacache, V., Fitton, L. C., Fagan, M. J., & O'Higgins, P. (2016). Validity and sensitivity of a human cranial finite element model: Implications for comparative studies of biting performance. Journal of anatomy, 228(1), (70-84). doi:10.1111/joa.12384. ISSN 0021-8782

Finite element analysis (FEA) is a modelling technique increasingly used in anatomical studies investigating skeletal form and function. In the case of the cranium this approach has been applied to both living and fossil taxa to (for example) investi... Read More