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Biomechanical evaluation of the unilateral crossbite on the asymmetrical development of the craniofacial complex. A mechano-morphological approach (2022)
Journal Article
Ortún-Terrazas, J., Fagan, M. J., Cegoñino, J., Illipronti-Filho, E., & del Palomar, A. P. (2022). Biomechanical evaluation of the unilateral crossbite on the asymmetrical development of the craniofacial complex. A mechano-morphological approach. Computer Methods and Programs in Biomedicine, 217, Article 106703. https://doi.org/10.1016/j.cmpb.2022.106703

Background and Objective: The occlusion effect on the craniofacial development is a controversial topic that has attracted the interest of many researchers but that remains unclear, mainly due to the difficulties on measure its mechanical response ex... Read More about Biomechanical evaluation of the unilateral crossbite on the asymmetrical development of the craniofacial complex. A mechano-morphological approach.

Back to the bones: do muscle area assessment techniques predict functional evolution across a macroevolutionary radiation? (2021)
Journal Article
Bates, K. T., Wang, L., Dempsey, M., Broyde, S., Fagan, M. J., & Cox, P. G. (2021). Back to the bones: do muscle area assessment techniques predict functional evolution across a macroevolutionary radiation?. Interface, 18(180), Article 20210324. https://doi.org/10.1098/rsif.2021.0324

Measures of attachment or accommodation area on the skeleton are a popular means of rapidly generating estimates of muscle proportions and functional performance for use in large-scale macroevolutionary studies. Herein, we provide the first evaluatio... Read More about Back to the bones: do muscle area assessment techniques predict functional evolution across a macroevolutionary radiation?.

Correction to: Evolutionary biomechanics: Hard tissues and soft evidence? (Proc. R. Soc. B (2021) 288 (20202809) DOI: 10.1098/rspb.2020.2809) (2021)
Journal Article
Broyde, S., Dempsey, M., Wang, L., Cox, P. G., Fagan, M., & Bates, K. T. (2021). Correction to: Evolutionary biomechanics: Hard tissues and soft evidence? (Proc. R. Soc. B (2021) 288 (20202809) DOI: 10.1098/rspb.2020.2809). Proceedings of the Royal Society B: Biological Sciences, 288(1950), Article 20202809. https://doi.org/10.1098/rspb.2021.0831

Further analysis of our finite element (FE) models, as part of ongoing work, has revealed a systematic error running through all 30 models in our original analysis. In all 30 FE models, the force magnitudes applied to represent maximum isometric cont... Read More about Correction to: Evolutionary biomechanics: Hard tissues and soft evidence? (Proc. R. Soc. B (2021) 288 (20202809) DOI: 10.1098/rspb.2020.2809).

Evolutionary biomechanics: hard tissues and soft evidence? (2021)
Journal Article
Broyde, S., Dempsey, M., Wang, L., Cox, P. G., Fagan, M., & Bates, K. T. (2021). Evolutionary biomechanics: hard tissues and soft evidence?. Proceedings of the Royal Society B: Biological Sciences, 288(1945), Article 20202809. https://doi.org/10.1098/rspb.2020.2809

Biomechanical modelling is a powerful tool for quantifying the evolution of functional performance in extinct animals to understand key anatomical innovations and selective pressures driving major evolutionary radiations. However, the fossil record i... Read More about Evolutionary biomechanics: hard tissues and soft evidence?.

Mathematical modeling of canonical and non-canonical NF-κB pathways in TNF stimulation (2020)
Journal Article
Ji, B., Zhang, Y., Zhen, C., Fagan, M. J., & Yang, Q. (2020). Mathematical modeling of canonical and non-canonical NF-κB pathways in TNF stimulation. Computer Methods and Programs in Biomedicine, 196, Article 105677. https://doi.org/10.1016/j.cmpb.2020.105677

Background and objective: NF-κB can be activated by the canonical and non-canonical pathways. These two pathways interplay via the TRAF1|NIK complex after stimulation by TNF. However existing mathematical models of two pathways are inadequate. In thi... Read More about Mathematical modeling of canonical and non-canonical NF-κB pathways in TNF stimulation.

Towards an early 3D-diagnosis of craniofacial asymmetry by computing the accurate midplane: A PCA-based method (2020)
Journal Article
Ortún-Terrazas, J., Fagan, M. J., Cegoñino, J., Illipronti-Filho, E., & Pérez del Palomar, A. (2020). Towards an early 3D-diagnosis of craniofacial asymmetry by computing the accurate midplane: A PCA-based method. Computer Methods and Programs in Biomedicine, 191, Article 105397. https://doi.org/10.1016/j.cmpb.2020.105397

Background and objective: Craniofacial asymmetry is a common growth disorder often caused by unilateral chewing. Although an early orthodontic treatment would avoid surgical procedures later in life, the uncertainty of defining the accurate sagittal... Read More about Towards an early 3D-diagnosis of craniofacial asymmetry by computing the accurate midplane: A PCA-based method.

Neurocranial development of the coelacanth and the evolution of the sarcopterygian head (2019)
Journal Article
Dutel, H., Galland, M., Tafforeau, P., Long, J. A., Fagan, M. J., Janvier, P., Herrel, A., Santin, M. D., Clément, G., & Herbin, M. (2019). Neurocranial development of the coelacanth and the evolution of the sarcopterygian head. Nature, 569, 556–559. https://doi.org/10.1038/s41586-019-1117-3

The neurocranium of sarcopterygian fishes was originally divided into an anterior (ethmosphenoid) and posterior (otoccipital) portion by an intracranial joint, and underwent major changes in its overall geometry before fusing into a single unit in lu... Read More about Neurocranial development of the coelacanth and the evolution of the sarcopterygian head.

Mathematical modelling of bone remodelling cycles including the NFκB signalling pathway (2019)
Journal Article
Ji, B., Zhang, Y., Zhen, C., Fagan, M. J., & Yang, Q. (2019). Mathematical modelling of bone remodelling cycles including the NFκB signalling pathway. Computers in biology and medicine, 107, 257-264. https://doi.org/10.1016/j.compbiomed.2019.03.003

RANKL can promote the differentiation of osteoclast precursors into mature osteoclasts by binding to RANK expressed on the surfaces of osteoclast progenitor cells during bone remodelling. The NF-κB signalling pathway is downstream of RANKL and transm... Read More about Mathematical modelling of bone remodelling cycles including the NFκB signalling pathway.

Bite force and cranial bone strain in four species of lizards (2018)
Journal Article
Ross, C. F., Porro, L. B., Herrel, A., Evans, S. E., & Fagan, M. J. (2018). Bite force and cranial bone strain in four species of lizards. The journal of experimental biology, 221(23), jeb.180240. https://doi.org/10.1242/jeb.180240

In vivo bone strain data provide direct evidence of strain patterns in the cranium during biting. Compared to mammals, in vivo bone strains in lizard skulls are poorly documented. This paper presents strain data from the skulls of Anolis equestris, G... Read More about Bite force and cranial bone strain in four species of lizards.

The role of miniaturization in the evolution of the mammalian jaw and middle ear (2018)
Journal Article
Lautenschlager, S., Gill, P. G., Luo, Z. X., Fagan, M. J., & Rayfield, E. J. (2018). The role of miniaturization in the evolution of the mammalian jaw and middle ear. Nature, 561(7724), 533-537. https://doi.org/10.1038/s41586-018-0521-4

The evolution of the mammalian jaw is one of the most important innovations in vertebrate history, and underpins the exceptional radiation and diversification of mammals over the last 220 million years. In particular, the transformation of the mandi... Read More about The role of miniaturization in the evolution of the mammalian jaw and middle ear.

Morphological evolution of the mammalian jaw adductor complex (2016)
Journal Article
Lautenschlager, S., Gill, P., Luo, Z.-X., Fagan, M. J., & Rayfield, E. J. (2017). Morphological evolution of the mammalian jaw adductor complex. Biological Reviews, 92(4), 1910-1940. https://doi.org/10.1111/brv.12314

The evolution of the mammalian jaw during the transition from non-mammalian synapsids to crown mammals is a key event in vertebrate history and characterised by the gradual reduction of its individual bones into a single element and the concomitant t... Read More about Morphological evolution of the mammalian jaw adductor complex.

A virtual approach to evaluate therapies for management of multiple myeloma induced bone disease: Modelling Therapies for Multiple Myeloma Induced Bone Disease (2015)
Journal Article
Ji, B., Genever, P. G., & Fagan, M. J. (2016). A virtual approach to evaluate therapies for management of multiple myeloma induced bone disease: Modelling Therapies for Multiple Myeloma Induced Bone Disease. International journal for numerical methods in biomedical engineering, 32(3), e02735. https://doi.org/10.1002/cnm.2735

Multiple myeloma bone disease is devastating for patients and a major cause of morbidity. The disease leads to bone destruction by inhibiting osteoblast activity while stimulating osteoclast activity. Recent advances in multiple myeloma research have... Read More about A virtual approach to evaluate therapies for management of multiple myeloma induced bone disease: Modelling Therapies for Multiple Myeloma Induced Bone Disease.

In vivo cranial bone strain and bite force in the agamid lizard Uromastyx geyri (2014)
Journal Article
Porro, L. B., Ross, C. F., Iriarte-Diaz, J., O'Reilly, J. C., Evans, S. E., & Fagan, M. J. (2014). In vivo cranial bone strain and bite force in the agamid lizard Uromastyx geyri. The journal of experimental biology, 217(11), 1983-1992. https://doi.org/10.1242/jeb.096362

In vivo bone strain data are the most direct evidence of deformation and strain regimes in the vertebrate cranium during feeding and can provide important insights into skull morphology. Strain data have been collected during feeding across a wide ra... Read More about In vivo cranial bone strain and bite force in the agamid lizard Uromastyx geyri.

Comparing the distribution of strains with the distribution of bone tissue in a human mandible: a finite element study (2012)
Journal Article
Gröning, F., Fagan, M., & O'Higgins, P. (2013). Comparing the distribution of strains with the distribution of bone tissue in a human mandible: a finite element study. Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology, 296(1), 9-18. https://doi.org/10.1002/ar.22597

Comparative anatomy and experimental studies suggest that the mass and distribution of tissue within a bone is adapted to the strains the bone experiences during function. Finite element analysis is a powerful tool that can be used to investigate thi... Read More about Comparing the distribution of strains with the distribution of bone tissue in a human mandible: a finite element study.

Functional evolution of the feeding system in rodents (2012)
Journal Article
Cox, P. G., Rayfield, E. J., Fagan, M. J., Herrel, A., Pataky, T. C., & Jeffery, N. (2012). Functional evolution of the feeding system in rodents. PLoS ONE, 7(4), e36299. https://doi.org/10.1371/journal.pone.0036299

The masticatory musculature of rodents has evolved to enable both gnawing at the incisors and chewing at the molars. In particular, the masseter muscle is highly specialised, having extended anteriorly to originate from the rostrum. All living rodent... Read More about Functional evolution of the feeding system in rodents.

Modeling the human mandible under masticatory loads: which input variables are important? (2012)
Journal Article
Gröning, F., Fagan, M., & O'higgins, P. (2012). Modeling the human mandible under masticatory loads: which input variables are important?. Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology, 295(5), 853-863. https://doi.org/10.1002/ar.22455

Finite element analyses (FEA) that have simulated masticatory loadings of the human mandible differ significantly with regard to their basic input variables such as material properties, constraints, and applied forces. With sensitivity analyses it is... Read More about Modeling the human mandible under masticatory loads: which input variables are important?.

Comment on "The effects of modelling simplifications on craniofacial finite element models: the alveoli (tooth sockets) and periodontal ligaments" (volume 44, issue 10, pages 1831-1838) (2012)
Journal Article
Gröning, F., & Fagan, M. (2012). Comment on "The effects of modelling simplifications on craniofacial finite element models: the alveoli (tooth sockets) and periodontal ligaments" (volume 44, issue 10, pages 1831-1838). Journal of biomechanics, 45(9), 1749-1750. https://doi.org/10.1016/j.jbiomech.2011.10.042

The earliest evidence for anatomically modern humans in northwestern Europe (2011)
Journal Article
Higham, T., Compton, T., Stringer, C., Jacobi, R., Shapiro, B., Trinkaus, E., Chandler, B., Gröning, F., Collins, C., Hillson, S., O’Higgins, P., FitzGerald, C., & Fagan, M. (2011). The earliest evidence for anatomically modern humans in northwestern Europe. Nature, 479(7374), 521-524. https://doi.org/10.1038/nature10484

The earliest anatomically modern humans in Europe are thought to have appeared around 43,000-42,000 calendar years before present (43-42 kyr cal BP), by association with Aurignacian sites and lithic assemblages assumed to have been made by modern hum... Read More about The earliest evidence for anatomically modern humans in northwestern Europe.

Finite element modelling of squirrel, guinea pig and rat skulls: using geometric morphometrics to assess sensitivity. (2011)
Journal Article
Cox, P. G., Fagan, M. J., Rayfield, E. J., & Jeffery, N. (2011). Finite element modelling of squirrel, guinea pig and rat skulls: using geometric morphometrics to assess sensitivity. Journal of anatomy, 219(6), 696-709. https://doi.org/10.1111/j.1469-7580.2011.01436.x

Rodents are defined by a uniquely specialized dentition and a highly complex arrangement of jaw-closing muscles. Finite element analysis (FEA) is an ideal technique to investigate the biomechanical implications of these specializations, but it is ess... Read More about Finite element modelling of squirrel, guinea pig and rat skulls: using geometric morphometrics to assess sensitivity..

The effects of the periodontal ligament on mandibular stiffness: a study combining finite element analysis and geometric morphometrics (2011)
Journal Article
Gröning, F., Fagan, M. J., & O'Higgins, P. (2011). The effects of the periodontal ligament on mandibular stiffness: a study combining finite element analysis and geometric morphometrics. Journal of biomechanics, 44(7), 1304-1312. https://doi.org/10.1016/j.jbiomech.2011.01.008

It is generally accepted that the periodontal ligament (PDL) plays a crucial role in transferring occlusal forces from the teeth to the alveolar bone. Studies using finite element analysis (FEA) have helped to better understand this role and show tha... Read More about The effects of the periodontal ligament on mandibular stiffness: a study combining finite element analysis and geometric morphometrics.