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Human platelet activation by Escherichia coli: roles for FcγRIIA and integrin αIIbβ3 (2016)
Journal Article
Watson, C. N., Cox, D., Watson, S. P., Arman, M., Henderson, I. R., & Kerrigan, S. W. (2016). Human platelet activation by Escherichia coli: roles for FcγRIIA and integrin αIIbβ3. Platelets, 27(6), 535-540. https://doi.org/10.3109/09537104.2016.1148129

Gram-negative Escherichia coli cause diseases such as sepsis and hemolytic uremic syndrome in which thrombotic disorders can be found. Direct platelet–bacterium interactions might contribute to some of these conditions; however, mechanisms of human p... Read More about Human platelet activation by Escherichia coli: roles for FcγRIIA and integrin αIIbβ3.

Activation of glycoprotein VI (GPVI) and C-type lectin-like receptor-2 (CLEC-2) underlies platelet activation by diesel exhaust particles and other charged/hydrophobic ligands (2015)
Journal Article
Alshehri, O. M., Montague, S., Watson, S., Carter, P., Sarker, N., Manne, B. K., …Watson, S. P. (2015). Activation of glycoprotein VI (GPVI) and C-type lectin-like receptor-2 (CLEC-2) underlies platelet activation by diesel exhaust particles and other charged/hydrophobic ligands. Biochemical Journal, 468(3), 459-473. https://doi.org/10.1042/BJ20150192

Platelets are activated by a range of stimuli that share little or no resemblance in structure to each other or to recognized ligands, including diesel exhaust particles (DEP), small peptides [4N1-1, Champs (computed helical anti-membrane proteins),... Read More about Activation of glycoprotein VI (GPVI) and C-type lectin-like receptor-2 (CLEC-2) underlies platelet activation by diesel exhaust particles and other charged/hydrophobic ligands.

Amplification of bacteria-induced platelet activation is triggered by Fc RIIA, integrin  IIb 3, and platelet factor 4 (2014)
Journal Article
Arman, M., Krauel, K., Tilley, D. O., Weber, C., Cox, D., Greinacher, A., …Watson, S. P. (2014). Amplification of bacteria-induced platelet activation is triggered by Fc RIIA, integrin  IIb 3, and platelet factor 4. Blood, 123(20), 3166-3174. https://doi.org/10.1182/blood-2013-11-540526

Bacterial adhesion to platelets is mediated via a range of strain-specific bacterial surface proteins that bind to a variety of platelet receptors. It is unclear how these interactions lead to platelet activation. We demonstrate a critical role for t... Read More about Amplification of bacteria-induced platelet activation is triggered by Fc RIIA, integrin  IIb 3, and platelet factor 4.


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