Activation of glycoprotein VI (GPVI) and C-type lectin-like receptor-2 (CLEC-2) underlies platelet activation by diesel exhaust particles and other charged/hydrophobic ligands
(2015)
Journal Article
Alshehri, O. M., Montague, S., Watson, S., Carter, P., Sarker, N., Manne, B. K., Miller, J. L., Herr, A. B., Pollitt, A. Y., O'Callaghan, C. A., Kunapuli, S., Arman, M., Hughes, C. E., & Watson, S. P. (2015). Activation of glycoprotein VI (GPVI) and C-type lectin-like receptor-2 (CLEC-2) underlies platelet activation by diesel exhaust particles and other charged/hydrophobic ligands. Biochemical Journal, 468(3), 459-473. https://doi.org/10.1042/BJ20150192
Platelets are activated by a range of stimuli that share little or no resemblance in structure to each other or to recognized ligands, including diesel exhaust particles (DEP), small peptides [4N1-1, Champs (computed helical anti-membrane proteins),... Read More about Activation of glycoprotein VI (GPVI) and C-type lectin-like receptor-2 (CLEC-2) underlies platelet activation by diesel exhaust particles and other charged/hydrophobic ligands.