Inhibition of arginine methylation impairs platelet function

Marsden, Alistair James; Riley, David R. J.; Barry, Antonia; Khalil, Jawad S; Guinn, Barbara Ann; Kemp, Neil T.; Rivero, Francisco; Beltran-Alvarez, Pedro

doi:10.1021/acsptsci.1c00135

All Outputs (2)

Investigating protein arginine methylation in platelets and hair (2023)
Thesis
Marsden, A. J. Investigating protein arginine methylation in platelets and hair. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4386508

Post-translational modification (PTM) of platelet proteins has long been known to have an effect on their ability to aggregate and form a thrombus. Arginine methylation (ArgMe) is catalysed by protein arginine methyltransferases (PRMTs) which... Read More about Investigating protein arginine methylation in platelets and hair.

Inhibition of arginine methylation impairs platelet function (2021)
Journal Article
Marsden, A. J., Riley, D. R. J., Barry, A., Khalil, J. S., Guinn, B. A., Kemp, N. T., …Beltran-Alvarez, P. (in press). Inhibition of arginine methylation impairs platelet function. ACS Pharmacology & Translational Science, https://doi.org/10.1021/acsptsci.1c00135

Protein arginine methyltransferases (PRMTs) catalyze the transfer of methyl groups to arginine residues in proteins. PRMT inhibitors are novel, promising drugs against cancer that are currently in clinical trials, which include oral administration of... Read More about Inhibition of arginine methylation impairs platelet function.