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Stereolithographic 3D printing of extrinsically self-healing composites (2019)
Journal Article
Sanders, P., Young, A. J., Qin, Y., Fancey, K. S., Reithofer, M. R., Guillet-Nicolas, R., …Chin, J. M. (2019). Stereolithographic 3D printing of extrinsically self-healing composites. Scientific reports, 9(1), doi:10.1038/s41598-018-36828-9

We demonstrate for the first time the direct stereolithographic 3D printing of an extrinsically self-healing composite, comprised of commercial photocurable resin modified with anisole and PMMA-filled microcapsules. The composites demonstrate solvent... Read More

A label-free aptamer-based nanogap capacitive biosensor with greatly diminished electrode polarization effects (2019)
Journal Article
Ghobaei Namhil, Z., Kemp, C., Verrelli, E., Iles, A., Pamme, N., Adawi, A. M., & Kemp, N. (2019). A label-free aptamer-based nanogap capacitive biosensor with greatly diminished electrode polarization effects. Physical chemistry chemical physics : PCCP, 21(2), 681-691. doi:10.1039/c8cp05510f

A significant impediment to the use of impedance spectroscopy in bio-sensing is the electrode polarization effect that arises from the movement of free ions to the electrode-solution interface, forming an electrical double layer (EDL). The EDL screen... Read More

Microcapsules as assay compartments formed through layer-by-layer deposition (2018)
Journal Article
Alorabi, A. Q., Tarn, M. D., Thomas, M., Paunov, V. N., & Pamme, N. (2018). Microcapsules as assay compartments formed through layer-by-layer deposition. Analytical Methods, 10(44), 5335-5340. doi:10.1039/c8ay02012d

We investigate the potential of using microcapsules, generated through layer-by-layer assembly, as reaction compartments for bioassays. A streptavidin-biotin and an esterase-fluorescein diacetate (FDA) assay were employed for proof-of-concept. Strept... Read More

Plastic scintillator-based microfluidic devices for miniaturized detection of Positron Emission Tomography radiopharmaceuticals (2018)
Journal Article
Tarn, M. D., Kızılyer, N. Y., Esfahani, M. M. N., Joshi, P., Brown, N. J., Pamme, N., …Archibald, S. J. (2018). Plastic scintillator-based microfluidic devices for miniaturized detection of Positron Emission Tomography radiopharmaceuticals. Chemistry : a European journal, 24(52), 13749-13753. doi:10.1002/chem.201802395

A miniaturized radio-HPLC detector has been developed comprising a microfluidic device fabricated from plastic scintillator in combination with a silicon photomultiplier light sensor, and tested with samples containing a positron-emitting radionuclid... Read More

Fabrication of tailorable pH responsive cationic amphiphilic microgels on a microfluidic device for drug release (2017)
Journal Article
Lu, B., Tarn, M. D., Pamme, N., & Georgiou, T. K. (2018). Fabrication of tailorable pH responsive cationic amphiphilic microgels on a microfluidic device for drug release. Journal of Polymer Science Part A: Polymer Chemistry, 56(1), 59-66. doi:10.1002/pola.28860

Cationic, amphiphilic microgels of differing compositions based on hydrophilic, pH, and thermoresponsive 2-(dimethylamino)ethyl methacrylate (DMAEMA) and hydrophobic, nonionic n-butyl acrylate (BuA) are synthesized using a lab-on-a-chip device. Hydro... Read More

On-chip polyelectrolyte coating onto magnetic droplets – towards continuous flow assembly of drug delivery capsules (2017)
Journal Article
Alorabi, A. Q., Tarn, M. D., Gómez-Pastora, J., Bringas, E., Ortiz, I., Paunov, V. N., & Pamme, N. (2017). On-chip polyelectrolyte coating onto magnetic droplets – towards continuous flow assembly of drug delivery capsules. Lab on a chip, 17(22), (3785-3795). doi:10.1039/c7lc00918f. ISSN 1473-0197

Polyelectrolyte (PE) microcapsules for drug delivery are typically fabricated via layer-by-layer (LbL) deposition of PE layers of alternating charge on sacrificial template microparticles, which usually requires multiple incubation and washing steps... Read More

A microfluidic device for rapid screening of E. coli O157:H7 based on IFAST and ATP bioluminescence assay for water analysis (2017)
Journal Article
Ngamsom, B., Truyts, A., Fourie, L., Kumar, S., Tarn, M. D., Iles, A., …Pamme, N. (2017). A microfluidic device for rapid screening of E. coli O157:H7 based on IFAST and ATP bioluminescence assay for water analysis. Chemistry : a European journal, 23(52), (12754-12757). doi:10.1002/chem.201703487. ISSN 0947-6539

© 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim We present a simple microfluidic system for rapid screening of Escherichia coli (E. coli) O157:H7 employing the specificity of immunomagnetic separation (IMS) via immiscible filtration assisted by s... Read More

Sample introduction interface for on-chip nucleic acid-based analysis of Helicobacter pylori from stool samples (2016)
Journal Article
Esfahani, M. M. N., Shaw, K. J., Esfahani, M. M., Kemp, C., Tarn, M. D., Melling, L., …Mosley, O. (2016). Sample introduction interface for on-chip nucleic acid-based analysis of Helicobacter pylori from stool samples. Lab on a chip, 16(11), 2108-2115. https://doi.org/10.1039/c6lc00228e

Despite recent advances in microfluidic-based integrated diagnostic systems, the sample introduction interface, especially with regards to large volume samples, has often been neglected. We present a sample introduction interface that allows direct o... Read More

Multiplex sorting of foodborne pathogens by on-chip free-flow magnetophoresis (2016)
Journal Article
Ngamsom, B., Esfahani, M. M., Phurimsak, C., Lopez-Martinez, M. J., Pamme, N., Broyer, P., …Raymond, J. (2016). Multiplex sorting of foodborne pathogens by on-chip free-flow magnetophoresis. Analytica Chimica Acta, 918, (69-76). doi:10.1016/j.aca.2016.03.014. ISSN 0003-2670

This study reports multiplex sorting of Salmonella typhimurium and Escherichia coli 0157, from broth cultures and from pathogen-spiked skinned chicken breast enrichment broths by employing microfluidic free-flow magnetophoresis. Magnetic beads of dif... Read More

Magnetic particle plug-based assays for biomarker analysis (2016)
Journal Article
Phurimsak, C., Tarn, M. D., & Pamme, N. (2016). Magnetic particle plug-based assays for biomarker analysis. Micromachines, 7(5), 77. doi:10.3390/mi7050077

Conventional immunoassays offer selective and quantitative detection of a number of biomarkers, but are laborious and time-consuming. Magnetic particle-based assays allow easy and rapid selection of analytes, but still suffer from the requirement of... Read More

Development of radiodetection systems towards miniaturised quality control of PET and SPECT radiopharmaceuticals (2016)
Journal Article
Taggart, M. P., Tarn, M. D., Esfahani, M. M. N., Schofield, D. M., Brown, N. J., Archibald, S. J., …Thompson, L. F. (2016). Development of radiodetection systems towards miniaturised quality control of PET and SPECT radiopharmaceuticals. Lab on a chip, 16(9), (1605-1616). doi:10.1039/c6lc00099a. ISSN 1473-0197

The ability to detect radiation in microfluidic devices is important for the on-chip analysis of radiopharmaceuticals, but previously reported systems have largely suffered from various limitations including cost, complexity of fabrication, and insuf... Read More

Positron detection in silica monoliths for miniaturised quality control of PET radiotracers (2016)
Journal Article
Tarn, M. D., Maneuski, D., Alexander, R., Brown, N. J., O’Shea, V., Pimlott, S. L., …Archibald, S. J. (2016). Positron detection in silica monoliths for miniaturised quality control of PET radiotracers. Chemical communications : Chem comm / the Royal Society of Chemistry, 52(45), 7221-7224. https://doi.org/10.1039/c6cc00660d

We demonstrate the use of the miniaturised Medipix positron sensor for detection of the clinical PET radiotracer, [⁶⁸Ga]gallium-citrate, on a silica-based monolith, towards microfluidic quality control. The system achieved a far superior signal-to-no... Read More

On-chip acoustophoretic isolation of microflora including S. typhimurium from raw chicken, beef and blood samples (2016)
Journal Article
Ngamsom, B., Lopez-Martinez, M. J., Raymond, J., Broyer, P., Patel, P., & Pamme, N. (2016). On-chip acoustophoretic isolation of microflora including S. typhimurium from raw chicken, beef and blood samples. Journal of microbiological methods, 123, (79-86). doi:10.1016/j.mimet.2016.01.016. ISSN 0167-7012

Pathogen analysis in food samples routinely involves lengthy growth-based pre-enrichment and selective enrichment of food matrices to increase the ratio of pathogen to background flora. Similarly, for blood culture analysis, pathogens must be isolate... Read More

Lab-on-a-chip workshop activities for secondary school students (2016)
Journal Article
Esfahani, M. M. N., Tarn, M. D., Choudhury, T. A., Hewitt, L. C., Mayo, A. J., Rubin, T. A., …Pamme, N. (2016). Lab-on-a-chip workshop activities for secondary school students. Biomicrofluidics, 10(1), (1-24). doi:10.1063/1.4940884. ISSN 1932-1058

The ability to engage and inspire younger generations in novel areas of science is important for bringing new researchers into a burgeoning field, such as lab-on-a-chip. We recently held a lab-on-a-chip workshop for secondary school students, for whi... Read More

Microfluidically fabricated pH-responsive anionic amphiphilic microgels for drug release (2015)
Journal Article
Lu, B., Tarn, M. D., Pamme, N., & Georgiou, T. K. (2016). Microfluidically fabricated pH-responsive anionic amphiphilic microgels for drug release. Journal of materials chemistry B, Materials for biology and medicine /, 4(18), (3086-3093). doi:10.1039/c5tb02378e. ISSN 2050-750X

© 2016 The Royal Society of Chemistry. Amphiphilic microgels of different composition based on the hydrophilic, pH-responsive acrylic acid (AA) and the hydrophobic, non-ionic n-butyl acrylate (BuA) were synthesised using a lab-on-a-chip device. Hydro... Read More

Diamagnetic repulsion of particles for multilaminar flow assays (2015)
Journal Article
Tarn, M. D., Elders, L. T., Peyman, S. A., & Pamme, N. (2015). Diamagnetic repulsion of particles for multilaminar flow assays. RSC advances, 5(126), (103776-103781). doi:10.1039/c5ra21867e. ISSN 2046-2069

© The Royal Society of Chemistry. We demonstrate diamagnetic repulsion forces for performing continuous multilaminar flow assays on particles based on their intrinsic properties and with a simple setup. The platform could be applied to sandwich assay... Read More

Artificial leaf device for hydrogen generation from immobilised C. reinhardtii microalgae (2015)
Journal Article
Das, A. A. K., Esfahani, M. M. N., Velev, O. D., Pamme, N., & Paunov, V. N. (2015). Artificial leaf device for hydrogen generation from immobilised C. reinhardtii microalgae. Journal of materials chemistry. publ. by The Royal Society of Chemistry. A, Materials for energy and sustainability /, 3(41), (20698-20707). doi:10.1039/c5ta07112g. ISSN 2050-7488

We developed a fully biomimetic leaf-like device for hydrogen production which allows incorporated fabric-immobilised microalgae culture to be simultaneously hydrated with media and harvested from the produced hydrogen in a continuous flow regime wit... Read More

Tailoring pH-responsive acrylic acid microgels with hydrophobic crosslinks for drug release (2015)
Journal Article
Lu, B., Tarn, M. D., Pamme, N., & Georgiou, T. K. (2015). Tailoring pH-responsive acrylic acid microgels with hydrophobic crosslinks for drug release. Journal of Materials Chemistry B, 3(22), 4524-4529. https://doi.org/10.1039/c5tb00222b

Amphiphilic microgels based on the hydrophilic acrylic acid (AA) and hydrophobic crosslinks of different compositions were synthesised using a lab-on-a-chip device. The microgels were formed by polymerising hydrophobic droplets. The droplets were gen... Read More

On-chip determination of C-reactive protein using magnetic particles in continuous flow (2014)
Journal Article
Phurimsak, C., Tarn, M. D., Peyman, S. A., Greenman, J., & Pamme, N. (2014). On-chip determination of C-reactive protein using magnetic particles in continuous flow. Analytical chemistry, 86(21), (10552-10559). doi:10.1021/ac5023265. ISSN 0003-2700

We demonstrate the application of a multilaminar flow platform, in which functionalized magnetic particles are deflected through alternating laminar flow streams of reagents and washing solutions via an external magnet, for the rapid detection of the... Read More

Phaseguide assisted liquid lamination for magnetic particle-based assays (2014)
Journal Article
Phurimsak, C., Yildirim, E., Tarn, M. D., Trietsch, S. J., Hankemeier, T., Pamme, N., & Vulto, P. (2014). Phaseguide assisted liquid lamination for magnetic particle-based assays. Lab on a chip, 14(13), (2334-2343). doi:10.1039/c4lc00139g. ISSN 1473-0197

We have developed a magnetic particle-based assay platform in which functionalised magnetic particles are transferred sequentially through laminated volumes of reagents and washing buffers. Lamination of aqueous liquids is achieved via the use of pha... Read More