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A method for determining average iron content of ferritin by measuring its optical dispersion (2019)
Journal Article
Gupta, R., Alamrani, N. A., Greenway, G. M., Pamme, N., & Goddard, N. J. (2019). A method for determining average iron content of ferritin by measuring its optical dispersion. Analytical chemistry, 91(11), 7366-7372. https://doi.org/10.1021/acs.analchem.9b01231

© 2019 American Chemical Society. We report a method where the refractive index increments of an iron storage protein, ferritin, and apoferritin (ferritin minus iron) were measured over the wavelength range of 450-678 nm to determine the average iron... Read More about A method for determining average iron content of ferritin by measuring its optical dispersion.

Developing a novel spheroid-on-chip microfluidic device for investigations into metastasis (2019)
Thesis
Collins, T. C. (2019). Developing a novel spheroid-on-chip microfluidic device for investigations into metastasis. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4221851

One in two people born after 1960 will develop cancer, with 90% of all cancer deaths arising from metastasis. Conventional 2D in vitro metastasis models do not fully replicate tumour complexity. In vivo models can address tumour complexity, but do no... Read More about Developing a novel spheroid-on-chip microfluidic device for investigations into metastasis.

Two-step numerical approach to predict ferrofluid droplet generation and manipulation inside multilaminar flow chambers (2019)
Journal Article
Gómez-Pastora, J., Amiri Roodan, V., Karampelas, I. H., Alorabi, A. Q., Tarn, M. D., Iles, A., …Ortiz, I. (2019). Two-step numerical approach to predict ferrofluid droplet generation and manipulation inside multilaminar flow chambers. Journal of physical chemistry. C, 123(15), 10065-10080. https://doi.org/10.1021/acs.jpcc.9b01393

Copyright © 2019 American Chemical Society. In this study, a computational fluid dynamics approach is implemented to investigate the dynamic behavior of continuous-flow droplet microfluidics. The developed approach predicts both droplet generation an... Read More about Two-step numerical approach to predict ferrofluid droplet generation and manipulation inside multilaminar flow chambers.

Stereolithographic 3D printing of extrinsically self-healing composites (2019)
Journal Article
Sanders, P., Young, A. J., Qin, Y., Fancey, K. S., Reithofer, M. R., Guillet-Nicolas, R., …Chin, J. M. (2019). Stereolithographic 3D printing of extrinsically self-healing composites. Scientific reports, 9(1), Article 388. https://doi.org/10.1038/s41598-018-36828-9

We demonstrate for the first time the direct stereolithographic 3D printing of an extrinsically self-healing composite, comprised of commercial photocurable resin modified with anisole and PMMA-filled microcapsules. The composites demonstrate solvent... Read More about Stereolithographic 3D printing of extrinsically self-healing composites.

A label-free aptamer-based nanogap capacitive biosensor with greatly diminished electrode polarization effects (2019)
Journal Article
Ghobaei Namhil, Z., Kemp, C., Verrelli, E., Iles, A., Pamme, N., Adawi, A. M., & Kemp, N. (2019). A label-free aptamer-based nanogap capacitive biosensor with greatly diminished electrode polarization effects. Physical chemistry chemical physics : PCCP, 21(2), 681-691. https://doi.org/10.1039/c8cp05510f

A significant impediment to the use of impedance spectroscopy in bio-sensing is the electrode polarization effect that arises from the movement of free ions to the electrode-solution interface, forming an electrical double layer (EDL). The EDL screen... Read More about A label-free aptamer-based nanogap capacitive biosensor with greatly diminished electrode polarization effects.

Microcapsules as assay compartments formed through layer-by-layer deposition (2018)
Journal Article
Alorabi, A. Q., Tarn, M. D., Thomas, M., Paunov, V. N., & Pamme, N. (2018). Microcapsules as assay compartments formed through layer-by-layer deposition. Analytical Methods, 10(44), 5335-5340. https://doi.org/10.1039/c8ay02012d

We investigate the potential of using microcapsules, generated through layer-by-layer assembly, as reaction compartments for bioassays. A streptavidin-biotin and an esterase-fluorescein diacetate (FDA) assay were employed for proof-of-concept. Strept... Read More about Microcapsules as assay compartments formed through layer-by-layer deposition.

Plastic scintillator-based microfluidic devices for miniaturized detection of Positron Emission Tomography radiopharmaceuticals (2018)
Journal Article
Tarn, M. D., Kızılyer, N. Y., Esfahani, M. M. N., Joshi, P., Brown, N. J., Pamme, N., …Archibald, S. J. (2018). Plastic scintillator-based microfluidic devices for miniaturized detection of Positron Emission Tomography radiopharmaceuticals. Chemistry: a European journal, 24(52), 13749-13753. https://doi.org/10.1002/chem.201802395

A miniaturized radio-HPLC detector has been developed comprising a microfluidic device fabricated from plastic scintillator in combination with a silicon photomultiplier light sensor, and tested with samples containing a positron-emitting radionuclid... Read More about Plastic scintillator-based microfluidic devices for miniaturized detection of Positron Emission Tomography radiopharmaceuticals.

CFD analysis and experimental validation of magnetic droplet generation and deflection across multilaminar flow streams (2018)
Conference Proceeding
Gómez-Pastora, J., Karampelas, I. H., Alorabi, A. Q., Tarn, M. D., Bringas, E., Iles, A., …Ortiz, I. (2018). CFD analysis and experimental validation of magnetic droplet generation and deflection across multilaminar flow streams. In Biotech, biomaterials and biomedical: TechConnect briefs 2018 (182-185)

© 2018 OOSV. All rights reserved. The use of droplet-based microfluidic systems has increased in the last decade due to the advantages these systems present such as compatibility with many chemical and biological reagents, capability of performing a... Read More about CFD analysis and experimental validation of magnetic droplet generation and deflection across multilaminar flow streams.

Nanogap capacitive biosensor for label-free aptamer-based protein detection (2018)
Thesis
Namhil, Z. G. (2018). Nanogap capacitive biosensor for label-free aptamer-based protein detection. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4220514

Recent advances in nanotechnology offer a new platform for the label free detection of biomolecules at ultra-low concentrations. Nano biosensors are emerging as a powerful method of improving device performance whilst minimizing device size, cost and... Read More about Nanogap capacitive biosensor for label-free aptamer-based protein detection.

Optical sensor for the analysis of biomarkers (2018)
Thesis
Al-Shemary, R. S. (2018). Optical sensor for the analysis of biomarkers. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4220996

The continuous measurement of biomarkers such as proteins and hormones in blood and serum are the cornerstone of healthcare monitoring and optimising treatment plans. Often such biomarkers are present in minute concentrations. Conventional analysis m... Read More about Optical sensor for the analysis of biomarkers.

Correction: On-chip polyelectrolyte coating onto magnetic droplets – towards continuous flow assembly of drug delivery capsules (2017)
Journal Article
Alorabi, A. Q., Tarn, M. D., Gómez-Pastora, J., Bringas, E., Ortiz, I., Paunov, V. N., & Pamme, N. (2017). Correction: On-chip polyelectrolyte coating onto magnetic droplets – towards continuous flow assembly of drug delivery capsules. Lab on a chip, 17(22), 3934. https://doi.org/10.1039/c7lc90110k

Correction for ‘On-chip polyelectrolyte coating onto magnetic droplets – towards continuous flow assembly of drug delivery capsules’ by Ali Q. Alorabi et al., Lab Chip, 2017, DOI: 10.1039/c7lc00918f.

Fabrication of tailorable pH responsive cationic amphiphilic microgels on a microfluidic device for drug release (2017)
Journal Article
Lu, B., Tarn, M. D., Pamme, N., & Georgiou, T. K. (2018). Fabrication of tailorable pH responsive cationic amphiphilic microgels on a microfluidic device for drug release. Journal of Polymer Science Part A: Polymer Chemistry, 56(1), 59-66. https://doi.org/10.1002/pola.28860

Cationic, amphiphilic microgels of differing compositions based on hydrophilic, pH, and thermoresponsive 2-(dimethylamino)ethyl methacrylate (DMAEMA) and hydrophobic, nonionic n-butyl acrylate (BuA) are synthesized using a lab-on-a-chip device. Hydro... Read More about Fabrication of tailorable pH responsive cationic amphiphilic microgels on a microfluidic device for drug release.

On-chip polyelectrolyte coating onto magnetic droplets – towards continuous flow assembly of drug delivery capsules (2017)
Journal Article
Alorabi, A. Q., Tarn, M. D., Gómez-Pastora, J., Bringas, E., Ortiz, I., Paunov, V. N., & Pamme, N. (2017). On-chip polyelectrolyte coating onto magnetic droplets – towards continuous flow assembly of drug delivery capsules. Lab on a chip, 17(22), 3785-3795. https://doi.org/10.1039/c7lc00918f

Polyelectrolyte (PE) microcapsules for drug delivery are typically fabricated via layer-by-layer (LbL) deposition of PE layers of alternating charge on sacrificial template microparticles, which usually requires multiple incubation and washing steps... Read More about On-chip polyelectrolyte coating onto magnetic droplets – towards continuous flow assembly of drug delivery capsules.

Surface enhanced Raman spectroscopy for single molecule detection and biosensing (2017)
Thesis
Marshall, A. R. L. (2017). Surface enhanced Raman spectroscopy for single molecule detection and biosensing. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4220864

The aim of this thesis is to design plasmonic nano-gaps capable of detecting materials down to sufficiently low concentrations such that single molecule characteristics are observed. We begin first, by discussing the theory of plasmonics. Then, we as... Read More about Surface enhanced Raman spectroscopy for single molecule detection and biosensing.

A microfluidic device for rapid screening of E. coli O157:H7 based on IFAST and ATP bioluminescence assay for water analysis (2017)
Journal Article
Ngamsom, B., Truyts, A., Fourie, L., Kumar, S., Tarn, M. D., Iles, A., …Pamme, N. (2017). A microfluidic device for rapid screening of E. coli O157:H7 based on IFAST and ATP bioluminescence assay for water analysis. Chemistry: a European journal, 23(52), 12754-12757. https://doi.org/10.1002/chem.201703487

© 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim We present a simple microfluidic system for rapid screening of Escherichia coli (E. coli) O157:H7 employing the specificity of immunomagnetic separation (IMS) via immiscible filtration assisted by s... Read More about A microfluidic device for rapid screening of E. coli O157:H7 based on IFAST and ATP bioluminescence assay for water analysis.

Definition of a magnetic susceptibility of conglomerates with magnetite particles. Particularities of defining single particle susceptibility (2017)
Journal Article
Sandulyak, A. A., Sandulyak, A. V., Ershova, V., Pamme, N., Ngmasom, B., & Iles, A. (2017). Definition of a magnetic susceptibility of conglomerates with magnetite particles. Particularities of defining single particle susceptibility. Journal of Magnetism and Magnetic Materials, 441, 724-734. https://doi.org/10.1016/j.jmmm.2017.06.027

Data of a magnetic susceptibility of ferro-and the ferrimagnetic particles of many technogenic, natural, special media are especially demanded for the solution of various tasks connected with purposeful magnetic impact on these particles. One of prod... Read More about Definition of a magnetic susceptibility of conglomerates with magnetite particles. Particularities of defining single particle susceptibility.

Magnetic particles-based chemiluminescence immunoassay for progesterone determination (2017)
Journal Article
Phakthong, W., Greenway, G. M., Pamme, N., Liawruangrath, B., & Liawruangrath, S. (2017). Magnetic particles-based chemiluminescence immunoassay for progesterone determination. Wārasān Khana Witthayāsāt, Mahāwitthayālai Chīang Mai = Journal of the Science Faculty of Chiang Mai University / Mahāwitthayālai Chīang Mai, 44(1), 215-223

© 2017, Chiang Mai University. All rights reserved. A magnetic particles-based chemiluminescence immunoassay was investigated for progesterone detection by using luminometer. In this work, progesterone was determined based on the competitive binding... Read More about Magnetic particles-based chemiluminescence immunoassay for progesterone determination.

On-chip magnetic particle-based immunoassays using multilaminar flow for clinical diagnostics (2017)
Book Chapter
Tarn, M. D., & Pamme, N. (2017). On-chip magnetic particle-based immunoassays using multilaminar flow for clinical diagnostics. In V. Taly, J. L. Viovy, & S. Descroix (Eds.), Microchip Diagnostics : Methods and Protocols (69-83). New York: Humana Press. https://doi.org/10.1007/978-1-4939-6734-6_6

Magnetic particles have become popular in recent years for immunoassays due to their high surface-to-volume ratio and the ease of their manipulation. However, such assays also require multiple reaction and washing steps that are both time-consuming a... Read More about On-chip magnetic particle-based immunoassays using multilaminar flow for clinical diagnostics.

Monolith-based68Ga processing: A new strategy for purification to facilitate direct radiolabelling methods (2016)
Journal Article
He, P., Burke, B. P., Clemente, G. S., Brown, N., Pamme, N., & Archibald, S. J. (2016). Monolith-based68Ga processing: A new strategy for purification to facilitate direct radiolabelling methods. Reaction Chemistry and Engineering, 1(4), 361-365. https://doi.org/10.1039/c6re00081a

The post-processing of68Ga generator eluate by means of a novel high capacity cation-exchange silica monolith column has been validated in this work. Quantitative release of a purified68Ga solution in high concentration can be achieved using weak aci... Read More about Monolith-based68Ga processing: A new strategy for purification to facilitate direct radiolabelling methods.

Sample introduction interface for on-chip nucleic acid-based analysis of Helicobacter pylori from stool samples (2016)
Journal Article
Esfahani, M. M. N., Shaw, K. J., Esfahani, M. M., Kemp, C., Tarn, M. D., Melling, L., …Mosley, O. (2016). Sample introduction interface for on-chip nucleic acid-based analysis of Helicobacter pylori from stool samples. Lab on a chip, 16(11), 2108-2115. https://doi.org/10.1039/c6lc00228e

Despite recent advances in microfluidic-based integrated diagnostic systems, the sample introduction interface, especially with regards to large volume samples, has often been neglected. We present a sample introduction interface that allows direct o... Read More about Sample introduction interface for on-chip nucleic acid-based analysis of Helicobacter pylori from stool samples.