University of Hull logo

High glucose enhances store-operated calcium entry by upregulating ORAI/STIM via calcineurin-NFAT signalling (2014)
Journal Article
Daskoulidou, N., Xu, S. Z., Zeng, B., Gomez, M. F., Berglund, L. M., Atkin, S. L., …Daskoulidou, N. (2015). High glucose enhances store-operated calcium entry by upregulating ORAI/STIM via calcineurin-NFAT signalling. Journal of Molecular Medicine, 93(5), 511-521. https://doi.org/10.1007/s00109-014-1234-2

© 2014, Springer-Verlag Berlin Heidelberg. Abstract: ORAI and stromal interaction molecule (STIM) are store-operated channel molecules that play essential roles in human physiology through a coupling mechanism of internal Ca 2+ store to Ca 2+ influx.... Read More

The ryanodine receptor agonist 4-chloro-3-ethylphenol blocks ORAI store-operated channels: 4-Chloro-3-ethylphenol inhibits ORAI channels (2014)
Journal Article
Zeng, B., Chen, G., Daskoulidou, N., & Xu, S. (2014). The ryanodine receptor agonist 4-chloro-3-ethylphenol blocks ORAI store-operated channels: 4-Chloro-3-ethylphenol inhibits ORAI channels. British Journal of Pharmacology, 171(5), 1250-1259. https://doi.org/10.1111/bph.12528

Background Depletion of the Ca2+ store by ryanodine receptor (RyR) agonists induces store‐operated Ca2+ entry (SOCE). 4‐Chloro‐3‐ethylphenol (4‐CEP) and 4‐chloro‐m‐cresol (4‐CmC) are RyR agonists commonly used as research tools and diagnostic reagen... Read More

Activation of TRPC cationic channels by mercurial compounds confers the cytotoxicity of mercury exposure (2011)
Journal Article
Xu, S., Zeng, B., Atkin, S. L., Daskoulidou, N., Chen, G., & Lukhele, B. (2012). Activation of TRPC cationic channels by mercurial compounds confers the cytotoxicity of mercury exposure. Toxicological Sciences, 125(1), 56 - 68. https://doi.org/10.1093/toxsci/kfr268

Mercury is an established worldwide environmental pollutant with well-known toxicity affecting neurodevelopment in humans, but the molecular basis of cytotoxicity and the detoxification procedure are still unclear. Here we examined the involvement of... Read More