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Protein kinase C mediates platelet secretion and thrombus formation through protein kinase D2 (2011)
Journal Article
Konopatskaya, O., Matthews, S. A., Harper, M. T., Gilio, K., Cosemans, J. M., Williams, C. M., …Poole, A. W. (2011). Protein kinase C mediates platelet secretion and thrombus formation through protein kinase D2. Blood, 118(2), (416-424). doi:10.1182/blood-2010-10-312199. ISSN 0006-4971

Platelets are highly specialized blood cells critically involved in hemostasis and thrombosis. Members of the protein kinase C (PKC) family have established roles in regulating platelet function and thrombosis, but the molecular mechanisms are not cl... Read More

PKCα regulates platelet granule secretion and thrombus formation in mice (2009)
Journal Article
Konopatskaya, O., Gilio, K., Harper, M. T., Zhao, Y., Cosemans, J. M. E. M., Karim, Z. A., …Poole, A. W. (2009). PKCα regulates platelet granule secretion and thrombus formation in mice. Journal of Clinical Investigation, 119(2), (399-407). doi:10.1172/JCI34665. ISSN 0021-9738

Platelets are central players in atherothrombosis development in coronary artery disease. The PKC family provides important intracellular mechanisms for regulating platelet activity, and platelets express several members of this family, including the... Read More