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The effect of exenatide on cardiovascular risk markers in women with Polycystic Ovary Syndrome (2019)
Journal Article
Dawson, A. J., Sathyapalan, T., Vince, R., Coady, A., Ajjan, R. A., Kilpatrick, E. S., & Atkin, S. L. (2019). The effect of exenatide on cardiovascular risk markers in women with Polycystic Ovary Syndrome. Frontiers in endocrinology, 10, https://doi.org/10.3389/fendo.2019.00189

Background: Polycystic ovary syndrome (PCOS) is associated with an adverse cardiovascular risk profile including a prothrombotic state. Exenatide has been shown to be effective at improving insulin sensitivity and weight loss in PCOS; therefore this... Read More

Circulating endothelial microparticles reduce in concentration following an exercise programme in women with polycystic ovary syndrome. (2019)
Journal Article
Kirk, R., Madden, L., Peart, D., Aye, M., Atkin, S., & Vince, R. (2019). Circulating endothelial microparticles reduce in concentration following an exercise programme in women with polycystic ovary syndrome. Frontiers in endocrinology, 10, https://doi.org/10.3389/fendo.2019.00200

Purpose: Endothelial dysfunction is a known comorbidity in women with polycystic ovary syndrome (PCOS). The aim was to assess if supervised, moderate intensity exercise could potentially impact markers of endothelial disruption; endothelial cell deri... Read More

Can sit-to-stand muscle power explain the ability to perform functional tasks in adults with severe obesity? (2018)
Journal Article
Orange, S. T., Marshall, P., Madden, L. A., & Vince, R. V. (2018). Can sit-to-stand muscle power explain the ability to perform functional tasks in adults with severe obesity?. Journal of sports sciences, 1-8. doi:10.1080/02640414.2018.1553500

This study examined the relationship between sit-to-stand (STS) power and physical function in adults with severe obesity. Thirty-eight adults (age: 44 ± 12 years; body mass index [BMI]: 45.2 ± 7.8 kg/m2) completed evaluations of STS power, strength... Read More

Dynamic change in insulin resistance induced by free fatty acids is unchanged though insulin sensitivity improves following endurance exercise in PCOS (2018)
Journal Article
Aye, M. M., Butler, A. E., Kilpatrick, E. S., Kirk, R., Vince, R., Rigby, A. S., …Atkin, S. L. (2018). Dynamic change in insulin resistance induced by free fatty acids is unchanged though insulin sensitivity improves following endurance exercise in PCOS. Frontiers in endocrinology, 9(OCT), doi:10.3389/fendo.2018.00592

Background: Insulin resistance (IR) is the hallmark of PCOS and it is known that exercise may decrease it. What is unknown is whether exercise may mechanistically alter the underlying IR, attenuating the dynamic lipid induced IR in insulin resistant... Read More

Test-Retest reliability of a commercial linear position transducer (GymAware PowerTool) to measure velocity and power in the Back Squat and Bench Press (2018)
Journal Article
Orange, S. T., Metcalfe, J. W., Vince, R. V., Marshall, P., Madden, L. A., & Liefeith, A. (2018). Test-Retest reliability of a commercial linear position transducer (GymAware PowerTool) to measure velocity and power in the Back Squat and Bench Press. Journal of strength and conditioning research, 1. doi:10.1519/jsc.0000000000002715

Orange, ST, Metcalfe, JW, Marshall, P, Vince, RV, Madden, LA, and Liefeith, A. Test-retest reliability of a commercial linear position transducer (GymAware PowerTool) to measure velocity and power in the back squat and bench press. J Strength Cond Re... Read More

Validity and reliability of a wearable inertial sensor to measure velocity and power in the back squat and bench press (2018)
Journal Article
Orange, S. T., Metcalfe, J. W., Liefeith, A., Marshall, P., Madden, L. A., Fewster, C. R., & Vince, R. V. (2018). Validity and reliability of a wearable inertial sensor to measure velocity and power in the back squat and bench press. Journal of strength and conditioning research, 1. doi:10.1519/jsc.0000000000002574

This study examined the validity and reliability of a wearable inertial sensor to measure velocity and power in the free-weight back squat and bench press. Twenty-nine youth rugby league players (18 ± 1 years) completed 2 test-retest sessions for the... Read More

Exercise prehabilitation in elective intra-cavity surgery: A role within the ERAS pathway? A narrative review (2018)
Journal Article
Orange, S. T., Northgraves, M. J., Marshall, P., Madden, L. A., & Vince, R. V. (2018). Exercise prehabilitation in elective intra-cavity surgery: A role within the ERAS pathway? A narrative review. International journal of surgery, 56, 328-333. doi:10.1016/j.ijsu.2018.04.054

The Enhanced Recovery after Surgery (ERAS) model integrates several elements of perioperative care into a standardised clinical pathway for surgical patients. ERAS programmes aim to reduce the rate of complications, improve surgical recovery, and lim... Read More

The short-term training and detraining effects of supervised versus unsupervised resistance exercise in aging adults (2018)
Journal Article
Orange, S. T., Marshall, P., Madden, L. A., & Vince, R. V. (2018). The short-term training and detraining effects of supervised versus unsupervised resistance exercise in aging adults. Journal of strength and conditioning research, doi:10.1519/jsc.0000000000002536. ISSN 1064-8011

This study compared the effects of a 4-week supervised (SUP) and unsupervised (UNSUP) resistance training programme followed by 12 weeks of detraining (DET). Thirty-six healthy aging adults (age: 53.6 ± 3.6 years; body mass index: 28.3 ± 5.1 kg/m2) w... Read More

The test-retest reliability of four functional mobility tests in apparently healthy adults (2016)
Journal Article
Northgraves, M. J., Hayes, S. C., Marshall, P., Madden, L. A., & Vince, R. V. (2016). The test-retest reliability of four functional mobility tests in apparently healthy adults. Isokinetics and Exercise Science, 24(3), (171-179). doi:10.3233/ies-160614. ISSN 0959-3020

Background: Simple field tests are often used to assess functional mobility in clinical settings. Despite having many benefits, these tests are susceptible to measurement error and individual variation. Objectives: To examine the test-retest and abso... Read More

Implications of a pre-exercise alkalosis-mediated attenuation of HSP72 on its response to a subsequent bout of exercise (2015)
Journal Article
Peart, D. J., Kirk, R. J., Madden, L. A., & Vince, R. V. (2016). Implications of a pre-exercise alkalosis-mediated attenuation of HSP72 on its response to a subsequent bout of exercise. Amino acids, 48(2), 499-504. doi:10.1007/s00726-015-2103-1

The aim of this study was to investigate if a pre-exercise alkalosis-mediated attenuation of HSP72 had any effect on the response of the same stress protein after a subsequent exercise. Seven physically active males [25.0 ± 6.5 years, 182.1 ± 6.0 cm,... Read More

Investigating strength and range of motion of the hip complex in ice hockey athletes (2015)
Journal Article
Vince, R. V., White, H. S. F., Wilcox, C. R. J., & Osgood, C. T. (2015). Investigating strength and range of motion of the hip complex in ice hockey athletes. Journal of sport rehabilitation, 24(3), 300-306. https://doi.org/10.1123/jsr.2014-0175

CONTEXT: Ice hockey athletes frequently injure the hip complex via a non-contact mechanism. We investigated patterns of strength and range of motion (ROM) to establish major differences compared to soccer athletes. Soccer athletes were compared to ic... Read More

Repeated supra-maximal sprint cycling with and without sodium bicarbonate supplementation induces endothelial microparticle release (2013)
Journal Article
Kirk, R. J., Peart, D. J., Madden, L. A., & Vince, R. V. (2014). Repeated supra-maximal sprint cycling with and without sodium bicarbonate supplementation induces endothelial microparticle release. European journal of sport science : the official journal of the European College of Sport Science, 14(4), 345-352. doi:10.1080/17461391.2013.785600

Under normal homeostatic conditions, the endothelium releases microparticles (MP), which are known to increase under stressful conditions and in disease states. CD105 (endoglin) and CD106 (vascular cell adhesion molecule-1) are expressed on the surfa... Read More

Polycystic ovary syndrome has no independent effect on vascular, inflammatory or thrombotic markers when matched for obesity (2013)
Journal Article
Kahal, H., Aburima, A., Ungvari, T., Rigby, A. S., Dawson, A. J., Coady, A. M., …Atkin, S. L. (2013). Polycystic ovary syndrome has no independent effect on vascular, inflammatory or thrombotic markers when matched for obesity. Clinical Endocrinology, 79(2), (252-258). doi:10.1111/cen.12137. ISSN 0300-0664

Introduction Previous studies investigating cardiovascular (CV) risk in obese women with polycystic ovary syndrome (PCOS) have been potentially confounded by not adequately accounting for body weight. Objective To assess if PCOS increases CV risk ind... Read More

Exercise-induced dehydration with and without environmental heat stress results in increased oxidative stress (2011)
Journal Article
McNaughton, L., Vince, R., Hillman, A., Mitchell, N., Siegler, J., & Taylor, L. (2011). Exercise-induced dehydration with and without environmental heat stress results in increased oxidative stress. Applied Physiology, Nutrition, and Metabolism, 36(5), (698-706). doi:10.1139/h11-080. ISSN 1715-5312

While in vitro work has revealed that dehydration and hyperthermia can elicit increased cellular and oxidative stress, in vivo research linking dehydration, hyperthermia, and oxidative stress is limited. The purpose of this study was to investigate t... Read More

Identification of methicillin-resistant Staphylococcus aureus-specific peptides for targeted photoantimicrobial chemotherapy (2011)
Journal Article
Vince, R. V., Alonso, C. M., Todman, M., Paget, T., Vince, R. V., Madden, L. A., …Greenman, J. (2011). Identification of methicillin-resistant Staphylococcus aureus-specific peptides for targeted photoantimicrobial chemotherapy. Photochemical & photobiological sciences : an international journal, 10(4), (515-522). doi:10.1039/c0pp00267d. ISSN 1474-905X

The increasing prevalence of multi-drug resistant bacteria, such as methicillin-resistant Staphylococcus aureus (MRSA), necessitates development of alternative modes of bacterial targeting which are not hindered by antibiotic resistance and minimise... Read More

The effect of hyperbaric oxygen preconditioning on heat shock protein 72 expression following in vitro stress in human monocytes (2010)
Journal Article
Midgley, A. W., Madden, L. A., Vince, R. V., & Laden, G. (2011). The effect of hyperbaric oxygen preconditioning on heat shock protein 72 expression following in vitro stress in human monocytes. Cell Stress and Chaperones, 16(3), 339-343. doi:10.1007/s12192-010-0246-2

Hyperbaric oxygen (HBO) is thought to confer protection to cells via a cellular response to free radicals. This process may involve increased expression of heat shock proteins, in particular the highly inducible heat shock protein 72 (Hsp72). Healthy... Read More

Hypoxia mediated release of endothelial microparticles and increased association of S100A12 with circulating neutrophils (2009)
Journal Article
Vince, R. V., Chrismas, B., Midgley, A. W., McNaughton, L. R., & Madden, L. A. (2009). Hypoxia mediated release of endothelial microparticles and increased association of S100A12 with circulating neutrophils. Oxidative Medicine and Cellular Longevity, 2(1), (2-6). doi:10.4161/oxim.2.1.7611. ISSN 1942-0900

Microparticles are released from the endothelium under normal homeostatic conditions and have been shown elevated in disease states, most notably those characterised by endothelial dysfunction. The endothelium is sensitive to oxidative stress/status... Read More

Release of VCAM-1 associated endothelial microparticles following simulated SCUBA dives (2008)
Journal Article
Midgley, A. W., Vince, R. V., Madden, L. A., McNaughton, L. R., Vince, R., Laden, G., & Taylor, L. (2009). Release of VCAM-1 associated endothelial microparticles following simulated SCUBA dives. European journal of applied physiology, 105(4), 507-513. doi:10.1007/s00421-008-0927-z

Microparticles (MP) are shed into the circulation from endothelium following activation or apoptosis. Vascular cell adhesion molecule-1 (VCAM-1) is expressed on endothelial cells following activation and here we report quantification of VCAM-1 positi... Read More

Microparticle-associated vascular adhesion molecule-1 and tissue factor follow a circadian rhythm in healthy human subjects (2008)
Journal Article
Madden, L. A., Vince, R. V., Sandström, M. E., Taylor, L., McNaughton, L., & Laden, G. (2008). Microparticle-associated vascular adhesion molecule-1 and tissue factor follow a circadian rhythm in healthy human subjects. Thrombosis and haemostasis, 99(5), 909 - 915. doi:10.1160/th08-01-0030

An increased risk of death or severe injury due to late-morning thrombotic events is well established. Tissue factor (TF) is the initiator of the coagulation cascade, and endothelial stresses, coupled with production of pro-coagulant microparticles (... Read More