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Glucose metabolism and metabolic flexibility in blood platelets (2018)
Journal Article
Aibibula, M., Naseem, K. M., & Sturmey, R. (2018). Glucose metabolism and metabolic flexibility in blood platelets. Journal of thrombosis and haemostasis : JTH, 16(11), 2300-2314. doi:10.1111/jth.14274

The metabolic integration processes required for platelet activation are unclear. The metabolic plasticity of human platelets were investigated. Activated platelets exhibit a glycolytic phenotype while preserving mitochondrial function. Platelets can... Read More

Genistein crosses the bioartificial oviduct and alters secretion composition (2017)
Journal Article
Simintiras, C. A., & Sturmey, R. G. (2017). Genistein crosses the bioartificial oviduct and alters secretion composition. Reproductive Toxicology, 71, (63-70). doi:10.1016/j.reprotox.2017.04.010. ISSN 0890-6238

The dietary derived isoflavone and oestrogen analogue, genistein, is known to perturb fundamental reproductive events such as implantation and embryo cleavage. However the question of whether genistein is able to traverse the oviduct epithelial monol... Read More

Maternal metabolic stress may affect oviduct gatekeeper function (2017)
Journal Article
Jordaens, L., van Hoeck, V., Maillo, V., Gutiérrez-Adán, A., Marei, W., Vlaeminck, B., …Leroy, J. L. M. R. (2017). Maternal metabolic stress may affect oviduct gatekeeper function. Reproduction, 153(6), (759-773). doi:10.1530/rep-16-0569. ISSN 1470-1626

We hypothesized that elevated non-esterified fatty acids (NEFA) modify in vitro bovine oviduct epithelial cell (BOEC) metabolism and barrier function. Hereto, BOECs were studied in a polarized system with 24h-treatments at day 9: 1) CONTROL (0µM NEFA... Read More

Modelling aspects of oviduct fluid formation in vitro (2016)
Journal Article
Simintiras, C. A., Arnold, G. J., Ulbrich, S. E., Leese, H. J., Sturmey, R. G., Froehlich, T., …Ulbrich, S. (2017). Modelling aspects of oviduct fluid formation in vitro. Reproduction, 153(1), (23-33). doi:10.1530/REP-15-0508. ISSN 1470-1626

© 2017 Society for Reproduction and Fertility. Oviduct fluid is the microenvironment that supports early reproductive processes including fertilisation, embryo cleavage and genome activation. However, the composition and regulation of this critical e... Read More

Sexually dimorphic gene expression in bovine conceptuses at the initiation of implantation (2016)
Journal Article
Lonergan, P., Rizos, D., Gutierrez-Adan, A., Spencer, T. E., Ealy, A. D., Sturmey, R. G., …Spencer, T. (2016). Sexually dimorphic gene expression in bovine conceptuses at the initiation of implantation. Biology of Reproduction, 95(4), 1-8. doi:10.1095/biolreprod.116.139857

In cattle, maternal recognition of pregnancy occurs on Day 16 via secretion of interferon tau (IFNT) by the conceptus. The endometrium can distinguish between embryos with different developmental competencies. In eutherian mammals, X-chromosome inact... Read More

Biological optimisation, the Goldilocks principle, and how much is lagom in the preimplantation embryo (2016)
Journal Article
Leese, H. J., Guérif, F., Allgar, V., Brison, D. R., Lundin, K., & Sturmey, R. G. (2016). Biological optimisation, the Goldilocks principle, and how much is lagom in the preimplantation embryo. Molecular Reproduction and Development, 83(9), (748-754). doi:10.1002/mrd.22684. ISSN 1040-452X

The quiet embryo hypothesis postulates that early embryo viability is associated with a relatively low metabolism (Leese. 2002. BioEssays 24: 845-849). This proposal is re-visited here using retrospective and prospective data on the metabolic activit... Read More

Expression and function of transient receptor potential channels in the female bovine reproductive tract (2016)
Journal Article
Leese, H. J., Sturmey, R. G., Atkin, S. L., & Ghavideldarestani, M. (2016). Expression and function of transient receptor potential channels in the female bovine reproductive tract. Theriogenology, 86(2), (551-561). doi:10.1016/j.theriogenology.2016.02.005. ISSN 0093-691X

© 2016 Elsevier Inc. The epithelium lining the oviduct is critical for early reproductive events, many of which are mediated via intracellular calcium ions. Despite this, little is known about the regulation of calcium homeostasis in the oviductal ep... Read More

Human cell dedifferentiation in mesenchymal condensates through controlled autophagy (2015)
Journal Article
McKeegan, P., James, S., Sturmey, R., Bray, E., Genever, P., Pennock, R., & Pryor, P. (2015). Human cell dedifferentiation in mesenchymal condensates through controlled autophagy. Scientific reports, 5(1), doi:10.1038/srep13113. ISSN 2045-2322

Tissue and whole organ regeneration is a dramatic biological response to injury that occurs across different plant and animal phyla. It frequently requires the dedifferentiation of mature cells to a condensed mesenchymal blastema, from which replacem... Read More

Human embryos from overweight and obese women display phenotypic and metabolic abnormalities (2014)
Journal Article
Leary, C., Leese, H. J., & Sturmey, R. G. (2015). Human embryos from overweight and obese women display phenotypic and metabolic abnormalities. Human Reproduction, 30(1), 122-132. doi:10.1093/humrep/deu276

STUDY QUESTION Is the developmental timing and metabolic regulation disrupted in embryos from overweight or obese women? SUMMARY ANSWER Oocytes from overweight or obese women are smaller than those from women of healthy weight, yet post-fertilization... Read More

Metabolic heterogeneity during preimplantation development: The missing link? (2014)
Journal Article
Leese, H. J., Sturmey, R. G., & Brison, D. R. (2014). Metabolic heterogeneity during preimplantation development: The missing link?. Human Reproduction Update, 20(5), 632-640. doi:10.1093/humupd/dmu018

BACKGROUND Most tissues in the body rely on the presence of gap junctions in order to couple their component cells electrically and metabolically via intercellular transport of ions, metabolites and signalling agents. As a result, cells within tissue... Read More

Parallels between embryo and cancer cell metabolism (2013)
Journal Article
Smith, D., Sturmey, R., Smith, D. G., Sturmey, R. G., & Sturmey, R. (2013). Parallels between embryo and cancer cell metabolism. Biochemical Society Transactions, 41(2), (664 - 669). doi:10.1042/BST20120352. ISSN 0300-5127

A key characteristic of cancer cells is the ability to switch from a predominantly oxidative metabolism to glycolysis and the production of lactate even when oxygen is plentiful. This metabolic switch, known as the Warburg effect, was first described... Read More

Expression and localization of creatine kinase in the preimplantation embryo (2012)
Journal Article
Forsey, K. E., Ellis, P. J., Sargent, C. A., Sturmey, R. G., & Leese, H. J. (2013). Expression and localization of creatine kinase in the preimplantation embryo. Molecular Reproduction and Development, 80(3), (185-192). doi:10.1002/mrd.22146. ISSN 1040-452X

Creatine Kinase (CK) catalyses the “creatine shuttle,” the reversible conversion of creatine phosphate to creatine with the liberation of ATP. This article examines the potential role of the creatine shuttle in the provision of ATP during... Read More

Variable imprinting of the MEST gene in human preimplantation embryos (2012)
Journal Article
Sturmey, R. G., Elder, K., Hemmings, K. E., Hinkins, M., Huntriss, J. D., Picton, H. M., & Rutherford, A. J. (2013). Variable imprinting of the MEST gene in human preimplantation embryos. European Journal of Human Genetics, 21(1), (40-47). doi:10.1038/ejhg.2012.102. ISSN 1018-4813

There is evidence that expression and methylation of the imprinted paternally expressed gene 1/mesoderm-specific transcript homologue (PEG1/MEST) gene may be affected by assisted reproductive technologies (ARTs) and infertility. In this study, we sou... Read More

Amino acid metabolism of bovine blastocysts: A biomarker of sex and viability (2010)
Journal Article
Sturmey, R. G., Bermejo-Alvarez, P., Gutierrez-Adan, A., Rizos, D., Leese, H. J., & Lonergan, P. (2010). Amino acid metabolism of bovine blastocysts: A biomarker of sex and viability. Molecular Reproduction and Development, 77(3), 285-296. doi:10.1002/mrd.21145

The ratio of male/female embryos may be modified by environmental factors such as maternal diet in vivo and the composition of embryo culture media in vitro. We have used amino acid profiling, a noninvasive marker of developmental potential to compar... Read More