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All Outputs (48)

Effect of metabolic status on conceptus–maternal interactions on day 19 in dairy cattle: II. Effects on the endometrial transcriptome (2017)
Journal Article
Bauersachs, S., Simintiras, C. A., Sturmey, R. G., Krebs, S., Bick, J., Blum, H., …Forde, N. (2017). Effect of metabolic status on conceptus–maternal interactions on day 19 in dairy cattle: II. Effects on the endometrial transcriptome. Biology of Reproduction, 97(3), 413-425. https://doi.org/10.1093/biolre/iox095

The aim of this study was to test the hypothesis that the metabolic stresses associated with lactation alter the ability of the endometrium to respond appropriately to the conceptus by examining endometrial gene expression on Day 19 of pregnancy. Imm... Read More about Effect of metabolic status on conceptus–maternal interactions on day 19 in dairy cattle: II. Effects on the endometrial transcriptome.

Genistein crosses the bioartificial oviduct and alters secretion composition (2017)
Journal Article
Simintiras, C. A., & Sturmey, R. G. (2017). Genistein crosses the bioartificial oviduct and alters secretion composition. Reproductive Toxicology, 71, 63-70. https://doi.org/10.1016/j.reprotox.2017.04.010

The dietary derived isoflavone and oestrogen analogue, genistein, is known to perturb fundamental reproductive events such as implantation and embryo cleavage. However the question of whether genistein is able to traverse the oviduct epithelial monol... Read More about Genistein crosses the bioartificial oviduct and alters secretion composition.

Maternal metabolic stress may affect oviduct gatekeeper function (2017)
Journal Article
Jordaens, L., van Hoeck, V., Maillo, V., Gutiérrez-Adán, A., Marei, W., Vlaeminck, B., …Leroy, J. L. M. R. (2017). Maternal metabolic stress may affect oviduct gatekeeper function. Reproduction, 153(6), 759-773. https://doi.org/10.1530/rep-16-0569

We hypothesized that elevated non-esterified fatty acids (NEFA) modify in vitro bovine oviduct epithelial cell (BOEC) metabolism and barrier function. Hereto, BOECs were studied in a polarized system with 24h-treatments at day 9: 1) CONTROL (0µM NEFA... Read More about Maternal metabolic stress may affect oviduct gatekeeper function.

Energy metabolism of platelets (2017)
Thesis
Aibibula, M. (2017). Energy metabolism of platelets. (Thesis). Hull York Medical School, the University of Hull and the University of York. Retrieved from https://hull-repository.worktribe.com/output/4221806

Undesired platelet activation is associated with a number of diseases characterised by metabolic imbalance, such as hyperlipidaemia. Changes in platelet energy metabolism associated with disease states are unclear. This thesis presents a detailed inv... Read More about Energy metabolism of platelets.

Modelling aspects of oviduct fluid formation in vitro (2016)
Journal Article
Simintiras, C. A., Arnold, G. J., Ulbrich, S. E., Leese, H. J., Sturmey, R. G., Froehlich, T., …Ulbrich, S. (2017). Modelling aspects of oviduct fluid formation in vitro. Reproduction, 153(1), 23-33. https://doi.org/10.1530/REP-15-0508

© 2017 Society for Reproduction and Fertility. Oviduct fluid is the microenvironment that supports early reproductive processes including fertilisation, embryo cleavage and genome activation. However, the composition and regulation of this critical e... Read More about Modelling aspects of oviduct fluid formation in vitro.

Sexually dimorphic gene expression in bovine conceptuses at the initiation of implantation (2016)
Journal Article
Forde, N., Maillo, V., O'Gaora, P., Simintiras, C. A., Sturmey, R. G., Ealy, A. D., …Lonergan, P. (2016). Sexually dimorphic gene expression in bovine conceptuses at the initiation of implantation. Biology of Reproduction, 95(4), Article ARTN 92. https://doi.org/10.1095/biolreprod.116.139857

In cattle, maternal recognition of pregnancy occurs on Day 16 via secretion of interferon tau (IFNT) by the conceptus. The endometrium can distinguish between embryos with different developmental competencies. In eutherian mammals, X-chromosome inact... Read More about Sexually dimorphic gene expression in bovine conceptuses at the initiation of implantation.

Biological optimisation, the Goldilocks principle, and how much is lagom in the preimplantation embryo (2016)
Journal Article
Leese, H. J., Guérif, F., Allgar, V., Brison, D. R., Lundin, K., & Sturmey, R. G. (2016). Biological optimisation, the Goldilocks principle, and how much is lagom in the preimplantation embryo. Molecular Reproduction and Development, 83(9), 748-754. https://doi.org/10.1002/mrd.22684

The quiet embryo hypothesis postulates that early embryo viability is associated with a relatively low metabolism (Leese. 2002. BioEssays 24: 845-849). This proposal is re-visited here using retrospective and prospective data on the metabolic activit... Read More about Biological optimisation, the Goldilocks principle, and how much is lagom in the preimplantation embryo.

Expression and function of transient receptor potential channels in the female bovine reproductive tract (2016)
Journal Article
Ghavideldarestani, M., Atkin, S. L., Leese, H. J., & Sturmey, R. G. (2016). Expression and function of transient receptor potential channels in the female bovine reproductive tract. Theriogenology, 86(2), 551-561. https://doi.org/10.1016/j.theriogenology.2016.02.005

© 2016 Elsevier Inc. The epithelium lining the oviduct is critical for early reproductive events, many of which are mediated via intracellular calcium ions. Despite this, little is known about the regulation of calcium homeostasis in the oviductal ep... Read More about Expression and function of transient receptor potential channels in the female bovine reproductive tract.

Human cell dedifferentiation in mesenchymal condensates through controlled autophagy (2015)
Journal Article
Pennock, R., Bray, E., Pryor, P., James, S., McKeegan, P., Sturmey, R., & Genever, P. (2015). Human cell dedifferentiation in mesenchymal condensates through controlled autophagy. Scientific reports, 5(1), Article ARTN 13113. https://doi.org/10.1038/srep13113

Tissue and whole organ regeneration is a dramatic biological response to injury that occurs across different plant and animal phyla. It frequently requires the dedifferentiation of mature cells to a condensed mesenchymal blastema, from which replacem... Read More about Human cell dedifferentiation in mesenchymal condensates through controlled autophagy.

The effect of maternal overweight and obesity on the viability and metabolism of human oocytes and early embryos (2015)
Thesis
Leary, C. (2015). The effect of maternal overweight and obesity on the viability and metabolism of human oocytes and early embryos. (Thesis). Hull York Medical School, the University of Hull and the University of York. Retrieved from https://hull-repository.worktribe.com/output/4217662

Overweight and obese (OWOB) women are reported to have a lower chance of becoming pregnant. The nutritional enrichment of the periconceptional environment apparent in obese women may be detrimental for embryo viability. This is the first study to exa... Read More about The effect of maternal overweight and obesity on the viability and metabolism of human oocytes and early embryos.

Embryo metabolism : what does it really mean? (2015)
Journal Article
Sturmey, R., & Lewis, N. (2015). Embryo metabolism : what does it really mean?. Animal reproduction / Colegio Brasileiro de Reproducao Animal, 12(3), 521-528

The study of early embryo metabolism has fascinated researchers in the field for nearly a century. Herein, we give a brief account of the general features of embryo metabolism and some consideration of the research performed to reach such conclusions... Read More about Embryo metabolism : what does it really mean?.

Metabolic regulation during early embryo development (2015)
Thesis
McKeegan, P. (2015). Metabolic regulation during early embryo development. (Thesis). Hull York Medical School, the University of Hull and the University of York. Retrieved from https://hull-repository.worktribe.com/output/4216544

The preimplantation embryo must satisfy dynamic changes in energy demand during development to the blastocyst stage. Energy is provided through regulated metabolic pathways including glycolysis, β-oxidation and oxidative phosphorylation. Oxygen consu... Read More about Metabolic regulation during early embryo development.

Human embryos from overweight and obese women display phenotypic and metabolic abnormalities (2014)
Journal Article
Leary, C., Leese, H. J., & Sturmey, R. G. (2015). Human embryos from overweight and obese women display phenotypic and metabolic abnormalities. Human Reproduction, 30(1), 122-132. https://doi.org/10.1093/humrep/deu276

STUDY QUESTION Is the developmental timing and metabolic regulation disrupted in embryos from overweight or obese women? SUMMARY ANSWER Oocytes from overweight or obese women are smaller than those from women of healthy weight, yet post-fertilization... Read More about Human embryos from overweight and obese women display phenotypic and metabolic abnormalities.

Amino acids in the uterine luminal fluid reflects the temporal changes in transporter expression in the endometrium and conceptus during early pregnancy in cattle (2014)
Journal Article
Forde, N., Simintiras, C. A., Sturmey, R., Mamo, S., Kelly, A. K., Spencer, T. E., …Lonergan, P. (2014). Amino acids in the uterine luminal fluid reflects the temporal changes in transporter expression in the endometrium and conceptus during early pregnancy in cattle. PLoS ONE, 9(6), e100010. https://doi.org/10.1371/journal.pone.0100010

In cattle, conceptus-maternal interactions are critical for the establishment and maintenance of pregnancy. A major component of this early interaction involves the transport of nutrients and secretion of key molecules by uterine epithelial cells to... Read More about Amino acids in the uterine luminal fluid reflects the temporal changes in transporter expression in the endometrium and conceptus during early pregnancy in cattle.

Metabolic heterogeneity during preimplantation development: The missing link? (2014)
Journal Article
Brison, D. R., Sturmey, R. G., & Leese, H. J. (2014). Metabolic heterogeneity during preimplantation development: The missing link?. Human Reproduction Update, 20(5), 632-640. https://doi.org/10.1093/humupd/dmu018

BACKGROUND Most tissues in the body rely on the presence of gap junctions in order to couple their component cells electrically and metabolically via intercellular transport of ions, metabolites and signalling agents. As a result, cells within tissue... Read More about Metabolic heterogeneity during preimplantation development: The missing link?.

Parallels between embryo and cancer cell metabolism (2013)
Journal Article
Smith, D., & Sturmey, R. (2013). Parallels between embryo and cancer cell metabolism. Biochemical Society Transactions, 41(2), 664 - 669. https://doi.org/10.1042/BST20120352

A key characteristic of cancer cells is the ability to switch from a predominantly oxidative metabolism to glycolysis and the production of lactate even when oxygen is plentiful. This metabolic switch, known as the Warburg effect, was first described... Read More about Parallels between embryo and cancer cell metabolism.

Expression and localization of creatine kinase in the preimplantation embryo (2012)
Journal Article
Forsey, K. E., Ellis, P. J., Sargent, C. A., Sturmey, R. G., & Leese, H. J. (2013). Expression and localization of creatine kinase in the preimplantation embryo. Molecular Reproduction and Development, 80(3), 185-192. https://doi.org/10.1002/mrd.22146

Creatine Kinase (CK) catalyses the “creatine shuttle,” the reversible conversion of creatine phosphate to creatine with the liberation of ATP. This article examines the potential role of the creatine shuttle in the provision of ATP during mouse preim... Read More about Expression and localization of creatine kinase in the preimplantation embryo.