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Regulation of sinus node pacemaking and atrioventricular node conduction by HCN channels in health and disease (2021)
Journal Article
Boyett, M. R., Yanni, J., Tellez, J., Bucchi, A., Mesirca, P., Cai, X., …D'Souza, A. (in press). Regulation of sinus node pacemaking and atrioventricular node conduction by HCN channels in health and disease. Progress in Biophysics and Molecular Biology, https://doi.org/10.1016/j.pbiomolbio.2021.06.008

The funny current, If, was first recorded in the heart 40 or more years ago by Dario DiFrancesco and others. Since then, we have learnt that If plays an important role in pacemaking in the sinus node, the innate pacemaker of the heart, and more recen... Read More about Regulation of sinus node pacemaking and atrioventricular node conduction by HCN channels in health and disease.

An age-associated reduction in Nav1.5 protein expression correlates with an increase in Nav1.8 protein expression in the right atrial appendage of the human heart. (2020)
Journal Article
Isaac, E., Cooper, S., Lancaster, M., Loubani, M., & Jones, S. (2020). An age-associated reduction in Nav1.5 protein expression correlates with an increase in Nav1.8 protein expression in the right atrial appendage of the human heart. Circulation Research, 127(Suppl_1), A493

Background: Nav1.5 is the predominantly expressed voltage-gated sodium channel (VGSC) isoform in the heart, responsible for phase 0 of the action potential. Our rodent studies have shown expression of neuronal isoform Nav1.8 protein in the adult hear... Read More about An age-associated reduction in Nav1.5 protein expression correlates with an increase in Nav1.8 protein expression in the right atrial appendage of the human heart..

Do age-associated changes of voltage-gated sodium channel isoforms expressed in the mammalian heart predispose the elderly to atrial fibrillation? (2020)
Journal Article
Isaac, E., Cooper, S. M., Jones, S. A., & Loubani, M. (2020). Do age-associated changes of voltage-gated sodium channel isoforms expressed in the mammalian heart predispose the elderly to atrial fibrillation?. World Journal of Cardiology, 12(4), 123-135. https://doi.org/10.4330/wjc.v12.i4.123

© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. Atrial fibrillation (AF) is the most common cardiac arrhythmia worldwide. The prevalence of the disease increases with age, strongly implying an age-related proc... Read More about Do age-associated changes of voltage-gated sodium channel isoforms expressed in the mammalian heart predispose the elderly to atrial fibrillation?.

K2p3.1 protein is expressed as a transmural gradient across the rat left ventricular free wall (2018)
Journal Article
Jones, S. A., Walton, R. D., Morton, M., & Lancaster, M. K. (2019). K2p3.1 protein is expressed as a transmural gradient across the rat left ventricular free wall. Journal of Cardiovascular Electrophysiology, 30(3), 383-391. https://doi.org/10.1111/jce.13805

Introduction: K 2p 3.1, also known as TASK-1, is a twin-pore acid-sensitive repolarizing K + channel, responsible for a background potassium current that significantly contributes to setting the resting membrane potential of cardiac myocytes. Inhibit... Read More about K2p3.1 protein is expressed as a transmural gradient across the rat left ventricular free wall.

Interactions of short-term and chronic treadmill training with aging of the left ventricle of the heart (2015)
Journal Article
Walton, R. D., Jones, S. A., Rostron, K. A., Kayani, A. C., Close, G. L., McArdle, A., & Lancaster, M. K. (2016). Interactions of short-term and chronic treadmill training with aging of the left ventricle of the heart. The journals of gerontology. Series A, Biological sciences and medical sciences, 71(8), 1005-1013. https://doi.org/10.1093/gerona/glv093

With aging, there is a decline in cardiac function accompanying increasing risk of arrhythmias. These effects are likely to be mechanistically associated with age-associated changes in calcium regulation within cardiac myocytes. Previous studies sugg... Read More about Interactions of short-term and chronic treadmill training with aging of the left ventricle of the heart.

Progressive age-associated activation of JNK associates with conduction disruption in the aged atrium (2015)
Journal Article
Jones, S. A., & Lancaster, M. K. (2015). Progressive age-associated activation of JNK associates with conduction disruption in the aged atrium. Mechanisms of ageing and development, 146-148, 72-80. https://doi.org/10.1016/j.mad.2015.05.001

Connexin43 (Cx43) is critical for maintaining electrical conduction across atrial muscle. During progressive ageing atrial conduction slows associating with increasing susceptibility to arrhythmias. Changes in Cx43 protein expression, or its phosphor... Read More about Progressive age-associated activation of JNK associates with conduction disruption in the aged atrium.

Effects of candesartan, an angiotensin II receptor type I blocker, on atrial remodeling in spontaneously hypertensive rats (2015)
Journal Article
Choisy, S. C., Kim, S., Hancox, J. C., Jones, S. A., & James, A. F. (2015). Effects of candesartan, an angiotensin II receptor type I blocker, on atrial remodeling in spontaneously hypertensive rats. Physiological Reports, 3(1), e12274. https://doi.org/10.14814/phy2.12274

Hypertension-induced structural remodeling of the left atrium (LA) has been suggested to involve the renin–angiotensin system. This study investigated whether treatment with an angiotensin receptor blocker, candesartan, regresses atrial remodeling in... Read More about Effects of candesartan, an angiotensin II receptor type I blocker, on atrial remodeling in spontaneously hypertensive rats.

Atrial remodeling and the substrate for atrial fibrillation in rat hearts with elevated afterload (2011)
Journal Article
Kim, S., Choisy, S. C., Barman, P., Zhang, H., Hancox, J. C., Jones, S. A., & James, A. F. (2011). Atrial remodeling and the substrate for atrial fibrillation in rat hearts with elevated afterload. Circulation. Arrhythmia and electrophysiology, 4(5), 761-769. https://doi.org/10.1161/CIRCEP.111.964783

BACKGROUND: Although arterial hypertension and left ventricular hypertrophy are considered good epidemiological indicators of the risk of atrial fibrillation (AF) in patients, the link between elevated afterload and AF remains unclear. We investigate... Read More about Atrial remodeling and the substrate for atrial fibrillation in rat hearts with elevated afterload.

Distinguishing Properties of Cells From the Myocardial Sleeves of the Pulmonary Veins: A Comparison of Normal and Abnormal Pacemakers (2008)
Journal Article
Jones, S. A., Yamamoto, M., Tellez, J. O., Billeter, R., Boyett, M. R., Honjo, H., & Lancaster, M. K. (2008). Distinguishing Properties of Cells From the Myocardial Sleeves of the Pulmonary Veins: A Comparison of Normal and Abnormal Pacemakers. Circulation. Arrhythmia and electrophysiology, 1(1), 39-48. https://doi.org/10.1161/CIRCEP.107.748467

BACKGROUND: A common source of arrhythmogenic spontaneous activity instigating atrial fibrillation is the myocardial tissue, or sleeves, at the base of the pulmonary veins. This study compared the properties of cells from the myocardial sleeves of th... Read More about Distinguishing Properties of Cells From the Myocardial Sleeves of the Pulmonary Veins: A Comparison of Normal and Abnormal Pacemakers.