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K2p3.1 protein is expressed as a transmural gradient across the rat left ventricular free wall (2018)
Journal Article
Jones, S. A., Walton, R. D., Morton, M., & Lancaster, M. K. (2019). K2p3.1 protein is expressed as a transmural gradient across the rat left ventricular free wall. Journal of Cardiovascular Electrophysiology, 30, 383-391. https://doi.org/10.1111/jce.13805

Introduction: K2p3.1, also known as TASK-1, is a twin-pore acid-sensitive repolarizing K+ channel, responsible for a background potassium current that significantly contributes to setting the resting membrane potential of cardiac myocytes. Inhibition... Read More

K2p3.1 protein is expressed as a transmural gradient across the rat left ventricular free wall (2018)
Journal Article
Jones, S. A., Walton, R. D., Morton, M., & Lancaster, M. K. (2018). K2p3.1 protein is expressed as a transmural gradient across the rat left ventricular free wall. Journal of Cardiovascular Electrophysiology, doi:10.1111/jce.13805

Introduction K2p3.1, also known as TASK‐1, is a twin‐pore acid‐sensitive repolarizing K+ channel, responsible for a background potassium current that significantly contributes to setting the resting membrane potential of cardiac myocytes. Inhibition... Read More

Interactions of short-term and chronic treadmill training with aging of the left ventricle of the heart (2015)
Journal Article
Jones, S. A., Walton, R. D., Close, G. L., Kayani, A. C., Lancaster, M. K., McArdle, A., & Rostron, K. A. (2016). Interactions of short-term and chronic treadmill training with aging of the left ventricle of the heart. The journals of gerontology. Series A, Biological sciences and medical sciences, 71(8), (1005-1013). doi:10.1093/gerona/glv093. ISSN 1079-5006

With aging, there is a decline in cardiac function accompanying increasing risk of arrhythmias. These effects are likely to be mechanistically associated with age-associated changes in calcium regulation within cardiac myocytes. Previous studies sugg... Read More

Progressive age-associated activation of JNK associates with conduction disruption in the aged atrium (2015)
Journal Article
Jones, S. A., & Lancaster, M. K. (2015). Progressive age-associated activation of JNK associates with conduction disruption in the aged atrium. Mechanisms of ageing and development, 146-148, (72-80). doi:10.1016/j.mad.2015.05.001. ISSN 0047-6374

Connexin43 (Cx43) is critical for maintaining electrical conduction across atrial muscle. During progressive ageing atrial conduction slows associating with increasing susceptibility to arrhythmias. Changes in Cx43 protein expression, or its phosphor... Read More

Effects of candesartan, an angiotensin II receptor type I blocker, on atrial remodeling in spontaneously hypertensive rats (2015)
Journal Article
Choisy, S. C., Kim, S., Hancox, J. C., Jones, S. A., & James, A. F. (2015). Effects of candesartan, an angiotensin II receptor type I blocker, on atrial remodeling in spontaneously hypertensive rats. Physiological Reports, 3(1), e12274. doi:10.14814/phy2.12274

Hypertension-induced structural remodeling of the left atrium (LA) has been suggested to involve the renin–angiotensin system. This study investigated whether treatment with an angiotensin receptor blocker, candesartan, regresses atrial remodeling in... Read More

Atrial remodeling and the substrate for atrial fibrillation in rat hearts with elevated afterload (2011)
Journal Article
Kim, S., Choisy, S. C. M., Barman, P., Zhang, H., Hancox, J. C., James, A. F., & Jones, S. A. (2011). Atrial remodeling and the substrate for atrial fibrillation in rat hearts with elevated afterload. Circulation. Arrhythmia and electrophysiology, 4(5), (761-769). doi:10.1161/CIRCEP.111.964783. ISSN 1941-3149

BACKGROUND: Although arterial hypertension and left ventricular hypertrophy are considered good epidemiological indicators of the risk of atrial fibrillation (AF) in patients, the link between elevated afterload and AF remains unclear. We investigate... Read More

Distinguishing Properties of Cells From the Myocardial Sleeves of the Pulmonary Veins: A Comparison of Normal and Abnormal Pacemakers (2008)
Journal Article
Jones, S. A., Yamamoto, M., Tellez, J. O., Billeter, R., Boyett, M. R., Honjo, H., & Lancaster, M. K. (2008). Distinguishing Properties of Cells From the Myocardial Sleeves of the Pulmonary Veins: A Comparison of Normal and Abnormal Pacemakers. Circulation. Arrhythmia and electrophysiology, 1(1), (39-48). doi:10.1161/CIRCEP.107.748467. ISSN 1941-3149

BACKGROUND: A common source of arrhythmogenic spontaneous activity instigating atrial fibrillation is the myocardial tissue, or sleeves, at the base of the pulmonary veins. This study compared the properties of cells from the myocardial sleeves of th... Read More