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Copy number variation of FCGR3B is associated with susceptibility to idiopathic pulmonary fibrosis (2010)
Journal Article
Bournazos, S., Bournazou, I., Murchison, J. T., Wallace, W. A., McFarlane, P., Hirani, N., …Hart, S. P. (2011). Copy number variation of FCGR3B is associated with susceptibility to idiopathic pulmonary fibrosis. Respiration, 81(2), 142-149. https://doi.org/10.1159/000321997

Background: Several genes exhibit copy number variation (CNV), including FCGR3B which encodes the IgG receptor FcγRIIIb. Engagement of Fcγ receptors by IgG complexes may contribute to the pathogenesis of idiopathic pulmonary fibrosis (IPF). Objective... Read More about Copy number variation of FCGR3B is associated with susceptibility to idiopathic pulmonary fibrosis.

Association of FcγRIIa R131H polymorphism with idiopathic pulmonary fibrosis severity and progression (2010)
Journal Article
Bournazos, S., Grinfeld, J., Alexander, K. M., Murchison, J. T., Wallace, W. A., McFarlane, P., …Hart, S. P. (2010). Association of FcγRIIa R131H polymorphism with idiopathic pulmonary fibrosis severity and progression. BMC Pulmonary Medicine, 10(1), Article ARTN 51. https://doi.org/10.1186/1471-2466-10-51

Background: A significant genetic component has been described for idiopathic pulmonary fibrosis (IPF). The R131H (rs1801274) polymorphism of the IgG receptor FcγRIIa determines receptor affinity for IgG subclasses and is associated with several chro... Read More about Association of FcγRIIa R131H polymorphism with idiopathic pulmonary fibrosis severity and progression.

Fcγ Receptor IIIb (CD16b) Polymorphisms are Associated with Susceptibility to Idiopathic Pulmonary Fibrosis (2010)
Journal Article
Bournazos, S., Bournazou, I., Murchison, J. T., Wallace, W. A., McFarlane, P., Hirani, N., …Hart, S. P. (2010). Fcγ Receptor IIIb (CD16b) Polymorphisms are Associated with Susceptibility to Idiopathic Pulmonary Fibrosis. Lung, 188(6), 475-481. https://doi.org/10.1007/s00408-010-9262-3

An excess of neutrophils in the alveoli and lung interstitium has been described in idiopathic pulmonary fibrosis (IPF). Engagement of neutrophil Fcγ receptors with IgG complexes may contribute to the pathogenesis of IPF. The neutrophil FcγRIIIb rece... Read More about Fcγ Receptor IIIb (CD16b) Polymorphisms are Associated with Susceptibility to Idiopathic Pulmonary Fibrosis.