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All Outputs (11)

Defining an ageing-related pathology, disease or syndrome: International Consensus Statement (2024)
Journal Article
Short, E., Zemel, M., Yu, E., Chung, T. Y., Yeo, L. L., Witkowski, J. M., Willis, R., Whitney, S. L., Weinberger, B., Weight, C., Webster, A., Watkins, A. J., Wakefield, R., Walker, J., Vyazovskiy, V., Vukanovic, V., Vinciguerra, M., Verschoor, C., Vernooij, M. W., Venkat, R., …Bhandari, S. (online). Defining an ageing-related pathology, disease or syndrome: International Consensus Statement. GeroScience, https://doi.org/10.1007/s11357-024-01315-9

Around the world, individuals are living longer, but an increased average lifespan does not always equate to an increased health span. With advancing age, the increased prevalence of ageing-related diseases can have a significant impact on health sta... Read More about Defining an ageing-related pathology, disease or syndrome: International Consensus Statement.

Practice review: Pharmacological management of severe chronic breathlessness in adults with advanced life-limiting diseases (2024)
Journal Article
Simon, S. T., Higginson, I. J., Bausewein, C., Jolley, C. J., Bajwah, S., Maddocks, M., Wilharm, C., Oluyase, A. O., & Pralong, A. (online). Practice review: Pharmacological management of severe chronic breathlessness in adults with advanced life-limiting diseases. Palliative medicine, https://doi.org/10.1177/02692163241270945

Background: Severe and refractory chronic breathlessness is a common and burdensome symptom in patients with advanced life-limiting disease. Its clinical management is challenging because of the lack of effective interventions. Aim: To provide practi... Read More about Practice review: Pharmacological management of severe chronic breathlessness in adults with advanced life-limiting diseases.

Mirtazapine to alleviate severe breathlessness in patients with COPD or ILD: an international, multicentre, double-blind, randomised, placebo-controlled, phase 3 mixed-method trial (BETTER-B) (2024)
Journal Article
Higginson, I. J., Brown, S. T., Oluyase, A. O., May, P., Maddocks, M., Costantini, M., Bajwah, S., Normand, C., Bausewein, C., Simon, S. T., Ryan, K., Currow, D. C., Johnson, M., Hart, S. P., Mather, H., Krajnik, M., Tanzi, S., Ghirotto, L., Bolton, C., Janowiak, P., …Brown, J. M. (2024). Mirtazapine to alleviate severe breathlessness in patients with COPD or ILD: an international, multicentre, double-blind, randomised, placebo-controlled, phase 3 mixed-method trial (BETTER-B). Lancet, 12(10), 763-774. https://doi.org/10.1016/S2213-2600%2824%2900187-5

Background
Breathlessness frequently becomes severe among people with respiratory disease. Mirtazapine, a widely used antidepressant, showed promise. We determined the effectiveness of mirtazapine to alleviate severe persisting breathlessness.
Meth... Read More about Mirtazapine to alleviate severe breathlessness in patients with COPD or ILD: an international, multicentre, double-blind, randomised, placebo-controlled, phase 3 mixed-method trial (BETTER-B).

Research priorities for progressive pulmonary fibrosis in the UK (2024)
Journal Article
Fabbri, L., Russell, A. M., Chaudhuri, N., Adams, W., Cowan, K., Conway, J., Dickinson, W., Gibbons, M., Hart, S., Jones, S., Lynch-Wilson, J., McMillan, T., Milward, S., Ward, M., Wright, L. E., & Jenkins, G. (2024). Research priorities for progressive pulmonary fibrosis in the UK. BMJ Open Respiratory Research, 11(1), Article e002368. https://doi.org/10.1136/bmjresp-2024-002368

INTRODUCTION: Health research bodies recommend patient involvement and engagement in research and healthcare planning, although their implementation is not yet widespread. This deficiency extends to progressive pulmonary fibrosis (PPF), where crucial... Read More about Research priorities for progressive pulmonary fibrosis in the UK.

Can tumour antigens act as biomarkers for the early detection of non-small cell lung cancer? (2024)
Journal Article
Mohamed, E., Fletcher, D., Hart, S., & Guinn, B.-A. (2024). Can tumour antigens act as biomarkers for the early detection of non-small cell lung cancer?. Onco, 4(2), 87-100. https://doi.org/10.3390/onco4020008

Lung cancer (LC) is one of the leading causes of cancer-related deaths. Pulmonary nodules are one of the risk factors and their discovery rate has been increasing due to enhanced performance of chest CT scans but more than 90% are non-malignant causi... Read More about Can tumour antigens act as biomarkers for the early detection of non-small cell lung cancer?.

Real-world experience of nintedanib for progressive fibrosing interstitial lung disease in the UK (2024)
Journal Article
Dixon, G., Hague, S., Mulholland, S., Adamali, H., Khin, A. M. N., Thould, H., Connon, R., Minnis, P., Murtagh, E., Khan, F., Toor, S., Lawrence, A., Naqvi, M., West, A., Coker, R. K., Ward, K., Yazbeck, L., Hart, S., Garfoot, T., Newman, K., …Barratt, S. L. (2024). Real-world experience of nintedanib for progressive fibrosing interstitial lung disease in the UK. ERJ Open Research, 10(1), Article 00529-2023. https://doi.org/10.1183/23120541.00529-2023

Background Nintedanib slows progression of lung function decline in patients with progressive fibrosing (PF) interstitial lung disease (ILD) and was recommended for this indication within the United Kingdom (UK) National Health Service in Scotland in... Read More about Real-world experience of nintedanib for progressive fibrosing interstitial lung disease in the UK.

Association study of human leukocyte antigen variants and idiopathic pulmonary fibrosis (2024)
Journal Article
Guillen-Guio, B., Paynton, M. L., Allen, R. J., Chin, D. P., Donoghue, L. J., Stockwell, A., Leavy, O. C., Hernandez-Beeftink, T., Reynolds, C., Cullinan, P., Martinez, F., Booth, H. L., Fahy, W. A., Hall, I. P., Hart, S. P., Hill, M. R., Hirani, N., Hubbard, R. B., McAnulty, R. J., Millar, A. B., …Hollox, E. J. (2024). Association study of human leukocyte antigen variants and idiopathic pulmonary fibrosis. ERJ Open Research, 10(1), https://doi.org/10.1183/23120541.00553-2023

Introduction Idiopathic pulmonary fibrosis (IPF) is a chronic interstitial pneumonia marked by progressive lung fibrosis and a poor prognosis. Recent studies have highlighted the potential role of infection in the pathogenesis of IPF, and a prior ass... Read More about Association study of human leukocyte antigen variants and idiopathic pulmonary fibrosis.

The Effect of Long-Term Azithromycin on Objective and Subjective Cough in Chronic Respiratory Disease: A Systematic Review and Meta-analysis of Randomised Controlled Trials and Noncomparative Studies (2024)
Journal Article
Sykes, D. L., Mason, P., Rahunathan, N., Hart, S. P., Morice, A. H., & Crooks, M. G. (2024). The Effect of Long-Term Azithromycin on Objective and Subjective Cough in Chronic Respiratory Disease: A Systematic Review and Meta-analysis of Randomised Controlled Trials and Noncomparative Studies. Lung, https://doi.org/10.1007/s00408-024-00729-8

Introduction: Azithromycin is an effective treatment for various respiratory conditions but its effect on cough is poorly understood. We synthesised data from randomised controlled trials (RCTs) and noncomparative studies (NCT) examining its effect o... Read More about The Effect of Long-Term Azithromycin on Objective and Subjective Cough in Chronic Respiratory Disease: A Systematic Review and Meta-analysis of Randomised Controlled Trials and Noncomparative Studies.

Effects of Azithromycin on Blood Inflammatory Gene Expression and Cytokine Production in Sarcoidosis (2024)
Journal Article
Fraser, S. D., Thackray-Nocera, S., Wright, C., Flockton, R., James, S. R., Crooks, M. G., Kaye, P. M., & Hart, S. P. (2024). Effects of Azithromycin on Blood Inflammatory Gene Expression and Cytokine Production in Sarcoidosis. Lung, https://doi.org/10.1007/s00408-024-00743-w

Introduction: In sarcoidosis granulomas, monocyte-derived macrophages are activated by pro-inflammatory cytokines including TNF and IL-6. Current drug treatment for sarcoidosis aims to suppress inflammation but disabling side effects can ensue. The m... Read More about Effects of Azithromycin on Blood Inflammatory Gene Expression and Cytokine Production in Sarcoidosis.