All Outputs (2)

T cell exhaustion potential of bacterial superantigens relevant in severe infections and cancer (2023)
Thesis
Tantoush, F. A. A. T cell exhaustion potential of bacterial superantigens relevant in severe infections and cancer. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4373985

Bacterial superantigens (SAgs) trigger oligoclonal activation of T cells by crosslinking MHC-class-II, on Ag-presenting cells, to the T cell receptor (TCR)/CD28, on T cells, which can be independent of Lck, a critical kinase normally involved... Read More about T cell exhaustion potential of bacterial superantigens relevant in severe infections and cancer.

Identification of the molecular pathways involved in paediatric and adult acute myeloid leukaemia (2022)
Thesis
Brown, E. Identification of the molecular pathways involved in paediatric and adult acute myeloid leukaemia. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4224412

Acute myeloid leukaemia (AML) affects 3100 people every year in the UK, around 1% of whom are under 19 years of age. Despite improvements in immunotherapeutic treatment opportunities for AML, the rates of survival particularly in adults remain poor.... Read More about Identification of the molecular pathways involved in paediatric and adult acute myeloid leukaemia.