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Human platelet activation by Escherichia coli: roles for FcγRIIA and integrin αIIbβ3 (2016)
Journal Article
Watson, C. N., Cox, D., Watson, S. P., Arman, M., Henderson, I. R., & Kerrigan, S. W. (2016). Human platelet activation by Escherichia coli: roles for FcγRIIA and integrin αIIbβ3. Platelets, 27(6), (535-540). doi:10.3109/09537104.2016.1148129. ISSN 0953-7104

Gram-negative Escherichia coli cause diseases such as sepsis and hemolytic uremic syndrome in which thrombotic disorders can be found. Direct platelet–bacterium interactions might contribute to some of these conditions; however, mechanisms of human p... Read More

Megakaryocytes assemble podosomes that degrade matrix and protrude through basement membrane (2013)
Journal Article
Schachtner, H., Calaminus, S. D. J., Sinclair, A., Monypenny, J., Blundell, M. P., Leon, C., …Machesky, L. M. (2013). Megakaryocytes assemble podosomes that degrade matrix and protrude through basement membrane. Blood, 121(13), 2542-2552. doi:10.1182/blood-2012-07-443457

Megakaryocytes give rise to platelets via extension of proplatelet arms, which are released through the vascular sinusoids into the bloodstream. Megakaryocytes and their precursors undergo varying interactions with the extracellular environment in th... Read More