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T-type Ca 2+ channel blocker mibefradil blocks ORAI channels via acting on extracellular surface (2019)
Journal Article
Li, P., Rubaiy, H. N., Chen, G., Hallett, T., Zaibi, N., Zeng, B., …Xu, S. (in press). T-type Ca 2+ channel blocker mibefradil blocks ORAI channels via acting on extracellular surface. British Journal of Pharmacology, https://doi.org/10.1111/bph.14788

Background and purpose Mibefradil (Mib), a T‐type Ca2+ channel blocker, has been investigated for treating solid tumours. However, its underlying mechanisms are still unclear. Here we aimed to investigate the pharmacological aspect of Mib on ORAI st... Read More

ORAI channels are critical for receptor-mediated endocytosis of albumin (2017)
Journal Article
Zeng, B., Chen, G., Garcia-Vaz, E., Bhandari, S., Daskoulidou, N., Berglund, L. M., …Xu, S. (2017). ORAI channels are critical for receptor-mediated endocytosis of albumin. Nature communications, 8(1), https://doi.org/10.1038/s41467-017-02094-y

Impaired albumin reabsorption by proximal tubular epithelial cells (PTECs) has been highlighted in diabetic nephropathy (DN), but little is known about the underlying molecular mechanisms. Here we find that ORAI1-3, are preferentially expressed in PT... Read More