All Outputs (35)

Molecular mechanisms of trehalose in modulating glucose homeostasis in diabetes (2019)
Journal Article
Yaribeygi, H., Yaribeygi, A., Sathyapalan, T., & Sahebkar, A. (2019). Molecular mechanisms of trehalose in modulating glucose homeostasis in diabetes. Diabetes and Metabolic Syndrome: Clinical Research and Reviews, 13(3), 2214-2218. https://doi.org/10.1016/j.dsx.2019.05.023

Diabetes mellitus is the most prevalent metabolic disorder contributing to significant morbidity and mortality in humans. Many preventative and therapeutic agents have been developed for normalizing glycemic profile in patients with diabetes. In addi... Read More about Molecular mechanisms of trehalose in modulating glucose homeostasis in diabetes.

Bariatric surgery modulates urinary levels of microRNAs involved in the regulation of renal function (2019)
Journal Article
Alkandari, A., Ashrafian, H., Sathyapalan, T., Darzi, A., Holmes, E., Athanasiou, T., Atkin, S. L., & Gooderham, N. J. (2019). Bariatric surgery modulates urinary levels of microRNAs involved in the regulation of renal function. Frontiers in endocrinology, 10(MAY), Article 319. https://doi.org/10.3389/fendo.2019.00319

Background: Obesity and diabetes cause chronic kidney disease with a common pathophysiology that is characterized by the accumulation of collagen in the extracellular matrix. Recent evidence has implicated the epithelial-to-mesenchymal transition (EM... Read More about Bariatric surgery modulates urinary levels of microRNAs involved in the regulation of renal function.

The effects of soy protein and cocoa with or without isoflavones on glycemic control in type 2 diabetes. A double-blind, randomized, placebo-controlled study (2019)
Journal Article
Konya, J., Sathyapalan, T., Kilpatrick, E. S., & Atkin, S. L. (2019). The effects of soy protein and cocoa with or without isoflavones on glycemic control in type 2 diabetes. A double-blind, randomized, placebo-controlled study. Frontiers in endocrinology, 10(MAY), Article 296. https://doi.org/10.3389/fendo.2019.00296

Objective: Soy and cocoa have been suggested to be beneficial for diabetes. The aim of this study was to identify the effects of soy protein, isoflavones, and cocoa on glycemic control parameters.

Research design and methods: The study was a paral... Read More about The effects of soy protein and cocoa with or without isoflavones on glycemic control in type 2 diabetes. A double-blind, randomized, placebo-controlled study.

Lipids and insulin regulate mitochondrial-derived peptide (MOTS-c) in PCOS and healthy subjects (2019)
Journal Article
Ramanjaneya, M., Jerobin, J., Bettahi, I., Bensila, M., Aye, M., Siveen, K. S., Sathyapalan, T., Skarulis, M., Abou‐Samra, A., & Atkin, S. L. (2019). Lipids and insulin regulate mitochondrial-derived peptide (MOTS-c) in PCOS and healthy subjects. Clinical Endocrinology, 91(2), 278-287. https://doi.org/10.1111/cen.14007

Objective: Polycystic ovarian syndrome (PCOS) is a heterogeneous endocrine disorder associated with mitochondrial dysfunction and insulin resistance (IR). MOTS-c, a mitochondrial peptide, promotes insulin sensitivity (IS) through activating AKT and A... Read More about Lipids and insulin regulate mitochondrial-derived peptide (MOTS-c) in PCOS and healthy subjects.

Targeting the balance of T helper cell responses by curcumin in inflammatory and autoimmune states (2019)
Journal Article
Rahimi, K., Ahmadi, A., Hassanzadeh, K., Soleimani, Z., Sathyapalan, T., Mohammadi, A., & Sahebkar, A. (2019). Targeting the balance of T helper cell responses by curcumin in inflammatory and autoimmune states. Autoimmunity Reviews, 18(7), 738-748. https://doi.org/10.1016/j.autrev.2019.05.012

CD4+ T helper (Th) cells are a crucial player in host defense but under certain conditions can contribute to the pathogenesis of inflammatory and autoimmune diseases. Beside the Th1/Th2 subset, several additional Th subsets have been identified, each... Read More about Targeting the balance of T helper cell responses by curcumin in inflammatory and autoimmune states.

Pre-diabetes mellitus newly diagnosed after myocardial infarction adversely affects prognosis in patients without known diabetes (2019)
Journal Article
Chattopadhyay, S., George, A., John, J., & Sathyapalan, T. (2019). Pre-diabetes mellitus newly diagnosed after myocardial infarction adversely affects prognosis in patients without known diabetes. Diabetes and Vascular Disease Research, 16(6), 489-497. https://doi.org/10.1177/1479164119845561

© The Author(s) 2019. Background: Effect of pre-diabetes mellitus on post-myocardial infarction prognosis is unclear. Methods: Retrospective cohort analysis of 1056 myocardial infarction survivors with fasting plasma glucose and 2-h post-load plasma... Read More about Pre-diabetes mellitus newly diagnosed after myocardial infarction adversely affects prognosis in patients without known diabetes.

Effects of curcumin on ion channels and pumps: A review (2019)
Journal Article
Tabeshpour, J., Banaeeyeh, S., Eisvand, F., Sathyapalan, T., Hashemzaei, M., & Sahebkar, A. (2019). Effects of curcumin on ion channels and pumps: A review. IUBMB Life, 71(7), 812-820. https://doi.org/10.1002/iub.2054

Curcumin, an orange‐yellow lipophilic polyphenolic molecule, is the active component of Curcuma longa, which is extensively used as a spice in most of the Asian countries. This natural compound is able to interact with a large number of molecular str... Read More about Effects of curcumin on ion channels and pumps: A review.

The effect of exenatide on cardiovascular risk markers in women with polycystic ovary syndrome (2019)
Journal Article
Dawson, A. J., Sathyapalan, T., Vince, R., Coady, A. M., Ajjan, R. A., Kilpatrick, E. S., & Atkin, S. L. (2019). The effect of exenatide on cardiovascular risk markers in women with polycystic ovary syndrome. Frontiers in endocrinology, 10(APR), Article 189. https://doi.org/10.3389/fendo.2019.00189

Background: Polycystic ovary syndrome (PCOS) is associated with an adverse cardiovascular risk profile including a prothrombotic state. Exenatide has been shown to be effective at improving insulin sensitivity and weight loss in PCOS; therefore this... Read More about The effect of exenatide on cardiovascular risk markers in women with polycystic ovary syndrome.

The effect of soy isoflavones on steroid metabolism (2019)
Journal Article
Swart, A. C., Johannes, I. D., Sathyapalan, T., & Atkin, S. L. (2019). The effect of soy isoflavones on steroid metabolism. Frontiers in endocrinology, 10(APR), Article 229. https://doi.org/10.3389/fendo.2019.00229

Objective: This study is a post-hoc analysis of steroid hormones before and after administration of pharmacological doses of soy isoflavones in a large cohort of men and women from two independent studies. Isoflavones are reported to inhibit mineralo... Read More about The effect of soy isoflavones on steroid metabolism.

Comparison of the neuroprotective effects of aspirin, atorvastatin, captopril and metformin in diabetes mellitus (2019)
Journal Article
Paseban, M., Mohebbati, R., Niazmand, S., Sathyapalan, T., & Sahebkar, A. (2019). Comparison of the neuroprotective effects of aspirin, atorvastatin, captopril and metformin in diabetes mellitus. Biomolecules, 9(4), 118. https://doi.org/10.3390/biom9040118

Objective: The aim of this study was to investigate the effect of combined intake of a high dose of aspirin, atorvastatin, captopril and metformin on oxidative stress in the brain cortex and hippocampus of streptozotocin (STZ)-induced diabetic rats.... Read More about Comparison of the neuroprotective effects of aspirin, atorvastatin, captopril and metformin in diabetes mellitus.

Harnessing CRISPR/Cas9 technology in cardiovascular disease (2019)
Journal Article
Rezaei, H., khadempar, S., Farahani, N., Hosseingholi, E. Z., hayat, S. M. G., Sathyapalan, T., & Sahebkar, A. H. (2020). Harnessing CRISPR/Cas9 technology in cardiovascular disease. Trends in Cardiovascular Medicine, 30(2), 93-101. https://doi.org/10.1016/j.tcm.2019.03.005

The CRISPR/Cas9 system is a precisely targeted bacterial defense system, used to control invading viruses. This technology has many potential applications including genetic changes in somatic and germ cells and the creation of knockout animals. Compa... Read More about Harnessing CRISPR/Cas9 technology in cardiovascular disease.

Effects of empagliflozin on metabolic parameters in polycystic ovary syndrome: a randomized controlled study (2019)
Journal Article
Javed, Z., Papageorgiou, M., Deshmukh, H., Rigby, A. S., Qamar, U., Abbas, J., Khan, A. Y., Kilpatrick, E. S., Atkin, S. L., & Sathyapalan, T. (2019). Effects of empagliflozin on metabolic parameters in polycystic ovary syndrome: a randomized controlled study. Clinical Endocrinology, 90(6), 805-813. https://doi.org/10.1111/cen.13968

Background: Empagliflozin is a sodium-glucose-cotransporter-2 inhibitor that improves cardiovascular risk and promotes weight loss in patients with type 2 diabetes. Polycystic ovary syndrome (PCOS) is associated with obesity and increased cardiovascu... Read More about Effects of empagliflozin on metabolic parameters in polycystic ovary syndrome: a randomized controlled study.

Systematic review and meta-analysis on the effect of soy on thyroid function (2019)
Journal Article
Otun, J., Sahebkar, A., Östlundh, L., Atkin, S. L., & Sathyapalan, T. (2019). Systematic review and meta-analysis on the effect of soy on thyroid function. Scientific reports, 9(1), Article 3964. https://doi.org/10.1038/s41598-019-40647-x

© 2019, The Author(s). Soy foods have had an important dietary role in Asian countries for centuries, and in recent years they have become increasingly popular in Western countries as a result of their suggested health benefits. Nevertheless, there... Read More about Systematic review and meta-analysis on the effect of soy on thyroid function.

Association of vitamin D metabolites with embryo development and fertilization in women with and without PCOS undergoing subfertility treatment (2019)
Journal Article
Cunningham, T. K., Allgar, V., Dargham, S. R., Kilpatrick, E., Sathyapalan, T., Maguiness, S., Mokhtar Rudin, H. R., Abdul Ghani, N. M., Latiff, A., & Atkin, S. L. (2019). Association of vitamin D metabolites with embryo development and fertilization in women with and without PCOS undergoing subfertility treatment. Frontiers in endocrinology, 10(JAN), Article 13. https://doi.org/10.3389/fendo.2019.00013

Objective: The relationship between fertilization rates and 1,25-dihydroxyvitamin D (1,25(OH)2D3), 25-hydroxyvitamin D2 (25(OH)D2), 25-hydroxyvitamin D3 (25(OH)D3), 24,25-dihydroxyvitamin D (24,25(OH)2D3), and 25-hydroxy-3epi-Vitamin D3 (3epi25(OH)D3... Read More about Association of vitamin D metabolites with embryo development and fertilization in women with and without PCOS undergoing subfertility treatment.

A randomized, controlled trial of vitamin D supplementation on cardiovascular risk factors, hormones, and liver markers in women with polycystic ovary syndrome (2019)
Journal Article
Javed, Z., Papageorgiou, M., Deshmukh, H., Kilpatrick, E., Mann, V., Corless, L., Abouda, G., Rigby, A. S., Atkin, S., & Sathyapalan, T. (2019). A randomized, controlled trial of vitamin D supplementation on cardiovascular risk factors, hormones, and liver markers in women with polycystic ovary syndrome. Nutrients, 11(1), 188. https://doi.org/10.3390/nu11010188

© 2019 by the authors. Licensee MDPI, Basel, Switzerland. Polycystic ovary syndrome (PCOS) increases the risk of metabolic syndrome and non-alcoholic-fatty-liver disease (NAFLD). Vitamin D supplementation may exert positive effects on liver biochemis... Read More about A randomized, controlled trial of vitamin D supplementation on cardiovascular risk factors, hormones, and liver markers in women with polycystic ovary syndrome.