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A Cross-Sectional Exploratory Study of Rat Sarcoid (Ras) Activation in Women with and Without Polycystic Ovary Syndrome (2025)
Journal Article
Niinuma, S. A., Habib, H., Takemoto, A. S.-N., Das, P., Sathyapalan, T., Atkin, S. L., & Butler, A. E. (2025). A Cross-Sectional Exploratory Study of Rat Sarcoid (Ras) Activation in Women with and Without Polycystic Ovary Syndrome. Cells, 14(5), Article 377. https://doi.org/10.3390/cells14050377

Objective: Rat sarcoma (Ras) proteins, Kirsten, Harvey, and Neuroblastoma rat sarcoma viral oncogene homolog (KRAS, HRAS, and NRAS, respectively), are a family of GTPases, which are key regulators of cellular growth, differentiation, and apoptosis th... Read More about A Cross-Sectional Exploratory Study of Rat Sarcoid (Ras) Activation in Women with and Without Polycystic Ovary Syndrome.

Predictive performance of noninvasive factors for liver fibrosis in severe obesity: a screening based on machine learning models (2025)
Journal Article
Jamialahmadi, T., Looha, M. A., Jangjoo, S., Emami, N., Abdalla, M. A., Ganjali, M., Salehabadi, S., Karav, S., Sathyapalan, T., Eid, A. H., Jangjoo, A., & Sahebkar, A. (2025). Predictive performance of noninvasive factors for liver fibrosis in severe obesity: a screening based on machine learning models. Journal of Diabetes & Metabolic Disorders, 24(1), Article 54. https://doi.org/10.1007/s40200-025-01564-1

Objectives: Liver fibrosis resulting from nonalcoholic fatty liver disease (NAFLD) and metabolic disorders is highly prevalent in patients with severe obesity and poses a significant health challenge. However, there is a lack of data on the effective... Read More about Predictive performance of noninvasive factors for liver fibrosis in severe obesity: a screening based on machine learning models.

Time Below Range and Its Influence on Hypoglycemia Awareness and Severe Hypoglycemia: Insights From the Association of British Clinical Diabetologists Study (2025)
Journal Article
Deshmukh, H., Wilmot, E. G., Choudhary, P., Ssemmondo, E., Barnes, D., Walker, N., Walton, C., Ryder, R. E., & Sathyapalan, T. (in press). Time Below Range and Its Influence on Hypoglycemia Awareness and Severe Hypoglycemia: Insights From the Association of British Clinical Diabetologists Study. Diabetes Care, https://doi.org/10.2337/dc24-1833

Matrix Metalloproteinases, Tissue Inhibitors of Metalloproteinases, and Their Ratios in Women with Polycystic Ovary Syndrome and Healthy Controls (2025)
Journal Article
Butler, A. E., Nandakumar, M., Sathyapalan, T., Brennan, E., & Atkin, S. L. (2025). Matrix Metalloproteinases, Tissue Inhibitors of Metalloproteinases, and Their Ratios in Women with Polycystic Ovary Syndrome and Healthy Controls. International Journal of Molecular Sciences, 26(1), Article 321. https://doi.org/10.3390/ijms26010321

Matrix metalloproteinases (MMPs) are M2 macrophage markers that are modulated by inflammation. A disintegrin and metalloproteinases (ADAMS) and those with thrombospondin motifs (ADAMTS) regulate the shedding of membrane-bound proteins, growth factors... Read More about Matrix Metalloproteinases, Tissue Inhibitors of Metalloproteinases, and Their Ratios in Women with Polycystic Ovary Syndrome and Healthy Controls.

Cardiovascular Risk Biomarkers in Women with and Without Polycystic Ovary Syndrome (2024)
Journal Article
Nandakumar, M., Das, P., Sathyapalan, T., Butler, A. E., & Atkin, S. L. (2025). Cardiovascular Risk Biomarkers in Women with and Without Polycystic Ovary Syndrome. Biomolecules, 15(1), Article 4. https://doi.org/10.3390/biom15010004

Objective: Polycystic ovary syndrome (PCOS) is a prevalent metabolic disorder with an increased risk for cardiovascular disease (CVD) that is enhanced by obesity. This study sought to determine whether a panel of cardiovascular risk proteins (CVRPs)... Read More about Cardiovascular Risk Biomarkers in Women with and Without Polycystic Ovary Syndrome.

Effect of introduction of intermittently scanned continuous glucose monitoring on glycaemic control in individuals living with type 2 diabetes mellitus treated with non-insulin therapies—A randomised controlled trial (2024)
Journal Article
Ssemmondo, E., Shah, N., Newham, M., Rigby, A., Buckland, R., Deshmukh, H., & Sathyapalan, T. (in press). Effect of introduction of intermittently scanned continuous glucose monitoring on glycaemic control in individuals living with type 2 diabetes mellitus treated with non-insulin therapies—A randomised controlled trial. Diabetes, Obesity and Metabolism, https://doi.org/10.1111/dom.16116

Aims: This pilot randomised controlled trial aimed to evaluate the effect of introducing isCGM on glycaemic control and diabetes distress in individuals with T2DM receiving non-insulin therapies. Materials and Methods: Forty adults with T2DM were ran... Read More about Effect of introduction of intermittently scanned continuous glucose monitoring on glycaemic control in individuals living with type 2 diabetes mellitus treated with non-insulin therapies—A randomised controlled trial.

The variability of measured and calculated low-density lipoprotein (LDL) cholesterol in statin-treated diabetes patients (2024)
Journal Article
Kilpatrick, E. S., Kallner, A., Atkin, S. L., & Sathyapalan, T. (2024). The variability of measured and calculated low-density lipoprotein (LDL) cholesterol in statin-treated diabetes patients. Annals of clinical biochemistry, https://doi.org/10.1177/00045632241305936

Background: The Sampson-NIH and Martin-Hopkins low-density lipoprotein cholesterol (LDL-C) equations are advocated as being superior to the Friedewald calculation. However, their mathematical complexity means they may have different biological and an... Read More about The variability of measured and calculated low-density lipoprotein (LDL) cholesterol in statin-treated diabetes patients.

Time to first remission and survival in patients with acromegaly: Evidence from the UK Acromegaly Register Study (UKAR) (2024)
Journal Article
Deshmukh, H., Ssemmondo, E., Adeleke, K., Mongolu, S., Aye, M., Orme, S., Flanagan, D., Abraham, P., Higham, C., & Sathyapalan, T. (2024). Time to first remission and survival in patients with acromegaly: Evidence from the UK Acromegaly Register Study (UKAR). Clinical Endocrinology, 101(3), 274-281. https://doi.org/10.1111/cen.15112

Objective: This study aimed to understand the effect of time to remission of acromegaly on survival in people living with acromegaly. Design, Patients and Measurement: This cross-sectional study used data from the UK Acromegaly Register. We considere... Read More about Time to first remission and survival in patients with acromegaly: Evidence from the UK Acromegaly Register Study (UKAR).

Baseline Clinical Factors Associated with Cessation of Growth Hormone Therapy in Patients with Severe Growth Hormone Deficiency-Real World Evidence (2024)
Journal Article
Nadarajah, N., Ssemmondo, E., Brooks, S., Akinyombo, R., Adeleke, K., Deshmukh, H., & Sathyapalan, T. (2024). Baseline Clinical Factors Associated with Cessation of Growth Hormone Therapy in Patients with Severe Growth Hormone Deficiency-Real World Evidence. International Journal of Endocrinology and Metabolism, 22(3), Article e147825. https://doi.org/10.5812/ijem-147825

Background: Growth hormone replacement is indicated in adults with severe growth hormone (GH) deficiency, adult growth hormone deficiency assessment (AGHDA) score of at least 11 and are receiving treatment for other pituitary hormone deficiencies. Th... Read More about Baseline Clinical Factors Associated with Cessation of Growth Hormone Therapy in Patients with Severe Growth Hormone Deficiency-Real World Evidence.

A Cross-Sectional Exploratory Study of Cardiovascular Risk Biomarkers in Non-Obese Women with and without Polycystic Ovary Syndrome: Association with Vitamin D (2024)
Journal Article
Nandakumar, M., Das, P., Sathyapalan, T., Butler, A. E., & Atkin, S. L. (2024). A Cross-Sectional Exploratory Study of Cardiovascular Risk Biomarkers in Non-Obese Women with and without Polycystic Ovary Syndrome: Association with Vitamin D. International Journal of Molecular Sciences, 25(12), Article 6330. https://doi.org/10.3390/ijms25126330

Vitamin D is proposed to have a protective effect against cardiovascular disease, though the mechanism is unclear. Vitamin D deficiency is common in polycystic ovary syndrome (PCOS), where it is strongly related to obesity, insulin resistance (IR) an... Read More about A Cross-Sectional Exploratory Study of Cardiovascular Risk Biomarkers in Non-Obese Women with and without Polycystic Ovary Syndrome: Association with Vitamin D.

Association of Vitamin D with Perfluorinated Alkyl Acids in Women with and without Non-Obese Polycystic Ovary Syndrome (2024)
Journal Article
Butler, A. E., Sathyapalan, T., Das, P., Brennan, E., & Atkin, S. L. (2024). Association of Vitamin D with Perfluorinated Alkyl Acids in Women with and without Non-Obese Polycystic Ovary Syndrome. Biomedicines, 12(6), Article 1255. https://doi.org/10.3390/biomedicines12061255

Background. Perfluorinated alkyl acids (PFAAs) are persistent organic pollutants affected by BMI and ethnicity, with contradictory reports of association with vitamin D deficiency. Methods. Twenty-nine Caucasian women with non-obese polycystic ovary... Read More about Association of Vitamin D with Perfluorinated Alkyl Acids in Women with and without Non-Obese Polycystic Ovary Syndrome.

Effect of Hypoglycemia and Rebound Hyperglycemia on Proteomic Cardiovascular Risk Biomarkers (2024)
Journal Article
Nandakumar, M., Sathyapalan, T., Atkin, S. L., & Butler, A. E. (2024). Effect of Hypoglycemia and Rebound Hyperglycemia on Proteomic Cardiovascular Risk Biomarkers. Biomedicines, 12(6), Article 1137. https://doi.org/10.3390/biomedicines12061137

Introduction: Hypoglycemia has been associated with cardiovascular events, and glucose variability has been suggested to be associated with increased cardiovascular risk. Therefore, in this study, we examined the effect on proteomic cardiovascular ri... Read More about Effect of Hypoglycemia and Rebound Hyperglycemia on Proteomic Cardiovascular Risk Biomarkers.

A Cross-Sectional Study of Glomerular Hyperfiltration in Polycystic Ovary Syndrome (2024)
Journal Article
Butler, A. E., Lubbad, W., Akbar, S., Kilpatrick, E. S., Sathyapalan, T., & Atkin, S. L. (2024). A Cross-Sectional Study of Glomerular Hyperfiltration in Polycystic Ovary Syndrome. International Journal of Molecular Sciences, 25(9), Article 4899. https://doi.org/10.3390/ijms25094899

Glomerular hyperfiltration (GH) has been reported to be higher in women with polycystic ovary syndrome (PCOS) and is an independent risk factor for renal function deterioration, metabolic, and cardiovascular disease. The aim of this study was to dete... Read More about A Cross-Sectional Study of Glomerular Hyperfiltration in Polycystic Ovary Syndrome.

The Effect of Thiazolidinediones in Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis of Randomised Controlled Trials (2024)
Journal Article
Abdalla, M. A., Shah, N., Deshmukh, H., Sahebkar, A., Östlundh, L., Al-Rifai, R. H., Atkin, S. L., & Sathyapalan, T. (2024). The Effect of Thiazolidinediones in Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis of Randomised Controlled Trials. Advances in Therapy, 41, 2168-2195. https://doi.org/10.1007/s12325-024-02848-3

Introduction: Polycystic ovary syndrome (PCOS) is a complex endocrine condition affecting women of reproductive age. It is characterised by insulin resistance and is a risk for type 2 diabetes mellitus (T2DM). The aim of this study was to review the... Read More about The Effect of Thiazolidinediones in Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis of Randomised Controlled Trials.

A Cross-Sectional Study of Protein Changes Associated with Dementia in Non-Obese Weight Matched Women with and without Polycystic Ovary Syndrome (2024)
Journal Article
Butler, A. E., Moin, A. S. M., Sathyapalan, T., & Atkin, S. L. (2024). A Cross-Sectional Study of Protein Changes Associated with Dementia in Non-Obese Weight Matched Women with and without Polycystic Ovary Syndrome. International Journal of Molecular Sciences, 25(4), Article 2409. https://doi.org/10.3390/ijms25042409

Dysregulated Alzheimer’s disease (AD)-associated protein expression is reported in polycystic ovary syndrome (PCOS), paralleling the expression reported in type 2 diabetes (T2D). We hypothesized, however, that these proteins would not differ between... Read More about A Cross-Sectional Study of Protein Changes Associated with Dementia in Non-Obese Weight Matched Women with and without Polycystic Ovary Syndrome.

Effect of intermittently scanned continuous glucose monitoring in people with diabetes with a psychosocial indication for initiation (2024)
Journal Article
Ssemmondo, E., Deshmukh, H., Wilmot, E. G., Adeleke, K. A., Shah, N., Walton, C., Barnes, D., Ryder, R. E., & Sathyapalan, T. (2024). Effect of intermittently scanned continuous glucose monitoring in people with diabetes with a psychosocial indication for initiation. Diabetes, Obesity and Metabolism, 26(4), 1340-1345. https://doi.org/10.1111/dom.15435

Aim: To understand the effect of intermittently scanned continuous glucose monitoring (isCGM) in people with diabetes with a ‘psychosocial’ indication for access. Methods: The study utilized baseline and follow-up data from the Association of British... Read More about Effect of intermittently scanned continuous glucose monitoring in people with diabetes with a psychosocial indication for initiation.

A Cross-Sectional Study of Alzheimer-Related Proteins in Women with Polycystic Ovary Syndrome (2024)
Journal Article
Butler, A. E., Moin, A. S. M., Sathyapalan, T., & Atkin, S. L. (2024). A Cross-Sectional Study of Alzheimer-Related Proteins in Women with Polycystic Ovary Syndrome. International Journal of Molecular Sciences, 25(2), Article 1158. https://doi.org/10.3390/ijms25021158

Polycystic ovary syndrome (PCOS) is the most common endocrine condition in women of reproductive age, and several risk factors found in PCOS are associated with an increased risk of Alzheimer's disease (AD). Proteins increased in AD have been reporte... Read More about A Cross-Sectional Study of Alzheimer-Related Proteins in Women with Polycystic Ovary Syndrome.

Clinical features of type 1 diabetes in older adults and the impact of intermittently scanned continuous glucose monitoring: An Association of British Clinical Diabetologists (ABCD) study (2024)
Journal Article
Deshmukh, H., Adeleke, K., Wilmot, E. G., Folwell, A., Barnes, D., Walker, N., Saunders, S., Ssemmondo, E., Walton, C., Patmore, J., Ryder, R. E., & Sathyapalan, T. (2024). Clinical features of type 1 diabetes in older adults and the impact of intermittently scanned continuous glucose monitoring: An Association of British Clinical Diabetologists (ABCD) study. Diabetes, Obesity and Metabolism, 26(4), 1333-1339. https://doi.org/10.1111/dom.15434

Aims: To evaluate the clinical features and impact of flash glucose monitoring in older adults with type 1 diabetes (T1D) across age groups defined as young-old, middle-old, and old-old. Materials and Methods: Clinicians were invited to submit anonym... Read More about Clinical features of type 1 diabetes in older adults and the impact of intermittently scanned continuous glucose monitoring: An Association of British Clinical Diabetologists (ABCD) study.

Advancements in the management of obesity: a review of current evidence and emerging therapies (2024)
Journal Article
Abdalla Ahmed, M. A., Ssemmondo, E., Mark-Wagstaff, C., & Sathyapalan, T. (2024). Advancements in the management of obesity: a review of current evidence and emerging therapies. Expert Review of Endocrinology and Metabolism, 19(3), 257-268. https://doi.org/10.1080/17446651.2024.2347258

Introduction: Obesity is the modern world’s current epidemic, with substantial health and economic impact. This study aimed to provide a narrative overview of the past, currently available, and future treatment options that offer therapeutic and prev... Read More about Advancements in the management of obesity: a review of current evidence and emerging therapies.