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New targets for therapy: antigen identification in adults with B-cell acute lymphoblastic leukaemia (2020)
Journal Article
Jordaens, S., Cooksey, L., Freire Boullosa, L., Van Tendeloo, V., Smits, E., Mills, K. I., …Guinn, B. (in press). New targets for therapy: antigen identification in adults with B-cell acute lymphoblastic leukaemia. Cancer Immunology, Immunotherapy, https://doi.org/10.1007/s00262-020-02484-0

Acute lymphoblastic leukaemia (ALL) in adults is a rare and difficult-to-treat cancer that is characterised by excess lymphoblasts in the bone marrow. Although many patients achieve remission with chemotherapy, relapse rates are high and the associat... Read More about New targets for therapy: antigen identification in adults with B-cell acute lymphoblastic leukaemia.

Spill-in counts in the quantification of 18F-florbetapir on Aβ-negative subjects: the effect of including white matter in the reference region (2019)
Journal Article
López-González, F. J., Moscoso, A., Efthimiou, N., Fernández-Ferreiro, A., Piñeiro-Fiel, M., Archibald, S. J., …Silva-Rodríguez, J. (2019). Spill-in counts in the quantification of 18F-florbetapir on Aβ-negative subjects: the effect of including white matter in the reference region. EJNMMI Physics, 6, https://doi.org/10.1186/s40658-019-0258-7

© 2019, The Author(s). Background: We aim to provide a systematic study of the impact of white matter (WM) spill-in on the calculation of standardized uptake value ratios (SUVRs) on Aβ-negative subjects, and we study the effect of including WM in... Read More about Spill-in counts in the quantification of 18F-florbetapir on Aβ-negative subjects: the effect of including white matter in the reference region.

Sero-profiling identifies ibrutinib as a treatment option for young adults with B-cell acute lymphoblastic leukaemia (2019)
Journal Article
Guinn, B., Jordaens, S., Cooksey, L., Coutinho, M., Van Tendeloo, V., Mills, K., & Orchard, K. (in press). Sero-profiling identifies ibrutinib as a treatment option for young adults with B-cell acute lymphoblastic leukaemia. British journal of haematology,

Acute lymphoblastic leukaemia (ALL) is a haematological malignancy that is characterized by the uncontrolled proliferation of immature lymphocytes. 80 % of cases occur in children where ALL is well understood and treated. However it has a devastating... Read More about Sero-profiling identifies ibrutinib as a treatment option for young adults with B-cell acute lymphoblastic leukaemia.

Retrospective Medical Record Research: Reflections of A Unsponsored Researcher (2019)
Journal Article
Bature, F., Guinn, B., Vseteckova, J., Pang, D., & Pappas, Y. (2019). Retrospective Medical Record Research: Reflections of A Unsponsored Researcher. Biomedical Journal of Scientific & Technical Research, 21(4), 16080-16086. https://doi.org/10.26717/BJSTR.2019.21.003642

This article is a reflective narrative by the author following the successful completion of a doctoral thesis involving the analysis of primary care data. The aim of the study was to identify patterns in signs and symptoms preceding a clinical diagno... Read More about Retrospective Medical Record Research: Reflections of A Unsponsored Researcher.

The effect of radioiodine treatment on the diseased thyroid gland (2019)
Journal Article
Riley, A. S., McKenzie, G. A. G., Green, V., Schettino, G., England, R. J. A., & Greenman, J. (in press). The effect of radioiodine treatment on the diseased thyroid gland. International Journal of Radiation Biology, 1-10. https://doi.org/10.1080/09553002.2019.1665206

Purpose: Radioiodine (I131) therapy is the treatment mainstay for several benign and malignant thyroid disorders, however I131 is known to cause DNA damage and liberation of thyroidal self-antigens inducing secondary immunoreactivity. The exact mecha... Read More about The effect of radioiodine treatment on the diseased thyroid gland.

Identification of survivin as a promising target for the immunotherapy of adult B-cell acute lymphoblastic leukemia (2017)
Journal Article
Freire Boullosa, L., Savaliya, P., Bonney, S., Orchard, L., Wickenden, H., Lee, C., …Guinn, B. (2017). Identification of survivin as a promising target for the immunotherapy of adult B-cell acute lymphoblastic leukemia. BMC research notes, 9, 3853-3866. https://doi.org/10.18632/oncotarget.23380

B-cell acute lymphoblastic leukemia (B-ALL) is a rare heterogeneous disease characterized by a block in lymphoid differentiation and a rapid clonal expansion of immature, non-functioning B cells. Adult B-ALL patients have a poor prognosis with less t... Read More about Identification of survivin as a promising target for the immunotherapy of adult B-cell acute lymphoblastic leukemia.

Signs and symptoms preceding the diagnosis of Alzheimer's disease: a systematic scoping review of literature from 1937 to 2016 (2017)
Journal Article
Bature, F., Guinn, B., Pang, D., & Pappas, Y. (2017). Signs and symptoms preceding the diagnosis of Alzheimer's disease: a systematic scoping review of literature from 1937 to 2016. BMJ open, 7(8), https://doi.org/10.1136/bmjopen-2016-015746

OBJECTIVE: Late diagnosis of Alzheimer's disease (AD) may be due to diagnostic uncertainties. We aimed to determine the sequence and timing of the appearance of established early signs and symptoms in people who are subsequently diagnosed with AD.... Read More about Signs and symptoms preceding the diagnosis of Alzheimer's disease: a systematic scoping review of literature from 1937 to 2016.

Effect of Rocket (Eruca sativa) Extract on MRSA Growth and Proteome: Metabolic Adjustments in Plant-Based Media (2017)
Journal Article
Doulgeraki, A. I., Efthimiou, G., Paramithiotis, S., Pappas, K. M., Typas, M. A., & Nychas, G. (2017). Effect of Rocket (Eruca sativa) Extract on MRSA Growth and Proteome: Metabolic Adjustments in Plant-Based Media. Frontiers in Microbiology, 8, https://doi.org/10.3389/fmicb.2017.00782

The emergence of methicillin-resistant Staphylococcus aureus (MRSA) in food has provoked a great concern about the presence of MRSA in associated foodstuff. Although MRSA is often detected in various retailed meat products, it seems that food handler... Read More about Effect of Rocket (Eruca sativa) Extract on MRSA Growth and Proteome: Metabolic Adjustments in Plant-Based Media.

Exposure to acute hypoxia induces a transient DNA damage response which includes Chk1 and TLK1 (2010)
Journal Article
Hammond, E., & Monteiro dos Santos Pires, I. (2010). Exposure to acute hypoxia induces a transient DNA damage response which includes Chk1 and TLK1. Cell cycle, 9(13), 2502 - 2507. https://doi.org/10.4161/cc.9.13.12059

Severe hypoxia has been demonstrated to induce a replication arrest which is associated with decreased levels of nucleotides. Chk1 is rapidly phosphorylated in response to severe hypoxia and in turn deactivates TLK1 through phosphorylation. Loss of C... Read More about Exposure to acute hypoxia induces a transient DNA damage response which includes Chk1 and TLK1.