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Clinical and prognostic association of total atrial and conduction time in patients with heart failure: a report from Studies Investigating Co-morbidities Aggravating Heart Failure (2019)
Journal Article
Nuzzi, V., Pellicori, P., Nikolaidou, T., Kallvikbacka-Bennett, A., Torromeo, C., Barilla, F., …Clark, A. (2019). Clinical and prognostic association of total atrial and conduction time in patients with heart failure: a report from Studies Investigating Co-morbidities Aggravating Heart Failure. European journal of heart failure, 20(7), 442–449. https://doi.org/10.2459/JCM.0000000000000802

Background The total atrial conduction time can be measured as the time from the onset of the P wave on the ECG to the peak of the A wave recorded at the mitral annulus using tissue Doppler imaging (A′; P-A′TDI); when prolonged, it might predict inci... Read More

Characteristics and outcome of acute heart failure patients according to the severity of peripheral oedema (2019)
Journal Article
Shoaib, A., Mamas, M. A., Ahmad, Q. S., McDonagh, T. M., Hardman, S. M., Rashid, M., …Cleland, J. G. F. (2019). Characteristics and outcome of acute heart failure patients according to the severity of peripheral oedema. International journal of cardiology, 285, 40-46. https://doi.org/10.1016/j.ijcard.2019.03.020

Background Most trials of patients hospitalized for heart failure focus on breathlessness (alveolar pulmonary oedema) but worsening peripheral oedema is also an important presentation. We investigated the relationship between the severity of periphe... Read More

Prevalence, pattern and clinical relevance of ultrasound indices of congestion in outpatients with heart failure (2019)
Journal Article
Pellicori, P., Shah, P., Cuthbert, J., Urbinati, A., Zhang, J., Kallvikbacka-Bennett, A., …Cleland, J. G. F. (in press). Prevalence, pattern and clinical relevance of ultrasound indices of congestion in outpatients with heart failure. European journal of heart failure, https://doi.org/10.1002/ejhf.1383

Aims Even if treatment controls symptoms, patients with heart failure may still be congested. We aimed at assessing the prevalence and clinical relevance of congestion in outpatients with chronic heart failure. Methods and results We recorded cl... Read More

Are there patients missing from community heart failure registers? An audit of clinical practice (2018)
Journal Article
Cuthbert, J. J., Gopal, J., Crundall-Goode, A., & Clark, A. L. (2019). Are there patients missing from community heart failure registers? An audit of clinical practice. European Journal of Preventive Cardiology, 26(3), 204748731881083. https://doi.org/10.1177/2047487318810839

Background General practitioners in the UK are financially incentivised, via the Quality Outcomes Framework, to maintain a record of all patients at their practice with heart failure and manage them appropriately. The prevalence of heart failure rec... Read More

Mode of presentation and mortality amongst patients hospitalized with heart failure? A report from the First Euro Heart Failure Survey (2018)
Journal Article
Shoaib, A., Farag, M., Nolan, J., Rigby, A., Patwala, A., Rashid, M., …Cleland, J. G. (2019). Mode of presentation and mortality amongst patients hospitalized with heart failure? A report from the First Euro Heart Failure Survey. Clinical Research in Cardiology, 108(5), 510-519. https://doi.org/10.1007/s00392-018-1380-6

© 2018, The Author(s). Background: Heart failure is heterogeneous in aetiology, pathophysiology, and presentation. Despite this diversity, clinical trials of patients hospitalized for HF deal with this problem as a single entity, which may be one rea... Read More

Warm water immersion in patients with chronic heart failure: a pilot study: Shah immerse: HF (2018)
Journal Article
Shah, P., Pellicori, P., Kallvikbacka-Bennett, A., Zhang, J., Pan, D., & Clark, A. L. (2019). Warm water immersion in patients with chronic heart failure: a pilot study: Shah immerse: HF. Clinical Research in Cardiology, 108(5), 468–476. https://doi.org/10.1007/s00392-018-1376-2

Background Patients with chronic conditions, such as heart failure, swim regularly and most rehabilitation exercises are conducted in warm hydrotherapy pools. However, little is known about the acute effects of warm water immersion (WWI) on cardiac... Read More

Estimated peak functional capacity: an accurate method for assessing change in peak oxygen consumption after cardiac rehabilitation? (2017)
Journal Article
Nichols, S., Gleadall-Siddall, D. O., Antony, R., Clark, A. L., Cleland, J. G. F., Carroll, S., & Ingle, L. (2018). Estimated peak functional capacity: an accurate method for assessing change in peak oxygen consumption after cardiac rehabilitation?. Clinical physiology and functional imaging, 38(4), 681-688. https://doi.org/10.1111/cpf.12468

Summary Objective Cardiopulmonary exercise testing (CPET) is the ‘gold standard’ method of determining VO2peak. When CPET is unavailable, VO2peak may be estimated from treadmill or cycle ergometer workloads and expressed as estimated metabolic equiva... Read More

Influence of case definition on incidence and outcome of acute coronary syndromes (2016)
Journal Article
Torabi, A., Cleland, J. G. F., Sherwi, N., Atkin, P., Panahi, H., Kilpatrick, E., …Rigby, A. (2016). Influence of case definition on incidence and outcome of acute coronary syndromes. Open heart, 3(2), e000487. https://doi.org/10.1136/openhrt-2016-000487

© 2016, BMJ Publishing Group. All rights reserved. Objective: Acute coronary syndromes (ACS) are common, but their incidence and outcome might depend greatly on how data are collected. We compared case ascertainment rates for ACS and myocardial infar... Read More

Microvascular dysfunction in the immediate aftermath of chronic total coronary occlusion recanalization (2016)
Journal Article
Ladwiniec, A., Cunnington, M. S., Rossington, J., Thackray, S., Alamgir, F., & Hoye, A. (2016). Microvascular dysfunction in the immediate aftermath of chronic total coronary occlusion recanalization. Catheterization and Cardiovascular Interventions, 87(6), 1071-1079. https://doi.org/10.1002/ccd.26392

Objectives The aim of this study was to compare microvascular resistance under both baseline and hyperemic conditions immediately after percutaneous coronary intervention (PCI) of a chronic total occlusion (CTO) with an unobstructed reference vessel... Read More

Medical therapy, percutaneous coronary intervention and prognosis in patients with chronic total occlusions (2015)
Journal Article
Ladwiniec, A., Allgar, V., Thackray, S., Alamgir, F., & Hoye, A. (2015). Medical therapy, percutaneous coronary intervention and prognosis in patients with chronic total occlusions. Heart, 101(23), 1907-1914. https://doi.org/10.1136/heartjnl-2015-308181

Objective There is little published data reporting outcomes for those found to have a chronic total coronary occlusion (CTO) that is electively treated medically versus those treated by percutaneous coronary intervention (PCI). We sought to compare l... Read More

Aspartame sensitivity? : a double blind randomised crossover study (2015)
Journal Article
Sathyapalan, T., Thatcher, N. J., Hammersley, R., Rigby, A. S., Pechlivanis, A., Gooderham, N. J., …Courts, F. (2015). Aspartame sensitivity? : a double blind randomised crossover study. PloS one, 10(3), e0116212. doi:10.1371/journal.pone.0116212

Background Aspartame is a commonly used intense artificial sweetener, being approximately 200 times sweeter than sucrose. There have been concerns over aspartame since approval in the 1980s including a large anecdotal database reporting severe sympto... Read More

Interplay between right ventricular function and cardiac resynchronization therapy : an analysis of the CARE-HF trial (cardiac resynchronization–heart failure) (2013)
Journal Article
Damy, T., Ghio, S., Rigby, A. S., Hittinger, L., Jacobs, S., Leyva, F., …Cleland, J. G. (2013). Interplay between right ventricular function and cardiac resynchronization therapy : an analysis of the CARE-HF trial (cardiac resynchronization–heart failure). Journal of the American College of Cardiology, 61(21), 2153-2160. https://doi.org/10.1016/j.jacc.2013.02.049

Objectives: The aim of this study was to investigate the impact of cardiac resynchronization therapy (CRT) on right ventricular (RV) function and the influence of RV dysfunction on the echocardiographic and clinical response to CRT among patients enr... Read More

Influence of step length on 6-minute walk test performance in patients with chronic heart failure (2011)
Journal Article
Pepera, G. K., Sandercock, G. R., Sloan, R., Cleland, J. J., Ingle, L., & Clark, A. L. (2012). Influence of step length on 6-minute walk test performance in patients with chronic heart failure. Physiotherapy, 98(4), 325-329. https://doi.org/10.1016/j.physio.2011.08.005

Objective: To investigate the influence of gait parameters including step length and walking speed during performance of the 6-minute walking test (6MWT) in patients with chronic heart failure (CHF). Design: Observational study. Setting: Specialist h... Read More

Prognostic significance of different measures of the ventilation-carbon dioxide relation in patients with suspected heart failure (2011)
Journal Article
Ingle, L., Sloan, R., Carroll, S., Goode, K., Cleland, J. G., & Clark, A. L. (2011). Prognostic significance of different measures of the ventilation-carbon dioxide relation in patients with suspected heart failure. European journal of heart failure, 13(5), 537-542. https://doi.org/10.1093/eurjhf/hfq238

Aims We studied the prognostic significance of the ventilatory equivalent of carbon dioxide production (VEqCO 2 ) at different time-points of a maximal cardiopulmonary exercise test (CPET) in patients with suspected heart failure (HF). Methods and... Read More

Experiences of air travel in patients with chronic heart failure (2011)
Journal Article
Ingle, L., Hobkirk, J., Damy, T., Nabb, S., Clark, A. L., & Cleland, J. G. (2012). Experiences of air travel in patients with chronic heart failure. International journal of cardiology, 158(1), (66-70). doi:10.1016/j.ijcard.2010.12.101. ISSN 0167-5273

AIM: To conduct a survey in a representative cohort of ambulatory patients with stable, well managed chronic heart failure (CHF) to discover their experiences of air travel. METHODS: An expert panel including a cardiologist, an exercise scientist, an... Read More

Impact of different diagnostic criteria on the prevalence and prognostic significance of exertional oscillatory ventilation in patients with chronic heart failure (2009)
Journal Article
Ingle, L., Isted, A., Witte, K. K., Cleland, J. G., & Clark, A. L. (2009). Impact of different diagnostic criteria on the prevalence and prognostic significance of exertional oscillatory ventilation in patients with chronic heart failure. European journal of cardiovascular prevention and rehabilitation, 16(4), 451-456. https://doi.org/10.1097/HJR.0b013e32832a4f54

INTRODUCTION: Exertional oscillatory ventilation (EOV) occurs in many patients with chronic heart failure. Two different definitions of EOV have been proposed by Corrá and Leite. We aimed to compare the prevalence of EOV and its prognostic significan... Read More

Prolonged Electrical Muscle Stimulation Exercise Improves Strength, Peak VO2, and Exercise Capacity in Patients With Stable Chronic Heart Failure (2009)
Journal Article
Banerjee, P., Caulfield, B., Crowe, L., & Clark, A. L. (2009). Prolonged Electrical Muscle Stimulation Exercise Improves Strength, Peak VO2, and Exercise Capacity in Patients With Stable Chronic Heart Failure. Journal of cardiac failure, 15(4), (319-326). doi:10.1016/j.cardfail.2008.11.005. ISSN 1071-9164

Background: Exercise training can help patients with chronic heart failure but may be limited in its applicability due to age and other comorbidities. This investigation evaluated training responses to prolonged electrical muscle stimulation (EMS) in... Read More

The prognostic value of individual NT-proBNP values in chronic heart failure does not change with advancing age (2009)
Journal Article
Frankenstein, L., Clark, A. L., Goode, K., Ingle, L., Remppis, A., Schellberg, D., …Zugck, C. (2009). The prognostic value of individual NT-proBNP values in chronic heart failure does not change with advancing age. Heart, 95(10), 825-829. https://doi.org/10.1136/hrt.2008.158626

Background: It is unclear whether age-related increases in N-terminal pro-brain natriuretic peptide (NT-proBNP) represent a normal physiological process - possibly affecting the prognostic power - of NT-proBNP - or reflect age-related subclinical pat... Read More

Perception of symptoms is out of proportion to cardiac pathology in patients with "diastolic heart failure" (2008)
Journal Article
Ingle, L., Cleland, J. G., & Clark, A. L. (2008). Perception of symptoms is out of proportion to cardiac pathology in patients with "diastolic heart failure". Heart, 94(6), 748-753. https://doi.org/10.1136/hrt.2007.131144

Background: Epidemiological studies suggest that "diastolic heart failure" (DHF) is common and has a prognosis similar to that of systolic heart failure (SHF). We wanted to assess whether patients with breathlessness who were being treated for DHF ha... Read More