All Outputs (21)

Expert opinion on the cough hypersensitivity syndrome in respiratory medicine (2014)
Journal Article
Morice, A. H., Millqvist, E., Belvisi, M. G., Bieksiene, K., Birring, S. S., Chung, K. F., …Smith, J. A. (2014). Expert opinion on the cough hypersensitivity syndrome in respiratory medicine. European respiratory journal, 44(5), 1132-1148. https://doi.org/10.1183/09031936.00218613

© ERS 2014. In 2011, a European Respiratory Society Task Force embarked on a process to determine the position and clinical relevance of the cough hypersensitivity syndrome, a disorder characterised by troublesome coughing often triggered by low leve... Read More about Expert opinion on the cough hypersensitivity syndrome in respiratory medicine.

Increased platelet reactivity in idiopathic pulmonary fibrosis is mediated by a plasma factor (2014)
Journal Article
Crooks, M. G., Fahim, A., Naseem, K. M., Morice, A. H., & Hart, S. P. (2014). Increased platelet reactivity in idiopathic pulmonary fibrosis is mediated by a plasma factor. PLoS ONE, 9(10), Article ARTN e111347. https://doi.org/10.1371/journal.pone.0111347

Introduction Idiopathic Pulmonary Fibrosis (IPF) is a progressive, incurable fibrotic interstitial lung disease with a prognosis worse than many cancers. Its pathogenesis is poorly understood. Activated platelets can release pro-fibrotic mediators th... Read More about Increased platelet reactivity in idiopathic pulmonary fibrosis is mediated by a plasma factor.

The FINISH-3 trial: A phase 3, international, randomized, single-blind, controlled trial of topical fibrocaps in intraoperative surgical hemostasis (2014)
Journal Article
Bochicchio, G. V., Gupta, N., Porte, R. J., Renkens, K. L., Pattyn, P., Topal, B., …Frohna, P. A. (2015). The FINISH-3 trial: A phase 3, international, randomized, single-blind, controlled trial of topical fibrocaps in intraoperative surgical hemostasis. Journal of The American College of Surgeons, 220(1), 70-81. https://doi.org/10.1016/j.jamcollsurg.2014.09.019

Background This Phase 3, international, randomized, single-blind, controlled trial (FINISH-3) compared the efficacy and safety of Fibrocaps, a ready-to-use, dry-powder fibrin sealant containing human plasma-derived thrombin and fibrinogen, vs gelatin... Read More about The FINISH-3 trial: A phase 3, international, randomized, single-blind, controlled trial of topical fibrocaps in intraoperative surgical hemostasis.

A randomized trial comparing treatments for varicose veins. (2014)
Journal Article
Brittenden, J., Cotton, S. C., Elders, A., Ramsay, C. R., Norrie, J., Burr, J., …Campbell, M. K. (2014). A randomized trial comparing treatments for varicose veins. New England Journal of Medicine, 371, 1218-1227. https://doi.org/10.1056/NEJMoa1400781

BACKGROUND Ultrasound-guided foam sclerotherapy and endovenous laser ablation are widely used alternatives to surgery for the treatment of varicose veins, but their comparative effectiveness and safety remain uncertain. METHODS In a randomized t... Read More about A randomized trial comparing treatments for varicose veins..

Worldwide survey of chronic cough: A manifestation of enhanced somatosensory response (2014)
Journal Article
Morice, A. H., Jakes, A. D., Faruqi, S., Birring, S. S., Mcgarvey, L., Canning, B., …Dicpinigaitis, P. (2014). Worldwide survey of chronic cough: A manifestation of enhanced somatosensory response. European respiratory journal, 44(5), 1149-1155. https://doi.org/10.1183/09031936.00217813

© ERS 2014. Reports from individual centres suggest a preponderance of females with chronic cough. Females also have heightened cough reflex sensitivity. Here we have reviewed the age and sex of unselected referrals to 11 cough clinics. To investigat... Read More about Worldwide survey of chronic cough: A manifestation of enhanced somatosensory response.

A comparison of the effectiveness of treating those with and without the complications of superficial venous insufficiency (2014)
Journal Article
Carradice, D., Wallace, T., Gohil, R., & Chetter, I. (2014). A comparison of the effectiveness of treating those with and without the complications of superficial venous insufficiency. Annals of Surgery, 260(2), 396-401. https://doi.org/10.1097/sla.0000000000000541

Objective: To test the hypothesis that patients with soft tissue changes related to superficial venous insufficiency (SVI) have greater benefits from treatment than those with only symptomatic varicose veins. Background: A commonly held view is that... Read More about A comparison of the effectiveness of treating those with and without the complications of superficial venous insufficiency.

Is opiate action in cough due to sedation? (2014)
Journal Article
Dickinson, R. S., Morjaria, J. B., Wright, C. E., & Morice, A. H. (2014). Is opiate action in cough due to sedation?. Therapeutic Advances in Chronic Disease, 5(5), 200-205. https://doi.org/10.1177/2040622314543220

Opiates have been used for cough suppression for centuries. It is unclear whether this antitussive action is due to their known sedative effects. We aimed to assess correlation between cough suppression and opiate usage. Methods: We performed a post... Read More about Is opiate action in cough due to sedation?.

Clinical response to primary letrozole therapy in elderly patients with early breast cancer : possible role for p53 as a biomarker (2014)
Journal Article
Garimella, V., Hussain, T., Agarwal, V., Radhakrishna, S., Fox, J. N., Kneeshaw, P. J., …Cawkwell, L. (2014). Clinical response to primary letrozole therapy in elderly patients with early breast cancer : possible role for p53 as a biomarker. International journal of surgery, 12(8), 821-826. https://doi.org/10.1016/j.ijsu.2014.06.009

Primary tamoxifen therapy has been widely used to treat elderly women with ER-positive breast cancer in the past. Aromatase inhibitors may be more beneficial than tamoxifen when used as primary endocrine therapy in elderly patients. We aimed to retro... Read More about Clinical response to primary letrozole therapy in elderly patients with early breast cancer : possible role for p53 as a biomarker.

A randomized placebo controlled trial to evaluate the effects of butamirate and dextromethorphan on capsaicin induced cough in healthy volunteers (2014)
Journal Article
Faruqi, S., Wright, C., Thompson, R., & Morice, A. H. (2014). A randomized placebo controlled trial to evaluate the effects of butamirate and dextromethorphan on capsaicin induced cough in healthy volunteers. British Journal of Clinical Pharmacology, 78(6), 1272-1280. https://doi.org/10.1111/bcp.12458

AIMS The examination of cough reflex sensitivity through inhalational challenge can be utilized to demonstrate pharmacological end points. Here we compare the effect of butamirate, dextromethorphan and placebo on capsaicin-induced cough in healthy vo... Read More about A randomized placebo controlled trial to evaluate the effects of butamirate and dextromethorphan on capsaicin induced cough in healthy volunteers.

Human TRPM8 and TRPA1 pain channels, including a gene variant with increased sensitivity to agonists (TRPA1 R797T), exhibit differential regulation by SRC-tyrosine kinase inhibitor (2014)
Journal Article
Morgan, K., Sadofsky, L. R., Crow, C., & Morice, A. H. (2014). Human TRPM8 and TRPA1 pain channels, including a gene variant with increased sensitivity to agonists (TRPA1 R797T), exhibit differential regulation by SRC-tyrosine kinase inhibitor. Bioscience Reports, 34(4), 469-478. https://doi.org/10.1042/BSR20140061

TRPM8 (transient receptor potential M8) and TRPA1 (transient receptor potential A1) are cold-temperature-sensitive nociceptors expressed in sensory neurons but their behaviour in neuronal cells is poorly understood. Therefore DNA expression construct... Read More about Human TRPM8 and TRPA1 pain channels, including a gene variant with increased sensitivity to agonists (TRPA1 R797T), exhibit differential regulation by SRC-tyrosine kinase inhibitor.

Unique responses are observed in transient receptor potential ankyrin 1 and vanilloid 1 (TRPA1 and TRPV1) co-expressing cells (2014)
Journal Article
Sadofsky, L. R., Sreekrishna, K. T., Lin, Y., Schinaman, R., Gorka, K., Mantri, Y., …Morice, A. H. (2014). Unique responses are observed in transient receptor potential ankyrin 1 and vanilloid 1 (TRPA1 and TRPV1) co-expressing cells. Cells, 3(2), 616-626. https://doi.org/10.3390/cells3020616

Transient receptor potential (TRP) ankyrin 1 (TRPA1) and vanilloid 1 (TRPV1) receptors are implicated in modulation of cough and nociception. In vivo, TRPA1 and TRPV1 are often co-expressed in neurons and TRPA1V1 hetero-tetramer formation is noted in... Read More about Unique responses are observed in transient receptor potential ankyrin 1 and vanilloid 1 (TRPA1 and TRPV1) co-expressing cells.

Clinical outcomes and quality of life 5 years after a randomized trial of concomitant or sequential phlebectomy following endovenous laser ablation for varicose veins (2014)
Journal Article
El-Sheikha, J., Nandhra, S., Carradice, D., Wallace, T., Samuel, N., Smith, G., & Chetter, I. C. (2014). Clinical outcomes and quality of life 5 years after a randomized trial of concomitant or sequential phlebectomy following endovenous laser ablation for varicose veins. British journal of surgery, 101(9), 1093-1097. https://doi.org/10.1002/bjs.9565

BackgroundEndovenous laser ablation (EVLA) is a popular treatment for superficial venous insufficiency. Debate continues regarding the optimal management of symptomatic varicose tributaries following ablation of the main saphenous trunk. This randomi... Read More about Clinical outcomes and quality of life 5 years after a randomized trial of concomitant or sequential phlebectomy following endovenous laser ablation for varicose veins.

On the definition of chronic cough and current treatment pathways: An international qualitative study (2014)
Journal Article
Faruqi, S., Murdoch, R. D., Allum, F., & Morice, A. H. (2014). On the definition of chronic cough and current treatment pathways: An international qualitative study. Cough, 10(1), Article 5. https://doi.org/10.1186/1745-9974-10-5

Background: The pathogenesis of chronic cough is not well understood and treatment options are limited. In this study we sought to explore the current understanding and management of chronic cough across an international group of specialists.Methods:... Read More about On the definition of chronic cough and current treatment pathways: An international qualitative study.

Chronicle: results of a randomised phase III trial in locally advanced rectal cancer after neoadjuvant chemoradiation randomising postoperative adjuvant capecitabine plus oxaliplatin (XELOX) versus control (2014)
Journal Article
Glynne-Jones, R., Counsell, N., Quirke, P., Mortensen, N., Maraveyas, A., Meadows, H. M., …Sebag-Montefiore, D. (2014). Chronicle: results of a randomised phase III trial in locally advanced rectal cancer after neoadjuvant chemoradiation randomising postoperative adjuvant capecitabine plus oxaliplatin (XELOX) versus control. Annals of oncology : official journal of the European Society for Medical Oncology / ESMO, 25(7), 1356-1362. https://doi.org/10.1093/annonc/mdu147

Background: In stage III colon cancer, oxaliplatin/5-fluorouracil (5-FU)-based adjuvant chemotherapy (FOLFOX) improves disease-free survival (DFS) and overall survival (OS). In rectal adenocarcinoma following neoadjuvant chemoradiation (CRT), we exam... Read More about Chronicle: results of a randomised phase III trial in locally advanced rectal cancer after neoadjuvant chemoradiation randomising postoperative adjuvant capecitabine plus oxaliplatin (XELOX) versus control.

Antitussive drugs-past, present, and future (2014)
Journal Article
Dicpinigaitis, P. V., Morice, A. H., Birring, S. S., McGarvey, L., Smith, J. A., Canning, B. J., & Page, C. P. (2014). Antitussive drugs-past, present, and future. Pharmacological Reviews, 66(2), 468-512. https://doi.org/10.1124/pr.111.005116

Cough remains a serious unmet clinical problem, both as a symptom of a range of other conditions such as asthma, chronic obstructive pulmonary disease, gastroesophageal reflux, and as a problem in its own right in patients with chronic cough of unkno... Read More about Antitussive drugs-past, present, and future.

Electrical stimulation vs. standard care for chronic ulcer healing: a systematic review and meta-analysis of randomised controlled trials (2014)
Journal Article
Barnes, R., Shahin, Y., Gohil, R., & Chetter, I. (2014). Electrical stimulation vs. standard care for chronic ulcer healing: a systematic review and meta-analysis of randomised controlled trials. European Journal of Clinical Investigation, 44(4), 429-440. https://doi.org/10.1111/eci.12244

Background We conducted a systematic review to investigate the effect of electrical stimulation on ulcer healing compared to usual treatment and/or sham stimulation. This systematic review also aimed to investigate the effect of different types of... Read More about Electrical stimulation vs. standard care for chronic ulcer healing: a systematic review and meta-analysis of randomised controlled trials.

Randomized clinical trial of selective versus routine preoperative duplex ultrasound imaging before arteriovenous fistula surgery: Duplex imaging before arteriovenous fistula surgery (2014)
Journal Article
Barnes, R., Chetter, I. C., & Smith, G. E. (2014). Randomized clinical trial of selective versus routine preoperative duplex ultrasound imaging before arteriovenous fistula surgery: Duplex imaging before arteriovenous fistula surgery. British journal of surgery, 101(5), 469-474. https://doi.org/10.1002/bjs.9435

BackgroundAnatomical suitability for arteriovenous fistula (AVF) formation was formerly determined by clinical examination alone. There are potential benefits from imaging to assess anatomical suitability. Existing studies examined the role of routin... Read More about Randomized clinical trial of selective versus routine preoperative duplex ultrasound imaging before arteriovenous fistula surgery: Duplex imaging before arteriovenous fistula surgery.

Effect of supervised exercise on physical function and balance in patients with intermittent claudication (2014)
Journal Article
Mockford, K. A., Gohil, R. A., Mazari, F., Khan, J. A., Vanicek, N., Coughlin, P. A., & Chetter, I. C. (2014). Effect of supervised exercise on physical function and balance in patients with intermittent claudication. British journal of surgery, 101(4), 356-362. https://doi.org/10.1002/bjs.9402

Background The aim of the study was to identify whether a standard supervised exercise programme (SEP) for patients with intermittent claudication improved specific measures of functional performance including balance. Methods A prospective observati... Read More about Effect of supervised exercise on physical function and balance in patients with intermittent claudication.

The effect of deep hypothermia on the human pulmonary circulation (2014)
Journal Article
Ariyaratnam, P., Loubani, M., Cale, A. R., Chaudhry, M., Cowen, M. E., Jarvis, M. A., …Morice, A. H. (2014). The effect of deep hypothermia on the human pulmonary circulation. Journal of Thermal Biology, 40(1), 20-24. https://doi.org/10.1016/j.jtherbio.2014.01.001

Objective: Acute rises in pulmonary artery pressures following complex cardiac surgery are associated with high morbidity and mortality. We hypothesised that periods of deep hypothermia predispose to elevated pulmonary pressures upon rewarming. We in... Read More about The effect of deep hypothermia on the human pulmonary circulation.

Increased platelet binding to circulating monocytes in idiopathic pulmonary fibrosis. (2014)
Journal Article
Fahim, A., Crooks, M. G., Morice, A. H., & Hart, S. P. (2014). Increased platelet binding to circulating monocytes in idiopathic pulmonary fibrosis. Lung, 192(2), 277-284. https://doi.org/10.1007/s00408-013-9546-5

Purpose Idiopathic pulmonary fibrosis (IPF) is the most common idiopathic interstitial pneumonia and its prognosis is poor. Epidemiological evidence suggests an association of IPF with vascular disease and thrombotic tendency, which may be related to... Read More about Increased platelet binding to circulating monocytes in idiopathic pulmonary fibrosis..